UniProtKB - Q9R0N8 (SYT6_MOUSE)
Synaptotagmin-6
Syt6
Functioni
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 261 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 261 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 267 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 319 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 319 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 320 | Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 321 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 321 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 321 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 324 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 327 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 327 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 393 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 399 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 453 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 455 | Calcium 4PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: ParkinsonsUK-UCL
- calcium-dependent protein binding Source: UniProtKB
- calcium ion binding Source: GO_Central
- clathrin binding Source: MGI
- identical protein binding Source: IntAct
- phosphatidylserine binding Source: ParkinsonsUK-UCL
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: BHF-UCL
- SNARE binding Source: GO_Central
- syntaxin binding Source: MGI
GO - Biological processi
- acrosomal vesicle exocytosis Source: MGI
- acrosome reaction Source: HGNC-UCL
- calcium-ion regulated exocytosis Source: GO_Central
- calcium ion-regulated exocytosis of neurotransmitter Source: GO_Central
- cellular response to calcium ion Source: GO_Central
- presynaptic dense core vesicle exocytosis Source: MGI
- regulation of calcium ion-dependent exocytosis Source: GO_Central
- regulation of dopamine secretion Source: GO_Central
- vesicle-mediated transport Source: GO_Central
Keywordsi
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptotagmin-6Alternative name(s): Synaptotagmin VI Short name: SytVI |
Gene namesi | Name:Syt6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1859544, Syt6 |
Subcellular locationi
Other locations
- synaptic vesicle membrane 1 Publication; Single-pass membrane protein 1 Publication
Other locations
Note: Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (PubMed:10531344).1 Publication
Cytosol
- cytosol 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- perinuclear endoplasmic reticulum Source: BHF-UCL
Plasma Membrane
- integral component of synaptic membrane Source: MGI
- plasma membrane Source: UniProtKB
Other locations
- exocytic vesicle Source: GO_Central
- extrinsic component of membrane Source: UniProtKB
- glutamatergic synapse Source: MGI
- integral component of membrane Source: BHF-UCL
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 59 | VesicularSequence analysisAdd BLAST | 59 | |
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 81 – 511 | CytoplasmicSequence analysisAdd BLAST | 431 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183955 | 1 – 511 | Synaptotagmin-6Add BLAST | 511 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 217 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
PaxDbi | Q9R0N8 |
PRIDEi | Q9R0N8 |
PTM databases
iPTMneti | Q9R0N8 |
PhosphoSitePlusi | Q9R0N8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000027849, Expressed in retina and 102 other tissues |
Genevisiblei | Q9R0N8, MM |
Interactioni
Subunit structurei
Isoform 1: Homodimer; disulfide-linked via the cysteine motif (PubMed:10531343, PubMed:10531344). Isoform 1: Can also form heterodimers with SYT3, SYT7, SYT9 and SYT10 (PubMed:10531343, PubMed:10531344, PubMed:10871604). Isoform 1:
Interacts with STX1A, STX1B and STX2; the interaction is Ca2+-dependent (PubMed:15774481). Isoform 2: Is not able to form homodimer and heterodimers (PubMed:10531344).
4 PublicationsBinary interactionsi
Hide detailsQ9R0N8
With | #Exp. | IntAct |
---|---|---|
Syt10 [Q9R0N4] | 2 | EBI-5239378,EBI-5239459 |
Syt3 [O35681] | 2 | EBI-5239378,EBI-457995 |
itself | 2 | EBI-5239378,EBI-5239378 |
Syt9 [Q9R0N9] | 2 | EBI-5239378,EBI-458006 |
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- clathrin binding Source: MGI
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: BHF-UCL
- SNARE binding Source: GO_Central
- syntaxin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 207672, 2 interactors |
IntActi | Q9R0N8, 3 interactors |
STRINGi | 10090.ENSMUSP00000088196 |
Miscellaneous databases
RNActi | Q9R0N8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 230 – 351 | C2 1PROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 362 – 495 | C2 2PROSITE-ProRule annotationAdd BLAST | 134 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 12 – 38 | Cysteine motifBy similarityAdd BLAST | 27 | |
Regioni | 483 – 511 | Necessary for cell membrane association (isoform 2)1 PublicationAdd BLAST | 29 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000157665 |
HOGENOMi | CLU_023008_8_1_1 |
InParanoidi | Q9R0N8 |
OMAi | HIMRHAR |
OrthoDBi | 925064at2759 |
TreeFami | TF315600 |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001565, Synaptotagmin IPR028701, SYT6 |
PANTHERi | PTHR10024:SF45, PTHR10024:SF45, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGVWGAGGP RCQAALAVLA SLCRARPPPL GLDVETCRSF ELQSPEQSPS
60 70 80 90 100
AADSGTSVSL LAVVVIVCGV ALVAVFLFLF WKLCWMPWRK KEASSPSSAN
110 120 130 140 150
PASETLQSPS SRGNMADKLK DPSALGFLEA AVKISHTSPD IPAEVQMSVK
160 170 180 190 200
EHIMRHTKLQ RQTTEPASST RHTSFKRHLP RQMHVSSVDY GNELPPAAAE
210 220 230 240 250
QPTSIGRIKP ELYKQKSVDG DDAKSEAAKS CGKINFSLRY DYESETLIVR
260 270 280 290 300
ILKAFDLPAK DFCGSSDPYV KIYLLPDRKC KLQTRVHRKT LNPTFDENFH
310 320 330 340 350
FPVPYEELAD RKLHLSVFDF DRFSRHDMIG EVILDNLFEA SDLSRETSIW
360 370 380 390 400
KDIQYATSES VDLGEIMFSL CYLPTAGRLT LTVIKCRNLK AMDITGYSDP
410 420 430 440 450
YVKVSLLCDG RRLKKKKTTI KKNTLNPIYN EAIIFDIPPE NMDQVSLLIS
460 470 480 490 500
VMDYDRVGHN EIIGVCRVGI NAEGLGRDHW NEMLAYPRKP IAHWHSLVEV
510
KKSFKEGTPR L
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F8MPS8 | A0A5F8MPS8_MOUSE | Synaptotagmin-6 | Syt6 | 529 | Annotation score: | ||
Q3UY13 | Q3UY13_MOUSE | Synaptotagmin-6 | Syt6 | 342 | Annotation score: | ||
Q8C8S6 | Q8C8S6_MOUSE | Synaptotagmin-6 | Syt6 | 438 | Annotation score: | ||
V9GWX4 | V9GWX4_MOUSE | Synaptotagmin-6 | Syt6 | 88 | Annotation score: | ||
D6RIM4 | D6RIM4_MOUSE | Synaptotagmin-6 | Syt6 | 93 | Annotation score: | ||
D6RHQ5 | D6RHQ5_MOUSE | Synaptotagmin-6 | Syt6 | 71 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 428 | I → V in BAA85775 (PubMed:10531343).Curated | 1 | |
Sequence conflicti | 428 | I → V in BAA85781 (PubMed:10531344).Curated | 1 | |
Sequence conflicti | 428 | I → V in BAA85782 (PubMed:10531344).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041729 | 1 – 85 | Missing in isoform 2. 1 PublicationAdd BLAST | 85 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB026803 mRNA Translation: BAA85775.1 AB026809 mRNA Translation: BAA85781.1 AB026810 mRNA Translation: BAA85782.1 AC123057 Genomic DNA No translation available. |
CCDSi | CCDS38575.1 [Q9R0N8-1] CCDS71296.1 [Q9R0N8-2] |
RefSeqi | NP_061270.2, NM_018800.4 [Q9R0N8-1] |
Genome annotation databases
Ensembli | ENSMUST00000090697; ENSMUSP00000088196; ENSMUSG00000027849 [Q9R0N8-1] ENSMUST00000117221; ENSMUSP00000113373; ENSMUSG00000027849 [Q9R0N8-2] ENSMUST00000121834; ENSMUSP00000112997; ENSMUSG00000027849 [Q9R0N8-1] |
GeneIDi | 54524 |
KEGGi | mmu:54524 |
UCSCi | uc008qsy.2, mouse [Q9R0N8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB026803 mRNA Translation: BAA85775.1 AB026809 mRNA Translation: BAA85781.1 AB026810 mRNA Translation: BAA85782.1 AC123057 Genomic DNA No translation available. |
CCDSi | CCDS38575.1 [Q9R0N8-1] CCDS71296.1 [Q9R0N8-2] |
RefSeqi | NP_061270.2, NM_018800.4 [Q9R0N8-1] |
3D structure databases
SMRi | Q9R0N8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207672, 2 interactors |
IntActi | Q9R0N8, 3 interactors |
STRINGi | 10090.ENSMUSP00000088196 |
PTM databases
iPTMneti | Q9R0N8 |
PhosphoSitePlusi | Q9R0N8 |
Proteomic databases
PaxDbi | Q9R0N8 |
PRIDEi | Q9R0N8 |
Protocols and materials databases
Antibodypediai | 53758, 319 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000090697; ENSMUSP00000088196; ENSMUSG00000027849 [Q9R0N8-1] ENSMUST00000117221; ENSMUSP00000113373; ENSMUSG00000027849 [Q9R0N8-2] ENSMUST00000121834; ENSMUSP00000112997; ENSMUSG00000027849 [Q9R0N8-1] |
GeneIDi | 54524 |
KEGGi | mmu:54524 |
UCSCi | uc008qsy.2, mouse [Q9R0N8-1] |
Organism-specific databases
CTDi | 148281 |
MGIi | MGI:1859544, Syt6 |
Phylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000157665 |
HOGENOMi | CLU_023008_8_1_1 |
InParanoidi | Q9R0N8 |
OMAi | HIMRHAR |
OrthoDBi | 925064at2759 |
TreeFami | TF315600 |
Miscellaneous databases
BioGRID-ORCSi | 54524, 1 hit in 17 CRISPR screens |
PROi | PR:Q9R0N8 |
RNActi | Q9R0N8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027849, Expressed in retina and 102 other tissues |
Genevisiblei | Q9R0N8, MM |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001565, Synaptotagmin IPR028701, SYT6 |
PANTHERi | PTHR10024:SF45, PTHR10024:SF45, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYT6_MOUSE | |
Accessioni | Q9R0N8Primary (citable) accession number: Q9R0N8 Secondary accession number(s): E9QJV2, Q9QUK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2003 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families