UniProtKB - Q9R0H2 (MUCEN_MOUSE)
Protein
Endomucin
Gene
Emcn
Organism
Mus musculus (Mouse)
Status
Functioni
Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.By similarity
GO - Molecular functioni
- carbohydrate binding Source: HGNC
GO - Biological processi
- angiogenesis Source: HGNC
- cell-cell adhesion Source: HGNC
- regulation of cell adhesion Source: HGNC
Names & Taxonomyi
Protein namesi | Recommended name: EndomucinAlternative name(s): Endomucin-1/2 Mucin-14 Short name: MUC-14 |
Gene namesi | Name:Emcn Synonyms:Muc14 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1891716, Emcn |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- plasma membrane Source: HGNC
Other locations
- integral component of membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 190 | ExtracellularSequence analysisAdd BLAST | 170 | |
Transmembranei | 191 – 211 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 212 – 261 | CytoplasmicSequence analysisAdd BLAST | 50 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000019291 | 21 – 261 | EndomucinAdd BLAST | 241 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 101 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 119 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 127 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 131 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 237 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Highly O-glycosylated. Sialic acid-rich glycoprotein.1 Publication
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q9R0H2 |
PaxDbi | Q9R0H2 |
PRIDEi | Q9R0H2 |
PTM databases
GlyGeni | Q9R0H2, 5 sites |
iPTMneti | Q9R0H2 |
PhosphoSitePlusi | Q9R0H2 |
Expressioni
Tissue specificityi
Highly expressed in heart and kidney, followed by brain, spleen, thymus, liver and lung. Exclusively expressed in endothelial cells.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000054690, Expressed in cochlea and 260 other tissues |
Genevisiblei | Q9R0H2, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000112603 |
Miscellaneous databases
RNActi | Q9R0H2, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 33 – 185 | Thr-richAdd BLAST | 153 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S6VA, Eukaryota |
GeneTreei | ENSGT00390000012139 |
InParanoidi | Q9R0H2 |
OMAi | NESTIMN |
OrthoDBi | 1471475at2759 |
PhylomeDBi | Q9R0H2 |
TreeFami | TF337783 |
Family and domain databases
InterProi | View protein in InterPro IPR010740, Endomucin |
PANTHERi | PTHR15869, PTHR15869, 1 hit |
Pfami | View protein in Pfam PF07010, Endomucin, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9R0H2-1) [UniParc]FASTAAdd to basket
Also known as: 1a
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRLLQATVLF FLLSNSLCHS EDGKDVQNDS IPTPAETSTT KASVTIPGIV
60 70 80 90 100
SVTNPNKPAD GTPPEGTTKS DVSQTSLVTT INSLTTPKHE VGTTTEGPLR
110 120 130 140 150
NESSTMKITV PNTPTSNANS TLPGSQNKTE NQSSIRTTEI SVTTQLLDAL
160 170 180 190 200
PKITATSSAS LTTAHTMSLL QDTEDRKIAT TPSTTPSYSS IILPVVIALV
210 220 230 240 250
VITLLVFTLV GLYRICWKRD PGTPENGNDQ PQSDKESVKL LTVKTISHES
260
GEHSAQGKTK N
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JDR2 | A0A0G2JDR2_MOUSE | Endomucin | Emcn | 219 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 18 | C → G in BAB22232 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 157 | S → P in AAD05208 (PubMed:9864158).Curated | 1 | |
Sequence conflicti | 256 | Q → R in BAB22232 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010828 | 91 – 141 | Missing in isoform 4. 1 PublicationAdd BLAST | 51 | |
Alternative sequenceiVSP_010827 | 91 – 129 | VGTTT…SQNKT → A in isoform 3. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_010829 | 129 – 142 | TENQS…TEISV → I in isoform 2. 3 PublicationsAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF060883 mRNA Translation: AAD05208.1 AB034693 mRNA Translation: BAA86226.1 AB034694 mRNA Translation: BAA86227.1 AK002616 mRNA Translation: BAB22232.1 BC003706 mRNA Translation: AAH03706.1 |
CCDSi | CCDS17861.1 [Q9R0H2-2] CCDS51075.1 [Q9R0H2-1] |
RefSeqi | NP_001156994.1, NM_001163522.1 [Q9R0H2-1] NP_058581.2, NM_016885.2 [Q9R0H2-2] XP_006501905.1, XM_006501842.2 [Q9R0H2-3] |
Genome annotation databases
Ensembli | ENSMUST00000119475; ENSMUSP00000114102; ENSMUSG00000054690 [Q9R0H2-2] ENSMUST00000122064; ENSMUSP00000112603; ENSMUSG00000054690 [Q9R0H2-1] |
GeneIDi | 59308 |
KEGGi | mmu:59308 |
UCSCi | uc008rmk.2, mouse [Q9R0H2-2] uc008rml.2, mouse [Q9R0H2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF060883 mRNA Translation: AAD05208.1 AB034693 mRNA Translation: BAA86226.1 AB034694 mRNA Translation: BAA86227.1 AK002616 mRNA Translation: BAB22232.1 BC003706 mRNA Translation: AAH03706.1 |
CCDSi | CCDS17861.1 [Q9R0H2-2] CCDS51075.1 [Q9R0H2-1] |
RefSeqi | NP_001156994.1, NM_001163522.1 [Q9R0H2-1] NP_058581.2, NM_016885.2 [Q9R0H2-2] XP_006501905.1, XM_006501842.2 [Q9R0H2-3] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000112603 |
PTM databases
GlyGeni | Q9R0H2, 5 sites |
iPTMneti | Q9R0H2 |
PhosphoSitePlusi | Q9R0H2 |
Proteomic databases
jPOSTi | Q9R0H2 |
PaxDbi | Q9R0H2 |
PRIDEi | Q9R0H2 |
Protocols and materials databases
Antibodypediai | 989, 203 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000119475; ENSMUSP00000114102; ENSMUSG00000054690 [Q9R0H2-2] ENSMUST00000122064; ENSMUSP00000112603; ENSMUSG00000054690 [Q9R0H2-1] |
GeneIDi | 59308 |
KEGGi | mmu:59308 |
UCSCi | uc008rmk.2, mouse [Q9R0H2-2] uc008rml.2, mouse [Q9R0H2-1] |
Organism-specific databases
CTDi | 51705 |
MGIi | MGI:1891716, Emcn |
Phylogenomic databases
eggNOGi | ENOG502S6VA, Eukaryota |
GeneTreei | ENSGT00390000012139 |
InParanoidi | Q9R0H2 |
OMAi | NESTIMN |
OrthoDBi | 1471475at2759 |
PhylomeDBi | Q9R0H2 |
TreeFami | TF337783 |
Miscellaneous databases
BioGRID-ORCSi | 59308, 0 hits in 17 CRISPR screens |
PROi | PR:Q9R0H2 |
RNActi | Q9R0H2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000054690, Expressed in cochlea and 260 other tissues |
Genevisiblei | Q9R0H2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR010740, Endomucin |
PANTHERi | PTHR15869, PTHR15869, 1 hit |
Pfami | View protein in Pfam PF07010, Endomucin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MUCEN_MOUSE | |
Accessioni | Q9R0H2Primary (citable) accession number: Q9R0H2 Secondary accession number(s): Q78KL2 Q9Z2I1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot