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Entry version 128 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Pericentriolar material 1 protein

Gene

Pcm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for centrosome assembly and function (PubMed:12112146). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (By similarity). Required to anchor microtubules to the centrosome (By similarity). Involved in the biogenesis of cilia (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pericentriolar material 1 protein
Short name:
PCM-1
Short name:
mPCM-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pcm1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1277958 Pcm1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002740382 – 2025Pericentriolar material 1 proteinAdd BLAST2024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei65PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei93PhosphoserineBy similarity1
Modified residuei110PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei159PhosphoserineBy similarity1
Modified residuei370PhosphoserineBy similarity1
Modified residuei372PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Modified residuei399N6-acetyllysineBy similarity1
Modified residuei593PhosphoserineBy similarity1
Modified residuei644PhosphoserineCombined sources1
Modified residuei857PhosphothreonineBy similarity1
Modified residuei859PhosphoserineCombined sources1
Modified residuei864PhosphoserineCombined sources1
Modified residuei867PhosphoserineCombined sources1
Modified residuei870PhosphoserineCombined sources1
Modified residuei875PhosphothreonineCombined sources1
Modified residuei957PhosphoserineBy similarity1
Modified residuei974PhosphoserineBy similarity1
Modified residuei985PhosphoserineBy similarity1
Modified residuei988PhosphoserineBy similarity1
Modified residuei1182PhosphoserineBy similarity1
Modified residuei1185PhosphoserineCombined sources1
Modified residuei1228PhosphoserineBy similarity1
Modified residuei1254PhosphoserineCombined sources1
Modified residuei1257PhosphoserineCombined sources1
Modified residuei1259PhosphoserineCombined sources1
Modified residuei1260PhosphoserineCombined sources1
Modified residuei1315PhosphoserineCombined sources1
Modified residuei1317PhosphoserineCombined sources1
Modified residuei1466PhosphothreonineBy similarity1
Modified residuei1571PhosphoserineCombined sources1
Modified residuei1695PhosphoserineBy similarity1
Modified residuei1729PhosphoserineCombined sources1
Modified residuei1766PhosphoserineCombined sources1
Modified residuei1769PhosphoserineCombined sources1
Modified residuei1777PhosphoserineCombined sources1
Modified residuei1783PhosphoserineCombined sources1
Modified residuei1959PhosphoserineBy similarity1
Modified residuei1978PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. Undergoes monoubiquitination catalyzed by the E3 ubiquitin-protein ligase MIB1 in proliferating cells, preventing cilia formation. Monoubiquitination by MIB1 is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, resulting in cilia formation initiation.By similarity
Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown. Phosphorylation by DYRK3 promotes disassembly of pericentriolar material.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9R0L6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9R0L6

PeptideAtlas

More...
PeptideAtlasi
Q9R0L6

PRoteomics IDEntifications database

More...
PRIDEi
Q9R0L6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9R0L6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9R0L6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9R0L6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the hippocampus and dentate gyrus, the columnar epithelial cells of bronchioles, the olfactory epithelium, the pericardium and the inner segment of the retina.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Maternally derived during fertilization. Expressed in the pericardium of the developing embryo and in the epidermal layer surrounding the digits.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031592 Expressed in 284 organ(s), highest expression level in cochlea

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9R0L6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9R0L6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates.

Interacts with BBS4, BBS8, CETN3, HAP1, NDE1, NDEL1, MAP1LC3B, GABARAPAL2, and GABARAP.

Interacts with CEP131; the interaction increases in response to ultraviolet light (UV) radiation. Associates with microtubule; association to microtubule is reduced in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling (By similarity).

Interacts with C2CD3 (PubMed:24469809).

Interacts with CCDC113 (By similarity).

Interacts with SSX2IP (PubMed:24356449).

Interacts with CCDC13 (By similarity).

Interacts with CEP290 (PubMed:17705300).

Interacts with PARD6A (By similarity).

Interacts with KIAA0753/OFIP, FOPNL/FOR20 and OFD1; the interaction with FOPNL/FOR20 and OFD1 may be mediated by KIAA0753/OFIP (PubMed:26643951).

Interacts with CCDC66 (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Cep290Q6A0784EBI-4284371,EBI-1811999

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
202047, 26 interactors

Protein interaction database and analysis system

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IntActi
Q9R0L6, 24 interactors

Molecular INTeraction database

More...
MINTi
Q9R0L6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039709

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili218 – 301Sequence analysisAdd BLAST84
Coiled coili399 – 426Sequence analysisAdd BLAST28
Coiled coili492 – 518Sequence analysisAdd BLAST27
Coiled coili652 – 772Sequence analysisAdd BLAST121
Coiled coili822 – 856Sequence analysisAdd BLAST35
Coiled coili985 – 1017Sequence analysisAdd BLAST33
Coiled coili1061 – 1086Sequence analysisAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PCM1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEGR Eukaryota
ENOG410YNFX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000006641

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9R0L6

KEGG Orthology (KO)

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KOi
K16537

Identification of Orthologs from Complete Genome Data

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OMAi
EFSVSIC

Database of Orthologous Groups

More...
OrthoDBi
500021at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328740

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031446 PCM1_C
IPR024138 Pericentriolar_Pcm1

The PANTHER Classification System

More...
PANTHERi
PTHR14164 PTHR14164, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15717 PCM1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9R0L6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATGGGPFEE VMHDQDLPNW SNDSVDDRLN NMEWGGQQKK ANRSSEKNKK
60 70 80 90 100
KFGVASDKRV TNAISPESSP GVGRRRTKIP HTFPHSRYMT QMSVPEQAEL
110 120 130 140 150
EKLKQRINFS DLDQRSIGSD SQGRATAANN KRQLSENRKP FNFLPMQINT
160 170 180 190 200
NKSKDATASL PKREMTTSAQ CKELFASALS NDLLQNCQVS EEDGRGEPAM
210 220 230 240 250
ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT HLIEHLKEQE
260 270 280 290 300
KSYMKFLQKI LARDPQQEPM EETENLKKQH DLLKRMLQQQ EQLRALQGRQ
310 320 330 340 350
AALLALQHKA EQAIAVMDDS VVTETTGSLS GVSITSELNE ELNDLIQRFH
360 370 380 390 400
NQLRDSQPPA VPDNRRQAES LSLTREISQS RNPSVSEHLP DEKVQLFSKM
410 420 430 440 450
RVLQEKKQKM DKLLGELHNL RDQHLNNSSF VPSTSLQRSG DKRSSTVALS
460 470 480 490 500
APVGFASAVN GEANSLISSV PCPATSLVSQ NESENEGHLN PAEKLQKLNE
510 520 530 540 550
VQKRLNELRE LVHYYEQTSD MMTDAVNENT KDEETEESEY DSEHENSEPV
560 570 580 590 600
TNIRNPQVAS TWNEVNTNSN TQCGSNNRDG RPVNSNCEIN NRSAANIRAL
610 620 630 640 650
NMPPLDCRYN REGEQRLHVA HGEDEEEEVE EEGVSGASLS SRRSSLVDEA
660 670 680 690 700
PEDEEFEQKI SRLMAAKEKL KQLQDLVAMV QDDDATQVVV PAASNLDDFY
710 720 730 740 750
AAEEDIKQNS NNARENSNKI DTGVNEKTRE KFYEAKLQQQ QRELKQLQEE
760 770 780 790 800
RKKLIEIQEK IQAVQKACPD LQLSATSISS GPTKKYLPAI TSTPTVNEND
810 820 830 840 850
SSTSKCVIDP EDSSVVDNEL WSDMRRHEML REELRQRRKQ LEALMAEHQR
860 870 880 890 900
RQGLAETSSP VAISLRSDGS ENLCTPQQSR TEKTMATWGG STQCALDEEG
910 920 930 940 950
DEDGYLSEGI VRTDEEEEEE QDASSNDNFP IYPPSMNQNS YNVKETKTRW
960 970 980 990 1000
KSNRPVSADG NYRPLAKTRQ QNISMQRQEN LRWVSELSYI EEKEQWQEQI
1010 1020 1030 1040 1050
NQLKKQLDFS VNICQTLMQD QQTLSCLLQT LLTGPYSVLP SNVASPQVHL
1060 1070 1080 1090 1100
IMHQLNQCYT QLTWQQNNVQ RLKQMLTELM RQQNQHPEKP RSKERGSSAS
1110 1120 1130 1140 1150
HPSSPNLFCP FSFPTQPVNL FNLPGFTNFP SFAPGMNFSP LFPSNFGDFS
1160 1170 1180 1190 1200
QNVSTPTEQQ QPLAQNPSGK TEYMAFPKPF ESSSSLGAEK QRNQKQPEEE
1210 1220 1230 1240 1250
AENTKTPWLY DQEGGVEKPF FKTGFTESVE KATNSNRKNQ PDTSRRRRQF
1260 1270 1280 1290 1300
DEESLESFSS MPDPIDPTTV TKTFKTRKAS AQASLASKDK TPKSKSKKRN
1310 1320 1330 1340 1350
STQLKSRVKN IGYESASVSS TCEPCKNRNR HSAQTEEPVQ AKLFSRKNHE
1360 1370 1380 1390 1400
QLEKIIKYSR SAEISSETGS DFSMFEALRD TIYSEVATLI SQNESRPHFL
1410 1420 1430 1440 1450
IELFHELQLL NTDYLRQRAL YALQDIVSRH ISESDEREGE NVKPVNSGTW
1460 1470 1480 1490 1500
VASNSELTPS ESLVTTDDET FEKNFERETH KVSEQNDADN VSVMSVSSNF
1510 1520 1530 1540 1550
EPFATDDLGN TVIHLDQALA RMREYERMKT ETESHSNMRC TCRVIEDEDG
1560 1570 1580 1590 1600
AAAAATVSNS EETPIIENHN SPQPISDVSA VPCPRIDTQQ LDRQIKAIMK
1610 1620 1630 1640 1650
EVIPFLKEHM DEVCSSQLLT SVRRMVLTLT QQNDESKEFV KFFHKQLGSI
1660 1670 1680 1690 1700
LQDSLAKFAG RKLKDCGEDL LVEISEVLFN ELAFFKLMQD LDNNSIAVKQ
1710 1720 1730 1740 1750
RCKRKIEAAG VRQSYAKEAK RILEGDHGSP AGEIDDEDKD KDETETVKQT
1760 1770 1780 1790 1800
QTSEVYDAKG PKNVRSDVSD QEEDEESERC PVSINLSKAE SQALTNYGSG
1810 1820 1830 1840 1850
EDENEDEEME DFEESPVDIQ TSLQANTETT EENEHDSQIL QHDLEKTPES
1860 1870 1880 1890 1900
TNVPSDQEPT SKNDQDSSPV KPCYLNILEN EQQLNSATHK DSLTTTDSSK
1910 1920 1930 1940 1950
QPEPLPLPLA ASETLVPRVK EVKSAQETPE SSLAGSPDTE SPVLVNDYEA
1960 1970 1980 1990 2000
ESGNISQKSD EEDFVKVEDL PLKLTVYSEE ELRKKMIEEE QKNHLSGEIC
2010 2020
EMQTEELAGN SQILKEPETV GAQSI
Length:2,025
Mass (Da):228,847
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39D790997E6C5418
GO
Isoform 2 (identifier: Q9R0L6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-263: R → RENEEEDVRTVDSAVGSGSVAESTSLNADVQSEASDTTAR

Show »
Length:2,064
Mass (Da):232,843
Checksum:i38384D030FEC47BE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GT33A0A1B0GT33_MOUSE
Pericentriolar material 1 protein
Pcm1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti305A → T in AAH53728 (PubMed:15489334).Curated1
Sequence conflicti408Q → R in AAH53728 (PubMed:15489334).Curated1
Sequence conflicti1216V → I in AAK39513 (Ref. 5) Curated1
Sequence conflicti1329N → S in AAK39513 (Ref. 5) Curated1
Sequence conflicti1819I → V in BAA87861 (PubMed:10579718).Curated1
Sequence conflicti1819I → V in AAK21980 (Ref. 5) Curated1
Sequence conflicti2018 – 2025ETVGAQSI → GKSYQF in BAC30604 (PubMed:16141072).Curated8

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022612263R → RENEEEDVRTVDSAVGSGSV AESTSLNADVQSEASDTTAR in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB029291 mRNA Translation: BAA87861.1
AC144926 Genomic DNA No translation available.
AC156554 Genomic DNA No translation available.
BC053728 mRNA Translation: AAH53728.1
AK011147 mRNA Translation: BAB27430.3
AK040482 mRNA Translation: BAC30604.1
AK141516 mRNA Translation: BAE24712.1
AY028080 Genomic DNA Translation: AAK21980.1
AF352180 mRNA Translation: AAK39513.1
AF369838 mRNA Translation: AAK39564.1
AF369839 mRNA Translation: AAK39565.1
AF039021 Genomic DNA Translation: AAC96068.1
AK020493 mRNA Translation: BAB32121.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS22261.1 [Q9R0L6-1]

NCBI Reference Sequences

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RefSeqi
NP_076151.2, NM_023662.3 [Q9R0L6-1]
XP_006509361.1, XM_006509298.2 [Q9R0L6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000045218; ENSMUSP00000039709; ENSMUSG00000031592 [Q9R0L6-1]
ENSMUST00000211247; ENSMUSP00000147887; ENSMUSG00000031592 [Q9R0L6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
18536

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:18536

UCSC genome browser

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UCSCi
uc009lnr.2 mouse [Q9R0L6-1]
uc009lns.1 mouse [Q9R0L6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029291 mRNA Translation: BAA87861.1
AC144926 Genomic DNA No translation available.
AC156554 Genomic DNA No translation available.
BC053728 mRNA Translation: AAH53728.1
AK011147 mRNA Translation: BAB27430.3
AK040482 mRNA Translation: BAC30604.1
AK141516 mRNA Translation: BAE24712.1
AY028080 Genomic DNA Translation: AAK21980.1
AF352180 mRNA Translation: AAK39513.1
AF369838 mRNA Translation: AAK39564.1
AF369839 mRNA Translation: AAK39565.1
AF039021 Genomic DNA Translation: AAC96068.1
AK020493 mRNA Translation: BAB32121.1
CCDSiCCDS22261.1 [Q9R0L6-1]
RefSeqiNP_076151.2, NM_023662.3 [Q9R0L6-1]
XP_006509361.1, XM_006509298.2 [Q9R0L6-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi202047, 26 interactors
IntActiQ9R0L6, 24 interactors
MINTiQ9R0L6
STRINGi10090.ENSMUSP00000039709

PTM databases

iPTMnetiQ9R0L6
PhosphoSitePlusiQ9R0L6
SwissPalmiQ9R0L6

Proteomic databases

jPOSTiQ9R0L6
PaxDbiQ9R0L6
PeptideAtlasiQ9R0L6
PRIDEiQ9R0L6

Genome annotation databases

EnsembliENSMUST00000045218; ENSMUSP00000039709; ENSMUSG00000031592 [Q9R0L6-1]
ENSMUST00000211247; ENSMUSP00000147887; ENSMUSG00000031592 [Q9R0L6-2]
GeneIDi18536
KEGGimmu:18536
UCSCiuc009lnr.2 mouse [Q9R0L6-1]
uc009lns.1 mouse [Q9R0L6-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5108
MGIiMGI:1277958 Pcm1

Phylogenomic databases

eggNOGiENOG410IEGR Eukaryota
ENOG410YNFX LUCA
GeneTreeiENSGT00390000006641
InParanoidiQ9R0L6
KOiK16537
OMAiEFSVSIC
OrthoDBi500021at2759
TreeFamiTF328740

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Pcm1 mouse

Protein Ontology

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PROi
PR:Q9R0L6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031592 Expressed in 284 organ(s), highest expression level in cochlea
ExpressionAtlasiQ9R0L6 baseline and differential
GenevisibleiQ9R0L6 MM

Family and domain databases

InterProiView protein in InterPro
IPR031446 PCM1_C
IPR024138 Pericentriolar_Pcm1
PANTHERiPTHR14164 PTHR14164, 1 hit
PfamiView protein in Pfam
PF15717 PCM1_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCM1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R0L6
Secondary accession number(s): E9QLK2
, O70287, Q3URH6, Q7TMS7, Q8C9V2, Q91Y27, Q91Y28, Q91Y51, Q923L0, Q9CRK8, Q9CT57
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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