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Entry version 173 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Slit homolog 2 protein

Gene

Slit2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development, may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system, appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Heparin-binding
Biological processChemotaxis, Differentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-376176 Signaling by ROBO receptors
R-MMU-428890 Role of ABL in ROBO-SLIT signaling
R-MMU-8985586 SLIT2:ROBO1 increases RHOA activity
R-MMU-9010553 Regulation of expression of SLITs and ROBOs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Slit homolog 2 protein
Short name:
Slit-2
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slit2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1315205 Slit2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show significant axon guidance errors in a variety of pathways, including corticofugal, callosal and thalamocortical tracts. Mice double-deficient in SLIT1 and SLIT2 show retinal axon guidance defects and a disorganized lateral olfactory tract (LOT).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000772826 – 1521Slit homolog 2 proteinAdd BLAST1496
ChainiPRO_000000772926 – 1113Slit homolog 2 protein N-productBy similarityAdd BLAST1088
ChainiPRO_00000077301114 – 1521Slit homolog 2 protein C-productBy similarityAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi277 ↔ 286By similarity
Disulfide bondi434 ↔ 457By similarity
Disulfide bondi436 ↔ 478By similarity
Disulfide bondi498 ↔ 504By similarity
Disulfide bondi502 ↔ 511By similarity
Glycosylationi556N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi615N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi660 ↔ 683By similarity
Disulfide bondi662 ↔ 704By similarity
Disulfide bondi719 ↔ 725By similarity
Disulfide bondi723 ↔ 732By similarity
Glycosylationi786N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi791N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi855 ↔ 878By similarity
Disulfide bondi857 ↔ 899By similarity
Disulfide bondi914 ↔ 925By similarity
Disulfide bondi919 ↔ 935By similarity
Disulfide bondi937 ↔ 946By similarity
Disulfide bondi953 ↔ 964By similarity
Disulfide bondi958 ↔ 976By similarity
Disulfide bondi978 ↔ 987By similarity
Disulfide bondi994 ↔ 1005By similarity
Disulfide bondi999 ↔ 1014By similarity
Glycosylationi1001N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1002N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1011N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1016 ↔ 1025By similarity
Disulfide bondi1032 ↔ 1045By similarity
Disulfide bondi1039 ↔ 1054By similarity
Disulfide bondi1056 ↔ 1065By similarity
Disulfide bondi1072 ↔ 1083By similarity
Disulfide bondi1077 ↔ 1092By similarity
Disulfide bondi1094 ↔ 1103By similarity
Disulfide bondi1117 ↔ 1128By similarity
Disulfide bondi1122 ↔ 1137By similarity
Disulfide bondi1139 ↔ 1148By similarity
Glycosylationi1175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1292N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1299 ↔ 1325By similarity
Disulfide bondi1333 ↔ 1338By similarity
Disulfide bondi1350 ↔ 1359By similarity
Disulfide bondi1367 ↔ 1377By similarity
Disulfide bondi1372 ↔ 1387By similarity
Disulfide bondi1389 ↔ 1398By similarity
Disulfide bondi1408 ↔ 1418By similarity
Disulfide bondi1413 ↔ 1428By similarity
Disulfide bondi1430 ↔ 1439By similarity
Disulfide bondi1445 ↔ 1484By similarity
Disulfide bondi1463 ↔ 1498By similarity
Disulfide bondi1474 ↔ 1514By similarity
Disulfide bondi1478 ↔ 1516By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1113 – 1114CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9R1B9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R1B9

PRoteomics IDEntifications database

More...
PRIDEi
Q9R1B9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9R1B9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9R1B9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in developing eye, in the optic stalk, and in the ventral diencephalon.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

According to PubMed:10864955 is expressed during retinal development by 14.5 dpc throughout the RGC layer, and is clearly restricted to the inner nuclear layer at 17.5 dpc. In the developing optic chiasm is strongly expressed at 12.5 dpc at the ventral midline of the diencephalon in the region in which the RGC axons enter the brain and turn to grow ventrally, the region expression includes the position of the glial knot. At 14.5 dpc expression is maintained at the ventral midline of the diencephalon, in a region directly dorsal to the site of axon divergence. Outside the developing brain. According to PubMed:10433822 prominently expressed in neural and mesodermally derived tissues. From 8.5 dpc to 9.5 dpc expressed strongly in the roof plate, floor plate, and notochord. Beginning at 10.5 dpc intense expression is also observed in the motor columns. By 13.5 dpc the expression decreased in the roof plate but is still retained in the floor plate and motor columns. In the rostral CNS between 8.5 dpc and 9.5 dpc expressed intensely in the dorsal neuroepithelium overlying the hindbrain, in the dorsal midline of the midbrain and forebrain, and in the ventral midbrain region. By 10.5 dpc to 11.5 dpc, additional intense expression is observed in the rhombic lip and the rostral midline. From 13.5 dpc to 17.5 dpc, the expression decreased dorsally and continued to be detected in the ventral mesencephalon and diencephalon. Outside neuronal development expressed between 8.5 dpc and 9.5 dpc in the clefts between the first, the second, and the third branchial arches. From 10.5 dpc to 11.5 dpc, expression is detected in the nasal pit, the developing eye, the otic vesicle, and the visceral grooves. From 13.5 dpc to 17.5 dpc expressed in the developing cochlea (in a pattern consistent with expression in the organ of Corti), in the olfactory epithelium and in the inner neuronal layer of the retina and in the optic nerve. At this stage also expressed in the tongue, in the tooth primordium, and in the outer root sheath of the whisker follicle in the layer surrounding the bulb. At 11.5 dpc is intensely expressed in the rostral lateral ridge flanking the forelimb buds and in lateral ridge tissue between the fore- and the hindlimb buds. Weak expression is observed in a segmented pattern in the posterior part of the sclerotome. Expression is notably absent in the base of the limb buds and weak expression is observed in the interdigital regions of the distal limb bud beginning at 11.5 dpc. By 13.5 dpc intensely expressed in interdigital mesenchyme.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031558 Expressed in 359 organ(s), highest expression level in metanephric ureteric bud

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9R1B9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9R1B9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with GREM1 (By similarity). Binds ROBO1 and ROBO2 with high affinity.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
203328, 1 interactor

Database of interacting proteins

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DIPi
DIP-61876N

Protein interaction database and analysis system

More...
IntActi
Q9R1B9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000127615

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 55LRRNTAdd BLAST30
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati56 – 77LRR 1Add BLAST22
Repeati80 – 101LRR 2Add BLAST22
Repeati104 – 125LRR 3Add BLAST22
Repeati128 – 149LRR 4Add BLAST22
Repeati152 – 173LRR 5Add BLAST22
Repeati176 – 197LRR 6Add BLAST22
Domaini209 – 259LRRCT 1Add BLAST51
Domaini264 – 300LRRNT 2Add BLAST37
Repeati301 – 322LRR 7Add BLAST22
Repeati325 – 346LRR 8Add BLAST22
Repeati349 – 370LRR 9Add BLAST22
Repeati373 – 394LRR 10Add BLAST22
Repeati397 – 418LRR 11Add BLAST22
Domaini430 – 480LRRCT 2Add BLAST51
Domaini489 – 525LRRNT 3Add BLAST37
Repeati526 – 547LRR 12Add BLAST22
Repeati551 – 572LRR 13Add BLAST22
Repeati575 – 596LRR 14Add BLAST22
Repeati599 – 620LRR 15Add BLAST22
Repeati623 – 644LRR 16Add BLAST22
Domaini656 – 706LRRCT 3Add BLAST51
Domaini710 – 746LRRNT 4Add BLAST37
Repeati747 – 769LRR 17Add BLAST23
Repeati770 – 791LRR 18Add BLAST22
Repeati794 – 815LRR 19Add BLAST22
Repeati818 – 839LRR 20Add BLAST22
Domaini851 – 901LRRCT 4Add BLAST51
Domaini912 – 947EGF-like 1PROSITE-ProRule annotationAdd BLAST36
Domaini949 – 988EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini990 – 1026EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini1028 – 1066EGF-like 4PROSITE-ProRule annotationAdd BLAST39
Domaini1068 – 1104EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini1113 – 1149EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini1152 – 1325Laminin G-likePROSITE-ProRule annotationAdd BLAST174
Domaini1329 – 1360EGF-like 7PROSITE-ProRule annotationAdd BLAST32
Domaini1363 – 1399EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini1404 – 1440EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini1445 – 1520CTCKPROSITE-ProRule annotationAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitro.

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4237 Eukaryota
COG4886 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158402

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9R1B9

KEGG Orthology (KO)

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KOi
K06839

Database of Orthologous Groups

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OrthoDBi
28488at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332887

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR003645 Fol_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 1 hit
PF00054 Laminin_G_1, 1 hit
PF13855 LRR_8, 7 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 6 hits
SM00274 FOLN, 3 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 17 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9R1B9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGIGWQTLS LSLGLVLSIL NKVAPQACPA QCSCSGSTVD CHGLALRSVP
60 70 80 90 100
RNIPRNTERL DLNGNNITRI TKIDFAGLRH LRVLQLMENR ISTIERGAFQ
110 120 130 140 150
DLKELERLRL NRNNLQLFPE LLFLGTAKLY RLDLSENQIQ AIPRKAFRGA
160 170 180 190 200
VDIKNLQLDY NQISCIEDGA FRALRDLEVL TLNNNNITRL SVASFNHMPK
210 220 230 240 250
LRTFRLHSNN LYCDCHLAWL SDWLRQRPRV GLYTQCMGPS HLRGHNVAEV
260 270 280 290 300
QKREFVCSGH QSFMAPSCSV LHCPAACTCS NNIVDCRGKG LTEIPTNLPE
310 320 330 340 350
TITEIRLEQN SIRVIPPGAF SPYKKLRRLD LSNNQISELA PDAFQGLRSL
360 370 380 390 400
NSLVLYGNKI TELPKSLFEG LFSLQLLLLN ANKINCLRVD AFQDLHNLNL
410 420 430 440 450
LSLYDNKLQT VAKGTFSALR AIQTMHLAQN PFICDCHLKW LADYLHTNPI
460 470 480 490 500
ETSGARCTSP RRLANKRIGQ IKSKKFRCSG TEDYRSKLSG DCFADLACPE
510 520 530 540 550
KCRCEGTTVD CSNQRLNKIP DHIPQYTAEL RLNNNEFTVL EATGIFKKLP
560 570 580 590 600
QLRKINFSNN KITDIEEGAF EGASGVNEIL LTSNRLENVQ HKMFKGLESL
610 620 630 640 650
KTLMLRSNRI SCVGNDSFIG LGSVRLLSLY DNQITTVAPG AFDSLHSLST
660 670 680 690 700
LNLLANPFNC NCHLAWLGEW LRRKRIVTGN PRCQKPYFLK EIPIQDVAIQ
710 720 730 740 750
DFTCDDGNDD NSCSPLSRCP SECTCLDTVV RCSNKGLKVL PKGIPKDVTE
760 770 780 790 800
LYLDGNQFTL VPKELSNYKH LTLIDLSNNR ISTLSNQSFS NMTQLLTLIL
810 820 830 840 850
SYNRLRCIPP RTFDGLKSLR LLSLHGNDIS VVPEGAFNDL SALSHLAIGA
860 870 880 890 900
NPLYCDCNMQ WLSDWVKSEY KEPGIARCAG PGEMADKLLL TTPSKKFTCQ
910 920 930 940 950
GPVDITIQAK CNPCLSNPCK NDGTCNNDPV DFYRCTCPYG FKGQDCDVPI
960 970 980 990 1000
HACISNPCKH GGTCHLKEGE NAGFWCTCAD GFEGENCEVN IDDCEDNDCE
1010 1020 1030 1040 1050
NNSTCVDGIN NYTCLCPPEY TGELCEEKLD FCAQDLNPCQ HDSKCILTPK
1060 1070 1080 1090 1100
GFKCDCTPGY IGEHCDIDFD DCQDNKCKNG AHCTDAVNGY TCVCPEGYSG
1110 1120 1130 1140 1150
LFCEFSPPMV LPRTSPCDNF DCQNGAQCII RINEPICQCL PGYLGEKCEK
1160 1170 1180 1190 1200
LVSVNFVNKE SYLQIPSAKV RPQTNITLQI ATDEDSGILL YKGDKDHIAV
1210 1220 1230 1240 1250
ELYRGRVRAS YDTGSHPASA IYSVETINDG NFHIVELLTL DSSLSLSVDG
1260 1270 1280 1290 1300
GSPKVITNLS KQSTLNFDSP LYVGGMPGKN NVASLRQAPG QNGTSFHGCI
1310 1320 1330 1340 1350
RNLYINSELQ DFRKMPMQTG ILPGCEPCHK KVCAHGMCQP SSQSGFTCEC
1360 1370 1380 1390 1400
EEGWMGPLCD QRTNDPCLGN KCVHGTCLPI NAFSYSCKCL EGHGGVLCDE
1410 1420 1430 1440 1450
EEDLFNPCQM IKCKHGKCRL SGVGQPYCEC NSGFTGDSCD REISCRGERI
1460 1470 1480 1490 1500
RDYYQKQQGY AACQTTKKVS RLECRGGCAG GQCCGPLRSK RRKYSFECTD
1510 1520
GSSFVDEVEK VVKCGCARCA S
Length:1,521
Mass (Da):168,783
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DC3626D46FDB711
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UYX7G3UYX7_MOUSE
Slit homolog 2 protein
Slit2
1,542Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UY21G3UY21_MOUSE
Slit homolog 2 protein
Slit2
1,525Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8T2A0A140T8T2_MOUSE
Slit homolog 2 protein
Slit2
1,533Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWQ3G3UWQ3_MOUSE
Slit homolog 2 protein
Slit2
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZW0G3UZW0_MOUSE
Slit homolog 2 protein
Slit2
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3X909G3X909_MOUSE
Slit homolog 2 protein
Slit2
851Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZ61G3UZ61_MOUSE
Slit homolog 2 protein
Slit2
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti73I → T in AAD44759 (PubMed:10433822).Curated1
Sequence conflicti903V → M in AAD04345 (PubMed:10349621).Curated1
Sequence conflicti1277P → S in AAH59267 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF144628 mRNA Translation: AAD44759.1
AC101004 Genomic DNA No translation available.
AC113542 Genomic DNA No translation available.
AC157351 Genomic DNA No translation available.
AF074960 mRNA Translation: AAD04345.1
BC059267 mRNA Translation: AAH59267.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS19280.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T42626

NCBI Reference Sequences

More...
RefSeqi
NP_848919.3, NM_178804.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000173107; ENSMUSP00000133840; ENSMUSG00000031558

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20563

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20563

UCSC genome browser

More...
UCSCi
uc008xjo.3 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144628 mRNA Translation: AAD44759.1
AC101004 Genomic DNA No translation available.
AC113542 Genomic DNA No translation available.
AC157351 Genomic DNA No translation available.
AF074960 mRNA Translation: AAD04345.1
BC059267 mRNA Translation: AAH59267.1
CCDSiCCDS19280.1
PIRiT42626
RefSeqiNP_848919.3, NM_178804.5

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi203328, 1 interactor
DIPiDIP-61876N
IntActiQ9R1B9, 1 interactor
STRINGi10090.ENSMUSP00000127615

PTM databases

iPTMnetiQ9R1B9
PhosphoSitePlusiQ9R1B9

Proteomic databases

MaxQBiQ9R1B9
PaxDbiQ9R1B9
PRIDEiQ9R1B9

Genome annotation databases

EnsembliENSMUST00000173107; ENSMUSP00000133840; ENSMUSG00000031558
GeneIDi20563
KEGGimmu:20563
UCSCiuc008xjo.3 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9353
MGIiMGI:1315205 Slit2

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000158402
InParanoidiQ9R1B9
KOiK06839
OrthoDBi28488at2759
TreeFamiTF332887

Enzyme and pathway databases

ReactomeiR-MMU-376176 Signaling by ROBO receptors
R-MMU-428890 Role of ABL in ROBO-SLIT signaling
R-MMU-8985586 SLIT2:ROBO1 increases RHOA activity
R-MMU-9010553 Regulation of expression of SLITs and ROBOs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Slit2 mouse

Protein Ontology

More...
PROi
PR:Q9R1B9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031558 Expressed in 359 organ(s), highest expression level in metanephric ureteric bud
ExpressionAtlasiQ9R1B9 baseline and differential
GenevisibleiQ9R1B9 MM

Family and domain databases

Gene3Di3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR003645 Fol_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 1 hit
PF00054 Laminin_G_1, 1 hit
PF13855 LRR_8, 7 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 3 hits
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 6 hits
SM00274 FOLN, 3 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 17 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLIT2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R1B9
Secondary accession number(s): E9QKB4, Q9Z166
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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