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Protein

Neuronal acetylcholine receptor subunit alpha-6

Gene

Chrna6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.By similarity

GO - Molecular functioni

  • acetylcholine-gated cation-selective channel activity Source: MGI
  • drug binding Source: MGI
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-MMU-629597 Highly calcium permeable nicotinic acetylcholine receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-6
Gene namesi
Name:Chrna6
Synonyms:Nica6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106213 Chrna6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 240ExtracellularSequence analysisAdd BLAST210
Transmembranei241 – 265HelicalSequence analysisAdd BLAST25
Transmembranei272 – 290HelicalSequence analysisAdd BLAST19
Transmembranei306 – 327HelicalSequence analysisAdd BLAST22
Topological domaini328 – 465CytoplasmicSequence analysisAdd BLAST138
Transmembranei466 – 485HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6183

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30By similarityAdd BLAST30
ChainiPRO_000000036131 – 494Neuronal acetylcholine receptor subunit alpha-6Add BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi158 ↔ 172By similarity
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi222 ↔ 223Associated with receptor activationBy similarity
Modified residuei401PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9R0W9
PRIDEiQ9R0W9

PTM databases

PhosphoSitePlusiQ9R0W9

Expressioni

Gene expression databases

BgeeiENSMUSG00000031491 Expressed in 51 organ(s), highest expression level in floor plate of diencephalon
GenevisibleiQ9R0W9 MM

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Interacts with LYPD6.By similarity

Protein-protein interaction databases

ComplexPortaliCPX-202 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3
CPX-212 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4
STRINGi10090.ENSMUSP00000033882

Structurei

3D structure databases

ProteinModelPortaliQ9R0W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiQ9R0W9
KOiK04808
OMAiVHFEVAI
OrthoDBiEOG091G0R20
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R0W9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNSRDQGNL HSGLCLWLCG FLALFKGSTG CESEEQLFHR LFAHYNRFIR
60 70 80 90 100
PVENVSDPVT VHFELAITQL ANVDEVNQIM ETNLWLRHIW KDYRLRWDPT
110 120 130 140 150
EYDGIETLRV PADNIWKPDI VLYNNAVGDF QVEGKTKALL KYDGVITWTP
160 170 180 190 200
PAIFKSSCPM DITFFPFDHQ NCSLKFGSWT YDKAEIDLLI IGSKVDMNDF
210 220 230 240 250
WENSEWEIVD ASGYKHDIKY NCCEEIYTDI TYSFYIRRLP MFYTINLIIP
260 270 280 290 300
CLFISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVI
310 320 330 340 350
PLVGEYLLFT MIFVTLSIVV TVFVLNIHYR TPATHTMPKW VKTIFLQAFP
360 370 380 390 400
SILMMRKPLD KTKEAGGVKD PKSHTKRPAK VKFTHRGESK LLKECHHCQK
410 420 430 440 450
SSDIAPGKRR SSQQPARWVA ENSEHSSDVE DVIESVQFIA ENMKSHNETN
460 470 480 490
EVEDDWKYMA MVVDRVFLWV FIIVCVFGTV GLFLQPLLGN TGKS
Length:494
Mass (Da):56,856
Last modified:July 27, 2011 - v2
Checksum:iA4655895692E2530
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63F → L in CAB53472 (Ref. 1) Curated1
Sequence conflicti493K → N in CAB53472 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245706 mRNA Translation: CAB53472.1
AK149262 mRNA Translation: BAE28777.1
CH466580 Genomic DNA Translation: EDL32787.1
BC031985 mRNA Translation: AAH31985.1
CCDSiCCDS40312.1
RefSeqiNP_067344.2, NM_021369.2
UniGeneiMm.283137

Genome annotation databases

EnsembliENSMUST00000033882; ENSMUSP00000033882; ENSMUSG00000031491
GeneIDi11440
KEGGimmu:11440
UCSCiuc009liv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245706 mRNA Translation: CAB53472.1
AK149262 mRNA Translation: BAE28777.1
CH466580 Genomic DNA Translation: EDL32787.1
BC031985 mRNA Translation: AAH31985.1
CCDSiCCDS40312.1
RefSeqiNP_067344.2, NM_021369.2
UniGeneiMm.283137

3D structure databases

ProteinModelPortaliQ9R0W9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-202 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3
CPX-212 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4
STRINGi10090.ENSMUSP00000033882

Chemistry databases

ChEMBLiCHEMBL6183

PTM databases

PhosphoSitePlusiQ9R0W9

Proteomic databases

PaxDbiQ9R0W9
PRIDEiQ9R0W9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033882; ENSMUSP00000033882; ENSMUSG00000031491
GeneIDi11440
KEGGimmu:11440
UCSCiuc009liv.1 mouse

Organism-specific databases

CTDi8973
MGIiMGI:106213 Chrna6

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiQ9R0W9
KOiK04808
OMAiVHFEVAI
OrthoDBiEOG091G0R20
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-MMU-629597 Highly calcium permeable nicotinic acetylcholine receptors

Miscellaneous databases

PROiPR:Q9R0W9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031491 Expressed in 51 organ(s), highest expression level in floor plate of diencephalon
GenevisibleiQ9R0W9 MM

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHA6_MOUSE
AccessioniPrimary (citable) accession number: Q9R0W9
Secondary accession number(s): Q3UEY4, Q8K0A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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