Nr1i2

Functionⁱ

Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	244	AgonistBy similarity	1
Binding siteⁱ	285	AgonistBy similarity	1
Binding siteⁱ	296	AgonistBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	38 – 104	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	67
Zinc fingerⁱ	38 – 58	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	74 – 99	NR C4-typePROSITE-ProRule annotationAdd BLAST	26

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
drug binding Source: UniProtKB
nuclear receptor activity
Source: RGD
Inferred from direct assayⁱ
- 10967130
nuclear receptor transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
steroid hormone receptor activity Source: InterPro
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
drug export Source: UniProtKB
exogenous drug catabolic process Source: UniProtKB
multicellular organism development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transcription, DNA-templated Source: Ensembl
positive regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
xenobiotic metabolic process Source: UniProtKB
xenobiotic transport Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway R-RNO-4090294 SUMOylation of intracellular receptors

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor subfamily 1 group I member 2 Alternative name(s): Orphan nuclear receptor PXR Pregnane X receptor
Gene namesⁱ	Name:Nr1i2 Synonyms:Pxr
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 11

Organism-specific databases

Rat genome database More...RGDⁱ	69057 Nr1i2

RGDⁱ

69057 Nr1i2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2146315

ChEMBLⁱ

CHEMBL2146315

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053550	1 – 431	Nuclear receptor subfamily 1 group I member 2Add BLAST		431

Proteomic databases

PaxDbⁱ	Q9R1A7
PRIDEⁱ	Q9R1A7

PTM databases

PhosphoSitePlusⁱ	Q9R1A7

PhosphoSitePlusⁱ

Q9R1A7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000002906 Expressed in 7 organ(s), highest expression level in liver
Genevisibleⁱ	Q9R1A7 RN

Interactionⁱ

Subunit structureⁱ

Heterodimer with RXRA. Interacts with NCOA1 (By similarity).By similarity

GO - Molecular functionⁱ

transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000003934

STRINGⁱ

10116.ENSRNOP00000003934

Chemistry databases

BindingDBⁱ

Q9R1A7

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9R1A7
SMRⁱ	Q9R1A7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	143 – 430	NR LBDPROSITE-ProRule annotationAdd BLAST		288

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	105 – 142	HingeAdd BLAST		38

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	63 – 89	Bipartite nuclear localization signalBy similarityAdd BLAST		27

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR1 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	38 – 58	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	74 – 99	NR C4-typePROSITE-ProRule annotationAdd BLAST		26

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136372
HOGENOMⁱ	HOG000220844
HOVERGENⁱ	HBG108655
InParanoidⁱ	Q9R1A7
KEGG Orthology (KO) More...KOⁱ	K08540
OMAⁱ	ANGYHFN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05X3
PhylomeDBⁱ	Q9R1A7
TreeFamⁱ	TF316304

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9R1A7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRPEERWNHV GLVQREEADS VLEEPINVDE EDGGLQICRV CGDKANGYHF 
        60         70         80         90        100
NVMTCEGCKG FFRRAMKRNV RLRCPFRKGT CEITRKTRRQ CQACRLRKCL 
       110        120        130        140        150
ESGMKKEMIM SDAAVEQRRA LIKRKKREKI EAPPPGGQGL TEEQQALIQE 
       160        170        180        190        200
LMDAQMQTFD TTFSHFKDFR LPAVFHSDCE LPEVLQASLL EDPATWSQIM 
       210        220        230        240        250
KDSVPMKISV QLRGEDGSIW NYQPPSKSDG KEIIPLLPHL ADVSTYMFKG 
       260        270        280        290        300
VINFAKVISH FRELPIEDQI SLLKGATFEM CILRFNTMFD TETGTWECGR 
       310        320        330        340        350
LAYCFEDPNG GFQKLLLDPL MKFHCMLKKL QLREEEYVLM QAISLFSPDR 
       360        370        380        390        400
PGVVQRSVVD QLQERFALTL KAYIECSRPY PAHRFLFLKI MAVLTELRSI 
       410        420        430 
NAQQTQQLLR IQDTHPFATP LMQELFSSTD G

Length:431

Mass (Da):49,660

Last modified:May 1, 2000 - v1

Checksum:ⁱ4B545F21F9439697

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151377 mRNA Translation: AAD47214.1
NCBI Reference Sequences More...RefSeqⁱ	NP_443212.1, NM_052980.2
UniGeneⁱ	Rn.207164

Genome annotation databases

Ensemblⁱ	ENSRNOT00000003934; ENSRNOP00000003934; ENSRNOG00000002906
GeneIDⁱ	84385
KEGGⁱ	rno:84385
UCSC genome browser More...UCSCⁱ	RGD:69057 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9R1A7	Nuclear receptor subfamily 1 group I member 2		MOUSE		431	UniRef90_O54915
nuclear receptor subfamily 1 group I member 2		MESAU		432
Nuclear receptor subfamily 1 group I member 2		CRIGR		432
UPI00038C2B8D		MICOH		456
UPI00042AA720		PERMB		432
+5

Protein	Similar proteins		Species	Score	Length	Source
Q9R1A7	Nuclear receptor subfamily 1 group I member 2		MOUSE		431	UniRef50_O54915
nuclear receptor subfamily 1 group I member 2		MESAU		432
Nuclear receptor subfamily 1 group I member 2		CRIGR		432
Nuclear receptor subfamily 1 group I member 2		SAIBB		475
LOW QUALITY PROTEIN: nuclear receptor subfamily 1 group I member 2		DELLE		414
+50

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151377 mRNA Translation: AAD47214.1
RefSeqⁱ	NP_443212.1, NM_052980.2
UniGeneⁱ	Rn.207164

3D structure databases

ProteinModelPortalⁱ	Q9R1A7
SMRⁱ	Q9R1A7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000003934

STRINGⁱ

10116.ENSRNOP00000003934

Chemistry databases

BindingDBⁱ	Q9R1A7
ChEMBLⁱ	CHEMBL2146315

PTM databases

PhosphoSitePlusⁱ	Q9R1A7

PhosphoSitePlusⁱ

Q9R1A7

Proteomic databases

PaxDbⁱ	Q9R1A7
PRIDEⁱ	Q9R1A7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000003934; ENSRNOP00000003934; ENSRNOG00000002906
GeneIDⁱ	84385
KEGGⁱ	rno:84385
UCSCⁱ	RGD:69057 rat

Organism-specific databases

CTDⁱ	8856
RGDⁱ	69057 Nr1i2

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00870000136372
HOGENOMⁱ	HOG000220844
HOVERGENⁱ	HBG108655
InParanoidⁱ	Q9R1A7
KOⁱ	K08540
OMAⁱ	ANGYHFN
OrthoDBⁱ	EOG091G05X3
PhylomeDBⁱ	Q9R1A7
TreeFamⁱ	TF316304

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway R-RNO-4090294 SUMOylation of intracellular receptors

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9R1A7

PROⁱ

PR:Q9R1A7

Gene expression databases

Bgeeⁱ	ENSRNOG00000002906 Expressed in 7 organ(s), highest expression level in liver
Genevisibleⁱ	Q9R1A7 RN

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NR1I2_RAT
Accessionⁱ	Q9R1A7Primary (citable) accession number: Q9R1A7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - Q9R1A7 (NR1I2_RAT)

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Nuclear receptor subfamily 1 group I member 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ