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Protein

Actin-related protein 2/3 complex subunit 1A

Gene

Arpc1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity).By similarity

GO - Molecular functioni

  • actin filament binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1A
Alternative name(s):
SOP2-like protein
Sid 329
Gene namesi
Name:Arpc1a
Synonyms:Sid329
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1928896 Arpc1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508531 – 370Actin-related protein 2/3 complex subunit 1AAdd BLAST370

Proteomic databases

EPDiQ9R0Q6
MaxQBiQ9R0Q6
PaxDbiQ9R0Q6
PeptideAtlasiQ9R0Q6
PRIDEiQ9R0Q6

PTM databases

iPTMnetiQ9R0Q6
PhosphoSitePlusiQ9R0Q6
SwissPalmiQ9R0Q6

Expressioni

Gene expression databases

BgeeiENSMUSG00000029621 Expressed in 295 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_ARPC1A
ExpressionAtlasiQ9R0Q6 baseline and differential
GenevisibleiQ9R0Q6 MM

Interactioni

Subunit structurei

Probable component of the Arp2/3 complex in which it may replace ARPC1B.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207984, 2 interactors
IntActiQ9R0Q6, 6 interactors
MINTiQ9R0Q6
STRINGi10090.ENSMUSP00000031625

Structurei

3D structure databases

ProteinModelPortaliQ9R0Q6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 45WD 1Add BLAST40
Repeati50 – 89WD 2Add BLAST40
Repeati140 – 179WD 3Add BLAST40
Repeati202 – 241WD 4Add BLAST40
Repeati244 – 284WD 5Add BLAST41
Repeati322 – 365WD 6Add BLAST44

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1523 Eukaryota
ENOG410XNWX LUCA
GeneTreeiENSGT00390000008339
HOGENOMiHOG000181752
HOVERGENiHBG050560
InParanoidiQ9R0Q6
KOiK05757
OMAiSAMRKFQ
OrthoDBiEOG091G096H
PhylomeDBiQ9R0Q6
TreeFamiTF315041

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030140 ARC1A
IPR017383 ARPC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10709 PTHR10709, 1 hit
PTHR10709:SF11 PTHR10709:SF11, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PIRSFiPIRSF038093 ARP2/3_su1, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9R0Q6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGS QWTKAHELKE
60 70 80 90 100
HNGHITGIDW APKSDRIVTC GADRNAYVWS QKDGIWKPTL VILRINRAAT
110 120 130 140 150
FVKWSPLENK FAVGSGARLI SVCYFESEND WWVSKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNNVLLAAG SCDFKCRVFS AYIKEVDEKP ASTPWGSKMP FGQLMSEFGG
210 220 230 240 250
SGTGGWVHGV SFSASGNRLA WVSHDSTVSV ADASKSVQVS TLRTEFLPLL
260 270 280 290 300
SVSFVSENSV VAAGHDCCPM LFNYDDRGCL TFVSKLDVPK QSIQRNMSAM
310 320 330 340 350
ERFRNMDKRA TTEDRNTALE TLHQNSITQV SIYEVDKQDC RKFCTTGIDG
360 370
AMTIWDFKTL ESSIQGLRIM
Length:370
Mass (Da):41,626
Last modified:May 1, 2000 - v1
Checksum:iB47F0151B27211B0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVI5D3YVI5_MOUSE
Actin-related protein 2/3 complex s...
Arpc1a
135Annotation score:
A0A0G2JF52A0A0G2JF52_MOUSE
Actin related protein 2/3 complex, ...
Arpc1a mCG_17259
262Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024984 mRNA Translation: BAA84685.1
AK076107 mRNA Translation: BAC36187.1
AK145663 mRNA Translation: BAE26575.1
BC001988 mRNA Translation: AAH01988.1
CCDSiCCDS19855.1
RefSeqiNP_062741.1, NM_019767.2
UniGeneiMm.371610

Genome annotation databases

EnsembliENSMUST00000031625; ENSMUSP00000031625; ENSMUSG00000029621
GeneIDi56443
KEGGimmu:56443
UCSCiuc009ama.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024984 mRNA Translation: BAA84685.1
AK076107 mRNA Translation: BAC36187.1
AK145663 mRNA Translation: BAE26575.1
BC001988 mRNA Translation: AAH01988.1
CCDSiCCDS19855.1
RefSeqiNP_062741.1, NM_019767.2
UniGeneiMm.371610

3D structure databases

ProteinModelPortaliQ9R0Q6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207984, 2 interactors
IntActiQ9R0Q6, 6 interactors
MINTiQ9R0Q6
STRINGi10090.ENSMUSP00000031625

PTM databases

iPTMnetiQ9R0Q6
PhosphoSitePlusiQ9R0Q6
SwissPalmiQ9R0Q6

Proteomic databases

EPDiQ9R0Q6
MaxQBiQ9R0Q6
PaxDbiQ9R0Q6
PeptideAtlasiQ9R0Q6
PRIDEiQ9R0Q6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031625; ENSMUSP00000031625; ENSMUSG00000029621
GeneIDi56443
KEGGimmu:56443
UCSCiuc009ama.1 mouse

Organism-specific databases

CTDi10552
MGIiMGI:1928896 Arpc1a

Phylogenomic databases

eggNOGiKOG1523 Eukaryota
ENOG410XNWX LUCA
GeneTreeiENSGT00390000008339
HOGENOMiHOG000181752
HOVERGENiHBG050560
InParanoidiQ9R0Q6
KOiK05757
OMAiSAMRKFQ
OrthoDBiEOG091G096H
PhylomeDBiQ9R0Q6
TreeFamiTF315041

Miscellaneous databases

ChiTaRSiArpc1a mouse
PROiPR:Q9R0Q6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029621 Expressed in 295 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_ARPC1A
ExpressionAtlasiQ9R0Q6 baseline and differential
GenevisibleiQ9R0Q6 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030140 ARC1A
IPR017383 ARPC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10709 PTHR10709, 1 hit
PTHR10709:SF11 PTHR10709:SF11, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PIRSFiPIRSF038093 ARP2/3_su1, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARC1A_MOUSE
AccessioniPrimary (citable) accession number: Q9R0Q6
Secondary accession number(s): Q3UL75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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