UniProtKB - Q9R1C0 (TAF7_MOUSE)
Transcription initiation factor TFIID subunit 7
Taf7
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: Ensembl
- H3K27me3 modified histone binding Source: Ensembl
- histone acetyltransferase binding Source: UniProtKB
- protein heterodimerization activity Source: MGI
- P-TEFb complex binding Source: MGI
- TFIIH-class transcription factor complex binding Source: MGI
- thyroid hormone receptor binding Source: MGI
- transcription coactivator activity Source: MGI
- transcription factor binding Source: MGI
- transcription regulatory region DNA binding Source: MGI
- vitamin D receptor binding Source: MGI
GO - Biological processi
- DNA-templated transcription, initiation Source: MGI
- intracellular estrogen receptor signaling pathway Source: MGI
- negative regulation of histone acetylation Source: MGI
- negative regulation of protein kinase activity Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- RNA polymerase II preinitiation complex assembly Source: GO_Central
- transcription by RNA polymerase II Source: MGI
- transcription initiation from RNA polymerase II promoter Source: MGI
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-674695 RNA Polymerase II Pre-transcription Events R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation R-MMU-73776 RNA Polymerase II Promoter Escape R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-MMU-75953 RNA Polymerase II Transcription Initiation R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor TFIID subunit 7Alternative name(s): RNA polymerase II TBP-associated factor subunit F Transcription initiation factor TFIID 55 kDa subunit Short name: TAF(II)55 Short name: TAFII-55 Short name: TAFII551 Publication |
Gene namesi | Name:Taf7 Synonyms:Taf2f |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1346348 Taf7 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Golgi apparatus
- Golgi apparatus Source: MGI
Nucleus
- MLL1 complex Source: UniProtKB
- nucleoplasm Source: MGI
- nucleus Source: MGI
- transcription factor TFIID complex Source: MGI
- transcription factor TFTC complex Source: MGI
Other locations
- cytoplasm Source: MGI
- transcription factor complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118882 | 1 – 341 | Transcription initiation factor TFIID subunit 7Add BLAST | 341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 171 | PhosphoserineCombined sources | 1 | |
Modified residuei | 200 | PhosphoserineBy similarity | 1 | |
Modified residuei | 201 | PhosphoserineBy similarity | 1 | |
Modified residuei | 213 | PhosphoserineBy similarity | 1 | |
Modified residuei | 256 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9R1C0 |
MaxQBi | Q9R1C0 |
PaxDbi | Q9R1C0 |
PeptideAtlasi | Q9R1C0 |
PRIDEi | Q9R1C0 |
PTM databases
iPTMneti | Q9R1C0 |
PhosphoSitePlusi | Q9R1C0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000051316 Expressed in 239 organ(s), highest expression level in placenta |
Genevisiblei | Q9R1C0 MM |
Interactioni
Subunit structurei
TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) (PubMed:10438527).
Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13.
Interacts with TAF1; the interaction is direct (By similarity).
Interacts with TAFII250, TAFII100, TAFII28, TAFII20, and TAFII18, but not with TAFII30 or TBP (PubMed:10438527).
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Binds to CIITA and TAF1 and inhibits their acetyltransferase activity, thereby repressing activated transcription and behaving as a repressor at these promoters (By similarity).
By similarity1 PublicationGO - Molecular functioni
- H3K27me3 modified histone binding Source: Ensembl
- histone acetyltransferase binding Source: UniProtKB
- protein heterodimerization activity Source: MGI
- TFIIH-class transcription factor complex binding Source: MGI
- thyroid hormone receptor binding Source: MGI
- transcription factor binding Source: MGI
- vitamin D receptor binding Source: MGI
Protein-protein interaction databases
BioGridi | 204884, 1 interactor |
ComplexPortali | CPX-916 TFTC histone acetylation complex CPX-932 General transcription factor complex TFIID CPX-959 General transcription factor complex TFIID, Taf4b variant |
CORUMi | Q9R1C0 |
IntActi | Q9R1C0, 1 interactor |
STRINGi | 10090.ENSMUSP00000065645 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 236 – 341 | Sequence analysisAdd BLAST | 106 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 3 – 5 | [KR]-[STA]-K motif | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4011 Eukaryota COG5414 LUCA |
GeneTreei | ENSGT00940000160861 |
HOGENOMi | HOG000035121 |
InParanoidi | Q9R1C0 |
KOi | K03132 |
OMAi | DEFIWPH |
OrthoDBi | 1348389at2759 |
PhylomeDBi | Q9R1C0 |
TreeFami | TF313044 |
Family and domain databases
CDDi | cd08047 TAF7, 1 hit |
InterProi | View protein in InterPro IPR037817 TAF7 IPR006751 TAFII55_prot_cons_reg |
PANTHERi | PTHR12228 PTHR12228, 1 hit |
Pfami | View protein in Pfam PF04658 TAFII55_N, 1 hit |
SMARTi | View protein in SMART SM01370 TAFII55_N, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSKNKDDAPH ELESQFILRL PPEYAATVRR AVQSGHVNLK DKLSIELHPD
60 70 80 90 100
GRHGIVRVDR VPLAAKLVDL PCVTESLKTI DKKTFYKTAD ISQMLVATVD
110 120 130 140 150
GDLYPPVEEA AATADPKANK KKDKDKEKKF VWNHGITLPL KNVRKRRFRK
160 170 180 190 200
TAKKKYIESP DVEKEVKRLL STDAEAVSTR WEIIAEDETK ETENQGLDIS
210 220 230 240 250
SPGMSGHRQG HDSLEHDELR EIFNDLSSSS EDEEDVNILD TEEDLERQLQ
260 270 280 290 300
DKLNESDEQH QENEGTNQLV MGIQKQIDNM KGKLQETQDR AKRQEDLIMK
310 320 330 340
VENLALKNRF QAVLDELKQK EDREKEQLSS LQEELESLLE K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF144562 mRNA Translation: AAD46767.1 AK029380 mRNA Translation: BAC26429.1 AK076362 mRNA Translation: BAC36313.1 BC029673 mRNA Translation: AAH29673.1 |
CCDSi | CCDS29189.1 |
RefSeqi | NP_786964.1, NM_175770.4 |
Genome annotation databases
Ensembli | ENSMUST00000066272; ENSMUSP00000065645; ENSMUSG00000051316 |
GeneIDi | 24074 |
KEGGi | mmu:24074 |
UCSCi | uc008eqi.2 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF144562 mRNA Translation: AAD46767.1 AK029380 mRNA Translation: BAC26429.1 AK076362 mRNA Translation: BAC36313.1 BC029673 mRNA Translation: AAH29673.1 |
CCDSi | CCDS29189.1 |
RefSeqi | NP_786964.1, NM_175770.4 |
3D structure databases
SMRi | Q9R1C0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 204884, 1 interactor |
ComplexPortali | CPX-916 TFTC histone acetylation complex CPX-932 General transcription factor complex TFIID CPX-959 General transcription factor complex TFIID, Taf4b variant |
CORUMi | Q9R1C0 |
IntActi | Q9R1C0, 1 interactor |
STRINGi | 10090.ENSMUSP00000065645 |
PTM databases
iPTMneti | Q9R1C0 |
PhosphoSitePlusi | Q9R1C0 |
Proteomic databases
EPDi | Q9R1C0 |
MaxQBi | Q9R1C0 |
PaxDbi | Q9R1C0 |
PeptideAtlasi | Q9R1C0 |
PRIDEi | Q9R1C0 |
Genome annotation databases
Ensembli | ENSMUST00000066272; ENSMUSP00000065645; ENSMUSG00000051316 |
GeneIDi | 24074 |
KEGGi | mmu:24074 |
UCSCi | uc008eqi.2 mouse |
Organism-specific databases
CTDi | 6879 |
MGIi | MGI:1346348 Taf7 |
Phylogenomic databases
eggNOGi | KOG4011 Eukaryota COG5414 LUCA |
GeneTreei | ENSGT00940000160861 |
HOGENOMi | HOG000035121 |
InParanoidi | Q9R1C0 |
KOi | K03132 |
OMAi | DEFIWPH |
OrthoDBi | 1348389at2759 |
PhylomeDBi | Q9R1C0 |
TreeFami | TF313044 |
Enzyme and pathway databases
Reactomei | R-MMU-674695 RNA Polymerase II Pre-transcription Events R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation R-MMU-73776 RNA Polymerase II Promoter Escape R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-MMU-75953 RNA Polymerase II Transcription Initiation R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance |
Miscellaneous databases
ChiTaRSi | Taf7 mouse |
PROi | PR:Q9R1C0 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000051316 Expressed in 239 organ(s), highest expression level in placenta |
Genevisiblei | Q9R1C0 MM |
Family and domain databases
CDDi | cd08047 TAF7, 1 hit |
InterProi | View protein in InterPro IPR037817 TAF7 IPR006751 TAFII55_prot_cons_reg |
PANTHERi | PTHR12228 PTHR12228, 1 hit |
Pfami | View protein in Pfam PF04658 TAFII55_N, 1 hit |
SMARTi | View protein in SMART SM01370 TAFII55_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAF7_MOUSE | |
Accessioni | Q9R1C0Primary (citable) accession number: Q9R1C0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | October 16, 2019 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot