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Entry version 165 (31 Jul 2019)
Sequence version 2 (01 Mar 2001)
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Protein

Neurogenic locus notch homolog protein 3

Gene

Notch3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, Receptor
Biological processDifferentiation, Notch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1912420 Pre-NOTCH Processing in Golgi
R-RNO-350054 Notch-HLH transcription pathway
R-RNO-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-RNO-9017802 Noncanonical activation of NOTCH3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurogenic locus notch homolog protein 3
Short name:
Notch 3
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Notch3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620761 Notch3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini41 – 1645ExtracellularSequence analysisAdd BLAST1605
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1646 – 1666HelicalSequence analysisAdd BLAST21
Topological domaini1667 – 2319CytoplasmicSequence analysisAdd BLAST653

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 40Sequence analysisAdd BLAST40
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000769841 – 2319Neurogenic locus notch homolog protein 3Add BLAST2279
ChainiPRO_00000076991631 – 2319Notch 3 extracellular truncationBy similarityAdd BLAST689
ChainiPRO_00000077001664 – 2319Notch 3 intracellular domainBy similarityAdd BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 56By similarity
Disulfide bondi50 ↔ 67By similarity
Disulfide bondi69 ↔ 78By similarity
Disulfide bondi84 ↔ 95By similarity
Disulfide bondi89 ↔ 108By similarity
Disulfide bondi110 ↔ 119By similarity
Disulfide bondi125 ↔ 136By similarity
Disulfide bondi130 ↔ 146By similarity
Disulfide bondi148 ↔ 157By similarity
Disulfide bondi164 ↔ 176By similarity
Disulfide bondi170 ↔ 185By similarity
Disulfide bondi187 ↔ 196By similarity
Disulfide bondi203 ↔ 214By similarity
Disulfide bondi208 ↔ 224By similarity
Disulfide bondi226 ↔ 235By similarity
Disulfide bondi242 ↔ 253By similarity
Disulfide bondi247 ↔ 262By similarity
Disulfide bondi264 ↔ 273By similarity
Disulfide bondi280 ↔ 293By similarity
Disulfide bondi287 ↔ 302By similarity
Disulfide bondi304 ↔ 313By similarity
Disulfide bondi320 ↔ 331By similarity
Disulfide bondi325 ↔ 340By similarity
Disulfide bondi342 ↔ 351By similarity
Disulfide bondi357 ↔ 368By similarity
Disulfide bondi362 ↔ 379By similarity
Disulfide bondi381 ↔ 390By similarity
Disulfide bondi397 ↔ 410By similarity
Disulfide bondi404 ↔ 419By similarity
Disulfide bondi421 ↔ 430By similarity
Disulfide bondi437 ↔ 448By similarity
Disulfide bondi442 ↔ 457By similarity
Disulfide bondi459 ↔ 468By similarity
Disulfide bondi475 ↔ 486By similarity
Disulfide bondi480 ↔ 495By similarity
Disulfide bondi497 ↔ 506By similarity
Disulfide bondi513 ↔ 524By similarity
Disulfide bondi518 ↔ 533By similarity
Disulfide bondi535 ↔ 544By similarity
Disulfide bondi551 ↔ 561By similarity
Disulfide bondi556 ↔ 570By similarity
Disulfide bondi572 ↔ 581By similarity
Disulfide bondi588 ↔ 599By similarity
Disulfide bondi593 ↔ 608By similarity
Disulfide bondi610 ↔ 619By similarity
Disulfide bondi626 ↔ 636By similarity
Disulfide bondi631 ↔ 645By similarity
Disulfide bondi647 ↔ 656By similarity
Disulfide bondi663 ↔ 674By similarity
Disulfide bondi668 ↔ 683By similarity
Disulfide bondi685 ↔ 694By similarity
Disulfide bondi701 ↔ 711By similarity
Disulfide bondi706 ↔ 720By similarity
Disulfide bondi722 ↔ 731By similarity
Disulfide bondi740 ↔ 751By similarity
Disulfide bondi745 ↔ 760By similarity
Disulfide bondi762 ↔ 771By similarity
Disulfide bondi777 ↔ 788By similarity
Disulfide bondi782 ↔ 798By similarity
Disulfide bondi800 ↔ 809By similarity
Disulfide bondi816 ↔ 828By similarity
Disulfide bondi822 ↔ 837By similarity
Disulfide bondi839 ↔ 848By similarity
Disulfide bondi855 ↔ 866By similarity
Disulfide bondi860 ↔ 875By similarity
Disulfide bondi877 ↔ 886By similarity
Disulfide bondi893 ↔ 903By similarity
Disulfide bondi898 ↔ 912By similarity
Disulfide bondi914 ↔ 923By similarity
Disulfide bondi930 ↔ 941By similarity
Disulfide bondi935 ↔ 950By similarity
Disulfide bondi952 ↔ 961By similarity
Disulfide bondi968 ↔ 979By similarity
Disulfide bondi973 ↔ 988By similarity
Disulfide bondi990 ↔ 999By similarity
Disulfide bondi1006 ↔ 1017By similarity
Disulfide bondi1011 ↔ 1024By similarity
Disulfide bondi1026 ↔ 1035By similarity
Disulfide bondi1042 ↔ 1063By similarity
Disulfide bondi1057 ↔ 1072By similarity
Disulfide bondi1074 ↔ 1083By similarity
Disulfide bondi1090 ↔ 1101By similarity
Disulfide bondi1095 ↔ 1110By similarity
Disulfide bondi1112 ↔ 1121By similarity
Disulfide bondi1128 ↔ 1139By similarity
Disulfide bondi1133 ↔ 1148By similarity
Disulfide bondi1150 ↔ 1159By similarity
Disulfide bondi1166 ↔ 1184By similarity
Disulfide bondi1178 ↔ 1193By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1181N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1195 ↔ 1204By similarity
Disulfide bondi1211 ↔ 1224By similarity
Disulfide bondi1216 ↔ 1234By similarity
Disulfide bondi1236 ↔ 1245By similarity
Disulfide bondi1252 ↔ 1263By similarity
Disulfide bondi1257 ↔ 1277By similarity
Disulfide bondi1279 ↔ 1288By similarity
Disulfide bondi1295 ↔ 1306By similarity
Disulfide bondi1300 ↔ 1315By similarity
Disulfide bondi1317 ↔ 1326By similarity
Glycosylationi1338N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1341 ↔ 1352By similarity
Disulfide bondi1346 ↔ 1363By similarity
Disulfide bondi1365 ↔ 1374By similarity
Disulfide bondi1389 ↔ 1412By similarity
Disulfide bondi1394 ↔ 1407By similarity
Disulfide bondi1403 ↔ 1419By similarity
Disulfide bondi1430 ↔ 1453By similarity
Disulfide bondi1435 ↔ 1448By similarity
Glycosylationi1440N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1444 ↔ 1460By similarity
Disulfide bondi1469 ↔ 1495By similarity
Disulfide bondi1477 ↔ 1490By similarity
Disulfide bondi1486 ↔ 1502By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2175Omega-N-methylarginineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity).By similarity
Phosphorylated.By similarity
Hydroxylated by HIF1AN.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1573 – 1574Cleavage; by furin-like proteaseBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R172

PRoteomics IDEntifications database

More...
PRIDEi
Q9R172

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in postnatal central nervous system (CNS) germinal zones and, in early postnatal life, within numerous cells throughout the CNS. It is more highly localized to ventricular germinal zones.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds.

Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3.

Interacts with PSMA1 (By similarity).

Interacts with HIF1AN (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000037570

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9R172

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 79EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini80 – 120EGF-like 2PROSITE-ProRule annotationAdd BLAST41
Domaini121 – 158EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini160 – 197EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini199 – 236EGF-like 5PROSITE-ProRule annotationAdd BLAST38
Domaini238 – 274EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini276 – 314EGF-like 7PROSITE-ProRule annotationAdd BLAST39
Domaini316 – 352EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini353 – 391EGF-like 9PROSITE-ProRule annotationAdd BLAST39
Domaini393 – 431EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini433 – 469EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini471 – 507EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini509 – 545EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini547 – 582EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini584 – 620EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini622 – 657EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini659 – 695EGF-like 17; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini697 – 732EGF-like 18PROSITE-ProRule annotationAdd BLAST36
Domaini736 – 772EGF-like 19PROSITE-ProRule annotationAdd BLAST37
Domaini773 – 810EGF-like 20PROSITE-ProRule annotationAdd BLAST38
Domaini812 – 849EGF-like 21; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini851 – 887EGF-like 22; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini889 – 924EGF-like 23; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini926 – 962EGF-like 24PROSITE-ProRule annotationAdd BLAST37
Domaini964 – 1000EGF-like 25PROSITE-ProRule annotationAdd BLAST37
Domaini1002 – 1036EGF-like 26PROSITE-ProRule annotationAdd BLAST35
Domaini1038 – 1084EGF-like 27PROSITE-ProRule annotationAdd BLAST47
Domaini1086 – 1122EGF-like 28PROSITE-ProRule annotationAdd BLAST37
Domaini1124 – 1160EGF-like 29; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1162 – 1205EGF-like 30; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini1207 – 1246EGF-like 31PROSITE-ProRule annotationAdd BLAST40
Domaini1248 – 1289EGF-like 32PROSITE-ProRule annotationAdd BLAST42
Domaini1291 – 1327EGF-like 33PROSITE-ProRule annotationAdd BLAST37
Domaini1337 – 1375EGF-like 34PROSITE-ProRule annotationAdd BLAST39
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1389 – 1429LNR 1Add BLAST41
Repeati1430 – 1467LNR 2Add BLAST38
Repeati1469 – 1507LNR 3Add BLAST39
Repeati1840 – 1869ANK 1Add BLAST30
Repeati1873 – 1903ANK 2Add BLAST31
Repeati1907 – 1936ANK 3Add BLAST30
Repeati1940 – 1969ANK 4Add BLAST30
Repeati1973 – 2002ANK 5Add BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The EGF-like domains 10 and 11 are required for binding the ligands JAG1 and DLL1.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.Curated

Keywords - Domaini

ANK repeat, EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KD9W Eukaryota
COG0666 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234369

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9R172

KEGG Orthology (KO)

More...
KOi
K20995

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9R172

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022331 Notch_3
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 19 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 4 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279 Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452 LNOTCHREPEAT
PR01986 NOTCH3

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 34 hits
SM00179 EGF_CA, 30 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 18 hits
PS00022 EGF_1, 33 hits
PS01186 EGF_2, 26 hits
PS50026 EGF_3, 34 hits
PS01187 EGF_CA, 16 hits
PS50258 LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9R172-1 [UniParc]FASTAAdd to basket
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MGPGARGRRR RRRLMALPPP PPPMRALPLL LLLLAGLGAA APPCLDGSPC
60 70 80 90 100
ANGGRCTHQQ PSREAACLCL PGWVGERCQL EDPCHSGPCA GRGVCQSSVV
110 120 130 140 150
AGVARFSCRC LRGFRGPDCS LPDPCFSSPC AHGAPCSVGS DGRYACACPP
160 170 180 190 200
GYQGRNCRSD IDECRAGASC RHGGTCINTP GSFHCLCPLG YTGLLCENPI
210 220 230 240 250
VPCAPSPCRN GGTCRQSSDV TYDCACLPGF EGQNCEVNVD DCPGHRCLNG
260 270 280 290 300
GTCVDGVNTY NCQCPPEWTG QFCTEDVDEC QLQPNACHNG GTCFNLLGGH
310 320 330 340 350
SCVCVNGWTG ESCSQNIDDC ATAVCFHGAT CHDRVASFYC ACPMGKTGLL
360 370 380 390 400
CHLDDACVSN PCHEDAICDT NPVSGRAICT CPPGFTGGAC DQDVDECSIG
410 420 430 440 450
ANPCEHLGRC VNTQGSFLCQ CGRGYTGPRC ETDVNECLSG PCRNQATCLD
460 470 480 490 500
RIGQFTCICM AGFTGTFCEV DIDECQSSPC VNGGVCKDRV NGFSCTCPSG
510 520 530 540 550
FSGSTCQLDV DECASTPCRN GAKCVDQPDG YECRCAEGFE GTLCERNVDD
560 570 580 590 600
CSPDPCHHGR CVDGIASFSC ACAPGYTGIR CESQVDECRS QPCRYGGKCL
610 620 630 640 650
DLVDKYLCRC PPGTTGVNCE VNIDDCASNP CTFGVCRDGI NRYDCVCQPG
660 670 680 690 700
FTGPLCNVEI NECASSPCGE GGSCVDGENG FHCLCPPGSL PPLCLPANHP
710 720 730 740 750
CAHKPCSHGV CHDAPGGFQC VCDPGWSGPR CSQSLAPDAC ESQPCQAGGT
760 770 780 790 800
CTSDGIGFHC TCAPGFQGHQ CEVLSPCTPS LCEHGGHCES DPDQLTVCSC
810 820 830 840 850
PPGWQGPRCQ QDVDECAGAS PCGPHGTCTN LPGSFRCICH GGYTGPFCDQ
860 870 880 890 900
DIDDCDPNPC LNGGSCQDGV GSFSCSCLSG FAGPRCARDV DECLSSPCGP
910 920 930 940 950
GTCTDHVASF TCTCPPGYGG FHCETDLLDC SPSSCFNGGT CVDGVNSFSC
960 970 980 990 1000
LCRPGYTGTH CQYKVDPCFS RPCLHGGICN PTHSGFECTC REGFTGNQCQ
1010 1020 1030 1040 1050
NPVDWCSQAP CQNGGRCVQT GAYCICPPEW SGPLCDIPSL PCTEAAAHMG
1060 1070 1080 1090 1100
VRLEQLCQAG GQCIDKDHSH YCVCPEGRMG SHCEQEVDPC TAQPCQHGGT
1110 1120 1130 1140 1150
CRGYMGGYVC ECPTGYSGDS CEDDVDECAS QPCQNGGSCI DLVAHYLCSC
1160 1170 1180 1190 1200
PPGTLGVLCE INEDDCGPGP SLDSGLRCLH NGTCVDLVGG FRCNCPPGYT
1210 1220 1230 1240 1250
GLHCEADINE CRPGTCHAAH TRDCLQDPGG HFRCICLPGF TGPRCQTALF
1260 1270 1280 1290 1300
PCESQPCQHG GQCRPSLGRG GGLTFTCHCV QPFWGLRCER VARSCRELQC
1310 1320 1330 1340 1350
PVGIPCQQTA RGPRCACPPG LSGPSCRVSR ASPSGATNTS CAATPCLHGG
1360 1370 1380 1390 1400
SCLPVQSVPF FRCVCAPGWG GPRCETPSAA PEVPEEPRCP RAACQAKRGD
1410 1420 1430 1440 1450
QNCDRECNSP GCGWDGGDCS LNVDDPWRQC EALQCWRLFN NSRCDPACSS
1460 1470 1480 1490 1500
PACLYDNFDC YSGGRDRTCN PVYKKYCADH FADGRCDQGC NTEECGWDGL
1510 1520 1530 1540 1550
DCASEVPALL ARGVLVLTVL LPPEELLRSS ADFLQRLSAI LRTSLRFRLD
1560 1570 1580 1590 1600
ARGQAMVFPY HRPSPGSESR VRRELGPEVI GSVVMLEIDN RLCLKSAEND
1610 1620 1630 1640 1650
HCFPDAQSAA DYLGALSAVE RLDFPYPLRD VRGEPLEPPE QSVPLLPLLV
1660 1670 1680 1690 1700
AGAVFLLVIF VLGVMVARRK REHSTLWFPE GFALHKDIAA GHKGRREPVG
1710 1720 1730 1740 1750
QDALGMKNMT KGESLMGEVA TDWNDSECPE AKRLKVEEPG MGAEEPVDCR
1760 1770 1780 1790 1800
QWTQHHLVAA DIRVAPAMAL TPPQGDADAD GMDVNVRGPD GFTPLMLASF
1810 1820 1830 1840 1850
CGGALEPMPA EEDEADDTSA SIISDLICQG AQLGARTDRT GETALHLAAR
1860 1870 1880 1890 1900
YARADAAKRL LDAGADTNAQ DHSGRTPLHT AVTADAQGVF QILIRNRSTD
1910 1920 1930 1940 1950
LDARMADGST ALILAARLAV EGMVEELIAS HADVNAVDEL GKSALHWAAA
1960 1970 1980 1990 2000
VNNVEATLAL LKNGANKDMQ DSKEETPLFL AAREGSYEAA KLLLDHFANR
2010 2020 2030 2040 2050
EITDHLDRLP RDVAQERLHQ DIVRLLDQPS GPRSPSGPHG LGPLLCPPGA
2060 2070 2080 2090 2100
FLPGLKAVQS GTKKSRRPPG KTGLGPQGTR GRGKKLTLAC PGPLADSSVT
2110 2120 2130 2140 2150
LSPVDSLDSP RPFGGPPASP GGFPLEGPYA TTATTVSLAQ LGASRAGPLG
2160 2170 2180 2190 2200
RQPPGGCVLS LGLLNPVAVP LDWARLPPPA PPGPSFLLPL APGSQLLNPA
2210 2220 2230 2240 2250
TPVSPHERPP PYLAAPGHGE EYPAAGTHSS PTKARFLRVP SEHPYLTPSP
2260 2270 2280 2290 2300
ESPEHWASPS PPSLSDWSDS TPSPATATSA TAAGALPAQP HPISVPSLPQ
2310
SQTQLGPQPE VTPKRQVMA
Length:2,319
Mass (Da):244,301
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i243BCA02D7C3283D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LQX7F1LQX7_RAT
Neurogenic locus notch homolog prot...
Notch3
2,319Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF164486 mRNA Translation: AAD46653.2

NCBI Reference Sequences

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RefSeqi
NP_064472.2, NM_020087.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
56761

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:56761

UCSC genome browser

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UCSCi
RGD:620761 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164486 mRNA Translation: AAD46653.2
RefSeqiNP_064472.2, NM_020087.2

3D structure databases

SMRiQ9R172
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037570

Proteomic databases

PaxDbiQ9R172
PRIDEiQ9R172

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56761
KEGGirno:56761
UCSCiRGD:620761 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4854
RGDi620761 Notch3

Phylogenomic databases

eggNOGiENOG410KD9W Eukaryota
COG0666 LUCA
HOGENOMiHOG000234369
InParanoidiQ9R172
KOiK20995
OrthoDBi7525at2759
PhylomeDBiQ9R172

Enzyme and pathway databases

ReactomeiR-RNO-1912420 Pre-NOTCH Processing in Golgi
R-RNO-350054 Notch-HLH transcription pathway
R-RNO-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-RNO-9017802 Noncanonical activation of NOTCH3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9R172

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022331 Notch_3
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 19 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 4 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01986 NOTCH3
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 34 hits
SM00179 EGF_CA, 30 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 18 hits
PS00022 EGF_1, 33 hits
PS01186 EGF_2, 26 hits
PS50026 EGF_3, 34 hits
PS01187 EGF_CA, 16 hits
PS50258 LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOTC3_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R172
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 1, 2001
Last modified: July 31, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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