Mta2

Functionⁱ

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	367 – 394	GATA-type; atypicalAdd BLAST		28

GO - Molecular functionⁱ

chromatin binding Source: InterPro
histone deacetylase activity
Source: MGI
Inferred from direct assayⁱ
- 10444591
histone deacetylase binding Source: MGI
RNA polymerase II repressing transcription factor binding Source: MGI
RNA polymerase II transcription factor binding Source: MGI
transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription coregulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20636338
transcription corepressor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20636338
transcription regulatory region sequence-specific DNA binding Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin remodeling
Source: MGI
Traceable author statementⁱ
- 14645126
DNA methylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 20720167
DNA packaging
Source: MGI
Traceable author statementⁱ
- 10444591
histone deacetylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 20636338
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 11749719
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 11749719
regulation of fibroblast migration Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3214815 HDACs deacetylate histones R-MMU-6804758 Regulation of TP53 Activity through Acetylation R-MMU-73762 RNA Polymerase I Transcription Initiation R-MMU-8943724 Regulation of PTEN gene transcription

Reactomeⁱ

R-MMU-3214815 HDACs deacetylate histones
R-MMU-6804758 Regulation of TP53 Activity through Acetylation
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Metastasis-associated protein MTA2 Alternative name(s): Metastasis-associated 1-like 1
Gene namesⁱ	Name:Mta2 Synonyms:Mta1l1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:1346340 Mta2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083497	1 – 668	Metastasis-associated protein MTA2Add BLAST		668

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	52	PhosphoserineBy similarity	1
Modified residueⁱ	54	PhosphoserineCombined sources	1
Modified residueⁱ	152	N6-acetyllysineBy similarity	1
Modified residueⁱ	433	PhosphoserineBy similarity	1
Modified residueⁱ	435	PhosphoserineCombined sources	1
Modified residueⁱ	460	N6-acetyllysineCombined sources	1
Cross-linkⁱ	492	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3); alternateBy similarity
Cross-linkⁱ	492	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linkⁱ	508	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	522	N6-acetyllysineCombined sources	1
Modified residueⁱ	531	N6-acetyllysineCombined sources	1
Modified residueⁱ	534	PhosphothreonineBy similarity	1
Cross-linkⁱ	559	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	595	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9R190
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9R190
PaxDbⁱ	Q9R190
PeptideAtlas More...PeptideAtlasⁱ	Q9R190
PRIDEⁱ	Q9R190

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00128230

REPRODUCTION-2DPAGEⁱ

IPI00128230

PTM databases

iPTMnetⁱ	Q9R190
PhosphoSitePlusⁱ	Q9R190
SwissPalmⁱ	Q9R190

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000071646 Expressed in 279 organ(s), highest expression level in thymus
CleanExⁱ	MM_MTA2
Genevisibleⁱ	Q9R190 MM

Interactionⁱ

Subunit structureⁱ

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 (By similarity). Interacts with PIMREG (By similarity). Interacts with NACC2 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Esrrb	Q61539	2	EBI-904134,EBI-2312731
Hdac1	O09106	7	EBI-904134,EBI-301912
Hdac2	P70288	7	EBI-904134,EBI-302251
Nr4a1	P12813	2	EBI-904134,EBI-10896863
Pou5f1	P20263	6	EBI-904134,EBI-1606219
Sall4	Q8BX22	3	EBI-904134,EBI-2312582

GO - Molecular functionⁱ

histone deacetylase binding Source: MGI
RNA polymerase II repressing transcription factor binding Source: MGI
RNA polymerase II transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204807, 50 interactors
ComplexPortalⁱ	CPX-953 MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-954 MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMⁱ	Q9R190
Database of interacting proteins More...DIPⁱ	DIP-36630N
IntActⁱ	Q9R190, 48 interactors
Molecular INTeraction database More...MINTⁱ	Q9R190
STRINGⁱ	10090.ENSMUSP00000093959

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9R190
SMRⁱ	Q9R190
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 144	BAHPROSITE-ProRule annotationAdd BLAST	144
Domainⁱ	145 – 256	ELM2PROSITE-ProRule annotationAdd BLAST	112
Domainⁱ	263 – 315	SANTPROSITE-ProRule annotationAdd BLAST	53

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	367 – 394	GATA-type; atypicalAdd BLAST		28

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3554 Eukaryota ENOG410XSAJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00580000081398
HOGENOMⁱ	HOG000045387
HOVERGENⁱ	HBG002598
InParanoidⁱ	Q9R190
KEGG Orthology (KO) More...KOⁱ	K11660
OMAⁱ	GPPTPIN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04Z4
PhylomeDBⁱ	Q9R190
TreeFamⁱ	TF106444

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00202 ZnF_GATA, 1 hit
InterProⁱ	View protein in InterPro IPR001025 BAH_dom IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR035170 MTA1_R1 IPR037964 MTA2 IPR001005 SANT/Myb IPR017884 SANT_dom IPR000679 Znf_GATA
PANTHERⁱ	PTHR10865:SF4 PTHR10865:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01426 BAH, 1 hit PF01448 ELM2, 1 hit PF00320 GATA, 1 hit PF17226 MTA_R1, 1 hit
SMARTⁱ	View protein in SMART SM00439 BAH, 1 hit SM01189 ELM2, 1 hit SM00717 SANT, 1 hit SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51038 BAH, 1 hit PS51156 ELM2, 1 hit PS51293 SANT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9R190-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD 
        60         70         80         90        100
ISSSLNSLAD SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT 
       110        120        130        140        150
HIRGKCSVTL LNETDILNQY LDKEDCFFYS LVFDPVQKTL LADQGEIRVG 
       160        170        180        190        200
CKFQAEIPDR LAEGESDNRN QQKMEMKVWD PDNPLTDRQI DQFLVVARAV 
       210        220        230        240        250
GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR NGYDLAKAMS 
       260        270        280        290        300
TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL 
       310        320        330        340        350
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV 
       360        370        380        390        400
GSKPGMNGAG FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK 
       410        420        430        440        450
YGGLKTPTQL EGAARGTTEP HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN 
       460        470        480        490        500
RQTFLLQTTK LTRLARRMCR DLLQPRRAAR RPYAPINANA IKAECSIRLP 
       510        520        530        540        550
KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT PINRNQLTQN 
       560        570        580        590        600
RGLGGIMVKR SYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD 
       610        620        630        640        650
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLMTVRPPVP 
       660 
LPASSHPAST NEPIVLED

Length:668

Mass (Da):75,030

Last modified:May 1, 2000 - v1

Checksum:ⁱ88996F779BA6F4D1

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	489	N → I in BAC40180 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF159259 mRNA Translation: AAD51281.1 AF348083 Genomic DNA Translation: AAL30174.1 AB047977 Genomic DNA Translation: BAB79231.1 AK088158 mRNA Translation: BAC40180.1 AK147099 mRNA Translation: BAE27675.1 AK159979 mRNA Translation: BAE35530.1 BC079847 mRNA Translation: AAH79847.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29561.1
NCBI Reference Sequences More...RefSeqⁱ	NP_035972.3, NM_011842.3
UniGeneⁱ	Mm.25339

Genome annotation databases

Ensemblⁱ	ENSMUST00000096240; ENSMUSP00000093959; ENSMUSG00000071646
GeneIDⁱ	23942
KEGGⁱ	mmu:23942
UCSC genome browser More...UCSCⁱ	uc008gof.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9R190	Uncharacterized protein (Fragment)		MOUSE		521	UniRef100_Q9R190
Metastasis-associated MTA1-like protein (Fragment)		Daphnia magna		161
Metastasis-associated MTA1-like protein (Fragment)		Daphnia magna		194
UPI0000475592		MOUSE		449

Protein	Similar proteins		Species	Score	Length	Source
Q9R190	Metastasis-associated protein MTA2		HUMAN		668	UniRef90_O94776
MTA2 isoform 1		PANTR		668
Uncharacterized protein		PANPA		668
Uncharacterized protein (Fragment)		MOUSE		521
Metastasis-associated MTA1-like protein (Fragment)		Daphnia magna		161
+129

Protein	Similar proteins		Species	Score	Length	Source
Q9R190	Metastasis-associated protein MTA2		HUMAN		668	UniRef50_O94776
Metastasis-associated protein MTA3	)	MOUSE		591
Metastasis-associated protein MTA3		BOVIN		590
MTA2 isoform 1		PANTR		668
Uncharacterized protein		PANPA		668
+685

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF159259 mRNA Translation: AAD51281.1 AF348083 Genomic DNA Translation: AAL30174.1 AB047977 Genomic DNA Translation: BAB79231.1 AK088158 mRNA Translation: BAC40180.1 AK147099 mRNA Translation: BAE27675.1 AK159979 mRNA Translation: BAE35530.1 BC079847 mRNA Translation: AAH79847.1
CCDSⁱ	CCDS29561.1
RefSeqⁱ	NP_035972.3, NM_011842.3
UniGeneⁱ	Mm.25339

3D structure databases

ProteinModelPortalⁱ	Q9R190
SMRⁱ	Q9R190
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204807, 50 interactors
ComplexPortalⁱ	CPX-953 MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-954 MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMⁱ	Q9R190
DIPⁱ	DIP-36630N
IntActⁱ	Q9R190, 48 interactors
MINTⁱ	Q9R190
STRINGⁱ	10090.ENSMUSP00000093959

PTM databases

iPTMnetⁱ	Q9R190
PhosphoSitePlusⁱ	Q9R190
SwissPalmⁱ	Q9R190

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00128230

REPRODUCTION-2DPAGEⁱ

IPI00128230

Proteomic databases

EPDⁱ	Q9R190
MaxQBⁱ	Q9R190
PaxDbⁱ	Q9R190
PeptideAtlasⁱ	Q9R190
PRIDEⁱ	Q9R190

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000096240; ENSMUSP00000093959; ENSMUSG00000071646
GeneIDⁱ	23942
KEGGⁱ	mmu:23942
UCSCⁱ	uc008gof.1 mouse

Organism-specific databases

CTDⁱ	9219
MGIⁱ	MGI:1346340 Mta2

Phylogenomic databases

eggNOGⁱ	KOG3554 Eukaryota ENOG410XSAJ LUCA
GeneTreeⁱ	ENSGT00580000081398
HOGENOMⁱ	HOG000045387
HOVERGENⁱ	HBG002598
InParanoidⁱ	Q9R190
KOⁱ	K11660
OMAⁱ	GPPTPIN
OrthoDBⁱ	EOG091G04Z4
PhylomeDBⁱ	Q9R190
TreeFamⁱ	TF106444

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3214815 HDACs deacetylate histones R-MMU-6804758 Regulation of TP53 Activity through Acetylation R-MMU-73762 RNA Polymerase I Transcription Initiation R-MMU-8943724 Regulation of PTEN gene transcription

Reactomeⁱ

R-MMU-3214815 HDACs deacetylate histones
R-MMU-6804758 Regulation of TP53 Activity through Acetylation
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9R190
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000071646 Expressed in 279 organ(s), highest expression level in thymus
CleanExⁱ	MM_MTA2
Genevisibleⁱ	Q9R190 MM

Family and domain databases

CDDⁱ	cd00202 ZnF_GATA, 1 hit
InterProⁱ	View protein in InterPro IPR001025 BAH_dom IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR035170 MTA1_R1 IPR037964 MTA2 IPR001005 SANT/Myb IPR017884 SANT_dom IPR000679 Znf_GATA
PANTHERⁱ	PTHR10865:SF4 PTHR10865:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF01426 BAH, 1 hit PF01448 ELM2, 1 hit PF00320 GATA, 1 hit PF17226 MTA_R1, 1 hit
SMARTⁱ	View protein in SMART SM00439 BAH, 1 hit SM01189 ELM2, 1 hit SM00717 SANT, 1 hit SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51038 BAH, 1 hit PS51156 ELM2, 1 hit PS51293 SANT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MTA2_MOUSE
Accessionⁱ	Q9R190Primary (citable) accession number: Q9R190 Secondary accession number(s): Q3TVT8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9R190 (MTA2_MOUSE)

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Metastasis-associated protein MTA2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ