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Protein

Endomucin

Gene

Emcn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Endomucin
Alternative name(s):
Endomucin-1/2
Mucin-14
Short name:
MUC-14
Gene namesi
Name:Emcn
Synonyms:Muc14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1891716 Emcn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 190ExtracellularSequence analysisAdd BLAST170
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 261CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001929121 – 261EndomucinAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei237PhosphoserineCombined sources1

Post-translational modificationi

Highly O-glycosylated. Sialic acid-rich glycoprotein.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9R0H2
PRIDEiQ9R0H2

PTM databases

iPTMnetiQ9R0H2
PhosphoSitePlusiQ9R0H2

Expressioni

Tissue specificityi

Highly expressed in heart and kidney, followed by brain, spleen, thymus, liver and lung. Exclusively expressed in endothelial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000054690 Expressed in 245 organ(s), highest expression level in cochlea
CleanExiMM_EMCN
ExpressionAtlasiQ9R0H2 baseline and differential
GenevisibleiQ9R0H2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112603

Structurei

3D structure databases

ProteinModelPortaliQ9R0H2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 185Thr-richAdd BLAST153

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MP Eukaryota
ENOG4111AC7 LUCA
GeneTreeiENSGT00390000012139
HOGENOMiHOG000013126
HOVERGENiHBG052537
InParanoidiQ9R0H2
KOiK16664
OMAiXIILPVV
OrthoDBiEOG091G16TF
PhylomeDBiQ9R0H2
TreeFamiTF337783

Family and domain databases

InterProiView protein in InterPro
IPR010740 Endomucin
PANTHERiPTHR15869 PTHR15869, 1 hit
PfamiView protein in Pfam
PF07010 Endomucin, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9R0H2-1) [UniParc]FASTAAdd to basket
Also known as: 1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLLQATVLF FLLSNSLCHS EDGKDVQNDS IPTPAETSTT KASVTIPGIV
60 70 80 90 100
SVTNPNKPAD GTPPEGTTKS DVSQTSLVTT INSLTTPKHE VGTTTEGPLR
110 120 130 140 150
NESSTMKITV PNTPTSNANS TLPGSQNKTE NQSSIRTTEI SVTTQLLDAL
160 170 180 190 200
PKITATSSAS LTTAHTMSLL QDTEDRKIAT TPSTTPSYSS IILPVVIALV
210 220 230 240 250
VITLLVFTLV GLYRICWKRD PGTPENGNDQ PQSDKESVKL LTVKTISHES
260
GEHSAQGKTK N
Length:261
Mass (Da):27,756
Last modified:May 1, 2000 - v1
Checksum:iEF797205E9BEF3F4
GO
Isoform 2 (identifier: Q9R0H2-2) [UniParc]FASTAAdd to basket
Also known as: 1b

The sequence of this isoform differs from the canonical sequence as follows:
     129-142: TENQSSIRTTEISV → I

Show »
Length:248
Mass (Da):26,323
Checksum:i9337753FF47A79BF
GO
Isoform 3 (identifier: Q9R0H2-3) [UniParc]FASTAAdd to basket
Also known as: 1c

The sequence of this isoform differs from the canonical sequence as follows:
     91-129: VGTTTEGPLRNESSTMKITVPNTPTSNANSTLPGSQNKT → A

Note: No experimental confirmation available.
Show »
Length:223
Mass (Da):23,813
Checksum:i614F7B5882F5CA30
GO
Isoform 4 (identifier: Q9R0H2-4) [UniParc]FASTAAdd to basket
Also known as: 1d

The sequence of this isoform differs from the canonical sequence as follows:
     91-141: Missing.

Note: No experimental confirmation available.
Show »
Length:210
Mass (Da):22,395
Checksum:i13168D7928F62E3A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JDR2A0A0G2JDR2_MOUSE
Endomucin
Emcn
219Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18C → G in BAB22232 (PubMed:16141072).Curated1
Sequence conflicti157S → P in AAD05208 (PubMed:9864158).Curated1
Sequence conflicti256Q → R in BAB22232 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01082891 – 141Missing in isoform 4. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_01082791 – 129VGTTT…SQNKT → A in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_010829129 – 142TENQS…TEISV → I in isoform 2. 3 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060883 mRNA Translation: AAD05208.1
AB034693 mRNA Translation: BAA86226.1
AB034694 mRNA Translation: BAA86227.1
AK002616 mRNA Translation: BAB22232.1
BC003706 mRNA Translation: AAH03706.1
CCDSiCCDS17861.1 [Q9R0H2-2]
CCDS51075.1 [Q9R0H2-1]
RefSeqiNP_001156994.1, NM_001163522.1 [Q9R0H2-1]
NP_058581.2, NM_016885.2 [Q9R0H2-2]
XP_006501905.1, XM_006501842.2 [Q9R0H2-3]
UniGeneiMm.27343

Genome annotation databases

EnsembliENSMUST00000119475; ENSMUSP00000114102; ENSMUSG00000054690 [Q9R0H2-2]
ENSMUST00000122064; ENSMUSP00000112603; ENSMUSG00000054690 [Q9R0H2-1]
GeneIDi59308
KEGGimmu:59308
UCSCiuc008rmk.2 mouse [Q9R0H2-2]
uc008rml.2 mouse [Q9R0H2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060883 mRNA Translation: AAD05208.1
AB034693 mRNA Translation: BAA86226.1
AB034694 mRNA Translation: BAA86227.1
AK002616 mRNA Translation: BAB22232.1
BC003706 mRNA Translation: AAH03706.1
CCDSiCCDS17861.1 [Q9R0H2-2]
CCDS51075.1 [Q9R0H2-1]
RefSeqiNP_001156994.1, NM_001163522.1 [Q9R0H2-1]
NP_058581.2, NM_016885.2 [Q9R0H2-2]
XP_006501905.1, XM_006501842.2 [Q9R0H2-3]
UniGeneiMm.27343

3D structure databases

ProteinModelPortaliQ9R0H2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112603

PTM databases

iPTMnetiQ9R0H2
PhosphoSitePlusiQ9R0H2

Proteomic databases

PaxDbiQ9R0H2
PRIDEiQ9R0H2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000119475; ENSMUSP00000114102; ENSMUSG00000054690 [Q9R0H2-2]
ENSMUST00000122064; ENSMUSP00000112603; ENSMUSG00000054690 [Q9R0H2-1]
GeneIDi59308
KEGGimmu:59308
UCSCiuc008rmk.2 mouse [Q9R0H2-2]
uc008rml.2 mouse [Q9R0H2-1]

Organism-specific databases

CTDi51705
MGIiMGI:1891716 Emcn

Phylogenomic databases

eggNOGiENOG410J0MP Eukaryota
ENOG4111AC7 LUCA
GeneTreeiENSGT00390000012139
HOGENOMiHOG000013126
HOVERGENiHBG052537
InParanoidiQ9R0H2
KOiK16664
OMAiXIILPVV
OrthoDBiEOG091G16TF
PhylomeDBiQ9R0H2
TreeFamiTF337783

Miscellaneous databases

PROiPR:Q9R0H2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054690 Expressed in 245 organ(s), highest expression level in cochlea
CleanExiMM_EMCN
ExpressionAtlasiQ9R0H2 baseline and differential
GenevisibleiQ9R0H2 MM

Family and domain databases

InterProiView protein in InterPro
IPR010740 Endomucin
PANTHERiPTHR15869 PTHR15869, 1 hit
PfamiView protein in Pfam
PF07010 Endomucin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMUCEN_MOUSE
AccessioniPrimary (citable) accession number: Q9R0H2
Secondary accession number(s): Q78KL2
, Q9DCN9, Q9ULC1, Q9Z2I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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