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Protein

Y+L amino acid transporter 1

Gene

Slc7a7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis via transport of L-arginine, and is involved in the transport of L-arginine in monocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-210991 Basigin interactions
R-RNO-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.3.8.7 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Y+L amino acid transporter 1
Alternative name(s):
Solute carrier family 7 member 7
y(+)L-type amino acid transporter 1
Short name:
Y+LAT1
Short name:
y+LAT-1
Gene namesi
Name:Slc7a7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi619902 Slc7a7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049361 – 512Y+L amino acid transporter 1Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9R0S5
PRIDEiQ9R0S5

PTM databases

iPTMnetiQ9R0S5
PhosphoSitePlusiQ9R0S5

Expressioni

Tissue specificityi

Expressed in kidney cortex and intestine.1 Publication

Gene expression databases

BgeeiENSRNOG00000010296 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ9R0S5 RN

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014391

Structurei

3D structure databases

ProteinModelPortaliQ9R0S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1287 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119037
HOGENOMiHOG000098892
HOVERGENiHBG000476
InParanoidiQ9R0S5
KOiK13867
OMAiYMVQPIF
OrthoDBiEOG091G07EM
PhylomeDBiQ9R0S5
TreeFamiTF313355

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R0S5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVASTKYEVA AQNEADEADG SAQGDGAGPA AEQVKLKKEI SLLNGVCLIV
60 70 80 90 100
GNMIGSGIFV SPKGVLMYSA SFGLSLVIWA VGGIFSVFGA LCYAELGTTI
110 120 130 140 150
KKSGASYAYI LEAFGGFLAF IRLWTSLLII EPTSQAVIAI TFANYMVQPL
160 170 180 190 200
FPSCGAPYAA GRLLAAACIC LLTFINCAYV KWGTLVQDIF TYAKVLALIA
210 220 230 240 250
VIIAGIVRLG QGATTNFEDS FEGSSFAMGD IALALYSALF SYSGWDTLNY
260 270 280 290 300
VTEEIRNPER NLPLSIGISM PIVTIIYLLT NVAYYSVLDI KDILASDAVA
310 320 330 340 350
VTFADQIFGI FNWTIPLAVA LSCFGGLNAS IVAASRLLFV GSREGHLPDA
360 370 380 390 400
ICMIHVERFT PVPSLLFNGI LALVYLCVED IFQLINYYSF SYWFFVGLSI
410 420 430 440 450
VGQLYLRWKE PDRPRPLKLS LFFPIVFCLC TIFLVAVPLY SDTINSLIGI
460 470 480 490 500
GIALSGLPFY FLIIRVPEHK RPLCLRRIVA STTRYLQIIC MSVAAEMDLE
510
DGELPKQGPK SK
Length:512
Mass (Da):55,641
Last modified:May 1, 2000 - v1
Checksum:i708905B2ACB0A824
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3A → N in AAF07216 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020520 mRNA Translation: BAA87325.1
AF200684 mRNA Translation: AAF07216.1
BC091142 mRNA Translation: AAH91142.1
RefSeqiNP_112631.1, NM_031341.1
XP_006252082.1, XM_006252020.3
XP_006252083.1, XM_006252021.3
XP_006252085.1, XM_006252023.3
XP_006252086.1, XM_006252024.3
XP_008768927.1, XM_008770705.2
XP_017455296.1, XM_017599807.1
XP_017455297.1, XM_017599808.1
XP_017455298.1, XM_017599809.1
UniGeneiRn.163294

Genome annotation databases

EnsembliENSRNOT00000014391; ENSRNOP00000014391; ENSRNOG00000010296
GeneIDi83509
KEGGirno:83509
UCSCiRGD:619902 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020520 mRNA Translation: BAA87325.1
AF200684 mRNA Translation: AAF07216.1
BC091142 mRNA Translation: AAH91142.1
RefSeqiNP_112631.1, NM_031341.1
XP_006252082.1, XM_006252020.3
XP_006252083.1, XM_006252021.3
XP_006252085.1, XM_006252023.3
XP_006252086.1, XM_006252024.3
XP_008768927.1, XM_008770705.2
XP_017455296.1, XM_017599807.1
XP_017455297.1, XM_017599808.1
XP_017455298.1, XM_017599809.1
UniGeneiRn.163294

3D structure databases

ProteinModelPortaliQ9R0S5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014391

Protein family/group databases

TCDBi2.A.3.8.7 the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetiQ9R0S5
PhosphoSitePlusiQ9R0S5

Proteomic databases

PaxDbiQ9R0S5
PRIDEiQ9R0S5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014391; ENSRNOP00000014391; ENSRNOG00000010296
GeneIDi83509
KEGGirno:83509
UCSCiRGD:619902 rat

Organism-specific databases

CTDi9056
RGDi619902 Slc7a7

Phylogenomic databases

eggNOGiKOG1287 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119037
HOGENOMiHOG000098892
HOVERGENiHBG000476
InParanoidiQ9R0S5
KOiK13867
OMAiYMVQPIF
OrthoDBiEOG091G07EM
PhylomeDBiQ9R0S5
TreeFamiTF313355

Enzyme and pathway databases

ReactomeiR-RNO-210991 Basigin interactions
R-RNO-352230 Amino acid transport across the plasma membrane

Miscellaneous databases

PROiPR:Q9R0S5

Gene expression databases

BgeeiENSRNOG00000010296 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ9R0S5 RN

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYLAT1_RAT
AccessioniPrimary (citable) accession number: Q9R0S5
Secondary accession number(s): Q9QZ66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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