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Protein

Nuclear receptor subfamily 1 group I member 2

Gene

Nr1i2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244AgonistBy similarity1
Binding sitei285AgonistBy similarity1
Binding sitei296AgonistBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 104Nuclear receptorPROSITE-ProRule annotationAdd BLAST67
Zinc fingeri38 – 58NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri74 – 99NR C4-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 1 group I member 2
Alternative name(s):
Orphan nuclear receptor PXR
Pregnane X receptor
Gene namesi
Name:Nr1i2
Synonyms:Pxr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi69057 Nr1i2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2146315

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535501 – 431Nuclear receptor subfamily 1 group I member 2Add BLAST431

Proteomic databases

PaxDbiQ9R1A7
PRIDEiQ9R1A7

PTM databases

PhosphoSitePlusiQ9R1A7

Expressioni

Gene expression databases

BgeeiENSRNOG00000002906 Expressed in 7 organ(s), highest expression level in liver
GenevisibleiQ9R1A7 RN

Interactioni

Subunit structurei

Heterodimer with RXRA. Interacts with NCOA1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003934

Chemistry databases

BindingDBiQ9R1A7

Structurei

3D structure databases

ProteinModelPortaliQ9R1A7
SMRiQ9R1A7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 430NR LBDPROSITE-ProRule annotationAdd BLAST288

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 142HingeAdd BLAST38

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi63 – 89Bipartite nuclear localization signalBy similarityAdd BLAST27

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 58NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri74 – 99NR C4-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000220844
HOVERGENiHBG108655
InParanoidiQ9R1A7
KOiK08540
OMAiANGYHFN
OrthoDBiEOG091G05X3
PhylomeDBiQ9R1A7
TreeFamiTF316304

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R1A7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPEERWNHV GLVQREEADS VLEEPINVDE EDGGLQICRV CGDKANGYHF
60 70 80 90 100
NVMTCEGCKG FFRRAMKRNV RLRCPFRKGT CEITRKTRRQ CQACRLRKCL
110 120 130 140 150
ESGMKKEMIM SDAAVEQRRA LIKRKKREKI EAPPPGGQGL TEEQQALIQE
160 170 180 190 200
LMDAQMQTFD TTFSHFKDFR LPAVFHSDCE LPEVLQASLL EDPATWSQIM
210 220 230 240 250
KDSVPMKISV QLRGEDGSIW NYQPPSKSDG KEIIPLLPHL ADVSTYMFKG
260 270 280 290 300
VINFAKVISH FRELPIEDQI SLLKGATFEM CILRFNTMFD TETGTWECGR
310 320 330 340 350
LAYCFEDPNG GFQKLLLDPL MKFHCMLKKL QLREEEYVLM QAISLFSPDR
360 370 380 390 400
PGVVQRSVVD QLQERFALTL KAYIECSRPY PAHRFLFLKI MAVLTELRSI
410 420 430
NAQQTQQLLR IQDTHPFATP LMQELFSSTD G
Length:431
Mass (Da):49,660
Last modified:May 1, 2000 - v1
Checksum:i4B545F21F9439697
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151377 mRNA Translation: AAD47214.1
RefSeqiNP_443212.1, NM_052980.2
UniGeneiRn.207164

Genome annotation databases

EnsembliENSRNOT00000003934; ENSRNOP00000003934; ENSRNOG00000002906
GeneIDi84385
KEGGirno:84385
UCSCiRGD:69057 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151377 mRNA Translation: AAD47214.1
RefSeqiNP_443212.1, NM_052980.2
UniGeneiRn.207164

3D structure databases

ProteinModelPortaliQ9R1A7
SMRiQ9R1A7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003934

Chemistry databases

BindingDBiQ9R1A7
ChEMBLiCHEMBL2146315

PTM databases

PhosphoSitePlusiQ9R1A7

Proteomic databases

PaxDbiQ9R1A7
PRIDEiQ9R1A7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003934; ENSRNOP00000003934; ENSRNOG00000002906
GeneIDi84385
KEGGirno:84385
UCSCiRGD:69057 rat

Organism-specific databases

CTDi8856
RGDi69057 Nr1i2

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000220844
HOVERGENiHBG108655
InParanoidiQ9R1A7
KOiK08540
OMAiANGYHFN
OrthoDBiEOG091G05X3
PhylomeDBiQ9R1A7
TreeFamiTF316304

Enzyme and pathway databases

ReactomeiR-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors

Miscellaneous databases

PROiPR:Q9R1A7

Gene expression databases

BgeeiENSRNOG00000002906 Expressed in 7 organ(s), highest expression level in liver
GenevisibleiQ9R1A7 RN

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNR1I2_RAT
AccessioniPrimary (citable) accession number: Q9R1A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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