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UniProtKB - Q9R0M0 (CELR2_MOUSE)
Protein
Cadherin EGF LAG seven-pass G-type receptor 2
Gene
Celsr2
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor that may have an important role in cell/cell signaling during nervous system formation.
GO - Molecular functioni
- calcium ion binding Source: InterPro
- G protein-coupled receptor activity Source: UniProtKB-KW
GO - Biological processi
- cell-cell adhesion Source: GO_Central
- cerebrospinal fluid secretion Source: MGI
- cilium assembly Source: MGI
- cilium movement Source: MGI
- dendrite morphogenesis Source: MGI
- homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
- neural plate anterior/posterior regionalization Source: BHF-UCL
- neuron migration Source: MGI
- regulation of cell-cell adhesion Source: MGI
- regulation of protein localization Source: MGI
- regulation of transcription, DNA-templated Source: BHF-UCL
- ventricular system development Source: MGI
- Wnt signaling pathway Source: BHF-UCL
Keywordsi
Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
Ligand | Calcium |
Protein family/group databases
MEROPSi | P02.953 |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin EGF LAG seven-pass G-type receptor 2Alternative name(s): Flamingo homolog |
Gene namesi | Name:Celsr2Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1858235, Celsr2 |
VEuPathDBi | HostDB:ENSMUSG00000068740 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: BHF-UCL
Other locations
- cytoplasm Source: BHF-UCL
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 2380 | ExtracellularSequence analysisAdd BLAST | 2349 | |
Transmembranei | 2381 – 2401 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2402 – 2413 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 2414 – 2433 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 2434 – 2438 | ExtracellularSequence analysis | 5 | |
Transmembranei | 2439 – 2459 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2460 – 2480 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 2481 – 2501 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2502 – 2518 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 2519 – 2539 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2540 – 2563 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 2564 – 2584 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2585 – 2591 | ExtracellularSequence analysis | 7 | |
Transmembranei | 2592 – 2612 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2613 – 2919 | CytoplasmicSequence analysisAdd BLAST | 307 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000012917 | 32 – 2919 | Cadherin EGF LAG seven-pass G-type receptor 2Add BLAST | 2888 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 486 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 557 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 701 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1036 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1076 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1182 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1212 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1292 ↔ 1303 | By similarity | ||
Disulfide bondi | 1297 ↔ 1312 | By similarity | ||
Disulfide bondi | 1314 ↔ 1323 | By similarity | ||
Disulfide bondi | 1332 ↔ 1343 | By similarity | ||
Disulfide bondi | 1337 ↔ 1353 | By similarity | ||
Disulfide bondi | 1355 ↔ 1365 | By similarity | ||
Glycosylationi | 1501 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1545 ↔ 1571 | By similarity | ||
Glycosylationi | 1565 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1578 ↔ 1589 | By similarity | ||
Disulfide bondi | 1583 ↔ 1598 | By similarity | ||
Modified residuei | 1591 | (3R)-3-hydroxyasparagineSequence analysis | 1 | |
Disulfide bondi | 1600 ↔ 1609 | By similarity | ||
Glycosylationi | 1741 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1791 ↔ 1802 | By similarity | ||
Disulfide bondi | 1797 ↔ 1817 | By similarity | ||
Disulfide bondi | 1819 ↔ 1828 | By similarity | ||
Glycosylationi | 1827 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1832 ↔ 1843 | By similarity | ||
Disulfide bondi | 1837 ↔ 1855 | By similarity | ||
Disulfide bondi | 1857 ↔ 1866 | By similarity | ||
Disulfide bondi | 1887 ↔ 1899 | By similarity | ||
Disulfide bondi | 1889 ↔ 1906 | By similarity | ||
Glycosylationi | 1900 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1908 ↔ 1921 | By similarity | ||
Disulfide bondi | 1924 ↔ 1936 | By similarity | ||
Disulfide bondi | 1926 ↔ 1943 | By similarity | ||
Disulfide bondi | 1945 ↔ 1954 | By similarity | ||
Disulfide bondi | 1957 ↔ 1969 | By similarity | ||
Glycosylationi | 2024 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2043 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2061 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2323 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2345 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, HydroxylationProteomic databases
MaxQBi | Q9R0M0 |
PaxDbi | Q9R0M0 |
PRIDEi | Q9R0M0 |
ProteomicsDBi | 281578 [Q9R0M0-1] 281579 [Q9R0M0-2] 336635 |
PTM databases
GlyConnecti | 2174, 4 N-Linked glycans (5 sites) |
GlyGeni | Q9R0M0, 17 sites, 4 N-linked glycans (5 sites) |
iPTMneti | Q9R0M0 |
PhosphoSitePlusi | Q9R0M0 |
Expressioni
Tissue specificityi
Expressed in the CNS and in the eye.1 Publication
Developmental stagei
Predominantly expressed in the developing CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. During gastrulation, it is expressed within the anterior neural ectoderm. At 10 dpc, expression is strong in the ventricular zones (VZ) in all sectors of the brain, and lower in the marginal zones (MZ). Between 12 and 15 dpc, expression is prominent in the brain. It is strong in VZ, lower in MZ, except in telecephalic MZ where it is predominant. The intensity is higher in all VZ, and lower in differentiating fields than in VZ, except in the cerebral hemispheres, and to a lesser extent in the tectum and cerebellum. A weak expression is also observed in the fetal lungs, kidney and epithelia. In the newborn and postnatal stages, expression remains restricted to the VZ as well as in migrating and postmigratory cells throughout the brain.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000068740, Expressed in frontal cortex and 317 other tissues |
Interactioni
Binary interactionsi
Q9R0M0
With | #Exp. | IntAct |
---|---|---|
atp6ap2.S [Q7T0S3] from Xenopus laevis. | 2 | EBI-8294754,EBI-8294706 |
Protein-protein interaction databases
IntActi | Q9R0M0, 2 interactors |
MINTi | Q9R0M0 |
STRINGi | 10090.ENSMUSP00000088046 |
Miscellaneous databases
RNActi | Q9R0M0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 182 – 289 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 290 – 399 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 400 – 505 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 506 – 610 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 611 – 712 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 713 – 815 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 816 – 921 | Cadherin 7PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 922 – 1023 | Cadherin 8PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 1028 – 1146 | Cadherin 9PROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 1228 – 1286 | EGF-like 1; atypicalPROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 1288 – 1318 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 1328 – 1366 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 1367 – 1571 | Laminin G-like 1PROSITE-ProRule annotationAdd BLAST | 205 | |
Domaini | 1574 – 1610 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1614 – 1791 | Laminin G-like 2PROSITE-ProRule annotationAdd BLAST | 178 | |
Domaini | 1787 – 1829 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 1830 – 1867 | EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 1883 – 1922 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 1924 – 1971 | Laminin EGF-likePROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 2316 – 2368 | GPSPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 156 – 194 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 2216 – 2241 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 2690 – 2884 | DisorderedSequence analysisAdd BLAST | 195 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 173 – 194 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 2226 – 2240 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2849 – 2868 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4289, Eukaryota |
GeneTreei | ENSGT00940000157493 |
HOGENOMi | CLU_000158_1_0_1 |
InParanoidi | Q9R0M0 |
OMAi | GCPTKKN |
OrthoDBi | 23882at2759 |
PhylomeDBi | Q9R0M0 |
TreeFami | TF320624 |
Family and domain databases
CDDi | cd00055, EGF_Lam, 1 hit cd00110, LamG, 2 hits |
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR032471, GAIN_dom_N IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR000203, GPS IPR001791, Laminin_G IPR002049, LE_dom |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00028, Cadherin, 8 hits PF00008, EGF, 2 hits PF16489, GAIN, 1 hit PF01825, GPS, 1 hit PF00053, Laminin_EGF, 1 hit PF02210, Laminin_G_2, 2 hits |
PRINTSi | PR00205, CADHERIN PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00112, CA, 9 hits SM00181, EGF, 6 hits SM00179, EGF_CA, 5 hits SM00180, EGF_Lam, 1 hit SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00282, LamG, 2 hits |
SUPFAMi | SSF49313, SSF49313, 9 hits SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 2 hits PS00232, CADHERIN_1, 7 hits PS50268, CADHERIN_2, 9 hits PS00022, EGF_1, 6 hits PS01186, EGF_2, 4 hits PS50026, EGF_3, 6 hits PS01248, EGF_LAM_1, 1 hit PS50027, EGF_LAM_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS50025, LAM_G_DOMAIN, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9R0M0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRSRAASAPL PTPLLPLLLL LLLLPPSPLL GDQVGPCRSL GSGGRSSSGA
60 70 80 90 100
CAPVGWLCPA SASNLWLYTS RCRESGIELT GHLVPHHDGL RVWCPESGAH
110 120 130 140 150
IPLPPSSEGC PWSCRLLGIG GHLSPQGTLT LPEEHPCLKA PRLRCQSCKL
160 170 180 190 200
AQAPGLRAGE GSPEESLGGR RKRNVNTAPQ FQPPSYQATV PENQPAGTSV
210 220 230 240 250
ASLRAIDPDE GEAGRLEYTM DALFDSRSNH FFSLDPITGV VTTAEELDRE
260 270 280 290 300
TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE
310 320 330 340 350
NLEVGYEVLT VRATDGDAPP NANILYRLLE GAGGSPSDAF EIDPRSGVIR
360 370 380 390 400
TRGPVDREEV ESYKLTVEAS DQGRDPGPRS STAIVFLSVE DDNDNAPQFS
410 420 430 440 450
EKRYVVQVRE DVTPGAPVLR VTASDRDKGS NALVHYSIMS GNARGQFYLD
460 470 480 490 500
AQTGALDVVS PLDYETTKEY TLRIRAQDGG RPPLSNVSGL VTVQVLDIND
510 520 530 540 550
NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL EYSLAGVGHD
560 570 580 590 600
FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTI
610 620 630 640 650
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG
660 670 680 690 700
NTRNRFSITS QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV
710 720 730 740 750
NVTDANTHRP VFQSSHYTVN VNEDRPAGTT VVLISATDED TGENARITYF
760 770 780 790 800
MEDSIPQFRI DADTGAVTTQ AELDYEDQVS YTLAITARDN GIPQKSDTTY
810 820 830 840 850
LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT DRDSGLNGRV
860 870 880 890 900
FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP
910 920 930 940 950
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE
960 970 980 990 1000
GTNAQIMYQI VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS
1010 1020 1030 1040 1050
APLVSRATVH VRLLDRNDNP PVLGNFEILF NNYVTNRSSS FPGGAIGRVP
1060 1070 1080 1090 1100
AHDPDISDSL TYSFERGNEL SLVLLNASTG ELRLSRALDN NRPLEAIMSV
1110 1120 1130 1140 1150
LVSDGVHSVT AQCSLRVTII TDEMLTHSIT LRLEDMSPER FLSPLLGLFI
1160 1170 1180 1190 1200
QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL
1210 1220 1230 1240 1250
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD
1260 1270 1280 1290 1300
SSAPFIASSS VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH
1310 1320 1330 1340 1350
GRCRSREGGY TCLCLDGYTG EHCEASTHSG RCTPGVCKNG GTCVNLLVGG
1360 1370 1380 1390 1400
FKCDCPSGDF EKPFCQVTTR SFPARSFITF RGLRQRFHFT LALSFATKER
1410 1420 1430 1440 1450
NGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS PFVPGGVSDG
1460 1470 1480 1490 1500
QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVSVDGCDTG VALRFGAMLG
1510 1520 1530 1540 1550
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR HFVGCMKDLQ
1560 1570 1580 1590 1600
VDSRHIDMAD FIANNGTVPG CPTKKIVCDS SICHNGGTCV NQWNAFSCEC
1610 1620 1630 1640 1650
PLGFGGKSCA QEMANPQRFL GSSLVAWHGL SLPISQPWHL SLMFRTRQAD
1660 1670 1680 1690 1700
GVLLQAVTRG RSTITLQLRA GHVVLSVEGT GLQASSLRLE PGRANDGDWH
1710 1720 1730 1740 1750
HAQLALGASG GPGHAILSFD YGQQKAEGNL GPRLHGLHLS NITVGGVPGP
1760 1770 1780 1790 1800
ASGVARGFRG CLQGVRVSET PEGISSLDPS RGESINVEPG CSWPDPCDSN
1810 1820 1830 1840 1850
PCPTNSYCSN DWDSYSCSCV LGYYGDNCTN VCDLNPCEHQ SVCTRKPNTP
1860 1870 1880 1890 1900
HGYICECLPN YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN
1910 1920 1930 1940 1950
KTSGECHCKE NHYRPPGSPT CLLCDCYPTG SLSRVCDPED GQCPCKPGVI
1960 1970 1980 1990 2000
GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI EAGIWWPRTR FGLPAAAPCP
2010 2020 2030 2040 2050
KGSFGTAVRH CDEHRGWLPP NLFNCTSVTF SELKGFAERL QRNESGLDSG
2060 2070 2080 2090 2100
RSQRLALLLR NATQHTSGYF GSDVKVAYQL ATRLLAHESA QRGFGLSATQ
2110 2120 2130 2140 2150
DVHFTENLLR VGSALLDAAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ
2160 2170 2180 2190 2200
NMRHTYLSPF TIVTPNIVIS VVRLDKGNFA GTKLPRYEAL RGERPPDLET
2210 2220 2230 2240 2250
TVILPESVFR EMPSMVRSAG PGEAQETEEL ARRQRRHPEL SQGEAVASVI
2260 2270 2280 2290 2300
IYHTLAGLLP HNYDPDKRSL RVPKRPVINT PVVSISVHDD EELLPRALDK
2310 2320 2330 2340 2350
PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE VVFRNESHVS
2360 2370 2380 2390 2400
CQCNHMTSFA VLMDMSRREN GEILPLKTLT YVALGVTLAA LMLTFLFLTL
2410 2420 2430 2440 2450
LRALRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY
2460 2470 2480 2490 2500
LCTFSWALLE ALHLYRALTE VRDVNASPMR FYYMLGWGVP AFITGLAVGL
2510 2520 2530 2540 2550
DPEGYGNPDF CWLSVYDTLI WSFAGPVAFA VSMSVFLYIL SARASCAAQR
2560 2570 2580 2590 2600
QGFEKKGPVS GLRSSFTVLL LLSATWLLAL LSVNSDTLLF HYLFAACNCV
2610 2620 2630 2640 2650
QGPFIFLSYV VLSKEVRKAL KFACSRKPSP DPALTTKSTL TSSYNCPSPY
2660 2670 2680 2690 2700
ADGRLYQPYG DSAGSLHSAS RSGKSQPSYI PFLLREESTL NPGQVPPGLG
2710 2720 2730 2740 2750
DPSGLFLEGQ AQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEAA
2760 2770 2780 2790 2800
FPGEQGWDSL LGPGAERLPL HSTPKDGGPG SGKVPWLGDF GTTTKENSGS
2810 2820 2830 2840 2850
GPLEERPREN GDALTREGSL GPLPGPSTQP HKGILKKKCL PTISEKSSLL
2860 2870 2880 2890 2900
RLPLEQGTGS SRGSSISEGS RHGPPPRPPP RQSLQEQLNG VMPVAMSIKA
2910
GTVDEDSSGS EFLFFNFLH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF7BHW1 | F7BHW1_MOUSE | Cadherin EGF LAG seven-pass G-type ... | Celsr2 | 900 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | S → T in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 334 | G → D in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 638 | D → H in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 721 | V → G in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 762 | A → G in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 823 | S → T in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 838 | S → L in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 914 | V → G in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1222 | Q → K in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1268 | P → L in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1280 | F → L in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1296 | P → T in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1315 – 1317 | LDG → RGC in BAA84070 (PubMed:10490098).Curated | 3 | |
Sequence conflicti | 1351 | F → I in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1359 | D → H in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1376 | S → P in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1384 | R → H in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1595 | A → T in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1631 | S → Y in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1641 | S → N in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1674 – 1677 | VLSV → RLSM in BAA84070 (PubMed:10490098).Curated | 4 | |
Sequence conflicti | 1688 | R → H in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1710 | G → R in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1720 | D → N in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1725 | K → T in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1774 – 1775 | IS → VH in BAA84070 (PubMed:10490098).Curated | 2 | |
Sequence conflicti | 1793 | W → L in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1808 | C → Y in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1813 | D → N in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 1911 | N → K in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 2198 | L → V in AAC68837 (PubMed:10790539).Curated | 1 | |
Sequence conflicti | 2198 | L → V in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 2282 | V → A in AAC68837 (PubMed:10790539).Curated | 1 | |
Sequence conflicti | 2282 | V → A in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 2534 | S → R in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 2570 | L → R in AAC68837 (PubMed:10790539).Curated | 1 | |
Sequence conflicti | 2638 | S → Y in AAC68837 (PubMed:10790539).Curated | 1 | |
Sequence conflicti | 2638 | S → Y in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 2760 | L → C in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 2795 | K → R in AAC68837 (PubMed:10790539).Curated | 1 | |
Sequence conflicti | 2802 | P → A in BAA84070 (PubMed:10490098).Curated | 1 | |
Sequence conflicti | 2899 | K → N in BAA84070 (PubMed:10490098).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025765 | 2912 – 2919 | Missing in isoform 2. 1 Publication | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028499 mRNA Translation: BAA84070.1 AF031573 mRNA Translation: AAC68837.1 AL671899 Genomic DNA No translation available. AL672200 Genomic DNA No translation available. CH466607 Genomic DNA Translation: EDL01967.1 BC005499 mRNA Translation: AAH05499.1 |
CCDSi | CCDS17759.1 [Q9R0M0-1] |
RefSeqi | NP_059088.2, NM_017392.3 [Q9R0M0-1] |
Genome annotation databases
Ensembli | ENSMUST00000090558; ENSMUSP00000088046; ENSMUSG00000068740 [Q9R0M0-1] |
GeneIDi | 53883 |
KEGGi | mmu:53883 |
UCSCi | uc008qyx.1, mouse |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028499 mRNA Translation: BAA84070.1 AF031573 mRNA Translation: AAC68837.1 AL671899 Genomic DNA No translation available. AL672200 Genomic DNA No translation available. CH466607 Genomic DNA Translation: EDL01967.1 BC005499 mRNA Translation: AAH05499.1 |
CCDSi | CCDS17759.1 [Q9R0M0-1] |
RefSeqi | NP_059088.2, NM_017392.3 [Q9R0M0-1] |
3D structure databases
SMRi | Q9R0M0 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9R0M0, 2 interactors |
MINTi | Q9R0M0 |
STRINGi | 10090.ENSMUSP00000088046 |
Protein family/group databases
MEROPSi | P02.953 |
GPCRDBi | Search... |
PTM databases
GlyConnecti | 2174, 4 N-Linked glycans (5 sites) |
GlyGeni | Q9R0M0, 17 sites, 4 N-linked glycans (5 sites) |
iPTMneti | Q9R0M0 |
PhosphoSitePlusi | Q9R0M0 |
Proteomic databases
MaxQBi | Q9R0M0 |
PaxDbi | Q9R0M0 |
PRIDEi | Q9R0M0 |
ProteomicsDBi | 281578 [Q9R0M0-1] 281579 [Q9R0M0-2] 336635 |
Protocols and materials databases
Antibodypediai | 2940, 221 antibodies from 29 providers |
DNASUi | 53883 |
Genome annotation databases
Ensembli | ENSMUST00000090558; ENSMUSP00000088046; ENSMUSG00000068740 [Q9R0M0-1] |
GeneIDi | 53883 |
KEGGi | mmu:53883 |
UCSCi | uc008qyx.1, mouse |
Organism-specific databases
CTDi | 1952 |
MGIi | MGI:1858235, Celsr2 |
VEuPathDBi | HostDB:ENSMUSG00000068740 |
Phylogenomic databases
eggNOGi | KOG4289, Eukaryota |
GeneTreei | ENSGT00940000157493 |
HOGENOMi | CLU_000158_1_0_1 |
InParanoidi | Q9R0M0 |
OMAi | GCPTKKN |
OrthoDBi | 23882at2759 |
PhylomeDBi | Q9R0M0 |
TreeFami | TF320624 |
Miscellaneous databases
BioGRID-ORCSi | 53883, 2 hits in 64 CRISPR screens |
ChiTaRSi | Celsr2, mouse |
PROi | PR:Q9R0M0 |
RNActi | Q9R0M0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000068740, Expressed in frontal cortex and 317 other tissues |
Family and domain databases
CDDi | cd00055, EGF_Lam, 1 hit cd00110, LamG, 2 hits |
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR032471, GAIN_dom_N IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR000203, GPS IPR001791, Laminin_G IPR002049, LE_dom |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00028, Cadherin, 8 hits PF00008, EGF, 2 hits PF16489, GAIN, 1 hit PF01825, GPS, 1 hit PF00053, Laminin_EGF, 1 hit PF02210, Laminin_G_2, 2 hits |
PRINTSi | PR00205, CADHERIN PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00112, CA, 9 hits SM00181, EGF, 6 hits SM00179, EGF_CA, 5 hits SM00180, EGF_Lam, 1 hit SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00282, LamG, 2 hits |
SUPFAMi | SSF49313, SSF49313, 9 hits SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 2 hits PS00232, CADHERIN_1, 7 hits PS50268, CADHERIN_2, 9 hits PS00022, EGF_1, 6 hits PS01186, EGF_2, 4 hits PS50026, EGF_3, 6 hits PS01248, EGF_LAM_1, 1 hit PS50027, EGF_LAM_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS50025, LAM_G_DOMAIN, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CELR2_MOUSE | |
Accessioni | Q9R0M0Primary (citable) accession number: Q9R0M0 Secondary accession number(s): A2AEE7, Q99K26, Q9Z2R4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 2, 2002 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 23, 2022 | |
This is version 181 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families