Celsr2

Functionⁱ

Receptor that may have an important role in cell/cell signaling during nervous system formation.

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
G protein-coupled receptor activity Source: UniProtKB-KW

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell-cell adhesion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
cerebrospinal fluid secretion
Source: MGI
Inferred from genetic interactionⁱ
- "Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus."
  Tissir F., Qu Y., Montcouquiol M., Zhou L., Komatsu K., Shi D., Fujimori T., Labeau J., Tyteca D., Courtoy P., Poumay Y., Uemura T., Goffinet A.M.
  Nat. Neurosci. 13:700-707(2010) [PubMed] [Europe PMC] [Abstract]
cilium assembly
Source: MGI
Inferred from mutant phenotypeⁱ
- "Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus."
  Tissir F., Qu Y., Montcouquiol M., Zhou L., Komatsu K., Shi D., Fujimori T., Labeau J., Tyteca D., Courtoy P., Poumay Y., Uemura T., Goffinet A.M.
  Nat. Neurosci. 13:700-707(2010) [PubMed] [Europe PMC] [Abstract]
cilium movement
Source: MGI
Inferred from mutant phenotypeⁱ
- "Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus."
  Tissir F., Qu Y., Montcouquiol M., Zhou L., Komatsu K., Shi D., Fujimori T., Labeau J., Tyteca D., Courtoy P., Poumay Y., Uemura T., Goffinet A.M.
  Nat. Neurosci. 13:700-707(2010) [PubMed] [Europe PMC] [Abstract]
dendrite morphogenesis Source: MGI
homophilic cell adhesion via plasma membrane adhesion molecules
Source: BHF-UCL
Inferred from direct assayⁱ
- "Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin."
  Shima Y., Kengaku M., Hirano T., Takeichi M., Uemura T.
  Dev. Cell 7:205-216(2004) [PubMed] [Europe PMC] [Abstract]
neural plate anterior/posterior regionalization
Source: BHF-UCL
Inferred from direct assayⁱ
- "Flamingo, a cadherin-type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis."
  Morgan R., El-Kadi A.M., Theokli C.
  Int. J. Dev. Biol. 47:245-252(2003) [PubMed] [Europe PMC] [Abstract]
neuron migration
Source: MGI
Inferred from mutant phenotypeⁱ
- "Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice."
  Qu Y., Glasco D.M., Zhou L., Sawant A., Ravni A., Fritzsch B., Damrau C., Murdoch J.N., Evans S., Pfaff S.L., Formstone C., Goffinet A.M., Chandrasekhar A., Tissir F.
  J. Neurosci. 30:9392-9401(2010) [PubMed] [Europe PMC] [Abstract]
regulation of cell-cell adhesion Source: MGI
regulation of protein localization
Source: MGI
Inferred from mutant phenotypeⁱ
- "Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus."
  Tissir F., Qu Y., Montcouquiol M., Zhou L., Komatsu K., Shi D., Fujimori T., Labeau J., Tyteca D., Courtoy P., Poumay Y., Uemura T., Goffinet A.M.
  Nat. Neurosci. 13:700-707(2010) [PubMed] [Europe PMC] [Abstract]
regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- "Flamingo, a cadherin-type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis."
  Morgan R., El-Kadi A.M., Theokli C.
  Int. J. Dev. Biol. 47:245-252(2003) [PubMed] [Europe PMC] [Abstract]
ventricular system development
Source: MGI
Inferred from mutant phenotypeⁱ
- "Congenital hydrocephalus in genetically engineered mice."
  Vogel P., Read R.W., Hansen G.M., Payne B.J., Small D., Sands A.T., Zambrowicz B.P.
  Vet. Pathol. 49:166-181(2012) [PubMed] [Europe PMC] [Abstract]
Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- "Flamingo, a cadherin-type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis."
  Morgan R., El-Kadi A.M., Theokli C.
  Int. J. Dev. Biol. 47:245-252(2003) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, G-protein coupled receptor, Receptor, Transducer
Ligand	Calcium

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	P02.006

MEROPSⁱ

P02.006

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cadherin EGF LAG seven-pass G-type receptor 2 Alternative name(s): Flamingo homolog
Gene namesⁱ	Name:Celsr2Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1858235 Celsr2

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	32 – 2380	ExtracellularSequence analysisAdd BLAST	2349
Transmembraneⁱ	2381 – 2401	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	2402 – 2413	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	2414 – 2433	Helical; Name=2Sequence analysisAdd BLAST	20
Topological domainⁱ	2434 – 2438	ExtracellularSequence analysis	5
Transmembraneⁱ	2439 – 2459	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	2460 – 2480	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	2481 – 2501	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	2502 – 2518	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	2519 – 2539	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	2540 – 2563	CytoplasmicSequence analysisAdd BLAST	24
Transmembraneⁱ	2564 – 2584	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	2585 – 2591	ExtracellularSequence analysis	7
Transmembraneⁱ	2592 – 2612	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	2613 – 2919	CytoplasmicSequence analysisAdd BLAST	307

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 31	Sequence analysisAdd BLAST		31
ChainⁱPRO_0000012917	32 – 2919	Cadherin EGF LAG seven-pass G-type receptor 2Add BLAST		2888

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	486	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	557	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	701	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1036	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1076	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1182	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1212	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1292 ↔ 1303	By similarity
Disulfide bondⁱ	1297 ↔ 1312	By similarity
Disulfide bondⁱ	1314 ↔ 1323	By similarity
Disulfide bondⁱ	1332 ↔ 1343	By similarity
Disulfide bondⁱ	1337 ↔ 1353	By similarity
Disulfide bondⁱ	1355 ↔ 1365	By similarity
Glycosylationⁱ	1501	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1545 ↔ 1571	By similarity
Glycosylationⁱ	1565	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1578 ↔ 1589	By similarity
Disulfide bondⁱ	1583 ↔ 1598	By similarity
Modified residueⁱ	1591	(3R)-3-hydroxyasparagineSequence analysis	1
Disulfide bondⁱ	1600 ↔ 1609	By similarity
Glycosylationⁱ	1741	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1791 ↔ 1802	By similarity
Disulfide bondⁱ	1797 ↔ 1817	By similarity
Disulfide bondⁱ	1819 ↔ 1828	By similarity
Glycosylationⁱ	1827	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1832 ↔ 1843	By similarity
Disulfide bondⁱ	1837 ↔ 1855	By similarity
Disulfide bondⁱ	1857 ↔ 1866	By similarity
Disulfide bondⁱ	1887 ↔ 1899	By similarity
Disulfide bondⁱ	1889 ↔ 1906	By similarity
Glycosylationⁱ	1900	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1908 ↔ 1921	By similarity
Disulfide bondⁱ	1924 ↔ 1936	By similarity
Disulfide bondⁱ	1926 ↔ 1943	By similarity
Disulfide bondⁱ	1945 ↔ 1954	By similarity
Disulfide bondⁱ	1957 ↔ 1969	By similarity
Glycosylationⁱ	2024	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	2043	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	2061	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	2323	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	2345	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbⁱ	Q9R0M0
PRIDEⁱ	Q9R0M0

PTM databases

GlyConnectⁱ	2174
iPTMnetⁱ	Q9R0M0
PhosphoSitePlusⁱ	Q9R0M0

Expressionⁱ

Tissue specificityⁱ

Expressed in the CNS and in the eye.1 Publication

Developmental stageⁱ

Predominantly expressed in the developing CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. During gastrulation, it is expressed within the anterior neural ectoderm. At 10 dpc, expression is strong in the ventricular zones (VZ) in all sectors of the brain, and lower in the marginal zones (MZ). Between 12 and 15 dpc, expression is prominent in the brain. It is strong in VZ, lower in MZ, except in telecephalic MZ where it is predominant. The intensity is higher in all VZ, and lower in differentiating fields than in VZ, except in the cerebral hemispheres, and to a lesser extent in the tectum and cerebellum. A weak expression is also observed in the fetal lungs, kidney and epithelia. In the newborn and postnatal stages, expression remains restricted to the VZ as well as in migrating and postmigratory cells throughout the brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000068740 Expressed in 294 organ(s), highest expression level in frontal cortex

Bgeeⁱ

ENSMUSG00000068740 Expressed in 294 organ(s), highest expression level in frontal cortex

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
atp6ap2	Q7T0S3	2	EBI-8294754,EBI-8294706	From Xenopus laevis.

With

Entry

#Exp.

IntAct

Notes

atp6ap2

Q7T0S3

2

EBI-8294754,EBI-8294706

From Xenopus laevis.

Protein-protein interaction databases

IntActⁱ	Q9R0M0, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q9R0M0
STRINGⁱ	10090.ENSMUSP00000088046

Structureⁱ

3D structure databases

SMRⁱ	Q9R0M0
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	182 – 289	Cadherin 1PROSITE-ProRule annotationAdd BLAST	108
Domainⁱ	290 – 399	Cadherin 2PROSITE-ProRule annotationAdd BLAST	110
Domainⁱ	400 – 505	Cadherin 3PROSITE-ProRule annotationAdd BLAST	106
Domainⁱ	506 – 610	Cadherin 4PROSITE-ProRule annotationAdd BLAST	105
Domainⁱ	611 – 712	Cadherin 5PROSITE-ProRule annotationAdd BLAST	102
Domainⁱ	713 – 815	Cadherin 6PROSITE-ProRule annotationAdd BLAST	103
Domainⁱ	816 – 921	Cadherin 7PROSITE-ProRule annotationAdd BLAST	106
Domainⁱ	922 – 1023	Cadherin 8PROSITE-ProRule annotationAdd BLAST	102
Domainⁱ	1028 – 1146	Cadherin 9PROSITE-ProRule annotationAdd BLAST	119
Domainⁱ	1228 – 1286	EGF-like 1; atypicalPROSITE-ProRule annotationAdd BLAST	59
Domainⁱ	1288 – 1318	EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST	31
Domainⁱ	1328 – 1366	EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST	39
Domainⁱ	1367 – 1571	Laminin G-like 1PROSITE-ProRule annotationAdd BLAST	205
Domainⁱ	1574 – 1610	EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	1614 – 1791	Laminin G-like 2PROSITE-ProRule annotationAdd BLAST	178
Domainⁱ	1787 – 1829	EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST	43
Domainⁱ	1830 – 1867	EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST	38
Domainⁱ	1883 – 1922	EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	1924 – 1971	Laminin EGF-likePROSITE-ProRule annotationAdd BLAST	48
Domainⁱ	2316 – 2368	GPSPROSITE-ProRule annotationAdd BLAST	53

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	2743 – 2748	Poly-Glu		6

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Curated

Keywords - Domainⁱ

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4289 Eukaryota ENOG410XTGH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000157493
HOGENOMⁱ	HOG000231346
InParanoidⁱ	Q9R0M0
KEGG Orthology (KO) More...KOⁱ	K04601
OMAⁱ	GCPTKKN
Database of Orthologous Groups More...OrthoDBⁱ	23882at2759
PhylomeDBⁱ	Q9R0M0
TreeFamⁱ	TF320624

Family and domain databases

Gene3Dⁱ	4.10.1240.10, 1 hit
InterProⁱ	View protein in InterPro IPR002126 Cadherin-like_dom IPR015919 Cadherin-like_sf IPR020894 Cadherin_CS IPR013320 ConA-like_dom_sf IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR032471 GAIN_dom_N IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR000832 GPCR_2_secretin-like IPR000203 GPS IPR002049 Laminin_EGF IPR001791 Laminin_G
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF00028 Cadherin, 8 hits PF00008 EGF, 2 hits PF16489 GAIN, 1 hit PF01825 GPS, 1 hit PF00053 Laminin_EGF, 1 hit PF02210 Laminin_G_2, 2 hits
PRINTSⁱ	PR00205 CADHERIN PR00249 GPCRSECRETIN
SMARTⁱ	View protein in SMART SM00112 CA, 9 hits SM00181 EGF, 6 hits SM00179 EGF_CA, 5 hits SM00180 EGF_Lam, 1 hit SM00303 GPS, 1 hit SM00008 HormR, 1 hit SM00282 LamG, 2 hits
SUPFAMⁱ	SSF49313 SSF49313, 9 hits SSF49899 SSF49899, 2 hits
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 2 hits PS00232 CADHERIN_1, 7 hits PS50268 CADHERIN_2, 9 hits PS00022 EGF_1, 6 hits PS01186 EGF_2, 4 hits PS50026 EGF_3, 6 hits PS01248 EGF_LAM_1, 1 hit PS50027 EGF_LAM_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit PS50221 GPS, 1 hit PS50025 LAM_G_DOMAIN, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9R0M0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSRAASAPL PTPLLPLLLL LLLLPPSPLL GDQVGPCRSL GSGGRSSSGA 
        60         70         80         90        100
CAPVGWLCPA SASNLWLYTS RCRESGIELT GHLVPHHDGL RVWCPESGAH 
       110        120        130        140        150
IPLPPSSEGC PWSCRLLGIG GHLSPQGTLT LPEEHPCLKA PRLRCQSCKL 
       160        170        180        190        200
AQAPGLRAGE GSPEESLGGR RKRNVNTAPQ FQPPSYQATV PENQPAGTSV 
       210        220        230        240        250
ASLRAIDPDE GEAGRLEYTM DALFDSRSNH FFSLDPITGV VTTAEELDRE 
       260        270        280        290        300
TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE 
       310        320        330        340        350
NLEVGYEVLT VRATDGDAPP NANILYRLLE GAGGSPSDAF EIDPRSGVIR 
       360        370        380        390        400
TRGPVDREEV ESYKLTVEAS DQGRDPGPRS STAIVFLSVE DDNDNAPQFS 
       410        420        430        440        450
EKRYVVQVRE DVTPGAPVLR VTASDRDKGS NALVHYSIMS GNARGQFYLD 
       460        470        480        490        500
AQTGALDVVS PLDYETTKEY TLRIRAQDGG RPPLSNVSGL VTVQVLDIND 
       510        520        530        540        550
NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL EYSLAGVGHD 
       560        570        580        590        600
FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTI 
       610        620        630        640        650
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG 
       660        670        680        690        700
NTRNRFSITS QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV 
       710        720        730        740        750
NVTDANTHRP VFQSSHYTVN VNEDRPAGTT VVLISATDED TGENARITYF 
       760        770        780        790        800
MEDSIPQFRI DADTGAVTTQ AELDYEDQVS YTLAITARDN GIPQKSDTTY 
       810        820        830        840        850
LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT DRDSGLNGRV 
       860        870        880        890        900
FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP 
       910        920        930        940        950
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE 
       960        970        980        990       1000
GTNAQIMYQI VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS 
      1010       1020       1030       1040       1050
APLVSRATVH VRLLDRNDNP PVLGNFEILF NNYVTNRSSS FPGGAIGRVP 
      1060       1070       1080       1090       1100
AHDPDISDSL TYSFERGNEL SLVLLNASTG ELRLSRALDN NRPLEAIMSV 
      1110       1120       1130       1140       1150
LVSDGVHSVT AQCSLRVTII TDEMLTHSIT LRLEDMSPER FLSPLLGLFI 
      1160       1170       1180       1190       1200
QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL 
      1210       1220       1230       1240       1250
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD 
      1260       1270       1280       1290       1300
SSAPFIASSS VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH 
      1310       1320       1330       1340       1350
GRCRSREGGY TCLCLDGYTG EHCEASTHSG RCTPGVCKNG GTCVNLLVGG 
      1360       1370       1380       1390       1400
FKCDCPSGDF EKPFCQVTTR SFPARSFITF RGLRQRFHFT LALSFATKER 
      1410       1420       1430       1440       1450
NGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS PFVPGGVSDG 
      1460       1470       1480       1490       1500
QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVSVDGCDTG VALRFGAMLG 
      1510       1520       1530       1540       1550
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR HFVGCMKDLQ 
      1560       1570       1580       1590       1600
VDSRHIDMAD FIANNGTVPG CPTKKIVCDS SICHNGGTCV NQWNAFSCEC 
      1610       1620       1630       1640       1650
PLGFGGKSCA QEMANPQRFL GSSLVAWHGL SLPISQPWHL SLMFRTRQAD 
      1660       1670       1680       1690       1700
GVLLQAVTRG RSTITLQLRA GHVVLSVEGT GLQASSLRLE PGRANDGDWH 
      1710       1720       1730       1740       1750
HAQLALGASG GPGHAILSFD YGQQKAEGNL GPRLHGLHLS NITVGGVPGP 
      1760       1770       1780       1790       1800
ASGVARGFRG CLQGVRVSET PEGISSLDPS RGESINVEPG CSWPDPCDSN 
      1810       1820       1830       1840       1850
PCPTNSYCSN DWDSYSCSCV LGYYGDNCTN VCDLNPCEHQ SVCTRKPNTP 
      1860       1870       1880       1890       1900
HGYICECLPN YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN 
      1910       1920       1930       1940       1950
KTSGECHCKE NHYRPPGSPT CLLCDCYPTG SLSRVCDPED GQCPCKPGVI 
      1960       1970       1980       1990       2000
GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI EAGIWWPRTR FGLPAAAPCP 
      2010       2020       2030       2040       2050
KGSFGTAVRH CDEHRGWLPP NLFNCTSVTF SELKGFAERL QRNESGLDSG 
      2060       2070       2080       2090       2100
RSQRLALLLR NATQHTSGYF GSDVKVAYQL ATRLLAHESA QRGFGLSATQ 
      2110       2120       2130       2140       2150
DVHFTENLLR VGSALLDAAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ 
      2160       2170       2180       2190       2200
NMRHTYLSPF TIVTPNIVIS VVRLDKGNFA GTKLPRYEAL RGERPPDLET 
      2210       2220       2230       2240       2250
TVILPESVFR EMPSMVRSAG PGEAQETEEL ARRQRRHPEL SQGEAVASVI 
      2260       2270       2280       2290       2300
IYHTLAGLLP HNYDPDKRSL RVPKRPVINT PVVSISVHDD EELLPRALDK 
      2310       2320       2330       2340       2350
PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE VVFRNESHVS 
      2360       2370       2380       2390       2400
CQCNHMTSFA VLMDMSRREN GEILPLKTLT YVALGVTLAA LMLTFLFLTL 
      2410       2420       2430       2440       2450
LRALRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY 
      2460       2470       2480       2490       2500
LCTFSWALLE ALHLYRALTE VRDVNASPMR FYYMLGWGVP AFITGLAVGL 
      2510       2520       2530       2540       2550
DPEGYGNPDF CWLSVYDTLI WSFAGPVAFA VSMSVFLYIL SARASCAAQR 
      2560       2570       2580       2590       2600
QGFEKKGPVS GLRSSFTVLL LLSATWLLAL LSVNSDTLLF HYLFAACNCV 
      2610       2620       2630       2640       2650
QGPFIFLSYV VLSKEVRKAL KFACSRKPSP DPALTTKSTL TSSYNCPSPY 
      2660       2670       2680       2690       2700
ADGRLYQPYG DSAGSLHSAS RSGKSQPSYI PFLLREESTL NPGQVPPGLG 
      2710       2720       2730       2740       2750
DPSGLFLEGQ AQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEAA 
      2760       2770       2780       2790       2800
FPGEQGWDSL LGPGAERLPL HSTPKDGGPG SGKVPWLGDF GTTTKENSGS 
      2810       2820       2830       2840       2850
GPLEERPREN GDALTREGSL GPLPGPSTQP HKGILKKKCL PTISEKSSLL 
      2860       2870       2880       2890       2900
RLPLEQGTGS SRGSSISEGS RHGPPPRPPP RQSLQEQLNG VMPVAMSIKA 
      2910 
GTVDEDSSGS EFLFFNFLH

Length:2,919

Mass (Da):316,986

Last modified:April 10, 2019 - v3

Checksum:ⁱA8F35C88C5808300

GO

Isoform 2 (identifier: Q9R0M0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
2912-2919: Missing.

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        10         20         30         40         50
MRSRAASAPL PTPLLPLLLL LLLLPPSPLL GDQVGPCRSL GSGGRSSSGA 
        60         70         80         90        100
CAPVGWLCPA SASNLWLYTS RCRESGIELT GHLVPHHDGL RVWCPESGAH 
       110        120        130        140        150
IPLPPSSEGC PWSCRLLGIG GHLSPQGTLT LPEEHPCLKA PRLRCQSCKL 
       160        170        180        190        200
AQAPGLRAGE GSPEESLGGR RKRNVNTAPQ FQPPSYQATV PENQPAGTSV 
       210        220        230        240        250
ASLRAIDPDE GEAGRLEYTM DALFDSRSNH FFSLDPITGV VTTAEELDRE 
       260        270        280        290        300
TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE 
       310        320        330        340        350
NLEVGYEVLT VRATDGDAPP NANILYRLLE GAGGSPSDAF EIDPRSGVIR 
       360        370        380        390        400
TRGPVDREEV ESYKLTVEAS DQGRDPGPRS STAIVFLSVE DDNDNAPQFS 
       410        420        430        440        450
EKRYVVQVRE DVTPGAPVLR VTASDRDKGS NALVHYSIMS GNARGQFYLD 
       460        470        480        490        500
AQTGALDVVS PLDYETTKEY TLRIRAQDGG RPPLSNVSGL VTVQVLDIND 
       510        520        530        540        550
NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL EYSLAGVGHD 
       560        570        580        590        600
FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTI 
       610        620        630        640        650
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG 
       660        670        680        690        700
NTRNRFSITS QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV 
       710        720        730        740        750
NVTDANTHRP VFQSSHYTVN VNEDRPAGTT VVLISATDED TGENARITYF 
       760        770        780        790        800
MEDSIPQFRI DADTGAVTTQ AELDYEDQVS YTLAITARDN GIPQKSDTTY 
       810        820        830        840        850
LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT DRDSGLNGRV 
       860        870        880        890        900
FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP 
       910        920        930        940        950
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE 
       960        970        980        990       1000
GTNAQIMYQI VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS 
      1010       1020       1030       1040       1050
APLVSRATVH VRLLDRNDNP PVLGNFEILF NNYVTNRSSS FPGGAIGRVP 
      1060       1070       1080       1090       1100
AHDPDISDSL TYSFERGNEL SLVLLNASTG ELRLSRALDN NRPLEAIMSV 
      1110       1120       1130       1140       1150
LVSDGVHSVT AQCSLRVTII TDEMLTHSIT LRLEDMSPER FLSPLLGLFI 
      1160       1170       1180       1190       1200
QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL 
      1210       1220       1230       1240       1250
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD 
      1260       1270       1280       1290       1300
SSAPFIASSS VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH 
      1310       1320       1330       1340       1350
GRCRSREGGY TCLCLDGYTG EHCEASTHSG RCTPGVCKNG GTCVNLLVGG 
      1360       1370       1380       1390       1400
FKCDCPSGDF EKPFCQVTTR SFPARSFITF RGLRQRFHFT LALSFATKER 
      1410       1420       1430       1440       1450
NGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS PFVPGGVSDG 
      1460       1470       1480       1490       1500
QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVSVDGCDTG VALRFGAMLG 
      1510       1520       1530       1540       1550
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR HFVGCMKDLQ 
      1560       1570       1580       1590       1600
VDSRHIDMAD FIANNGTVPG CPTKKIVCDS SICHNGGTCV NQWNAFSCEC 
      1610       1620       1630       1640       1650
PLGFGGKSCA QEMANPQRFL GSSLVAWHGL SLPISQPWHL SLMFRTRQAD 
      1660       1670       1680       1690       1700
GVLLQAVTRG RSTITLQLRA GHVVLSVEGT GLQASSLRLE PGRANDGDWH 
      1710       1720       1730       1740       1750
HAQLALGASG GPGHAILSFD YGQQKAEGNL GPRLHGLHLS NITVGGVPGP 
      1760       1770       1780       1790       1800
ASGVARGFRG CLQGVRVSET PEGISSLDPS RGESINVEPG CSWPDPCDSN 
      1810       1820       1830       1840       1850
PCPTNSYCSN DWDSYSCSCV LGYYGDNCTN VCDLNPCEHQ SVCTRKPNTP 
      1860       1870       1880       1890       1900
HGYICECLPN YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN 
      1910       1920       1930       1940       1950
KTSGECHCKE NHYRPPGSPT CLLCDCYPTG SLSRVCDPED GQCPCKPGVI 
      1960       1970       1980       1990       2000
GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI EAGIWWPRTR FGLPAAAPCP 
      2010       2020       2030       2040       2050
KGSFGTAVRH CDEHRGWLPP NLFNCTSVTF SELKGFAERL QRNESGLDSG 
      2060       2070       2080       2090       2100
RSQRLALLLR NATQHTSGYF GSDVKVAYQL ATRLLAHESA QRGFGLSATQ 
      2110       2120       2130       2140       2150
DVHFTENLLR VGSALLDAAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ 
      2160       2170       2180       2190       2200
NMRHTYLSPF TIVTPNIVIS VVRLDKGNFA GTKLPRYEAL RGERPPDLET 
      2210       2220       2230       2240       2250
TVILPESVFR EMPSMVRSAG PGEAQETEEL ARRQRRHPEL SQGEAVASVI 
      2260       2270       2280       2290       2300
IYHTLAGLLP HNYDPDKRSL RVPKRPVINT PVVSISVHDD EELLPRALDK 
      2310       2320       2330       2340       2350
PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE VVFRNESHVS 
      2360       2370       2380       2390       2400
CQCNHMTSFA VLMDMSRREN GEILPLKTLT YVALGVTLAA LMLTFLFLTL 
      2410       2420       2430       2440       2450
LRALRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY 
      2460       2470       2480       2490       2500
LCTFSWALLE ALHLYRALTE VRDVNASPMR FYYMLGWGVP AFITGLAVGL 
      2510       2520       2530       2540       2550
DPEGYGNPDF CWLSVYDTLI WSFAGPVAFA VSMSVFLYIL SARASCAAQR 
      2560       2570       2580       2590       2600
QGFEKKGPVS GLRSSFTVLL LLSATWLLAL LSVNSDTLLF HYLFAACNCV 
      2610       2620       2630       2640       2650
QGPFIFLSYV VLSKEVRKAL KFACSRKPSP DPALTTKSTL TSSYNCPSPY 
      2660       2670       2680       2690       2700
ADGRLYQPYG DSAGSLHSAS RSGKSQPSYI PFLLREESTL NPGQVPPGLG 
      2710       2720       2730       2740       2750
DPSGLFLEGQ AQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEAA 
      2760       2770       2780       2790       2800
FPGEQGWDSL LGPGAERLPL HSTPKDGGPG SGKVPWLGDF GTTTKENSGS 
      2810       2820       2830       2840       2850
GPLEERPREN GDALTREGSL GPLPGPSTQP HKGILKKKCL PTISEKSSLL 
      2860       2870       2880       2890       2900
RLPLEQGTGS SRGSSISEGS RHGPPPRPPP RQSLQEQLNG VMPVAMSIKA 
      2910 
GTVDEDSSGS E

Note: No experimental confirmation available.

Show »

Length:2,911

Mass (Da):315,920

Checksum:ⁱEDADE52D5C0F8913

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F7BHW1	F7BHW1_MOUSE		Cadherin EGF LAG seven-pass G-type ... Cadherin EGF LAG seven-pass G-type receptor 2	Celsr2	900	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	3	S → T in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	334	G → D in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	638	D → H in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	721	V → G in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	762	A → G in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	823	S → T in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	838	S → L in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	914	V → G in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1222	Q → K in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1268	P → L in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1280	F → L in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1296	P → T in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1315 – 1317	LDG → RGC in BAA84070 (PubMed:10490098).Curated	3
Sequence conflictⁱ	1351	F → I in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1359	D → H in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1376	S → P in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1384	R → H in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1595	A → T in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1631	S → Y in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1641	S → N in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1674 – 1677	VLSV → RLSM in BAA84070 (PubMed:10490098).Curated	4
Sequence conflictⁱ	1688	R → H in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1710	G → R in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1720	D → N in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1725	K → T in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1774 – 1775	IS → VH in BAA84070 (PubMed:10490098).Curated	2
Sequence conflictⁱ	1793	W → L in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1808	C → Y in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1813	D → N in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	1911	N → K in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	2198	L → V in AAC68837 (PubMed:10790539).Curated	1
Sequence conflictⁱ	2198	L → V in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	2282	V → A in AAC68837 (PubMed:10790539).Curated	1
Sequence conflictⁱ	2282	V → A in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	2534	S → R in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	2570	L → R in AAC68837 (PubMed:10790539).Curated	1
Sequence conflictⁱ	2638	S → Y in AAC68837 (PubMed:10790539).Curated	1
Sequence conflictⁱ	2638	S → Y in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	2760	L → C in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	2795	K → R in AAC68837 (PubMed:10790539).Curated	1
Sequence conflictⁱ	2802	P → A in BAA84070 (PubMed:10490098).Curated	1
Sequence conflictⁱ	2899	K → N in BAA84070 (PubMed:10490098).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_025765	2912 – 2919	Missing in isoform 2. 1 Publication		8

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028499 mRNA Translation: BAA84070.1 AF031573 mRNA Translation: AAC68837.1 AL671899 Genomic DNA No translation available. AL672200 Genomic DNA No translation available. CH466607 Genomic DNA Translation: EDL01967.1 BC005499 mRNA Translation: AAH05499.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17759.1 [Q9R0M0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_059088.2, NM_017392.3 [Q9R0M0-1]

Genome annotation databases

Ensemblⁱ	ENSMUST00000090558; ENSMUSP00000088046; ENSMUSG00000068740 [Q9R0M0-1]
GeneIDⁱ	53883
KEGGⁱ	mmu:53883
UCSC genome browser More...UCSCⁱ	uc008qyx.1 mouse

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q9R0M0	Isoform 2 of Cadherin EGF LAG seven-pass G-type receptor 2		MOUSE		2911	UniRef100_Q9R0M0
UPI0003D7433D		MOUSE		1796

Protein	Similar proteins		Species	Score	Length	Source
Q9R0M0	Cadherin EGF LAG seven-pass G-type receptor 2		HUMAN		2923	UniRef90_Q9R0M0
Isoform 2 of Cadherin EGF LAG seven-pass G-type receptor 2		MOUSE		2911
Cadherin EGF LAG seven-pass G-type receptor 2		PIG		3059
Cadherin, EGF LAG seven-pass G-type receptor 2 (Fragment)		MUSPF		71
Cadherin EGF LAG seven-pass G-type receptor 2		HORSE		2969
+263

Protein	Similar proteins		Species	Score	Length	Source
Q9R0M0	Cadherin EGF LAG seven-pass G-type receptor 2		HUMAN		2923	UniRef50_Q9R0M0
Isoform 2 of Cadherin EGF LAG seven-pass G-type receptor 2		MOUSE		2911
Cadherin EGF LAG seven-pass G-type receptor 2		PIG		3059
Cadherin, EGF LAG seven-pass G-type receptor 2 (Fragment)		MUSPF		71
Cadherin EGF LAG seven-pass G-type receptor 2		HORSE		2969
+344

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028499 mRNA Translation: BAA84070.1 AF031573 mRNA Translation: AAC68837.1 AL671899 Genomic DNA No translation available. AL672200 Genomic DNA No translation available. CH466607 Genomic DNA Translation: EDL01967.1 BC005499 mRNA Translation: AAH05499.1
CCDSⁱ	CCDS17759.1 [Q9R0M0-1]
RefSeqⁱ	NP_059088.2, NM_017392.3 [Q9R0M0-1]

3D structure databases

SMRⁱ	Q9R0M0
ModBaseⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9R0M0, 2 interactors
MINTⁱ	Q9R0M0
STRINGⁱ	10090.ENSMUSP00000088046

Protein family/group databases

MEROPSⁱ	P02.006
GPCRDBⁱ	Search...

PTM databases

GlyConnectⁱ	2174
iPTMnetⁱ	Q9R0M0
PhosphoSitePlusⁱ	Q9R0M0

Proteomic databases

PaxDbⁱ	Q9R0M0
PRIDEⁱ	Q9R0M0

Genome annotation databases

Ensemblⁱ	ENSMUST00000090558; ENSMUSP00000088046; ENSMUSG00000068740 [Q9R0M0-1]
GeneIDⁱ	53883
KEGGⁱ	mmu:53883
UCSCⁱ	uc008qyx.1 mouse

Organism-specific databases

CTDⁱ	1952
MGIⁱ	MGI:1858235 Celsr2

Phylogenomic databases

eggNOGⁱ	KOG4289 Eukaryota ENOG410XTGH LUCA
GeneTreeⁱ	ENSGT00940000157493
HOGENOMⁱ	HOG000231346
InParanoidⁱ	Q9R0M0
KOⁱ	K04601
OMAⁱ	GCPTKKN
OrthoDBⁱ	23882at2759
PhylomeDBⁱ	Q9R0M0
TreeFamⁱ	TF320624

Miscellaneous databases

ChiTaRSⁱ	Celsr2 mouse
Protein Ontology More...PROⁱ	PR:Q9R0M0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000068740 Expressed in 294 organ(s), highest expression level in frontal cortex

Bgeeⁱ

ENSMUSG00000068740 Expressed in 294 organ(s), highest expression level in frontal cortex

Family and domain databases

Gene3Dⁱ	4.10.1240.10, 1 hit
InterProⁱ	View protein in InterPro IPR002126 Cadherin-like_dom IPR015919 Cadherin-like_sf IPR020894 Cadherin_CS IPR013320 ConA-like_dom_sf IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR032471 GAIN_dom_N IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR000832 GPCR_2_secretin-like IPR000203 GPS IPR002049 Laminin_EGF IPR001791 Laminin_G
Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF00028 Cadherin, 8 hits PF00008 EGF, 2 hits PF16489 GAIN, 1 hit PF01825 GPS, 1 hit PF00053 Laminin_EGF, 1 hit PF02210 Laminin_G_2, 2 hits
PRINTSⁱ	PR00205 CADHERIN PR00249 GPCRSECRETIN
SMARTⁱ	View protein in SMART SM00112 CA, 9 hits SM00181 EGF, 6 hits SM00179 EGF_CA, 5 hits SM00180 EGF_Lam, 1 hit SM00303 GPS, 1 hit SM00008 HormR, 1 hit SM00282 LamG, 2 hits
SUPFAMⁱ	SSF49313 SSF49313, 9 hits SSF49899 SSF49899, 2 hits
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 2 hits PS00232 CADHERIN_1, 7 hits PS50268 CADHERIN_2, 9 hits PS00022 EGF_1, 6 hits PS01186 EGF_2, 4 hits PS50026 EGF_3, 6 hits PS01248 EGF_LAM_1, 1 hit PS50027 EGF_LAM_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit PS50221 GPS, 1 hit PS50025 LAM_G_DOMAIN, 2 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CELR2_MOUSE
Accessionⁱ	Q9R0M0Primary (citable) accession number: Q9R0M0 Secondary accession number(s): A2AEE7, Q99K26, Q9Z2R4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
	Last sequence update:	April 10, 2019
	Last modified:	October 16, 2019
	This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9R0M0 (CELR2_MOUSE)

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Cadherin EGF LAG seven-pass G-type receptor 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Plasma Membrane

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Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

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Experimental Info

Alternative sequence

Sequence databases

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Genome annotation databases

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Gene expression databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ