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Protein

N-alpha-acetyltransferase 80

Gene

Naa80

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation. In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp. May act as a tumor suppressor.By similarity

Catalytic activityi

Acetyl-CoA + an N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] = an N-terminal N(alpha)-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein] + CoA.By similarity
Acetyl-CoA + an N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] = an N-terminal N(alpha)-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein] + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei113SubstrateBy similarity1
Binding sitei207Acetyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 80By similarity (EC:2.3.1.-By similarity)
Alternative name(s):
N-acetyltransferase 6Curated
Protein fusion-2 homolog1 Publication
Short name:
Protein fus-21 Publication
Gene namesi
Name:Naa80By similarity
Synonyms:Fus2, Nat6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1888902 Nat6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000745371 – 314N-alpha-acetyltransferase 80Add BLAST314

Proteomic databases

MaxQBiQ9R123
PaxDbiQ9R123
PRIDEiQ9R123

PTM databases

iPTMnetiQ9R123
PhosphoSitePlusiQ9R123

Expressioni

Gene expression databases

BgeeiENSMUSG00000079334 Expressed in 230 organ(s), highest expression level in liver
CleanExiMM_NAT6
ExpressionAtlasiQ9R123 baseline and differential
GenevisibleiQ9R123 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091300

Structurei

3D structure databases

ProteinModelPortaliQ9R123
SMRiQ9R123
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 243N-acetyltransferasePROSITE-ProRule annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni118 – 121Substrate bindingBy similarity4
Regioni169 – 171Acetyl-CoA bindingBy similarity3
Regioni177 – 182Acetyl-CoA bindingBy similarity6

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated

Phylogenomic databases

eggNOGiKOG3397 Eukaryota
ENOG41126M5 LUCA
GeneTreeiENSGT00390000000980
HOGENOMiHOG000113734
HOVERGENiHBG031735
InParanoidiQ9R123
OMAiGCPIFWM
OrthoDBiEOG091G0SQB
PhylomeDBiQ9R123
TreeFamiTF106312

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR039840 NAT6
PANTHERiPTHR13538:SF4 PTHR13538:SF4, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9R123-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELILSTSPA KLTLDPARQP ELTLRFNLSK LTLDPARQPE LSLSPRLAEL
60 70 80 90 100
TLDPTCHPEM SLSPGPAELT LDPQHQAKEL PVPKLPELIL EPVHCRPELM
110 120 130 140 150
SACADLINDQ WPRSRASRLH SLGQSSDAFP LCLMLLSPQP TPGAAPVVVG
160 170 180 190 200
HARLSRVLDQ PHSLLVETVV VARPLRGRGF GRRLMEGLEA FARARGFRRL
210 220 230 240 250
HLTTHDQLYF YAHLGYQLGE PVQGLAFTNR RLSTTVLRAF SKPPCPQPPC
260 270 280 290 300
KEPILAAQAV PRSSKGPPLP PPPPLPQSLT ASPPPSPEPL PQSPLETCYR
310
DLKGCPIFWM EKDI
Length:314
Mass (Da):34,583
Last modified:May 1, 2000 - v1
Checksum:iC10445FF34332A73
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZCE0B7ZCE0_MOUSE
N-alpha-acetyltransferase 80
Naa80 Nat6
204Annotation score:
A0A0R4J2B1A0A0R4J2B1_MOUSE
N-alpha-acetyltransferase 80
Naa80 Nat6
105Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172275 mRNA Translation: AAD48062.1
AF338323 Genomic DNA Translation: AAL57174.1
BC026545 mRNA Translation: AAH26545.1
AH009891 Genomic DNA Translation: AAG23428.1
AF417492 mRNA Translation: AAM14421.1
AF417493 mRNA Translation: AAM14423.1
AF417494 mRNA Translation: AAM14425.1
AF417495 mRNA Translation: AAM14427.1
AF417497 mRNA Translation: AAM14431.1
AF417498 mRNA Translation: AAM14433.1
CCDSiCCDS23498.1
RefSeqiNP_062724.1, NM_019750.4
UniGeneiMm.10305
Mm.475658

Genome annotation databases

EnsembliENSMUST00000093785; ENSMUSP00000091300; ENSMUSG00000079334
GeneIDi56441
KEGGimmu:56441
UCSCiuc009rly.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172275 mRNA Translation: AAD48062.1
AF338323 Genomic DNA Translation: AAL57174.1
BC026545 mRNA Translation: AAH26545.1
AH009891 Genomic DNA Translation: AAG23428.1
AF417492 mRNA Translation: AAM14421.1
AF417493 mRNA Translation: AAM14423.1
AF417494 mRNA Translation: AAM14425.1
AF417495 mRNA Translation: AAM14427.1
AF417497 mRNA Translation: AAM14431.1
AF417498 mRNA Translation: AAM14433.1
CCDSiCCDS23498.1
RefSeqiNP_062724.1, NM_019750.4
UniGeneiMm.10305
Mm.475658

3D structure databases

ProteinModelPortaliQ9R123
SMRiQ9R123
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091300

PTM databases

iPTMnetiQ9R123
PhosphoSitePlusiQ9R123

Proteomic databases

MaxQBiQ9R123
PaxDbiQ9R123
PRIDEiQ9R123

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093785; ENSMUSP00000091300; ENSMUSG00000079334
GeneIDi56441
KEGGimmu:56441
UCSCiuc009rly.1 mouse

Organism-specific databases

CTDi56441
MGIiMGI:1888902 Nat6

Phylogenomic databases

eggNOGiKOG3397 Eukaryota
ENOG41126M5 LUCA
GeneTreeiENSGT00390000000980
HOGENOMiHOG000113734
HOVERGENiHBG031735
InParanoidiQ9R123
OMAiGCPIFWM
OrthoDBiEOG091G0SQB
PhylomeDBiQ9R123
TreeFamiTF106312

Miscellaneous databases

PROiPR:Q9R123
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079334 Expressed in 230 organ(s), highest expression level in liver
CleanExiMM_NAT6
ExpressionAtlasiQ9R123 baseline and differential
GenevisibleiQ9R123 MM

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR039840 NAT6
PANTHERiPTHR13538:SF4 PTHR13538:SF4, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNAA80_MOUSE
AccessioniPrimary (citable) accession number: Q9R123
Secondary accession number(s): Q8QZY5, Q8R014, Q9ERM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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