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Protein

Non-receptor tyrosine-protein kinase TYK2

Gene

Tyk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities.

Miscellaneous

Tyk2 deficient mice display reduced responses to interferon-alpha/beta and IL-12 and a selective deficiency in STAT3 activation in these pathways. Interferon-gamma signaling is also impaired.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei927ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1020Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi900 – 908ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.10.2 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1059683 Interleukin-6 signaling
R-MMU-110056 MAPK3 (ERK1) activation
R-MMU-112411 MAPK1 (ERK2) activation
R-MMU-6783783 Interleukin-10 signaling
R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling
R-MMU-6788467 IL-6-type cytokine receptor ligand interactions
R-MMU-8854691 Interleukin-20 family signaling
R-MMU-8984722 Interleukin-35 Signalling
R-MMU-9020591 Interleukin-12 signaling
R-MMU-9020933 Interleukin-23 signaling
R-MMU-9020956 Interleukin-27 signaling
R-MMU-909733 Interferon alpha/beta signaling
R-MMU-912694 Regulation of IFNA signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-receptor tyrosine-protein kinase TYK2 (EC:2.7.10.2)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tyk2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1929470 Tyk2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2321619

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000881781 – 1184Non-receptor tyrosine-protein kinase TYK2Add BLAST1184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei295PhosphotyrosineBy similarity1
Modified residuei525PhosphoserineCombined sources1
Modified residuei604PhosphotyrosineCombined sources1
Modified residuei881PhosphoserineBy similarity1
Modified residuei1051Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9R117

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R117

PRoteomics IDEntifications database

More...
PRIDEi
Q9R117

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9R117

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9R117

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_TYK2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TXE3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with JAKMIP1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-388 Interleukin-12-receptor complex
CPX-389 Interleukin-23-receptor complex

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000001036

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E1ZX-ray2.50A884-1174[»]
4E20X-ray2.60A885-1174[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9R117

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9R117

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 430FERMPROSITE-ProRule annotationAdd BLAST398
Domaini449 – 529SH2; atypicalAdd BLAST81
Domaini589 – 866Protein kinase 1PROSITE-ProRule annotationAdd BLAST278
Domaini894 – 1166Protein kinase 2PROSITE-ProRule annotationAdd BLAST273

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FERM domain mediates interaction with JAKMIP1.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0197 Eukaryota
COG0515 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159869

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006195

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9R117

KEGG Orthology (KO)

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KOi
K11219

Identification of Orthologs from Complete Genome Data

More...
OMAi
KYQGQAP

Database of Orthologous Groups

More...
OrthoDBi
58906at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR016045 Tyr_kinase_non-rcpt_TYK2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000636 TyrPK_Jak, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01823 JANUSKINASE
PR00109 TYRKINASE
PR01827 YKINASETYK2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM00219 TyrKc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9R117-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGTMPLCGR RAILEDSKAD GTEAQPLVPT GCLMVLLHWP GPEGGEPWVT
60 70 80 90 100
FSQTSLTAEE VCIHIAHKVG ITPPCLNLFA LYNAQAKVWL PPNHILDTSQ
110 120 130 140 150
DMNLYFRMRF YFRNWHGMNP QEPAVYRCGF PGAETSSDRA EQGVQLLDSA
160 170 180 190 200
SFEYLFEQGK HEFMNDVVSL RDLSSEEEIH HFKNESLGMA FLHLCHLALS
210 220 230 240 250
RGVPLEEMAR EISFKNCIPH SFRQHIRQHN VLTRLRLHRV FRRFLRAFRP
260 270 280 290 300
GHLSQQVVMV KYLATLERLA PRFGSERIPV CHLEVLAQPE RDPCYIQNSG
310 320 330 340 350
QTAGDPGPEL PSGPPTHEVL VTGTGGIQWH PLQTQESERG NSRGNPHGSR
360 370 380 390 400
SGKKPKAPKA GEHLTESPQE PPWTYFCDFQ DISHVVLKER RVHIHLQDNK
410 420 430 440 450
CLLLCLCSQA EALSFVALVD GYFRLTADSS HYLCHEVAPP RLVTSIQNGI
460 470 480 490 500
HGPLMDPFVQ AKLWPEDGLY LIQWSTSHLH RLILTVAHRN PAFSNGPRGL
510 520 530 540 550
RLRKFPITQQ PGAFVLDGWG RSFASLGDLR LALQGCSLRA GDDCFPLHHC
560 570 580 590 600
CLPRPREISN LVIMRGSRAH TRPLNLSQLS FHRVHQDEIT QLSHLGQGTR
610 620 630 640 650
TNVYEGLLRV GGPDEGKVDN GCPPEPGGTS GQQLRVVLKV LDPSHHDIAL
660 670 680 690 700
AFYETASLMS QVSHMHLAFL HGVCVRGSEN IIVTEFVEHG PLDVWLRRQR
710 720 730 740 750
GQVPMTWKMV VAQQLASALS YLEDKNLVHG NVCGRNILLA RLGLEEGTNP
760 770 780 790 800
FIKLSDPGVG QGALSREERV ERIPWTAPEC LSGGTSSLGT ATDMWGFGAT
810 820 830 840 850
LLEICFDGEA PLQGRGPSEK ERFYTKKHQL PEPSSPELAT LTRQCLTYEP
860 870 880 890 900
AQRPSFRTIL RDLTRLQPQN LVGTSAVNSD SPASDPTVFH KRYLKKIRDL
910 920 930 940 950
GEGHFGKVSL YCYDPTNDGT GEMVAVKALK EGCGPQLRSG WQREIEILRT
960 970 980 990 1000
LYHEHIVKYK GCCEDQGEKS VQLVMEYVPL GSLRDYLPRH CVGLAQLLLF
1010 1020 1030 1040 1050
AQQICEGMAY LHAQHYIHRD LAARNVLLDN DRLVKIGDFG LAKAVPEGHE
1060 1070 1080 1090 1100
YYRVREDGDS PVFWYAPECL KECKFYYASD VWSFGVTLYE LLTYCDSNQS
1110 1120 1130 1140 1150
PHMKFTELIG HTQGQMTVLR LTELLERGER LPRPDRCPCE IYHLMKNCWE
1160 1170 1180
TEASFRPTFQ NLVPILQTAQ EKYQGQVPSV FSVC
Length:1,184
Mass (Da):133,315
Last modified:January 31, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B42052073463AC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QJS1E9QJS1_MOUSE
Tyrosine-protein kinase
Tyk2
1,207Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SVI6A0A1L1SVI6_MOUSE
Non-receptor tyrosine-protein kinas...
Tyk2
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD49423 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH94240 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EDL25160 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195C → F in AAC34580 (PubMed:11070173).Curated1
Sequence conflicti238H → R in AAC34580 (PubMed:11070173).Curated1
Sequence conflicti359K → E in AAC34580 (PubMed:11070173).Curated1
Sequence conflicti835S → C in AAC34580 (PubMed:11070173).1
Sequence conflicti1103M → T in AAC34580 (PubMed:11070173).1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF173032 mRNA Translation: AAD49423.1 Different initiation.
AF052607 Genomic DNA Translation: AAC34580.2
AK159303 mRNA Translation: BAE34973.1
AC163637 Genomic DNA No translation available.
CH466522 Genomic DNA Translation: EDL25160.1 Sequence problems.
BC094240 mRNA Translation: AAH94240.1 Different initiation.
BC019789 mRNA Translation: AAH19789.1

NCBI Reference Sequences

More...
RefSeqi
NP_061263.2, NM_018793.2
XP_011240881.1, XM_011242579.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.20249
Mm.450004

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000214454; ENSMUSP00000150214; ENSMUSG00000032175

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54721

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:54721

UCSC genome browser

More...
UCSCi
uc009oke.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173032 mRNA Translation: AAD49423.1 Different initiation.
AF052607 Genomic DNA Translation: AAC34580.2
AK159303 mRNA Translation: BAE34973.1
AC163637 Genomic DNA No translation available.
CH466522 Genomic DNA Translation: EDL25160.1 Sequence problems.
BC094240 mRNA Translation: AAH94240.1 Different initiation.
BC019789 mRNA Translation: AAH19789.1
RefSeqiNP_061263.2, NM_018793.2
XP_011240881.1, XM_011242579.2
UniGeneiMm.20249
Mm.450004

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E1ZX-ray2.50A884-1174[»]
4E20X-ray2.60A885-1174[»]
ProteinModelPortaliQ9R117
SMRiQ9R117
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-388 Interleukin-12-receptor complex
CPX-389 Interleukin-23-receptor complex
STRINGi10090.ENSMUSP00000001036

Chemistry databases

ChEMBLiCHEMBL2321619

PTM databases

iPTMnetiQ9R117
PhosphoSitePlusiQ9R117

Proteomic databases

EPDiQ9R117
PaxDbiQ9R117
PRIDEiQ9R117

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000214454; ENSMUSP00000150214; ENSMUSG00000032175
GeneIDi54721
KEGGimmu:54721
UCSCiuc009oke.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7297
MGIiMGI:1929470 Tyk2

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000159869
HOVERGENiHBG006195
InParanoidiQ9R117
KOiK11219
OMAiKYQGQAP
OrthoDBi58906at2759

Enzyme and pathway databases

BRENDAi2.7.10.2 3474
ReactomeiR-MMU-1059683 Interleukin-6 signaling
R-MMU-110056 MAPK3 (ERK1) activation
R-MMU-112411 MAPK1 (ERK2) activation
R-MMU-6783783 Interleukin-10 signaling
R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling
R-MMU-6788467 IL-6-type cytokine receptor ligand interactions
R-MMU-8854691 Interleukin-20 family signaling
R-MMU-8984722 Interleukin-35 Signalling
R-MMU-9020591 Interleukin-12 signaling
R-MMU-9020933 Interleukin-23 signaling
R-MMU-9020956 Interleukin-27 signaling
R-MMU-909733 Interferon alpha/beta signaling
R-MMU-912694 Regulation of IFNA signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tyk2 mouse

Protein Ontology

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PROi
PR:Q9R117

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

CleanExiMM_TYK2
GenevisibleiQ3TXE3 MM

Family and domain databases

InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR016045 Tyr_kinase_non-rcpt_TYK2_N
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PIRSFiPIRSF000636 TyrPK_Jak, 1 hit
PRINTSiPR01823 JANUSKINASE
PR00109 TYRKINASE
PR01827 YKINASETYK2
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF47031 SSF47031, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYK2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R117
Secondary accession number(s): O88431
, Q3TXE3, Q52KQ2, Q8VE41
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: January 31, 2018
Last modified: January 16, 2019
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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