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Entry version 169 (16 Oct 2019)
Sequence version 3 (10 Apr 2019)
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Protein

Cadherin EGF LAG seven-pass G-type receptor 2

Gene

Celsr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
LigandCalcium

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 2
Alternative name(s):
Flamingo homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Celsr2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1858235 Celsr2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 2380ExtracellularSequence analysisAdd BLAST2349
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2381 – 2401Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2402 – 2413CytoplasmicSequence analysisAdd BLAST12
Transmembranei2414 – 2433Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini2434 – 2438ExtracellularSequence analysis5
Transmembranei2439 – 2459Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2460 – 2480CytoplasmicSequence analysisAdd BLAST21
Transmembranei2481 – 2501Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2502 – 2518ExtracellularSequence analysisAdd BLAST17
Transmembranei2519 – 2539Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2540 – 2563CytoplasmicSequence analysisAdd BLAST24
Transmembranei2564 – 2584Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2585 – 2591ExtracellularSequence analysis7
Transmembranei2592 – 2612Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2613 – 2919CytoplasmicSequence analysisAdd BLAST307

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001291732 – 2919Cadherin EGF LAG seven-pass G-type receptor 2Add BLAST2888

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi486N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi557N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi701N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1036N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1076N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1212N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1292 ↔ 1303By similarity
Disulfide bondi1297 ↔ 1312By similarity
Disulfide bondi1314 ↔ 1323By similarity
Disulfide bondi1332 ↔ 1343By similarity
Disulfide bondi1337 ↔ 1353By similarity
Disulfide bondi1355 ↔ 1365By similarity
Glycosylationi1501N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1545 ↔ 1571By similarity
Glycosylationi1565N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1578 ↔ 1589By similarity
Disulfide bondi1583 ↔ 1598By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1591(3R)-3-hydroxyasparagineSequence analysis1
Disulfide bondi1600 ↔ 1609By similarity
Glycosylationi1741N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1791 ↔ 1802By similarity
Disulfide bondi1797 ↔ 1817By similarity
Disulfide bondi1819 ↔ 1828By similarity
Glycosylationi1827N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1832 ↔ 1843By similarity
Disulfide bondi1837 ↔ 1855By similarity
Disulfide bondi1857 ↔ 1866By similarity
Disulfide bondi1887 ↔ 1899By similarity
Disulfide bondi1889 ↔ 1906By similarity
Glycosylationi1900N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1908 ↔ 1921By similarity
Disulfide bondi1924 ↔ 1936By similarity
Disulfide bondi1926 ↔ 1943By similarity
Disulfide bondi1945 ↔ 1954By similarity
Disulfide bondi1957 ↔ 1969By similarity
Glycosylationi2024N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2043N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2061N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2345N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R0M0

PRoteomics IDEntifications database

More...
PRIDEi
Q9R0M0

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2174

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9R0M0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9R0M0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the CNS and in the eye.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Predominantly expressed in the developing CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. During gastrulation, it is expressed within the anterior neural ectoderm. At 10 dpc, expression is strong in the ventricular zones (VZ) in all sectors of the brain, and lower in the marginal zones (MZ). Between 12 and 15 dpc, expression is prominent in the brain. It is strong in VZ, lower in MZ, except in telecephalic MZ where it is predominant. The intensity is higher in all VZ, and lower in differentiating fields than in VZ, except in the cerebral hemispheres, and to a lesser extent in the tectum and cerebellum. A weak expression is also observed in the fetal lungs, kidney and epithelia. In the newborn and postnatal stages, expression remains restricted to the VZ as well as in migrating and postmigratory cells throughout the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000068740 Expressed in 294 organ(s), highest expression level in frontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
atp6ap2Q7T0S32EBI-8294754,EBI-8294706From Xenopus laevis.

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9R0M0, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9R0M0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000088046

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9R0M0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini182 – 289Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini290 – 399Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini400 – 505Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini506 – 610Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini611 – 712Cadherin 5PROSITE-ProRule annotationAdd BLAST102
Domaini713 – 815Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini816 – 921Cadherin 7PROSITE-ProRule annotationAdd BLAST106
Domaini922 – 1023Cadherin 8PROSITE-ProRule annotationAdd BLAST102
Domaini1028 – 1146Cadherin 9PROSITE-ProRule annotationAdd BLAST119
Domaini1228 – 1286EGF-like 1; atypicalPROSITE-ProRule annotationAdd BLAST59
Domaini1288 – 1318EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST31
Domaini1328 – 1366EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini1367 – 1571Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini1574 – 1610EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1614 – 1791Laminin G-like 2PROSITE-ProRule annotationAdd BLAST178
Domaini1787 – 1829EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1830 – 1867EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini1883 – 1922EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1924 – 1971Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2316 – 2368GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2743 – 2748Poly-Glu6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4289 Eukaryota
ENOG410XTGH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157493

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231346

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9R0M0

KEGG Orthology (KO)

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KOi
K04601

Identification of Orthologs from Complete Genome Data

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OMAi
GCPTKKN

Database of Orthologous Groups

More...
OrthoDBi
23882at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9R0M0

TreeFam database of animal gene trees

More...
TreeFami
TF320624

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00205 CADHERIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 9 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9R0M0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSRAASAPL PTPLLPLLLL LLLLPPSPLL GDQVGPCRSL GSGGRSSSGA
60 70 80 90 100
CAPVGWLCPA SASNLWLYTS RCRESGIELT GHLVPHHDGL RVWCPESGAH
110 120 130 140 150
IPLPPSSEGC PWSCRLLGIG GHLSPQGTLT LPEEHPCLKA PRLRCQSCKL
160 170 180 190 200
AQAPGLRAGE GSPEESLGGR RKRNVNTAPQ FQPPSYQATV PENQPAGTSV
210 220 230 240 250
ASLRAIDPDE GEAGRLEYTM DALFDSRSNH FFSLDPITGV VTTAEELDRE
260 270 280 290 300
TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE
310 320 330 340 350
NLEVGYEVLT VRATDGDAPP NANILYRLLE GAGGSPSDAF EIDPRSGVIR
360 370 380 390 400
TRGPVDREEV ESYKLTVEAS DQGRDPGPRS STAIVFLSVE DDNDNAPQFS
410 420 430 440 450
EKRYVVQVRE DVTPGAPVLR VTASDRDKGS NALVHYSIMS GNARGQFYLD
460 470 480 490 500
AQTGALDVVS PLDYETTKEY TLRIRAQDGG RPPLSNVSGL VTVQVLDIND
510 520 530 540 550
NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL EYSLAGVGHD
560 570 580 590 600
FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTI
610 620 630 640 650
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG
660 670 680 690 700
NTRNRFSITS QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV
710 720 730 740 750
NVTDANTHRP VFQSSHYTVN VNEDRPAGTT VVLISATDED TGENARITYF
760 770 780 790 800
MEDSIPQFRI DADTGAVTTQ AELDYEDQVS YTLAITARDN GIPQKSDTTY
810 820 830 840 850
LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT DRDSGLNGRV
860 870 880 890 900
FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP
910 920 930 940 950
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE
960 970 980 990 1000
GTNAQIMYQI VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS
1010 1020 1030 1040 1050
APLVSRATVH VRLLDRNDNP PVLGNFEILF NNYVTNRSSS FPGGAIGRVP
1060 1070 1080 1090 1100
AHDPDISDSL TYSFERGNEL SLVLLNASTG ELRLSRALDN NRPLEAIMSV
1110 1120 1130 1140 1150
LVSDGVHSVT AQCSLRVTII TDEMLTHSIT LRLEDMSPER FLSPLLGLFI
1160 1170 1180 1190 1200
QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL
1210 1220 1230 1240 1250
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD
1260 1270 1280 1290 1300
SSAPFIASSS VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH
1310 1320 1330 1340 1350
GRCRSREGGY TCLCLDGYTG EHCEASTHSG RCTPGVCKNG GTCVNLLVGG
1360 1370 1380 1390 1400
FKCDCPSGDF EKPFCQVTTR SFPARSFITF RGLRQRFHFT LALSFATKER
1410 1420 1430 1440 1450
NGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS PFVPGGVSDG
1460 1470 1480 1490 1500
QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVSVDGCDTG VALRFGAMLG
1510 1520 1530 1540 1550
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR HFVGCMKDLQ
1560 1570 1580 1590 1600
VDSRHIDMAD FIANNGTVPG CPTKKIVCDS SICHNGGTCV NQWNAFSCEC
1610 1620 1630 1640 1650
PLGFGGKSCA QEMANPQRFL GSSLVAWHGL SLPISQPWHL SLMFRTRQAD
1660 1670 1680 1690 1700
GVLLQAVTRG RSTITLQLRA GHVVLSVEGT GLQASSLRLE PGRANDGDWH
1710 1720 1730 1740 1750
HAQLALGASG GPGHAILSFD YGQQKAEGNL GPRLHGLHLS NITVGGVPGP
1760 1770 1780 1790 1800
ASGVARGFRG CLQGVRVSET PEGISSLDPS RGESINVEPG CSWPDPCDSN
1810 1820 1830 1840 1850
PCPTNSYCSN DWDSYSCSCV LGYYGDNCTN VCDLNPCEHQ SVCTRKPNTP
1860 1870 1880 1890 1900
HGYICECLPN YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN
1910 1920 1930 1940 1950
KTSGECHCKE NHYRPPGSPT CLLCDCYPTG SLSRVCDPED GQCPCKPGVI
1960 1970 1980 1990 2000
GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI EAGIWWPRTR FGLPAAAPCP
2010 2020 2030 2040 2050
KGSFGTAVRH CDEHRGWLPP NLFNCTSVTF SELKGFAERL QRNESGLDSG
2060 2070 2080 2090 2100
RSQRLALLLR NATQHTSGYF GSDVKVAYQL ATRLLAHESA QRGFGLSATQ
2110 2120 2130 2140 2150
DVHFTENLLR VGSALLDAAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ
2160 2170 2180 2190 2200
NMRHTYLSPF TIVTPNIVIS VVRLDKGNFA GTKLPRYEAL RGERPPDLET
2210 2220 2230 2240 2250
TVILPESVFR EMPSMVRSAG PGEAQETEEL ARRQRRHPEL SQGEAVASVI
2260 2270 2280 2290 2300
IYHTLAGLLP HNYDPDKRSL RVPKRPVINT PVVSISVHDD EELLPRALDK
2310 2320 2330 2340 2350
PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE VVFRNESHVS
2360 2370 2380 2390 2400
CQCNHMTSFA VLMDMSRREN GEILPLKTLT YVALGVTLAA LMLTFLFLTL
2410 2420 2430 2440 2450
LRALRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY
2460 2470 2480 2490 2500
LCTFSWALLE ALHLYRALTE VRDVNASPMR FYYMLGWGVP AFITGLAVGL
2510 2520 2530 2540 2550
DPEGYGNPDF CWLSVYDTLI WSFAGPVAFA VSMSVFLYIL SARASCAAQR
2560 2570 2580 2590 2600
QGFEKKGPVS GLRSSFTVLL LLSATWLLAL LSVNSDTLLF HYLFAACNCV
2610 2620 2630 2640 2650
QGPFIFLSYV VLSKEVRKAL KFACSRKPSP DPALTTKSTL TSSYNCPSPY
2660 2670 2680 2690 2700
ADGRLYQPYG DSAGSLHSAS RSGKSQPSYI PFLLREESTL NPGQVPPGLG
2710 2720 2730 2740 2750
DPSGLFLEGQ AQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEAA
2760 2770 2780 2790 2800
FPGEQGWDSL LGPGAERLPL HSTPKDGGPG SGKVPWLGDF GTTTKENSGS
2810 2820 2830 2840 2850
GPLEERPREN GDALTREGSL GPLPGPSTQP HKGILKKKCL PTISEKSSLL
2860 2870 2880 2890 2900
RLPLEQGTGS SRGSSISEGS RHGPPPRPPP RQSLQEQLNG VMPVAMSIKA
2910
GTVDEDSSGS EFLFFNFLH
Length:2,919
Mass (Da):316,986
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8F35C88C5808300
GO
Isoform 2 (identifier: Q9R0M0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2912-2919: Missing.

Note: No experimental confirmation available.
Show »
Length:2,911
Mass (Da):315,920
Checksum:iEDADE52D5C0F8913
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7BHW1F7BHW1_MOUSE
Cadherin EGF LAG seven-pass G-type ...
Celsr2
900Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3S → T in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti334G → D in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti638D → H in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti721V → G in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti762A → G in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti823S → T in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti838S → L in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti914V → G in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1222Q → K in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1268P → L in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1280F → L in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1296P → T in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1315 – 1317LDG → RGC in BAA84070 (PubMed:10490098).Curated3
Sequence conflicti1351F → I in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1359D → H in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1376S → P in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1384R → H in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1595A → T in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1631S → Y in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1641S → N in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1674 – 1677VLSV → RLSM in BAA84070 (PubMed:10490098).Curated4
Sequence conflicti1688R → H in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1710G → R in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1720D → N in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1725K → T in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1774 – 1775IS → VH in BAA84070 (PubMed:10490098).Curated2
Sequence conflicti1793W → L in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1808C → Y in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1813D → N in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti1911N → K in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti2198L → V in AAC68837 (PubMed:10790539).Curated1
Sequence conflicti2198L → V in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti2282V → A in AAC68837 (PubMed:10790539).Curated1
Sequence conflicti2282V → A in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti2534S → R in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti2570L → R in AAC68837 (PubMed:10790539).Curated1
Sequence conflicti2638S → Y in AAC68837 (PubMed:10790539).Curated1
Sequence conflicti2638S → Y in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti2760L → C in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti2795K → R in AAC68837 (PubMed:10790539).Curated1
Sequence conflicti2802P → A in BAA84070 (PubMed:10490098).Curated1
Sequence conflicti2899K → N in BAA84070 (PubMed:10490098).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0257652912 – 2919Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB028499 mRNA Translation: BAA84070.1
AF031573 mRNA Translation: AAC68837.1
AL671899 Genomic DNA No translation available.
AL672200 Genomic DNA No translation available.
CH466607 Genomic DNA Translation: EDL01967.1
BC005499 mRNA Translation: AAH05499.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17759.1 [Q9R0M0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_059088.2, NM_017392.3 [Q9R0M0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000090558; ENSMUSP00000088046; ENSMUSG00000068740 [Q9R0M0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
53883

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:53883

UCSC genome browser

More...
UCSCi
uc008qyx.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028499 mRNA Translation: BAA84070.1
AF031573 mRNA Translation: AAC68837.1
AL671899 Genomic DNA No translation available.
AL672200 Genomic DNA No translation available.
CH466607 Genomic DNA Translation: EDL01967.1
BC005499 mRNA Translation: AAH05499.1
CCDSiCCDS17759.1 [Q9R0M0-1]
RefSeqiNP_059088.2, NM_017392.3 [Q9R0M0-1]

3D structure databases

SMRiQ9R0M0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9R0M0, 2 interactors
MINTiQ9R0M0
STRINGi10090.ENSMUSP00000088046

Protein family/group databases

MEROPSiP02.006

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyConnecti2174
iPTMnetiQ9R0M0
PhosphoSitePlusiQ9R0M0

Proteomic databases

PaxDbiQ9R0M0
PRIDEiQ9R0M0

Genome annotation databases

EnsembliENSMUST00000090558; ENSMUSP00000088046; ENSMUSG00000068740 [Q9R0M0-1]
GeneIDi53883
KEGGimmu:53883
UCSCiuc008qyx.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1952
MGIiMGI:1858235 Celsr2

Phylogenomic databases

eggNOGiKOG4289 Eukaryota
ENOG410XTGH LUCA
GeneTreeiENSGT00940000157493
HOGENOMiHOG000231346
InParanoidiQ9R0M0
KOiK04601
OMAiGCPTKKN
OrthoDBi23882at2759
PhylomeDBiQ9R0M0
TreeFamiTF320624

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Celsr2 mouse

Protein Ontology

More...
PROi
PR:Q9R0M0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000068740 Expressed in 294 organ(s), highest expression level in frontal cortex

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 9 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELR2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R0M0
Secondary accession number(s): A2AEE7, Q99K26, Q9Z2R4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: April 10, 2019
Last modified: October 16, 2019
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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