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Protein

Cadherin-17

Gene

Cdh17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-17
Alternative name(s):
BILL-cadherin
Liver-intestine cadherin
Short name:
LI-cadherin
P130
Gene namesi
Name:Cdh17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1095414 Cdh17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 786ExtracellularSequence analysisAdd BLAST761
Transmembranei787 – 807HelicalSequence analysisAdd BLAST21
Topological domaini808 – 827CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000000381326 – 827Cadherin-17Add BLAST802

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi573N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi721N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9R100
PaxDbiQ9R100
PRIDEiQ9R100

PTM databases

iPTMnetiQ9R100
PhosphoSitePlusiQ9R100

Expressioni

Tissue specificityi

Highest expression is found in intestine with lower expression in spleen, bone marrow, lung and testis. No expression detected in liver, kidney, heart, brain or skeletal muscle. Expressed in precursor B-cells and myeloid cells.1 Publication

Developmental stagei

Expression increases in pro- and pre-B-I cells, decreases in large and small pre-B-II cells, and increases again in immature and mature B-cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000028217 Expressed in 49 organ(s), highest expression level in jejunum
CleanExiMM_CDH17
ExpressionAtlasiQ9R100 baseline and differential
GenevisibleiQ9R100 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198636, 4 interactors
IntActiQ9R100, 1 interactor
STRINGi10090.ENSMUSP00000029871

Structurei

3D structure databases

ProteinModelPortaliQ9R100
SMRiQ9R100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 127Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini128 – 243Cadherin 2PROSITE-ProRule annotationAdd BLAST116
Domaini244 – 339Cadherin 3PROSITE-ProRule annotationAdd BLAST96
Domaini340 – 448Cadherin 4PROSITE-ProRule annotationAdd BLAST109
Domaini449 – 565Cadherin 5PROSITE-ProRule annotationAdd BLAST117
Domaini566 – 666Cadherin 6PROSITE-ProRule annotationAdd BLAST101
Domaini667 – 776Cadherin 7PROSITE-ProRule annotationAdd BLAST110

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00740000115559
HOGENOMiHOG000231613
HOVERGENiHBG050767
InParanoidiQ9R100
KOiK06811
OMAiGMPTVGM
OrthoDBiEOG091G033T
PhylomeDBiQ9R100
TreeFamiTF316817

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 7 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9R100-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSAQLHFLC LLTLYLTCGY GEEGKFSGPL KPMTFSIFEG QEPSQVIFQF
60 70 80 90 100
KTNPPAVTFE LTGETDGIFK IEKDGLLYHT RALDRETRAV HHLQLAALDS
110 120 130 140 150
HGAIVDGPVP ITIEVKDIND NRPTFLQSKY EGSVRQNSRP GKPFMYVNAT
160 170 180 190 200
DLDDPATPNG QLFYQIVIQL PQINDVMYFQ IDSKTGAISL TPEGSQELDP
210 220 230 240 250
VKNPSYNLVV SVKDMGGQSE NSFSDTTYVD ISIRENIWKA PEPVEIRENS
260 270 280 290 300
TDPHPIKITQ VQWNDPGAQY SLVNKEKLSP FPFSIDQEGN IYVTQALDRE
310 320 330 340 350
EKNSHVFFAT AKDENGKPLA YPLEIYVKVI DINDNPPTCL SPVTVFEVQE
360 370 380 390 400
NEPLGNSIGI FEAHDMDEAN NINSILKYKL VDQTPKVPSD GLFLIGEYEG
410 420 430 440 450
KVQLSKQSLK KQDSPQYNLS IEVSDVDFKT LCYIQVNVID INDQIPIFET
460 470 480 490 500
SNYGSKTLSE DTAIGSTILI IQATDADEPF TGSSKILYKI VQGDTEGRLE
510 520 530 540 550
VVTDPTTNAG YVKIKKPLDF ETQPVSSIVF QAENPEPLVK GIEYNASSFA
560 570 580 590 600
SFELIVTDVN EVPVFPQRIF QANVSEDAAV GSRVGNVTAR DPEGLTVSYS
610 620 630 640 650
LKGNMRGWLK IDSVTGEIFS AAPLDRETES VYRVQVVATE VGGSSLSSTA
660 670 680 690 700
DFHLVLTDVN DNPPRLAKDY TGLFFCHPLS APGSLIFEVT DDDQQSLRRP
710 720 730 740 750
KFTFALGREG LQSDWEVSKI NGTHARLSTR HTRFEEQVYN IPIRINDGGQ
760 770 780 790 800
PPMEGTVFLP VTFCQCVEGS CFRPAGRQDG IPTVGMAVGI LLTTFLVIGI
810 820
ILAVVFIRMR KDKVENPQSP ENKPLRS
Length:827
Mass (Da):91,645
Last modified:May 1, 2000 - v1
Checksum:iCDCECEA5A76E2B58
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AKS7A2AKS7_MOUSE
Cadherin 17, isoform CRA_a
Cdh17 mCG_5094
728Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177669 mRNA Translation: AAD51125.1
D87912 mRNA Translation: BAB03264.1
BC042891 mRNA Translation: AAH42891.1
CCDSiCCDS17972.1
RefSeqiNP_062727.1, NM_019753.4
XP_006537646.1, XM_006537583.2
XP_006537647.1, XM_006537584.3
UniGeneiMm.33402

Genome annotation databases

EnsembliENSMUST00000029871; ENSMUSP00000029871; ENSMUSG00000028217
GeneIDi12557
KEGGimmu:12557
UCSCiuc008rzy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177669 mRNA Translation: AAD51125.1
D87912 mRNA Translation: BAB03264.1
BC042891 mRNA Translation: AAH42891.1
CCDSiCCDS17972.1
RefSeqiNP_062727.1, NM_019753.4
XP_006537646.1, XM_006537583.2
XP_006537647.1, XM_006537584.3
UniGeneiMm.33402

3D structure databases

ProteinModelPortaliQ9R100
SMRiQ9R100
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198636, 4 interactors
IntActiQ9R100, 1 interactor
STRINGi10090.ENSMUSP00000029871

PTM databases

iPTMnetiQ9R100
PhosphoSitePlusiQ9R100

Proteomic databases

MaxQBiQ9R100
PaxDbiQ9R100
PRIDEiQ9R100

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029871; ENSMUSP00000029871; ENSMUSG00000028217
GeneIDi12557
KEGGimmu:12557
UCSCiuc008rzy.2 mouse

Organism-specific databases

CTDi1015
MGIiMGI:1095414 Cdh17

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00740000115559
HOGENOMiHOG000231613
HOVERGENiHBG050767
InParanoidiQ9R100
KOiK06811
OMAiGMPTVGM
OrthoDBiEOG091G033T
PhylomeDBiQ9R100
TreeFamiTF316817

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Miscellaneous databases

PROiPR:Q9R100
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028217 Expressed in 49 organ(s), highest expression level in jejunum
CleanExiMM_CDH17
ExpressionAtlasiQ9R100 baseline and differential
GenevisibleiQ9R100 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 7 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCAD17_MOUSE
AccessioniPrimary (citable) accession number: Q9R100
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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