UniProtKB - Q9R190 (MTA2_MOUSE)
Protein
Metastasis-associated protein MTA2
Gene
Mta2
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 367 – 394 | GATA-type; atypicalAdd BLAST | 28 |
GO - Molecular functioni
- chromatin binding Source: InterPro
- histone deacetylase activity Source: MGI
- histone deacetylase binding Source: MGI
- RNA polymerase II repressing transcription factor binding Source: MGI
- RNA polymerase II transcription factor binding Source: MGI
- sequence-specific DNA binding Source: InterPro
- transcription coactivator activity Source: GO_Central
- transcription coregulator activity Source: UniProtKB
- transcription corepressor activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- chromatin remodeling Source: MGI
- DNA methylation Source: MGI
- DNA packaging Source: MGI
- histone deacetylation Source: GO_Central
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of fibroblast migration Source: MGI
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-3214815, HDACs deacetylate histones R-MMU-6804758, Regulation of TP53 Activity through Acetylation R-MMU-73762, RNA Polymerase I Transcription Initiation R-MMU-8943724, Regulation of PTEN gene transcription |
Names & Taxonomyi
Protein namesi | Recommended name: Metastasis-associated protein MTA2Alternative name(s): Metastasis-associated 1-like 1 |
Gene namesi | Name:Mta2 Synonyms:Mta1l1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1346340, Mta2 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- histone deacetylase complex Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
- NuRD complex Source: MGI
Other locations
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083497 | 1 – 668 | Metastasis-associated protein MTA2Add BLAST | 668 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 52 | PhosphoserineBy similarity | 1 | |
Modified residuei | 54 | PhosphoserineCombined sources | 1 | |
Modified residuei | 152 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 433 | PhosphoserineBy similarity | 1 | |
Modified residuei | 435 | PhosphoserineCombined sources | 1 | |
Modified residuei | 460 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 492 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3); alternateBy similarity | ||
Cross-linki | 492 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 508 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 522 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 531 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 534 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 559 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 595 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9R190 |
jPOSTi | Q9R190 |
MaxQBi | Q9R190 |
PaxDbi | Q9R190 |
PeptideAtlasi | Q9R190 |
PRIDEi | Q9R190 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00128230 |
PTM databases
iPTMneti | Q9R190 |
PhosphoSitePlusi | Q9R190 |
SwissPalmi | Q9R190 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000071646, Expressed in thymus and 297 other tissues |
Genevisiblei | Q9R190, MM |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ9R190
GO - Molecular functioni
- histone deacetylase binding Source: MGI
- RNA polymerase II repressing transcription factor binding Source: MGI
- RNA polymerase II transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204807, 54 interactors |
ComplexPortali | CPX-953, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-954, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q9R190 |
DIPi | DIP-36630N |
IntActi | Q9R190, 48 interactors |
MINTi | Q9R190 |
STRINGi | 10090.ENSMUSP00000093959 |
Miscellaneous databases
RNActi | Q9R190, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 144 | BAHPROSITE-ProRule annotationAdd BLAST | 144 | |
Domaini | 145 – 256 | ELM2PROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 263 – 315 | SANTPROSITE-ProRule annotationAdd BLAST | 53 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 367 – 394 | GATA-type; atypicalAdd BLAST | 28 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3554, Eukaryota |
GeneTreei | ENSGT00950000182752 |
HOGENOMi | CLU_006585_2_0_1 |
InParanoidi | Q9R190 |
OMAi | KPPLMAV |
OrthoDBi | 802091at2759 |
PhylomeDBi | Q9R190 |
TreeFami | TF106444 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR035170, MTA1_R1 IPR037964, MTA2 IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
PANTHERi | PTHR10865, PTHR10865, 1 hit PTHR10865:SF4, PTHR10865:SF4, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit PF17226, MTA_R1, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9R190-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD
60 70 80 90 100
ISSSLNSLAD SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT
110 120 130 140 150
HIRGKCSVTL LNETDILNQY LDKEDCFFYS LVFDPVQKTL LADQGEIRVG
160 170 180 190 200
CKFQAEIPDR LAEGESDNRN QQKMEMKVWD PDNPLTDRQI DQFLVVARAV
210 220 230 240 250
GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR NGYDLAKAMS
260 270 280 290 300
TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL
310 320 330 340 350
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV
360 370 380 390 400
GSKPGMNGAG FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK
410 420 430 440 450
YGGLKTPTQL EGAARGTTEP HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN
460 470 480 490 500
RQTFLLQTTK LTRLARRMCR DLLQPRRAAR RPYAPINANA IKAECSIRLP
510 520 530 540 550
KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT PINRNQLTQN
560 570 580 590 600
RGLGGIMVKR SYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD
610 620 630 640 650
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLMTVRPPVP
660
LPASSHPAST NEPIVLED
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 489 | N → I in BAC40180 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF159259 mRNA Translation: AAD51281.1 AF348083 Genomic DNA Translation: AAL30174.1 AB047977 Genomic DNA Translation: BAB79231.1 AK088158 mRNA Translation: BAC40180.1 AK147099 mRNA Translation: BAE27675.1 AK159979 mRNA Translation: BAE35530.1 BC079847 mRNA Translation: AAH79847.1 |
CCDSi | CCDS29561.1 |
RefSeqi | NP_035972.3, NM_011842.3 |
Genome annotation databases
Ensembli | ENSMUST00000096240; ENSMUSP00000093959; ENSMUSG00000071646 |
GeneIDi | 23942 |
KEGGi | mmu:23942 |
UCSCi | uc008gof.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF159259 mRNA Translation: AAD51281.1 AF348083 Genomic DNA Translation: AAL30174.1 AB047977 Genomic DNA Translation: BAB79231.1 AK088158 mRNA Translation: BAC40180.1 AK147099 mRNA Translation: BAE27675.1 AK159979 mRNA Translation: BAE35530.1 BC079847 mRNA Translation: AAH79847.1 |
CCDSi | CCDS29561.1 |
RefSeqi | NP_035972.3, NM_011842.3 |
3D structure databases
SMRi | Q9R190 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204807, 54 interactors |
ComplexPortali | CPX-953, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-954, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q9R190 |
DIPi | DIP-36630N |
IntActi | Q9R190, 48 interactors |
MINTi | Q9R190 |
STRINGi | 10090.ENSMUSP00000093959 |
PTM databases
iPTMneti | Q9R190 |
PhosphoSitePlusi | Q9R190 |
SwissPalmi | Q9R190 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00128230 |
Proteomic databases
EPDi | Q9R190 |
jPOSTi | Q9R190 |
MaxQBi | Q9R190 |
PaxDbi | Q9R190 |
PeptideAtlasi | Q9R190 |
PRIDEi | Q9R190 |
Protocols and materials databases
Antibodypediai | 1799, 394 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000096240; ENSMUSP00000093959; ENSMUSG00000071646 |
GeneIDi | 23942 |
KEGGi | mmu:23942 |
UCSCi | uc008gof.1, mouse |
Organism-specific databases
CTDi | 9219 |
MGIi | MGI:1346340, Mta2 |
Phylogenomic databases
eggNOGi | KOG3554, Eukaryota |
GeneTreei | ENSGT00950000182752 |
HOGENOMi | CLU_006585_2_0_1 |
InParanoidi | Q9R190 |
OMAi | KPPLMAV |
OrthoDBi | 802091at2759 |
PhylomeDBi | Q9R190 |
TreeFami | TF106444 |
Enzyme and pathway databases
Reactomei | R-MMU-3214815, HDACs deacetylate histones R-MMU-6804758, Regulation of TP53 Activity through Acetylation R-MMU-73762, RNA Polymerase I Transcription Initiation R-MMU-8943724, Regulation of PTEN gene transcription |
Miscellaneous databases
BioGRID-ORCSi | 23942, 4 hits in 21 CRISPR screens |
ChiTaRSi | Mta2, mouse |
PROi | PR:Q9R190 |
RNActi | Q9R190, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000071646, Expressed in thymus and 297 other tissues |
Genevisiblei | Q9R190, MM |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR035170, MTA1_R1 IPR037964, MTA2 IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
PANTHERi | PTHR10865, PTHR10865, 1 hit PTHR10865:SF4, PTHR10865:SF4, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit PF17226, MTA_R1, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTA2_MOUSE | |
Accessioni | Q9R190Primary (citable) accession number: Q9R190 Secondary accession number(s): Q3TVT8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot