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Protein

Mannose-P-dolichol utilization defect 1 protein

Gene

Mpdu1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.By similarity

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-P-dolichol utilization defect 1 protein
Alternative name(s):
Suppressor of Lec15 and Lec35 glycosylation mutation homolog
Short name:
SL15
Gene namesi
Name:Mpdu1
Synonyms:Supl15h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1346040 Mpdu1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei128 – 145HelicalSequence analysisAdd BLAST18
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002210352 – 247Mannose-P-dolichol utilization defect 1 proteinAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9R0Q9
MaxQBiQ9R0Q9
PaxDbiQ9R0Q9
PRIDEiQ9R0Q9

PTM databases

PhosphoSitePlusiQ9R0Q9

Expressioni

Gene expression databases

CleanExiMM_MPDU1

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018905

Structurei

3D structure databases

ProteinModelPortaliQ9R0Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 105PQ-loop 1Add BLAST67
Domaini159 – 216PQ-loop 2Add BLAST58

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3211 Eukaryota
ENOG4111FE3 LUCA
HOGENOMiHOG000189346
HOVERGENiHBG000421
InParanoidiQ9R0Q9
PhylomeDBiQ9R0Q9

Family and domain databases

InterProiView protein in InterPro
IPR016817 MannP-dilichol_defect-1
IPR006603 PQ-loop_rpt
PANTHERiPTHR12226 PTHR12226, 1 hit
PfamiView protein in Pfam
PF04193 PQ-loop, 2 hits
PIRSFiPIRSF023381 MannP-dilichol_defect-1p, 1 hit
SMARTiView protein in SMART
SM00679 CTNS, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9R0Q9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGEADGRFK GLLVPILLPE KCYDQLFVQW DLLHVPCLKI LLSKGLGLGI
60 70 80 90 100
VAGSLLVKLP QVFKLLGAKS AEGLSLQSVM LELVALTGTV VYSITNNFPF
110 120 130 140 150
SSWGEALFLT LQTVAICFLV MHYRGETVKG VAFLACYAMV LLALLSPLTP
160 170 180 190 200
LAVVTLLQAS NVPAVVVGKL LQAATNYRNG HTGQLSAITV FMLFGGSLAR
210 220 230 240
IFTSVQETGD PLMAGVFVVS SLCNGLIAAQ VLFYWNAKAP HKQKKEQ
Length:247
Mass (Da):26,498
Last modified:May 1, 2000 - v1
Checksum:iD639EAFFFE1CA11C
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8R0J2Q8R0J2_MOUSE
Mannose-P-dolichol utilization defe...
Mpdu1
247Annotation score:
E9PVP3E9PVP3_MOUSE
Mannose-P-dolichol utilization defe...
Mpdu1
120Annotation score:
Q5F2B1Q5F2B1_MOUSE
Mannose-P-dolichol utilization defe...
Mpdu1
148Annotation score:
F6ZGG4F6ZGG4_MOUSE
Mannose-P-dolichol utilization defe...
Mpdu1
129Annotation score:
F6XX36F6XX36_MOUSE
Mannose-P-dolichol utilization defe...
Mpdu1
197Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148L → V in BAA28603 (Ref. 2) Curated1
Sequence conflicti171L → LL in BAA28603 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024713 mRNA Translation: BAA78781.1
AB025354 Genomic DNA Translation: BAA78782.1
AB014471 Genomic DNA Translation: BAA28603.1
CCDSiCCDS24903.1
UniGeneiMm.89579

Genome annotation databases

UCSCiuc007jqw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024713 mRNA Translation: BAA78781.1
AB025354 Genomic DNA Translation: BAA78782.1
AB014471 Genomic DNA Translation: BAA28603.1
CCDSiCCDS24903.1
UniGeneiMm.89579

3D structure databases

ProteinModelPortaliQ9R0Q9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018905

PTM databases

PhosphoSitePlusiQ9R0Q9

Proteomic databases

EPDiQ9R0Q9
MaxQBiQ9R0Q9
PaxDbiQ9R0Q9
PRIDEiQ9R0Q9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007jqw.2 mouse

Organism-specific databases

MGIiMGI:1346040 Mpdu1

Phylogenomic databases

eggNOGiKOG3211 Eukaryota
ENOG4111FE3 LUCA
HOGENOMiHOG000189346
HOVERGENiHBG000421
InParanoidiQ9R0Q9
PhylomeDBiQ9R0Q9

Miscellaneous databases

ChiTaRSiMpdu1 mouse
PROiPR:Q9R0Q9
SOURCEiSearch...

Gene expression databases

CleanExiMM_MPDU1

Family and domain databases

InterProiView protein in InterPro
IPR016817 MannP-dilichol_defect-1
IPR006603 PQ-loop_rpt
PANTHERiPTHR12226 PTHR12226, 1 hit
PfamiView protein in Pfam
PF04193 PQ-loop, 2 hits
PIRSFiPIRSF023381 MannP-dilichol_defect-1p, 1 hit
SMARTiView protein in SMART
SM00679 CTNS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMPU1_MOUSE
AccessioniPrimary (citable) accession number: Q9R0Q9
Secondary accession number(s): O70203, Q9R0P7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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