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Protein

Ras-related protein Rab-9A

Gene

Rab9a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transport of proteins between the endosomes and the trans-Golgi network (By similarity). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65GTP; via amide nitrogenCombined sources1
Binding sitei155GTP; via amide nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22GTPCombined sources1 Publication9
Nucleotide bindingi62 – 66GTPBy similarity5
Nucleotide bindingi124 – 127GTPCombined sources1 Publication4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-9A
Alternative name(s):
Sid 99
Gene namesi
Name:Rab9a
Synonyms:Rab9, Sid99
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1890695 Rab9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211402 – 201Ras-related protein Rab-9AAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei34PhosphoserineCombined sources1
Modified residuei179PhosphoserineBy similarity1
Modified residuei187PhosphothreonineBy similarity1
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9R0M6
MaxQBiQ9R0M6
PaxDbiQ9R0M6
PRIDEiQ9R0M6

PTM databases

iPTMnetiQ9R0M6
PhosphoSitePlusiQ9R0M6

Expressioni

Gene expression databases

BgeeiENSMUSG00000079316 Expressed in 269 organ(s), highest expression level in brown adipose tissue
CleanExiMM_RAB9
ExpressionAtlasiQ9R0M6 baseline and differential
GenevisibleiQ9R0M6 MM

Interactioni

Subunit structurei

Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain) (By similarity). Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:25220469). Interacts with SGSM2 (PubMed:26620560). The GTP-bound form but not the GDP-bound form interacts with HPS4 (PubMed:26620560, PubMed:20048159). The GTP-bound form but not the GDP-bound form interacts with BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (By similarity).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207943, 1 interactor
DIPiDIP-61068N
IntActiQ9R0M6, 4 interactors
MINTiQ9R0M6
STRINGi10090.ENSMUSP00000123325

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9R0M6
SMRiQ9R0M6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9R0M6

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0394 Eukaryota
ENOG410XNZV LUCA
GeneTreeiENSGT00760000119125
HOVERGENiHBG009351
InParanoidiQ9R0M6
KOiK07899
OMAiRSSCCMP
PhylomeDBiQ9R0M6
TreeFamiTF326442

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9R0M6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKSSLFKI ILLGDGGVGK SSLMNRYVTN KFDSQLFHTI GVEFLNKDLE
60 70 80 90 100
VDGHFVTMQI WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN
110 120 130 140 150
WKKEFIYYAD VKEPESFPFV ILGNKTDIKE RQVSTEEAQA WCKDNGDYPY
160 170 180 190 200
FETSAKDSTN VAAAFEEAVR RILATEDRSE HLIQTDTVNL HRKPKPNSSC

C
Length:201
Mass (Da):22,910
Last modified:May 1, 2000 - v1
Checksum:i43F490EAA67D2C9A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AFP5A2AFP5_MOUSE
RAB9, member RAS oncogene family
Rab9
202Annotation score:
A2AFP4A2AFP4_MOUSE
RAB9, member RAS oncogene family
Rab9
59Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027290 mRNA Translation: BAA84709.1
AK010710 mRNA Translation: BAB27135.1
AK017301 mRNA Translation: BAB30681.1
AK032133 mRNA Translation: BAC27720.1
BC008160 mRNA Translation: AAH08160.1
CCDSiCCDS30527.1
RefSeqiNP_062747.1, NM_019773.2
XP_006528985.1, XM_006528922.1
UniGeneiMm.25306

Genome annotation databases

EnsembliENSMUST00000112091; ENSMUSP00000123325; ENSMUSG00000079316
GeneIDi56382
KEGGimmu:56382
UCSCiuc009uwu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027290 mRNA Translation: BAA84709.1
AK010710 mRNA Translation: BAB27135.1
AK017301 mRNA Translation: BAB30681.1
AK032133 mRNA Translation: BAC27720.1
BC008160 mRNA Translation: AAH08160.1
CCDSiCCDS30527.1
RefSeqiNP_062747.1, NM_019773.2
XP_006528985.1, XM_006528922.1
UniGeneiMm.25306

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YZLX-ray1.85A2-175[»]
4QXAX-ray2.30A1-199[»]
ProteinModelPortaliQ9R0M6
SMRiQ9R0M6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207943, 1 interactor
DIPiDIP-61068N
IntActiQ9R0M6, 4 interactors
MINTiQ9R0M6
STRINGi10090.ENSMUSP00000123325

PTM databases

iPTMnetiQ9R0M6
PhosphoSitePlusiQ9R0M6

Proteomic databases

EPDiQ9R0M6
MaxQBiQ9R0M6
PaxDbiQ9R0M6
PRIDEiQ9R0M6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112091; ENSMUSP00000123325; ENSMUSG00000079316
GeneIDi56382
KEGGimmu:56382
UCSCiuc009uwu.2 mouse

Organism-specific databases

CTDi56382
MGIiMGI:1890695 Rab9

Phylogenomic databases

eggNOGiKOG0394 Eukaryota
ENOG410XNZV LUCA
GeneTreeiENSGT00760000119125
HOVERGENiHBG009351
InParanoidiQ9R0M6
KOiK07899
OMAiRSSCCMP
PhylomeDBiQ9R0M6
TreeFamiTF326442

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

EvolutionaryTraceiQ9R0M6
PROiPR:Q9R0M6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079316 Expressed in 269 organ(s), highest expression level in brown adipose tissue
CleanExiMM_RAB9
ExpressionAtlasiQ9R0M6 baseline and differential
GenevisibleiQ9R0M6 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB9A_MOUSE
AccessioniPrimary (citable) accession number: Q9R0M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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