Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Synaptotagmin-5

Gene

Syt5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca2+-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.1 Publication

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi138Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi138Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi139Calcium 1By similarity1
Metal bindingi139Calcium 2By similarity1
Metal bindingi145Calcium 1By similarity1
Metal bindingi145Calcium 2By similarity1
Metal bindingi197Calcium 1By similarity1
Metal bindingi197Calcium 2By similarity1
Metal bindingi198Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi198Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi199Calcium 1By similarity1
Metal bindingi199Calcium 2By similarity1
Metal bindingi199Calcium 3By similarity1
Metal bindingi202Calcium 3By similarity1
Metal bindingi203Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi205Calcium 1By similarity1
Metal bindingi205Calcium 2By similarity1
Metal bindingi205Calcium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-5
Alternative name(s):
Synaptotagmin IX1 Publication
Synaptotagmin V
Short name:
SytV
Gene namesi
Name:Syt5
Synonyms:Syt91 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1926368 Syt5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24VesicularSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 386CytoplasmicSequence analysisAdd BLAST341

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839521 – 386Synaptotagmin-5Add BLAST386

Proteomic databases

MaxQBiQ9R0N5
PaxDbiQ9R0N5
PeptideAtlasiQ9R0N5
PRIDEiQ9R0N5

PTM databases

iPTMnetiQ9R0N5
PhosphoSitePlusiQ9R0N5
SwissPalmiQ9R0N5

Expressioni

Gene expression databases

BgeeiENSMUSG00000004961 Expressed in 134 organ(s), highest expression level in frontal cortex
CleanExiMM_SYT5
MM_SYT9
ExpressionAtlasiQ9R0N5 baseline and differential
GenevisibleiQ9R0N5 MM

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with both alpha- and beta-tubulin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207314, 1 interactor
IntActiQ9R0N5, 2 interactors
STRINGi10090.ENSMUSP00000070322

Structurei

3D structure databases

ProteinModelPortaliQ9R0N5
SMRiQ9R0N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 211C2 1PROSITE-ProRule annotationAdd BLAST88
Domaini253 – 344C2 2PROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232127
HOVERGENiHBG005010
InParanoidiQ9R0N5
OMAiCRRRMGK
OrthoDBiEOG091G0XMQ
PhylomeDBiQ9R0N5
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028689 SYT5
PANTHERiPTHR10024:SF282 PTHR10024:SF282, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9R0N5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPEPPTLGS PAPKTPPDSS RIRQGAVPAW VLATIVLGSG LLVFSSCFCL
60 70 80 90 100
YRKRCRRRMG KKSQAQAQVH LQEVKELGRS YIDKVQPEIE ELDRSPSMPG
110 120 130 140 150
QQVSDKHQLG RLQYSLDYDF QTGQLLVGIL QAQGLAALDL GGSSDPYVSV
160 170 180 190 200
YLLPDKRRRH ETKVHRQTLN PHFGETFAFK VPYVELGGRV LVMAVYDFDR
210 220 230 240 250
FSRNDAIGEV RVPMSSVNLG RPVQAWRELQ VAPKEEQEKL GDICFSLRYV
260 270 280 290 300
PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN
310 320 330 340 350
TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAVG
360 370 380
GAGLRHWADM LANPRRPIAQ WHSLRPPDRA RPIPAP
Length:386
Mass (Da):43,130
Last modified:May 1, 2000 - v1
Checksum:iF884902E032082F6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNV9A0A0U1RNV9_MOUSE
Synaptotagmin-5
Syt5
48Annotation score:
A0A0U1RPH1A0A0U1RPH1_MOUSE
Synaptotagmin-5
Syt5
105Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026806 mRNA Translation: BAA85778.1
BC047148 mRNA Translation: AAH47148.1
CCDSiCCDS20738.1
RefSeqiNP_058604.1, NM_016908.2
XP_006540252.1, XM_006540189.3
XP_006540253.1, XM_006540190.3
UniGeneiMm.358663

Genome annotation databases

EnsembliENSMUST00000065957; ENSMUSP00000070322; ENSMUSG00000004961
GeneIDi53420
UCSCiuc009exy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026806 mRNA Translation: BAA85778.1
BC047148 mRNA Translation: AAH47148.1
CCDSiCCDS20738.1
RefSeqiNP_058604.1, NM_016908.2
XP_006540252.1, XM_006540189.3
XP_006540253.1, XM_006540190.3
UniGeneiMm.358663

3D structure databases

ProteinModelPortaliQ9R0N5
SMRiQ9R0N5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207314, 1 interactor
IntActiQ9R0N5, 2 interactors
STRINGi10090.ENSMUSP00000070322

PTM databases

iPTMnetiQ9R0N5
PhosphoSitePlusiQ9R0N5
SwissPalmiQ9R0N5

Proteomic databases

MaxQBiQ9R0N5
PaxDbiQ9R0N5
PeptideAtlasiQ9R0N5
PRIDEiQ9R0N5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065957; ENSMUSP00000070322; ENSMUSG00000004961
GeneIDi53420
UCSCiuc009exy.1 mouse

Organism-specific databases

CTDi6861
MGIiMGI:1926368 Syt5

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232127
HOVERGENiHBG005010
InParanoidiQ9R0N5
OMAiCRRRMGK
OrthoDBiEOG091G0XMQ
PhylomeDBiQ9R0N5
TreeFamiTF315600

Miscellaneous databases

PROiPR:Q9R0N5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004961 Expressed in 134 organ(s), highest expression level in frontal cortex
CleanExiMM_SYT5
MM_SYT9
ExpressionAtlasiQ9R0N5 baseline and differential
GenevisibleiQ9R0N5 MM

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028689 SYT5
PANTHERiPTHR10024:SF282 PTHR10024:SF282, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSYT5_MOUSE
AccessioniPrimary (citable) accession number: Q9R0N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again