UniProtKB - Q9R0N8 (SYT6_MOUSE)

BLAST

>sp|Q9R0N8|SYT6_MOUSE Synaptotagmin-6 OS=Mus musculus OX=10090 GN=Syt6 PE=1 SV=2
MSGVWGAGGPRCQAALAVLASLCRARPPPLGLDVETCRSFELQSPEQSPSAADSGTSVSL
LAVVVIVCGVALVAVFLFLFWKLCWMPWRKKEASSPSSANPASETLQSPSSRGNMADKLK
DPSALGFLEAAVKISHTSPDIPAEVQMSVKEHIMRHTKLQRQTTEPASSTRHTSFKRHLP
RQMHVSSVDYGNELPPAAAEQPTSIGRIKPELYKQKSVDGDDAKSEAAKSCGKINFSLRY
DYESETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFH
FPVPYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWKDIQYATSES
VDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTI
KKNTLNPIYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGINAEGLGRDHW
NEMLAYPRKPIAHWHSLVEVKKSFKEGTPRL

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History
Entry version 145 (07 Nov 2018)
Sequence version 2 (27 Jul 2011)
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Protein

Synaptotagmin-6

Gene

Syt6

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in Ca²⁺-dependent exocytosis of secretory vesicles through Ca²⁺ and phospholipid binding to the C2 domain or may serve as Ca²⁺ sensors in the process of vesicular trafficking and exocytosis (By similarity). May mediate Ca²⁺-regulation of exocytosis in acrosomal reaction in sperm (PubMed:15774481).By similarity1 Publication

Cofactorⁱ

Ca²⁺By similarityNote: Binds 3 Ca²⁺ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	261	Calcium 1By similarity	1
Metal bindingⁱ	261	Calcium 2By similarity	1
Metal bindingⁱ	267	Calcium 1By similarity	1
Metal bindingⁱ	319	Calcium 1By similarity	1
Metal bindingⁱ	319	Calcium 2By similarity	1
Metal bindingⁱ	320	Calcium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	321	Calcium 1By similarity	1
Metal bindingⁱ	321	Calcium 2By similarity	1
Metal bindingⁱ	321	Calcium 3By similarity	1
Metal bindingⁱ	324	Calcium 3By similarity	1
Metal bindingⁱ	327	Calcium 2By similarity	1
Metal bindingⁱ	327	Calcium 3By similarity	1

GO - Molecular functionⁱ

calcium-dependent phospholipid binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 8626542
calcium-dependent protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15774481
calcium ion binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
clathrin binding Source: MGI
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 10531343
phosphatidylserine binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 12860971
protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 10531344
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10531343
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acrosomal vesicle exocytosis Source: MGI
acrosome reaction
Source: HGNC
Inferred from direct assayⁱ
- 15774481
calcium ion regulated exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to calcium ion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
presynaptic dense core vesicle exocytosis Source: MGI
regulation of dopamine secretion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
synaptic vesicle exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Metal-binding

Ligand

Calcium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synaptotagmin-6 Alternative name(s): Synaptotagmin VI Short name: SytVI
Gene namesⁱ	Name:Syt6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1859544 Syt6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 59	VesicularSequence analysisAdd BLAST	59
Transmembraneⁱ	60 – 80	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	81 – 511	CytoplasmicSequence analysisAdd BLAST	431

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000183955	1 – 511	Synaptotagmin-6Add BLAST		511

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	217	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9R0N8
PRIDEⁱ	Q9R0N8

PTM databases

iPTMnetⁱ	Q9R0N8
PhosphoSitePlusⁱ	Q9R0N8

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is expressed in the olfactory bulb. Isoform 2 is expressed in the brain (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000027849 Expressed in 77 organ(s), highest expression level in retina
CleanExⁱ	MM_SYT6
ExpressionAtlasⁱ	Q9R0N8 baseline and differential
Genevisibleⁱ	Q9R0N8 MM

Interactionⁱ

Subunit structureⁱ

Isoform 1: Homodimer; disulfide-linked via the cysteine motif (PubMed:10531343, PubMed:10531344). Isoform 1: Can also form heterodimers with SYT3, SYT7, SYT9 and SYT10 (PubMed:10531343, PubMed:10531344, PubMed:10871604). Isoform 1: Interacts with STX1A, STX1B and STX2; the interaction is Ca²⁺-dependent (PubMed:15774481). Isoform 2: Is not able to form homodimer and heterodimers (PubMed:10531344).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		2	EBI-5239378,EBI-5239378
Syt10	Q9R0N4	2	EBI-5239378,EBI-5239459
Syt3	O35681	2	EBI-5239378,EBI-457995
Syt9	Q9R0N9	2	EBI-5239378,EBI-458006

GO - Molecular functionⁱ

calcium-dependent protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15774481
clathrin binding Source: MGI
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 10531343
protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 10531344
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10531343
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q9R0N8, 3 interactors
STRINGⁱ	10090.ENSMUSP00000088196

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9R0N8
SMRⁱ	Q9R0N8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	232 – 333	C2 1PROSITE-ProRule annotationAdd BLAST		102
Domainⁱ	364 – 467	C2 2PROSITE-ProRule annotationAdd BLAST		104

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	12 – 38	Cysteine motifBy similarityAdd BLAST		27
Regionⁱ	483 – 511	Necessary for cell membrane association (isoform 2)1 PublicationAdd BLAST		29

Domainⁱ

The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity

Sequence similaritiesⁱ

Belongs to the synaptotagmin family.Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IT3F Eukaryota ENOG410YBMV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118973
HOGENOMⁱ	HOG000232128
HOVERGENⁱ	HBG005010
InParanoidⁱ	Q9R0N8
KEGG Orthology (KO) More...KOⁱ	K19906
OMAⁱ	TRHISFK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XMQ
TreeFamⁱ	TF315600

Family and domain databases

Gene3Dⁱ	2.60.40.150, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR001565 Synaptotagmin IPR028701 SYT6
PANTHERⁱ	PTHR10024:SF45 PTHR10024:SF45, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits
PRINTSⁱ	PR00360 C2DOMAIN PR00399 SYNAPTOTAGMN
SMARTⁱ	View protein in SMART SM00239 C2, 2 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9R0N8-1) [UniParc]FASTA Add to basket

Also known as: SytVI

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGVWGAGGP RCQAALAVLA SLCRARPPPL GLDVETCRSF ELQSPEQSPS 
        60         70         80         90        100
AADSGTSVSL LAVVVIVCGV ALVAVFLFLF WKLCWMPWRK KEASSPSSAN 
       110        120        130        140        150
PASETLQSPS SRGNMADKLK DPSALGFLEA AVKISHTSPD IPAEVQMSVK 
       160        170        180        190        200
EHIMRHTKLQ RQTTEPASST RHTSFKRHLP RQMHVSSVDY GNELPPAAAE 
       210        220        230        240        250
QPTSIGRIKP ELYKQKSVDG DDAKSEAAKS CGKINFSLRY DYESETLIVR 
       260        270        280        290        300
ILKAFDLPAK DFCGSSDPYV KIYLLPDRKC KLQTRVHRKT LNPTFDENFH 
       310        320        330        340        350
FPVPYEELAD RKLHLSVFDF DRFSRHDMIG EVILDNLFEA SDLSRETSIW 
       360        370        380        390        400
KDIQYATSES VDLGEIMFSL CYLPTAGRLT LTVIKCRNLK AMDITGYSDP 
       410        420        430        440        450
YVKVSLLCDG RRLKKKKTTI KKNTLNPIYN EAIIFDIPPE NMDQVSLLIS 
       460        470        480        490        500
VMDYDRVGHN EIIGVCRVGI NAEGLGRDHW NEMLAYPRKP IAHWHSLVEV 
       510 
KKSFKEGTPR L

Length:511

Mass (Da):57,204

Last modified:July 27, 2011 - v2

Checksum:ⁱC37C9305E3D05572

Isoform 2 (identifier: Q9R0N8-2) [UniParc]FASTA Add to basket

Also known as: SytVIdeltaTM1

The sequence of this isoform differs from the canonical sequence as follows:
1-85: Missing.

« Hide

        10         20         30         40         50
MPWRKKEASS PSSANPASET LQSPSSRGNM ADKLKDPSAL GFLEAAVKIS 
        60         70         80         90        100
HTSPDIPAEV QMSVKEHIMR HTKLQRQTTE PASSTRHTSF KRHLPRQMHV 
       110        120        130        140        150
SSVDYGNELP PAAAEQPTSI GRIKPELYKQ KSVDGDDAKS EAAKSCGKIN 
       160        170        180        190        200
FSLRYDYESE TLIVRILKAF DLPAKDFCGS SDPYVKIYLL PDRKCKLQTR 
       210        220        230        240        250
VHRKTLNPTF DENFHFPVPY EELADRKLHL SVFDFDRFSR HDMIGEVILD 
       260        270        280        290        300
NLFEASDLSR ETSIWKDIQY ATSESVDLGE IMFSLCYLPT AGRLTLTVIK 
       310        320        330        340        350
CRNLKAMDIT GYSDPYVKVS LLCDGRRLKK KKTTIKKNTL NPIYNEAIIF 
       360        370        380        390        400
DIPPENMDQV SLLISVMDYD RVGHNEIIGV CRVGINAEGL GRDHWNEMLA 
       410        420 
YPRKPIAHWH SLVEVKKSFK EGTPRL

Show »

Length:426

Mass (Da):48,343

Checksum:ⁱ699B22C7B06C3179

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q3UY13	Q3UY13_MOUSE	Synaptotagmin-6 Synaptotagmin-6	Syt6	342	Annotation score:
Q8C8S6	Q8C8S6_MOUSE	Synaptotagmin-6 Synaptotagmin-6	Syt6	438	Annotation score:
D6RIM4	D6RIM4_MOUSE	Synaptotagmin-6 Synaptotagmin-6	Syt6	93	Annotation score:
V9GWX4	V9GWX4_MOUSE	Synaptotagmin-6 Synaptotagmin-6	Syt6	88	Annotation score:
D6RHQ5	D6RHQ5_MOUSE	Synaptotagmin-6 Synaptotagmin-6	Syt6	71	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	428	I → V in BAA85775 (PubMed:10531343).Curated	1
Sequence conflictⁱ	428	I → V in BAA85781 (PubMed:10531344).Curated	1
Sequence conflictⁱ	428	I → V in BAA85782 (PubMed:10531344).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041729	1 – 85	Missing in isoform 2. 1 PublicationAdd BLAST		85

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB026803 mRNA Translation: BAA85775.1 AB026809 mRNA Translation: BAA85781.1 AB026810 mRNA Translation: BAA85782.1 AC123057 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS38575.1 [Q9R0N8-1] CCDS71296.1 [Q9R0N8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_061270.2, NM_018800.4 [Q9R0N8-1]
UniGeneⁱ	Mm.488213 Mm.88818

Genome annotation databases

Ensemblⁱ	ENSMUST00000090697; ENSMUSP00000088196; ENSMUSG00000027849 [Q9R0N8-1] ENSMUST00000117221; ENSMUSP00000113373; ENSMUSG00000027849 [Q9R0N8-2] ENSMUST00000121834; ENSMUSP00000112997; ENSMUSG00000027849 [Q9R0N8-1]
GeneIDⁱ	54524
KEGGⁱ	mmu:54524
UCSC genome browser More...UCSCⁱ	uc008qsy.2 mouse [Q9R0N8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9R0N8	Syt6 protein		MOUSE		426	UniRef100_Q9R0N8
Isoform 2 of Synaptotagmin-6		MOUSE		426

Protein	Similar proteins		Species	Score	Length	Source
Q9R0N8	Synaptotagmin-6		RAT		511	UniRef90_Q9R0N8
Synaptotagmin-6		HUMAN		510
Syt6 protein		MOUSE		426
Synaptotagmin-6-like protein		CRIGR		536
SYT6 isoform 5		PONAB		528
+136

Protein	Similar proteins		Species	Score	Length	Source
Q9R0N8	Synaptotagmin-6		RAT		511	UniRef50_Q9R0N8
Synaptotagmin-6		HUMAN		510
Synaptotagmin-C		DIPOM		537
Syt6 protein		MOUSE		426
Synaptotagmin-6-like protein		CRIGR		536
+722

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB026803 mRNA Translation: BAA85775.1 AB026809 mRNA Translation: BAA85781.1 AB026810 mRNA Translation: BAA85782.1 AC123057 Genomic DNA No translation available.
CCDSⁱ	CCDS38575.1 [Q9R0N8-1] CCDS71296.1 [Q9R0N8-2]
RefSeqⁱ	NP_061270.2, NM_018800.4 [Q9R0N8-1]
UniGeneⁱ	Mm.488213 Mm.88818

3D structure databases

ProteinModelPortalⁱ	Q9R0N8
SMRⁱ	Q9R0N8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9R0N8, 3 interactors
STRINGⁱ	10090.ENSMUSP00000088196

PTM databases

iPTMnetⁱ	Q9R0N8
PhosphoSitePlusⁱ	Q9R0N8

Proteomic databases

PaxDbⁱ	Q9R0N8
PRIDEⁱ	Q9R0N8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000090697; ENSMUSP00000088196; ENSMUSG00000027849 [Q9R0N8-1] ENSMUST00000117221; ENSMUSP00000113373; ENSMUSG00000027849 [Q9R0N8-2] ENSMUST00000121834; ENSMUSP00000112997; ENSMUSG00000027849 [Q9R0N8-1]
GeneIDⁱ	54524
KEGGⁱ	mmu:54524
UCSCⁱ	uc008qsy.2 mouse [Q9R0N8-1]

Organism-specific databases

CTDⁱ	148281
MGIⁱ	MGI:1859544 Syt6

Phylogenomic databases

eggNOGⁱ	ENOG410IT3F Eukaryota ENOG410YBMV LUCA
GeneTreeⁱ	ENSGT00760000118973
HOGENOMⁱ	HOG000232128
HOVERGENⁱ	HBG005010
InParanoidⁱ	Q9R0N8
KOⁱ	K19906
OMAⁱ	TRHISFK
OrthoDBⁱ	EOG091G0XMQ
TreeFamⁱ	TF315600

Miscellaneous databases

ChiTaRSⁱ	Syt6 mouse
Protein Ontology More...PROⁱ	PR:Q9R0N8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027849 Expressed in 77 organ(s), highest expression level in retina
CleanExⁱ	MM_SYT6
ExpressionAtlasⁱ	Q9R0N8 baseline and differential
Genevisibleⁱ	Q9R0N8 MM

Family and domain databases

Gene3Dⁱ	2.60.40.150, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR001565 Synaptotagmin IPR028701 SYT6
PANTHERⁱ	PTHR10024:SF45 PTHR10024:SF45, 1 hit
Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits
PRINTSⁱ	PR00360 C2DOMAIN PR00399 SYNAPTOTAGMN
SMARTⁱ	View protein in SMART SM00239 C2, 2 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYT6_MOUSE
Accessionⁱ	Q9R0N8Primary (citable) accession number: Q9R0N8 Secondary accession number(s): E9QJV2, Q9QUK7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - Q9R0N8 (SYT6_MOUSE)

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Synaptotagmin-6

Syt6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Cytosol

Plasma membrane

Cytosol

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ