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Protein
Submitted name:

MCG15085

Gene

Try4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1592389 Activation of Matrix Metalloproteinases
R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-MMU-6798695 Neutrophil degranulation
R-MMU-6803157 Antimicrobial peptides

Protein family/group databases

MEROPSiS01.057

Names & Taxonomyi

Protein namesi
Submitted name:
MCG15085Imported
Submitted name:
Pancreatic trypsinImported
Submitted name:
Trypsin 4Imported
Submitted name:
Trypsinogen 8Imported
Gene namesi
Name:Try4Imported
Synonyms:Try5Imported, trypsinogenImported
ORF Names:mCG_15085Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:102757 Try4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_501509994416 – 246Sequence analysisAdd BLAST231

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000054106 Expressed in 40 organ(s), highest expression level in islet of Langerhans

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031913

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 244Peptidase S1InterPro annotationAdd BLAST221

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
KOiK01312
OMAiGGQKVPQ
OrthoDBiEOG091G0DF7
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R0T7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRALLFLALV GAAVAFPVDD DDKIVGGYTC RENSVPYQVS LNSGYHFCGG
60 70 80 90 100
SLINDQWVVS AAHCYKSRIQ VRLGEHNINV LEGNEQFVNS AKIIKHPNFN
110 120 130 140 150
SRTLNNDIML IKLASPVTLN ARVATVALPS SCAPAGTQCL ISGWGNTLSF
160 170 180 190 200
GVNNPDLLQC LDAPLLPQAD CEASYPGKIT NNMICVGFLE GGKDSCQGDS
210 220 230 240
GGPVVCNGQL QGIVSWGYGC ALKDNPGVYT KVCNYVDWIQ NTIAAN
Length:246
Mass (Da):26,274
Last modified:May 1, 2000 - v1
Checksum:iB6A9F4C99079633F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125228 Genomic DNA No translation available.
AE000664 Genomic DNA Translation: AAB69056.1
BC061135 mRNA Translation: AAH61135.1
AB017032 Genomic DNA Translation: BAA74761.1
AK003064 mRNA Translation: BAB22542.1
AK008667 mRNA Translation: BAB25821.1
CH466533 Genomic DNA Translation: EDL13537.1
RefSeqiNP_035776.1, NM_011646.5
UniGeneiMm.383263

Genome annotation databases

EnsembliENSMUST00000031913; ENSMUSP00000031913; ENSMUSG00000054106
GeneIDi22074
KEGGimmu:22074
UCSCiuc009bos.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125228 Genomic DNA No translation available.
AE000664 Genomic DNA Translation: AAB69056.1
BC061135 mRNA Translation: AAH61135.1
AB017032 Genomic DNA Translation: BAA74761.1
AK003064 mRNA Translation: BAB22542.1
AK008667 mRNA Translation: BAB25821.1
CH466533 Genomic DNA Translation: EDL13537.1
RefSeqiNP_035776.1, NM_011646.5
UniGeneiMm.383263

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031913

Protein family/group databases

MEROPSiS01.057

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031913; ENSMUSP00000031913; ENSMUSG00000054106
GeneIDi22074
KEGGimmu:22074
UCSCiuc009bos.1 mouse

Organism-specific databases

CTDi22074
MGIiMGI:102757 Try4

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
KOiK01312
OMAiGGQKVPQ
OrthoDBiEOG091G0DF7
TreeFamiTF331065

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1592389 Activation of Matrix Metalloproteinases
R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-MMU-6798695 Neutrophil degranulation
R-MMU-6803157 Antimicrobial peptides

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054106 Expressed in 40 organ(s), highest expression level in islet of Langerhans

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9R0T7_MOUSE
AccessioniPrimary (citable) accession number: Q9R0T7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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