UniProtKB - Q9R1C7 (PR40A_MOUSE)

BLAST

>sp|Q9R1C7|PR40A_MOUSE Pre-mRNA-processing factor 40 homolog A OS=Mus musculus OX=10090 GN=Prpf40a PE=1 SV=1
MRPGTGAERGGLMVSEMESQPPSRGPGDGERRLSGSNLCSSSWVSADGFLRRRPSMGHPG
MHYAPMGMHPMGQRANMPPVPHGMMPQMMPPMGGPPMGQMPGMMSSVMSGMMMSHMSQAS
MQPALPPGVNSMDVAAGAASGAKSMWTEHKSPDGRTYYYNTETKQSTWEKPDDLKTPAEQ
LLSKCPWKEYKSDSGKPYYYNSQTKESRWAKPKELEDLEGYQNTIVAGGLITKSNLHAMI
KAEESSKQEECTTASTAPVPTTEIPTTMSTMAAAEAAAAVVAAAAAAAAAANANTSTTPT
NTVGSVPVAPEPEVTSIVATAVDNENTVTVSTEEQAQLANTTAIQDLSGDISSNTGEEPA
KQETVSDFTPKKEEEESQPAKKTYTWNTKEEAKQAFKELLKEKRVPSNASWEQAMKMIIN
DPRYSALAKLSEKKQAFNAYKVQTEKEEKEEARSKYKEAKESFQRFLENHEKMTSTTRYK
KAEQMFGEMEVWNAISERDRLEIYEDVLFFLSKKEKEQAKQLRKRNWEALKNILDNMANV
TYSTTWSEAQQYLMDNPTFAEDEELQNMDKEDALICFEEHIRALEKEEEEEKQKTLLRER
RRQRKNRESFQIFLDELHEHGQLHSMSSWMELYPTISSDIRFTNMLGQPGSTALDLFKFY
VEDLKARYHDEKKIIKDILKDKGFVVEVNTTFEDFVAIISSTKRSTTLDAGNIKLAFNSL
LEKAEAREREREKEEARKMKRKESAFKSMLKQATPPIELDAVWEDIRERFVKEPAFEDIT
LESERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKRSRSRSGSESDDDDSHSKKK
RQRSESHSASERSSSAESERSYKKSKKHKKKSKKRRHKSDSPESDTEREKDKKEKDRDSE
KDRSRQRSESKHKSPKKKTGKDSGNWDTSGSELSEGELEKRRRTLLEQLDDDQ

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History
Entry version 154 (07 Nov 2018)
Sequence version 1 (01 May 2000)
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Protein

Pre-mRNA-processing factor 40 homolog A

Gene

Prpf40a

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.1 Publication

GO - Molecular functionⁱ

proline-rich region binding
Source: MGI
Inferred from direct assayⁱ
- 17915251
RNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell migration Source: UniProtKB
cytoskeleton organization Source: UniProtKB
mRNA splicing, via spliceosome
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cell shape Source: UniProtKB
regulation of cytokinesis Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing

Biological process

mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-MMU-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pre-mRNA-processing factor 40 homolog A Alternative name(s): Formin-binding protein 11 Short name: FBP-11 Formin-binding protein 3
Gene namesⁱ	Name:Prpf40a Synonyms:Fbp11, Fnbp3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1860512 Prpf40a

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076086	1 – 953	Pre-mRNA-processing factor 40 homolog AAdd BLAST		953

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	9	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	34	PhosphoserineCombined sources	1
Modified residueⁱ	151	PhosphoserineBy similarity	1
Cross-linkⁱ	191	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	196	N6-acetyllysineCombined sources	1
Cross-linkⁱ	241	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	341	PhosphothreonineBy similarity	1
Modified residueⁱ	369	PhosphothreonineBy similarity	1
Cross-linkⁱ	371	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	372	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	719	PhosphoserineBy similarity	1
Modified residueⁱ	783	PhosphoserineBy similarity	1
Modified residueⁱ	879	PhosphoserineBy similarity	1
Modified residueⁱ	881	PhosphoserineBy similarity	1
Modified residueⁱ	884	PhosphoserineBy similarity	1
Modified residueⁱ	928	PhosphothreonineCombined sources	1
Modified residueⁱ	929	PhosphoserineCombined sources	1
Modified residueⁱ	931	PhosphoserineCombined sources	1
Modified residueⁱ	934	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9R1C7
PaxDbⁱ	Q9R1C7
PeptideAtlas More...PeptideAtlasⁱ	Q9R1C7
PRIDEⁱ	Q9R1C7

PTM databases

iPTMnetⁱ	Q9R1C7
PhosphoSitePlusⁱ	Q9R1C7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000061136 Expressed in 298 organ(s), highest expression level in testis
ExpressionAtlasⁱ	Q9R1C7 baseline and differential
Genevisibleⁱ	Q9R1C7 MM

Interactionⁱ

Subunit structureⁱ

Interacts with the N-terminus of HTT and with the phosphorylated C-terminal domain of POLR2A (By similarity). Interacts with AKAP8L, SF1, SRPK1, CARD8, ATBF1 and MECP2. Interacts through the WW domains with formin proline-rich regions and with WASL/N-WASP.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AKAP8L	Q9ULX6	3	EBI-645554,EBI-357530	From Homo sapiens.

With

Entry

#Exp.

IntAct

Notes

AKAP8L

Q9ULX6

EBI-645554,EBI-357530

From Homo sapiens.

GO - Molecular functionⁱ

proline-rich region binding
Source: MGI
Inferred from direct assayⁱ
- 17915251

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	207833, 7 interactors
ELMⁱ	Q9R1C7
IntActⁱ	Q9R1C7, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q9R1C7
STRINGⁱ	10090.ENSMUSP00000075655

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9R1C7
SMRⁱ	Q9R1C7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	140 – 173	WW 1PROSITE-ProRule annotationAdd BLAST	34
Domainⁱ	181 – 214	WW 2PROSITE-ProRule annotationAdd BLAST	34
Domainⁱ	389 – 443	FF 1Add BLAST	55
Domainⁱ	456 – 510	FF 2Add BLAST	55
Domainⁱ	523 – 583	FF 3Add BLAST	61
Domainⁱ	603 – 663	FF 4Add BLAST	61
Domainⁱ	668 – 723	FF 5Add BLAST	56
Domainⁱ	738 – 795	FF 6Add BLAST	58

Domainⁱ

The WW domains are essential for localization to nuclear speckles.

Sequence similaritiesⁱ

Belongs to the PRPF40 family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0152 Eukaryota COG5104 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150980
HOGENOMⁱ	HOG000231802
HOVERGENⁱ	HBG059634
InParanoidⁱ	Q9R1C7
KEGG Orthology (KO) More...KOⁱ	K12821
OMAⁱ	IWEDFIK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06F8
PhylomeDBⁱ	Q9R1C7
TreeFamⁱ	TF318732

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00201 WW, 2 hits
Gene3Dⁱ	1.10.10.440, 5 hits
InterProⁱ	View protein in InterPro IPR002713 FF_domain IPR036517 FF_domain_sf IPR039726 Prp40/Urn1 IPR001202 WW_dom IPR036020 WW_dom_sf
PANTHERⁱ	PTHR11864 PTHR11864, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01846 FF, 5 hits PF00397 WW, 2 hits
SMARTⁱ	View protein in SMART SM00441 FF, 5 hits SM00456 WW, 2 hits
SUPFAMⁱ	SSF51045 SSF51045, 2 hits SSF81698 SSF81698, 5 hits
PROSITEⁱ	View protein in PROSITE PS51676 FF, 6 hits PS01159 WW_DOMAIN_1, 2 hits PS50020 WW_DOMAIN_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9R1C7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPGTGAERG GLMVSEMESQ PPSRGPGDGE RRLSGSNLCS SSWVSADGFL 
        60         70         80         90        100
RRRPSMGHPG MHYAPMGMHP MGQRANMPPV PHGMMPQMMP PMGGPPMGQM 
       110        120        130        140        150
PGMMSSVMSG MMMSHMSQAS MQPALPPGVN SMDVAAGAAS GAKSMWTEHK 
       160        170        180        190        200
SPDGRTYYYN TETKQSTWEK PDDLKTPAEQ LLSKCPWKEY KSDSGKPYYY 
       210        220        230        240        250
NSQTKESRWA KPKELEDLEG YQNTIVAGGL ITKSNLHAMI KAEESSKQEE 
       260        270        280        290        300
CTTASTAPVP TTEIPTTMST MAAAEAAAAV VAAAAAAAAA ANANTSTTPT 
       310        320        330        340        350
NTVGSVPVAP EPEVTSIVAT AVDNENTVTV STEEQAQLAN TTAIQDLSGD 
       360        370        380        390        400
ISSNTGEEPA KQETVSDFTP KKEEEESQPA KKTYTWNTKE EAKQAFKELL 
       410        420        430        440        450
KEKRVPSNAS WEQAMKMIIN DPRYSALAKL SEKKQAFNAY KVQTEKEEKE 
       460        470        480        490        500
EARSKYKEAK ESFQRFLENH EKMTSTTRYK KAEQMFGEME VWNAISERDR 
       510        520        530        540        550
LEIYEDVLFF LSKKEKEQAK QLRKRNWEAL KNILDNMANV TYSTTWSEAQ 
       560        570        580        590        600
QYLMDNPTFA EDEELQNMDK EDALICFEEH IRALEKEEEE EKQKTLLRER 
       610        620        630        640        650
RRQRKNRESF QIFLDELHEH GQLHSMSSWM ELYPTISSDI RFTNMLGQPG 
       660        670        680        690        700
STALDLFKFY VEDLKARYHD EKKIIKDILK DKGFVVEVNT TFEDFVAIIS 
       710        720        730        740        750
STKRSTTLDA GNIKLAFNSL LEKAEARERE REKEEARKMK RKESAFKSML 
       760        770        780        790        800
KQATPPIELD AVWEDIRERF VKEPAFEDIT LESERKRIFK DFMHVLEHEC 
       810        820        830        840        850
QHHHSKNKKH SKKSKKHHRK RSRSRSGSES DDDDSHSKKK RQRSESHSAS 
       860        870        880        890        900
ERSSSAESER SYKKSKKHKK KSKKRRHKSD SPESDTEREK DKKEKDRDSE 
       910        920        930        940        950
KDRSRQRSES KHKSPKKKTG KDSGNWDTSG SELSEGELEK RRRTLLEQLD 

DDQ

Length:953

Mass (Da):108,481

Last modified:May 1, 2000 - v1

Checksum:ⁱ3C627AB7404D2285

Isoform 2 (identifier: Q9R1C7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
14-55: Missing.

« Hide

        10         20         30         40         50
MRPGTGAERG GLMMGHPGMH YAPMGMHPMG QRANMPPVPH GMMPQMMPPM 
        60         70         80         90        100
GGPPMGQMPG MMSSVMSGMM MSHMSQASMQ PALPPGVNSM DVAAGAASGA 
       110        120        130        140        150
KSMWTEHKSP DGRTYYYNTE TKQSTWEKPD DLKTPAEQLL SKCPWKEYKS 
       160        170        180        190        200
DSGKPYYYNS QTKESRWAKP KELEDLEGYQ NTIVAGGLIT KSNLHAMIKA 
       210        220        230        240        250
EESSKQEECT TASTAPVPTT EIPTTMSTMA AAEAAAAVVA AAAAAAAAAN 
       260        270        280        290        300
ANTSTTPTNT VGSVPVAPEP EVTSIVATAV DNENTVTVST EEQAQLANTT 
       310        320        330        340        350
AIQDLSGDIS SNTGEEPAKQ ETVSDFTPKK EEEESQPAKK TYTWNTKEEA 
       360        370        380        390        400
KQAFKELLKE KRVPSNASWE QAMKMIINDP RYSALAKLSE KKQAFNAYKV 
       410        420        430        440        450
QTEKEEKEEA RSKYKEAKES FQRFLENHEK MTSTTRYKKA EQMFGEMEVW 
       460        470        480        490        500
NAISERDRLE IYEDVLFFLS KKEKEQAKQL RKRNWEALKN ILDNMANVTY 
       510        520        530        540        550
STTWSEAQQY LMDNPTFAED EELQNMDKED ALICFEEHIR ALEKEEEEEK 
       560        570        580        590        600
QKTLLRERRR QRKNRESFQI FLDELHEHGQ LHSMSSWMEL YPTISSDIRF 
       610        620        630        640        650
TNMLGQPGST ALDLFKFYVE DLKARYHDEK KIIKDILKDK GFVVEVNTTF 
       660        670        680        690        700
EDFVAIISST KRSTTLDAGN IKLAFNSLLE KAEARERERE KEEARKMKRK 
       710        720        730        740        750
ESAFKSMLKQ ATPPIELDAV WEDIRERFVK EPAFEDITLE SERKRIFKDF 
       760        770        780        790        800
MHVLEHECQH HHSKNKKHSK KSKKHHRKRS RSRSGSESDD DDSHSKKKRQ 
       810        820        830        840        850
RSESHSASER SSSAESERSY KKSKKHKKKS KKRRHKSDSP ESDTEREKDK 
       860        870        880        890        900
KEKDRDSEKD RSRQRSESKH KSPKKKTGKD SGNWDTSGSE LSEGELEKRR 
       910 
RTLLEQLDDD Q

Note: No experimental confirmation available.

Show »

Length:911

Mass (Da):103,963

Checksum:ⁱ7BE2E454CC5365CA

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A2AQW6	A2AQW6_MOUSE	Pre-mRNA-processing factor 40 homol... Pre-mRNA-processing factor 40 homolog A	Prpf40a	100	Annotation score:
A0A1B0GRU8	A0A1B0GRU8_MOUSE	Pre-mRNA-processing factor 40 homol... Pre-mRNA-processing factor 40 homolog A	Prpf40a	926	Annotation score:
A0A1B0GSF1	A0A1B0GSF1_MOUSE	Pre-mRNA-processing factor 40 homol... Pre-mRNA-processing factor 40 homolog A	Prpf40a	129	Annotation score:
A0A1B0GT17	A0A1B0GT17_MOUSE	Pre-mRNA-processing factor 40 homol... Pre-mRNA-processing factor 40 homolog A	Prpf40a	84	Annotation score:
A0A1B0GSH6	A0A1B0GSH6_MOUSE	Pre-mRNA-processing factor 40 homol... Pre-mRNA-processing factor 40 homolog A	Prpf40a	87	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	334	E → A in BAC40061 (PubMed:16141072).Curated		1
Sequence conflictⁱ	355	T → I in BAC40061 (PubMed:16141072).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_008049	14 – 55	Missing in isoform 2. 1 PublicationAdd BLAST		42

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF135439 mRNA Translation: AAD39463.1 AK041205 mRNA Translation: BAC30863.1 AK051375 mRNA Translation: BAC34617.1 AK087963 mRNA Translation: BAC40061.2 U40747 mRNA Translation: AAC52475.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16038.1 [Q9R1C7-1]
PIRⁱ	S64713
NCBI Reference Sequences More...RefSeqⁱ	NP_061255.1, NM_018785.2 [Q9R1C7-1]
UniGeneⁱ	Mm.257474 Mm.392945 Mm.393219

Genome annotation databases

Ensemblⁱ	ENSMUST00000076313; ENSMUSP00000075655; ENSMUSG00000061136 [Q9R1C7-1] ENSMUST00000210789; ENSMUSP00000147599; ENSMUSG00000061136 [Q9R1C7-2]
GeneIDⁱ	56194
KEGGⁱ	mmu:56194
UCSC genome browser More...UCSCⁱ	uc008jrk.2 mouse [Q9R1C7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9R1C7	Pre-mRNA-processing factor 40 homolog A	)	HUMAN		957	UniRef90_O75400
pre-mRNA-processing factor 40 homolog A isoform X1		Enhydra lutris kenyoni		1040
PRP40 pre-mRNA processing factor 40-like protein A (Fragment)		MUSPF		183
pre-mRNA-processing factor 40 homolog A isoform X1		PHYCD		1039
pre-mRNA-processing factor 40 homolog A isoform X1		DELLE		975
+298

Protein	Similar proteins		Species	Score	Length	Source
Q9R1C7	Pre-mRNA-processing factor 40 homolog A	)	HUMAN		957	UniRef50_O75400
pre-mRNA-processing factor 40 homolog A isoform X1		Enhydra lutris kenyoni		1040
PRP40 pre-mRNA processing factor 40-like protein A (Fragment)		MUSPF		183
pre-mRNA-processing factor 40 homolog A isoform X1		TURTR		1039
pre-mRNA-processing factor 40 homolog A isoform X1		PHYCD		1039
+816

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF135439 mRNA Translation: AAD39463.1 AK041205 mRNA Translation: BAC30863.1 AK051375 mRNA Translation: BAC34617.1 AK087963 mRNA Translation: BAC40061.2 U40747 mRNA Translation: AAC52475.1
CCDSⁱ	CCDS16038.1 [Q9R1C7-1]
PIRⁱ	S64713
RefSeqⁱ	NP_061255.1, NM_018785.2 [Q9R1C7-1]
UniGeneⁱ	Mm.257474 Mm.392945 Mm.393219

3D structure databases

ProteinModelPortalⁱ	Q9R1C7
SMRⁱ	Q9R1C7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	207833, 7 interactors
ELMⁱ	Q9R1C7
IntActⁱ	Q9R1C7, 6 interactors
MINTⁱ	Q9R1C7
STRINGⁱ	10090.ENSMUSP00000075655

PTM databases

iPTMnetⁱ	Q9R1C7
PhosphoSitePlusⁱ	Q9R1C7

Proteomic databases

EPDⁱ	Q9R1C7
PaxDbⁱ	Q9R1C7
PeptideAtlasⁱ	Q9R1C7
PRIDEⁱ	Q9R1C7

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	56194
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000076313; ENSMUSP00000075655; ENSMUSG00000061136 [Q9R1C7-1] ENSMUST00000210789; ENSMUSP00000147599; ENSMUSG00000061136 [Q9R1C7-2]
GeneIDⁱ	56194
KEGGⁱ	mmu:56194
UCSCⁱ	uc008jrk.2 mouse [Q9R1C7-1]

Organism-specific databases

CTDⁱ	55660
MGIⁱ	MGI:1860512 Prpf40a

Phylogenomic databases

eggNOGⁱ	KOG0152 Eukaryota COG5104 LUCA
GeneTreeⁱ	ENSGT00930000150980
HOGENOMⁱ	HOG000231802
HOVERGENⁱ	HBG059634
InParanoidⁱ	Q9R1C7
KOⁱ	K12821
OMAⁱ	IWEDFIK
OrthoDBⁱ	EOG091G06F8
PhylomeDBⁱ	Q9R1C7
TreeFamⁱ	TF318732

Enzyme and pathway databases

Reactomeⁱ	R-MMU-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9R1C7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000061136 Expressed in 298 organ(s), highest expression level in testis
ExpressionAtlasⁱ	Q9R1C7 baseline and differential
Genevisibleⁱ	Q9R1C7 MM

Family and domain databases

CDDⁱ	cd00201 WW, 2 hits
Gene3Dⁱ	1.10.10.440, 5 hits
InterProⁱ	View protein in InterPro IPR002713 FF_domain IPR036517 FF_domain_sf IPR039726 Prp40/Urn1 IPR001202 WW_dom IPR036020 WW_dom_sf
PANTHERⁱ	PTHR11864 PTHR11864, 1 hit
Pfamⁱ	View protein in Pfam PF01846 FF, 5 hits PF00397 WW, 2 hits
SMARTⁱ	View protein in SMART SM00441 FF, 5 hits SM00456 WW, 2 hits
SUPFAMⁱ	SSF51045 SSF51045, 2 hits SSF81698 SSF81698, 5 hits
PROSITEⁱ	View protein in PROSITE PS51676 FF, 6 hits PS01159 WW_DOMAIN_1, 2 hits PS50020 WW_DOMAIN_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PR40A_MOUSE
Accessionⁱ	Q9R1C7Primary (citable) accession number: Q9R1C7 Secondary accession number(s): Q61049 , Q8BQ76, Q8BRW4, Q8C2U1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9R1C7 (PR40A_MOUSE)

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Pre-mRNA-processing factor 40 homolog A

Prpf40a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ