Emcn

Functionⁱ

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.By similarity

GO - Molecular functionⁱ

carbohydrate binding Source: HGNC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: HGNC
cell-cell adhesion Source: HGNC
regulation of cell adhesion Source: HGNC

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endomucin Alternative name(s): Endomucin-1/2 Mucin-14 Short name: MUC-14
Gene namesⁱ	Name:Emcn Synonyms:Muc14
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1891716 Emcn

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 190	ExtracellularSequence analysisAdd BLAST	170
Transmembraneⁱ	191 – 211	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	212 – 261	CytoplasmicSequence analysisAdd BLAST	50

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000019291	21 – 261	EndomucinAdd BLAST		241

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	28	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	101	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	119	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	127	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	131	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	237	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Highly O-glycosylated. Sialic acid-rich glycoprotein.1 Publication

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9R0H2
PRIDEⁱ	Q9R0H2

PTM databases

iPTMnetⁱ	Q9R0H2
PhosphoSitePlusⁱ	Q9R0H2

Expressionⁱ

Tissue specificityⁱ

Highly expressed in heart and kidney, followed by brain, spleen, thymus, liver and lung. Exclusively expressed in endothelial cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000054690 Expressed in 245 organ(s), highest expression level in cochlea
CleanExⁱ	MM_EMCN
ExpressionAtlasⁱ	Q9R0H2 baseline and differential
Genevisibleⁱ	Q9R0H2 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000112603

STRINGⁱ

10090.ENSMUSP00000112603

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9R0H2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	33 – 185	Thr-richAdd BLAST		153

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J0MP Eukaryota ENOG4111AC7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012139
HOGENOMⁱ	HOG000013126
HOVERGENⁱ	HBG052537
InParanoidⁱ	Q9R0H2
KEGG Orthology (KO) More...KOⁱ	K16664
OMAⁱ	XIILPVV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G16TF
PhylomeDBⁱ	Q9R0H2
TreeFamⁱ	TF337783

Family and domain databases

InterProⁱ	View protein in InterPro IPR010740 Endomucin
PANTHERⁱ	PTHR15869 PTHR15869, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07010 Endomucin, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9R0H2-1) [UniParc]FASTA Add to basket

Also known as: 1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLQATVLF FLLSNSLCHS EDGKDVQNDS IPTPAETSTT KASVTIPGIV 
        60         70         80         90        100
SVTNPNKPAD GTPPEGTTKS DVSQTSLVTT INSLTTPKHE VGTTTEGPLR 
       110        120        130        140        150
NESSTMKITV PNTPTSNANS TLPGSQNKTE NQSSIRTTEI SVTTQLLDAL 
       160        170        180        190        200
PKITATSSAS LTTAHTMSLL QDTEDRKIAT TPSTTPSYSS IILPVVIALV 
       210        220        230        240        250
VITLLVFTLV GLYRICWKRD PGTPENGNDQ PQSDKESVKL LTVKTISHES 
       260 
GEHSAQGKTK N

Length:261

Mass (Da):27,756

Last modified:May 1, 2000 - v1

Checksum:ⁱEF797205E9BEF3F4

GO

Isoform 2 (identifier: Q9R0H2-2) [UniParc]FASTA Add to basket

Also known as: 1b

The sequence of this isoform differs from the canonical sequence as follows:
129-142: TENQSSIRTTEISV → I

« Hide

        10         20         30         40         50
MRLLQATVLF FLLSNSLCHS EDGKDVQNDS IPTPAETSTT KASVTIPGIV 
        60         70         80         90        100
SVTNPNKPAD GTPPEGTTKS DVSQTSLVTT INSLTTPKHE VGTTTEGPLR 
       110        120        130        140        150
NESSTMKITV PNTPTSNANS TLPGSQNKIT TQLLDALPKI TATSSASLTT 
       160        170        180        190        200
AHTMSLLQDT EDRKIATTPS TTPSYSSIIL PVVIALVVIT LLVFTLVGLY 
       210        220        230        240 
RICWKRDPGT PENGNDQPQS DKESVKLLTV KTISHESGEH SAQGKTKN

Show »

Length:248

Mass (Da):26,323

Checksum:ⁱ9337753FF47A79BF

GO

Isoform 3 (identifier: Q9R0H2-3) [UniParc]FASTA Add to basket

Also known as: 1c

The sequence of this isoform differs from the canonical sequence as follows:
91-129: VGTTTEGPLRNESSTMKITVPNTPTSNANSTLPGSQNKT → A

« Hide

        10         20         30         40         50
MRLLQATVLF FLLSNSLCHS EDGKDVQNDS IPTPAETSTT KASVTIPGIV 
        60         70         80         90        100
SVTNPNKPAD GTPPEGTTKS DVSQTSLVTT INSLTTPKHE AENQSSIRTT 
       110        120        130        140        150
EISVTTQLLD ALPKITATSS ASLTTAHTMS LLQDTEDRKI ATTPSTTPSY 
       160        170        180        190        200
SSIILPVVIA LVVITLLVFT LVGLYRICWK RDPGTPENGN DQPQSDKESV 
       210        220 
KLLTVKTISH ESGEHSAQGK TKN

Note: No experimental confirmation available.

Show »

Length:223

Mass (Da):23,813

Checksum:ⁱ614F7B5882F5CA30

GO

Isoform 4 (identifier: Q9R0H2-4) [UniParc]FASTA Add to basket

Also known as: 1d

The sequence of this isoform differs from the canonical sequence as follows:
91-141: Missing.

« Hide

        10         20         30         40         50
MRLLQATVLF FLLSNSLCHS EDGKDVQNDS IPTPAETSTT KASVTIPGIV 
        60         70         80         90        100
SVTNPNKPAD GTPPEGTTKS DVSQTSLVTT INSLTTPKHE VTTQLLDALP 
       110        120        130        140        150
KITATSSASL TTAHTMSLLQ DTEDRKIATT PSTTPSYSSI ILPVVIALVV 
       160        170        180        190        200
ITLLVFTLVG LYRICWKRDP GTPENGNDQP QSDKESVKLL TVKTISHESG 
       210
EHSAQGKTKN

Note: No experimental confirmation available.

Show »

Length:210

Mass (Da):22,395

Checksum:ⁱ13168D7928F62E3A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2JDR2	A0A0G2JDR2_MOUSE		Endomucin Endomucin	Emcn	219	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	18	C → G in BAB22232 (PubMed:16141072).Curated	1
Sequence conflictⁱ	157	S → P in AAD05208 (PubMed:9864158).Curated	1
Sequence conflictⁱ	256	Q → R in BAB22232 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_010828	91 – 141	Missing in isoform 4. 1 PublicationAdd BLAST	51
Alternative sequenceⁱVSP_010827	91 – 129	VGTTT…SQNKT → A in isoform 3. 1 PublicationAdd BLAST	39
Alternative sequenceⁱVSP_010829	129 – 142	TENQS…TEISV → I in isoform 2. 3 PublicationsAdd BLAST	14

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF060883 mRNA Translation: AAD05208.1 AB034693 mRNA Translation: BAA86226.1 AB034694 mRNA Translation: BAA86227.1 AK002616 mRNA Translation: BAB22232.1 BC003706 mRNA Translation: AAH03706.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17861.1 [Q9R0H2-2] CCDS51075.1 [Q9R0H2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001156994.1, NM_001163522.1 [Q9R0H2-1] NP_058581.2, NM_016885.2 [Q9R0H2-2] XP_006501905.1, XM_006501842.2 [Q9R0H2-3]
UniGeneⁱ	Mm.27343

Genome annotation databases

Ensemblⁱ	ENSMUST00000119475; ENSMUSP00000114102; ENSMUSG00000054690 [Q9R0H2-2] ENSMUST00000122064; ENSMUSP00000112603; ENSMUSG00000054690 [Q9R0H2-1]
GeneIDⁱ	59308
KEGGⁱ	mmu:59308
UCSC genome browser More...UCSCⁱ	uc008rmk.2 mouse [Q9R0H2-2] uc008rml.2 mouse [Q9R0H2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9R0H2-3	Endomucin (Fragment)		MOUSE		219	UniRef90_Q9R0H2-3
Isoform 4 of Endomucin		MOUSE		210
Uncharacterized protein		MOUSE		198
Q9R0H2-4	Isoform 3 of Endomucin		MOUSE		223	UniRef90_Q9R0H2-3
Endomucin (Fragment)		MOUSE		219
Uncharacterized protein		MOUSE		198

Protein	Similar proteins		Species	Score	Length	Source
Q9R0H2	Endomucin		HUMAN		261	UniRef50_Q9ULC0
Endomucin		PONAB		260
Endomucin		RAT		250
Endomucin		GORGO		261
Uncharacterized protein		PANPA		260
+108
Q9R0H2-3	Endomucin (Fragment)		MOUSE		219	UniRef50_Q9R0H2-3
Endomucin		FELCA		211
Uncharacterized protein		PROCO		193
Uncharacterized protein		CERAT		211
Endomucin		NEOVI		201
+20
Q9R0H2-4	Isoform 3 of Endomucin		MOUSE		223	UniRef50_Q9R0H2-3
Endomucin		FELCA		211
Uncharacterized protein		PROCO		193
Uncharacterized protein		CERAT		211
Endomucin		NEOVI		201
+20

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF060883 mRNA Translation: AAD05208.1 AB034693 mRNA Translation: BAA86226.1 AB034694 mRNA Translation: BAA86227.1 AK002616 mRNA Translation: BAB22232.1 BC003706 mRNA Translation: AAH03706.1
CCDSⁱ	CCDS17861.1 [Q9R0H2-2] CCDS51075.1 [Q9R0H2-1]
RefSeqⁱ	NP_001156994.1, NM_001163522.1 [Q9R0H2-1] NP_058581.2, NM_016885.2 [Q9R0H2-2] XP_006501905.1, XM_006501842.2 [Q9R0H2-3]
UniGeneⁱ	Mm.27343

3D structure databases

ProteinModelPortalⁱ	Q9R0H2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000112603

STRINGⁱ

10090.ENSMUSP00000112603

PTM databases

iPTMnetⁱ	Q9R0H2
PhosphoSitePlusⁱ	Q9R0H2

Proteomic databases

PaxDbⁱ	Q9R0H2
PRIDEⁱ	Q9R0H2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000119475; ENSMUSP00000114102; ENSMUSG00000054690 [Q9R0H2-2] ENSMUST00000122064; ENSMUSP00000112603; ENSMUSG00000054690 [Q9R0H2-1]
GeneIDⁱ	59308
KEGGⁱ	mmu:59308
UCSCⁱ	uc008rmk.2 mouse [Q9R0H2-2] uc008rml.2 mouse [Q9R0H2-1]

Organism-specific databases

CTDⁱ	51705
MGIⁱ	MGI:1891716 Emcn

Phylogenomic databases

eggNOGⁱ	ENOG410J0MP Eukaryota ENOG4111AC7 LUCA
GeneTreeⁱ	ENSGT00390000012139
HOGENOMⁱ	HOG000013126
HOVERGENⁱ	HBG052537
InParanoidⁱ	Q9R0H2
KOⁱ	K16664
OMAⁱ	XIILPVV
OrthoDBⁱ	EOG091G16TF
PhylomeDBⁱ	Q9R0H2
TreeFamⁱ	TF337783

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9R0H2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000054690 Expressed in 245 organ(s), highest expression level in cochlea
CleanExⁱ	MM_EMCN
ExpressionAtlasⁱ	Q9R0H2 baseline and differential
Genevisibleⁱ	Q9R0H2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR010740 Endomucin
PANTHERⁱ	PTHR15869 PTHR15869, 1 hit
Pfamⁱ	View protein in Pfam PF07010 Endomucin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MUCEN_MOUSE
Accessionⁱ	Q9R0H2Primary (citable) accession number: Q9R0H2 Secondary accession number(s): Q78KL2 , Q9DCN9, Q9ULC1, Q9Z2I1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9R0H2 (MUCEN_MOUSE)

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Endomucin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ