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Protein

Signal peptidase complex catalytic subunit SEC11A

Gene

Sec11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56By similarity1

GO - Molecular functioni

  • peptidase activity Source: GO_Central
  • serine-type peptidase activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

ReactomeiR-MMU-422085 Synthesis, secretion, and deacylation of Ghrelin

Protein family/group databases

MEROPSiS26.009

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11A (EC:3.4.21.89)
Alternative name(s):
Endopeptidase SP18
Microsomal signal peptidase 18 kDa subunit
Short name:
SPase 18 kDa subunit
SEC11 homolog A
SEC11-like protein 1
SPC18
Sid 2895
Gene namesi
Name:Sec11a
Synonyms:Sec11l1, Sid2895, Spc18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1929464 Sec11a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 36Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini37 – 179LumenalSequence analysisAdd BLAST143

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095441 – 179Signal peptidase complex catalytic subunit SEC11AAdd BLAST179

Proteomic databases

EPDiQ9R0P6
MaxQBiQ9R0P6
PaxDbiQ9R0P6
PRIDEiQ9R0P6

PTM databases

iPTMnetiQ9R0P6
PhosphoSitePlusiQ9R0P6
SwissPalmiQ9R0P6

Expressioni

Gene expression databases

BgeeiENSMUSG00000025724 Expressed in 305 organ(s), highest expression level in renal corpuscle
CleanExiMM_SEC11A
ExpressionAtlasiQ9R0P6 baseline and differential
GenevisibleiQ9R0P6 MM

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

BioGridi208039, 2 interactors
STRINGi10090.ENSMUSP00000026818

Structurei

3D structure databases

ProteinModelPortaliQ9R0P6
SMRiQ9R0P6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342 Eukaryota
COG0681 LUCA
GeneTreeiENSGT00390000015600
HOVERGENiHBG057279
InParanoidiQ9R0P6
KOiK13280
TreeFamiTF313648

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR019758 Pept_S26A_signal_pept_1_CS
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR001733 Peptidase_S26B
IPR037712 SEC11A/SEC11B
PANTHERiPTHR10806 PTHR10806, 1 hit
PTHR10806:SF8 PTHR10806:SF8, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00728 SIGNALPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02228 sigpep_I_arch, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00761 SPASE_I_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9R0P6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSLDFLDDV RRMNKRQLYY QVLNFGMIVS SALMIWKGLM VITGSESPIV
60 70 80 90 100
VVLSGSMEPA FHRGDLLFLT NRVEDPIRVG EIVVFRIEGR EIPIVHRVLK
110 120 130 140 150
IHEKQDGHIK FLTKGDNNAV DDRGLYKQGQ HWLEKKDVVG RARGFVPYIG
160 170
IVTILMNDYP KFKYAVLFLL GLFVLVHRE
Length:179
Mass (Da):20,626
Last modified:May 1, 2000 - v1
Checksum:iDFDAEF037309167F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTS1D3YTS1_MOUSE
Signal peptidase complex catalytic ...
Sec11a Sec11l1, mCG_15305
247Annotation score:
D3Z569D3Z569_MOUSE
Signal peptidase complex catalytic ...
Sec11a Sec11l1, mCG_15305
190Annotation score:
D3YWT0D3YWT0_MOUSE
Signal peptidase complex catalytic ...
Sec11a
170Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025405 mRNA Translation: BAA84690.1
AK007449 mRNA Translation: BAB25044.1
BC010484 mRNA Translation: AAH10484.1
CCDSiCCDS21401.1
RefSeqiNP_064335.1, NM_019951.1
UniGeneiMm.43760

Genome annotation databases

EnsembliENSMUST00000026818; ENSMUSP00000026818; ENSMUSG00000025724
GeneIDi56529
KEGGimmu:56529
UCSCiuc009ibn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025405 mRNA Translation: BAA84690.1
AK007449 mRNA Translation: BAB25044.1
BC010484 mRNA Translation: AAH10484.1
CCDSiCCDS21401.1
RefSeqiNP_064335.1, NM_019951.1
UniGeneiMm.43760

3D structure databases

ProteinModelPortaliQ9R0P6
SMRiQ9R0P6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208039, 2 interactors
STRINGi10090.ENSMUSP00000026818

Protein family/group databases

MEROPSiS26.009

PTM databases

iPTMnetiQ9R0P6
PhosphoSitePlusiQ9R0P6
SwissPalmiQ9R0P6

Proteomic databases

EPDiQ9R0P6
MaxQBiQ9R0P6
PaxDbiQ9R0P6
PRIDEiQ9R0P6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026818; ENSMUSP00000026818; ENSMUSG00000025724
GeneIDi56529
KEGGimmu:56529
UCSCiuc009ibn.1 mouse

Organism-specific databases

CTDi23478
MGIiMGI:1929464 Sec11a

Phylogenomic databases

eggNOGiKOG3342 Eukaryota
COG0681 LUCA
GeneTreeiENSGT00390000015600
HOVERGENiHBG057279
InParanoidiQ9R0P6
KOiK13280
TreeFamiTF313648

Enzyme and pathway databases

ReactomeiR-MMU-422085 Synthesis, secretion, and deacylation of Ghrelin

Miscellaneous databases

PROiPR:Q9R0P6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025724 Expressed in 305 organ(s), highest expression level in renal corpuscle
CleanExiMM_SEC11A
ExpressionAtlasiQ9R0P6 baseline and differential
GenevisibleiQ9R0P6 MM

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR019758 Pept_S26A_signal_pept_1_CS
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR001733 Peptidase_S26B
IPR037712 SEC11A/SEC11B
PANTHERiPTHR10806 PTHR10806, 1 hit
PTHR10806:SF8 PTHR10806:SF8, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00728 SIGNALPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02228 sigpep_I_arch, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00761 SPASE_I_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC11A_MOUSE
AccessioniPrimary (citable) accession number: Q9R0P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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