UniProtKB - Q9R0Q7 (TEBP_MOUSE)
Prostaglandin E synthase 3
Ptges3
Functioni
Catalytic activityi
- EC:5.3.99.3By similarity
: prostaglandin biosynthesis Pathwayi
This protein is involved in the pathway prostaglandin biosynthesis, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway prostaglandin biosynthesis and in Lipid metabolism.
GO - Molecular functioni
- chaperone binding Source: GO_Central
- DNA polymerase binding Source: BHF-UCL
- enzyme binding Source: MGI
- Hsp90 protein binding Source: MGI
- p53 binding Source: MGI
- prostaglandin-E synthase activity Source: UniProtKB
- telomerase activity Source: MGI
- unfolded protein binding Source: UniProtKB
GO - Biological processi
- cell population proliferation Source: MGI
- chaperone cofactor-dependent protein refolding Source: MGI
- chaperone-mediated protein complex assembly Source: MGI
- glucocorticoid receptor signaling pathway Source: MGI
- glycogen biosynthetic process Source: MGI
- lung saccule development Source: MGI
- negative regulation of cell death Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of phosphorylation Source: MGI
- positive regulation of telomerase activity Source: BHF-UCL
- prostaglandin biosynthetic process Source: MGI
- prostaglandin metabolic process Source: MGI
- protein folding Source: GO_Central
- protein stabilization Source: MGI
- sensory perception of pain Source: MGI
- skin development Source: MGI
- telomerase holoenzyme complex assembly Source: BHF-UCL
- telomere maintenance via telomerase Source: BHF-UCL
Keywordsi
Molecular function | Isomerase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism |
Enzyme and pathway databases
Reactomei | R-MMU-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-MMU-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-MMU-3371511, HSF1 activation R-MMU-3371568, Attenuation phase R-MMU-8937144, Aryl hydrocarbon receptor signalling R-MMU-8939211, ESR-mediated signaling R-MMU-9018519, Estrogen-dependent gene expression |
UniPathwayi | UPA00662 |
Names & Taxonomyi
Protein namesi | Recommended name: Prostaglandin E synthase 3 (EC:5.3.99.3By similarity)Alternative name(s): Cytosolic prostaglandin E2 synthase Short name: cPGES Hsp90 co-chaperone Progesterone receptor complex p23 Sid 3177 Telomerase-binding protein p23 |
Gene namesi | Name:Ptges3 Synonyms:Sid3177, Tebp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929282, Ptges3 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- actin filament Source: MGI
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: GO_Central
- telomerase holoenzyme complex Source: MGI
Other locations
- chaperone complex Source: MGI
- intracellular membrane-bounded organelle Source: MGI
- neuron projection Source: MGI
- neuronal cell body Source: MGI
- perinuclear region of cytoplasm Source: MGI
- protein-containing complex Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218953 | 1 – 160 | Prostaglandin E synthase 3Add BLAST | 160 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 33 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 35 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 44 | PhosphoserineCombined sources | 1 | |
Cross-linki | 65 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 85 | PhosphoserineBy similarity | 1 | |
Modified residuei | 100 | PhosphoserineCombined sources | 1 | |
Modified residuei | 113 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 118 | PhosphoserineCombined sources | 1 | |
Modified residuei | 148 | PhosphoserineCombined sources | 1 | |
Modified residuei | 151 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9R0Q7 |
jPOSTi | Q9R0Q7 |
MaxQBi | Q9R0Q7 |
PaxDbi | Q9R0Q7 |
PRIDEi | Q9R0Q7 |
ProteomicsDBi | 254692 |
PTM databases
iPTMneti | Q9R0Q7 |
PhosphoSitePlusi | Q9R0Q7 |
SwissPalmi | Q9R0Q7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000071072, Expressed in cumulus cell and 307 other tissues |
Genevisiblei | Q9R0Q7, MM |
Interactioni
Subunit structurei
Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2. Binds to the progesterone receptor.
Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex.
Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation.
Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2.
By similarityGO - Molecular functioni
- chaperone binding Source: GO_Central
- DNA polymerase binding Source: BHF-UCL
- enzyme binding Source: MGI
- Hsp90 protein binding Source: MGI
- p53 binding Source: MGI
- unfolded protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 207917, 24 interactors |
IntActi | Q9R0Q7, 3 interactors |
MINTi | Q9R0Q7 |
STRINGi | 10090.ENSMUSP00000050292 |
Miscellaneous databases
RNActi | Q9R0Q7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 90 | CSPROSITE-ProRule annotationAdd BLAST | 90 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 157 – 160 | PXLE motifBy similarity | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 108 – 160 | Asp/Glu-richAdd BLAST | 53 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3158, Eukaryota |
GeneTreei | ENSGT00940000154256 |
HOGENOMi | CLU_078883_1_2_1 |
InParanoidi | Q9R0Q7 |
OMAi | WSKWKDE |
OrthoDBi | 1461729at2759 |
PhylomeDBi | Q9R0Q7 |
TreeFami | TF315077 |
Family and domain databases
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR007052, CS_dom IPR008978, HSP20-like_chaperone |
Pfami | View protein in Pfam PF04969, CS, 1 hit |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS51203, CS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL
60 70 80 90 100
NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS
110 120 130 140 150
VDFNNWKDWE DDSDEDMSNF DRFSEMMDHM GGDEDVDLPE VDGADDDSQD
160
SDDEKMPDLE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z7C6 | D3Z7C6_MOUSE | Prostaglandin E synthase 3 | Ptges3 | 130 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 87 – 88 | PR → LG in AAD39543 (Ref. 3) Curated | 2 | |
Sequence conflicti | 108 | D → N in AAP34198 (PubMed:14563409).Curated | 1 | |
Sequence conflicti | 108 | D → N in BAB25906 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY281130 mRNA Translation: AAP34198.1 AB024935 mRNA Translation: BAA84684.1 AF153479 mRNA Translation: AAD39543.1 AK008805 mRNA Translation: BAB25906.1 AK075932 mRNA Translation: BAC36062.1 AK075987 mRNA Translation: BAC36099.1 AK077538 mRNA Translation: BAC36854.1 AK168073 mRNA Translation: BAE40047.1 AK168210 mRNA Translation: BAE40169.1 AK168721 mRNA Translation: BAE40563.1 BC003708 mRNA Translation: AAH03708.1 BC085264 mRNA Translation: AAH85264.1 |
CCDSi | CCDS36087.1 |
RefSeqi | NP_062740.1, NM_019766.4 |
Genome annotation databases
Ensembli | ENSMUST00000052798; ENSMUSP00000050292; ENSMUSG00000071072 |
GeneIDi | 56351 |
KEGGi | mmu:56351 |
UCSCi | uc007hld.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY281130 mRNA Translation: AAP34198.1 AB024935 mRNA Translation: BAA84684.1 AF153479 mRNA Translation: AAD39543.1 AK008805 mRNA Translation: BAB25906.1 AK075932 mRNA Translation: BAC36062.1 AK075987 mRNA Translation: BAC36099.1 AK077538 mRNA Translation: BAC36854.1 AK168073 mRNA Translation: BAE40047.1 AK168210 mRNA Translation: BAE40169.1 AK168721 mRNA Translation: BAE40563.1 BC003708 mRNA Translation: AAH03708.1 BC085264 mRNA Translation: AAH85264.1 |
CCDSi | CCDS36087.1 |
RefSeqi | NP_062740.1, NM_019766.4 |
3D structure databases
SMRi | Q9R0Q7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207917, 24 interactors |
IntActi | Q9R0Q7, 3 interactors |
MINTi | Q9R0Q7 |
STRINGi | 10090.ENSMUSP00000050292 |
PTM databases
iPTMneti | Q9R0Q7 |
PhosphoSitePlusi | Q9R0Q7 |
SwissPalmi | Q9R0Q7 |
Proteomic databases
EPDi | Q9R0Q7 |
jPOSTi | Q9R0Q7 |
MaxQBi | Q9R0Q7 |
PaxDbi | Q9R0Q7 |
PRIDEi | Q9R0Q7 |
ProteomicsDBi | 254692 |
Protocols and materials databases
Antibodypediai | 28360, 725 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000052798; ENSMUSP00000050292; ENSMUSG00000071072 |
GeneIDi | 56351 |
KEGGi | mmu:56351 |
UCSCi | uc007hld.1, mouse |
Organism-specific databases
CTDi | 10728 |
MGIi | MGI:1929282, Ptges3 |
Phylogenomic databases
eggNOGi | KOG3158, Eukaryota |
GeneTreei | ENSGT00940000154256 |
HOGENOMi | CLU_078883_1_2_1 |
InParanoidi | Q9R0Q7 |
OMAi | WSKWKDE |
OrthoDBi | 1461729at2759 |
PhylomeDBi | Q9R0Q7 |
TreeFami | TF315077 |
Enzyme and pathway databases
UniPathwayi | UPA00662 |
Reactomei | R-MMU-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-MMU-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-MMU-3371511, HSF1 activation R-MMU-3371568, Attenuation phase R-MMU-8937144, Aryl hydrocarbon receptor signalling R-MMU-8939211, ESR-mediated signaling R-MMU-9018519, Estrogen-dependent gene expression |
Miscellaneous databases
BioGRID-ORCSi | 56351, 4 hits in 52 CRISPR screens |
ChiTaRSi | Ptges3, mouse |
PROi | PR:Q9R0Q7 |
RNActi | Q9R0Q7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000071072, Expressed in cumulus cell and 307 other tissues |
Genevisiblei | Q9R0Q7, MM |
Family and domain databases
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR007052, CS_dom IPR008978, HSP20-like_chaperone |
Pfami | View protein in Pfam PF04969, CS, 1 hit |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS51203, CS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TEBP_MOUSE | |
Accessioni | Q9R0Q7Primary (citable) accession number: Q9R0Q7 Secondary accession number(s): Q542V4, Q9D7V0, Q9WV83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families