Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 164 (16 Oct 2019)
Sequence version 5 (27 Jul 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Peroxisomal acyl-coenzyme A oxidase 1

Gene

Acox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei139FADBy similarity1
Binding sitei178FAD; via amide nitrogenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei421Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-390247 Beta-oxidation of very long chain fatty acids
R-MMU-9033241 Peroxisomal protein import

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00661

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 1By similarity (EC:1.3.3.6By similarity)
Short name:
AOXBy similarity
Alternative name(s):
Palmitoyl-CoA oxidaseBy similarity
Cleaved into the following 3 chains:
Peroxisomal acyl-CoA oxidase 1, A chainBy similarity
Peroxisomal acyl-CoA oxidase 1, B chainBy similarity
Peroxisomal acyl-CoA oxidase 1, C chainBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Acox1Imported
Synonyms:Acox, Paox
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1330812 Acox1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Severe microvesicular hepatic steatosis, sustained activation of Ppara, spontaneous massive peroxisome proliferation and eventual development of hepatocellular carcinomas.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002046781 – 661Peroxisomal acyl-CoA oxidase 1, A chainAdd BLAST661
ChainiPRO_00004475021 – 438Peroxisomal acyl-CoA oxidase 1, B chainBy similarityAdd BLAST438
ChainiPRO_0000447503439 – 661Peroxisomal acyl-CoA oxidase 1, C chainBy similarityAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphoserineBy similarity1
Modified residuei65N6-acetyllysineCombined sources1
Modified residuei89N6-succinyllysineCombined sources1
Modified residuei90N6-succinyllysineCombined sources1
Modified residuei159N6-succinyllysineCombined sources1
Modified residuei216N6-acetyllysineCombined sources1
Modified residuei241N6-succinyllysineCombined sources1
Modified residuei255N6-acetyllysineBy similarity1
Modified residuei267N6-acetyllysineCombined sources1
Modified residuei272N6-acetyllysineCombined sources1
Modified residuei349N6-succinyllysineCombined sources1
Modified residuei437N6-acetyllysine; alternateCombined sources1
Modified residuei437N6-succinyllysine; alternateCombined sources1
Modified residuei446N6-acetyllysine; alternateCombined sources1
Modified residuei446N6-succinyllysine; alternateCombined sources1
Modified residuei500N6-acetyllysineBy similarity1
Modified residuei512N6-acetyllysine; alternateCombined sources1
Modified residuei512N6-succinyllysine; alternateCombined sources1
Modified residuei542N6-succinyllysineCombined sources1
Modified residuei637N6-acetyllysine; alternateCombined sources1
Modified residuei637N6-succinyllysine; alternateCombined sources1
Modified residuei643N6-succinyllysineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei652N6-acetyllysineCombined sources1
Modified residuei655N6-succinyllysineCombined sources1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei468 – 469CleavageBy similarity2

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9R0H0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R0H0

PeptideAtlas

More...
PeptideAtlasi
Q9R0H0

PRoteomics IDEntifications database

More...
PRIDEi
Q9R0H0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9R0H0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9R0H0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9R0H0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels of isoform 1 are found in liver and kidney while highest levels of isoform 2 are found in white adipose tissue. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 is expressed at higher levels in brain, heart, lung, muscle, white adipose tissue and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020777 Expressed in 322 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9R0H0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9R0H0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with LONP2 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
197926, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9R0H0, 4 interactors

Molecular INTeraction database

More...
MINTi
Q9R0H0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000063325

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9R0H0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi659 – 661Microbody targeting signal3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0136 Eukaryota
COG1960 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157287

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000181256

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9R0H0

KEGG Orthology (KO)

More...
KOi
K00232

Identification of Orthologs from Complete Genome Data

More...
OMAi
GRRFFTM

Database of Orthologous Groups

More...
OrthoDBi
416859at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300672

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01150 AXO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.540.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034171 ACO
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000168 Acyl-CoA_oxidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9R0H0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPDLRKERA AATFNPELIT HILDGSPENT RRRREIENLI LNDPDFQHED
60 70 80 90 100
YNFLTRSQRY EVAVKKSATM VKKMREFGIA DPEEIMWFKK LHMVNFVEPV
110 120 130 140 150
GLNYSMFIPT LLNQGTTAQQ EKWMHPSQEL QIIGTYAQTE MGHGTHLRGL
160 170 180 190 200
ETTATYDPKT QEFILNSPTV TSIKWWPGGL GKTSNHAIVL AQLITRGECY
210 220 230 240 250
GLHAFVVPIR EIGTHKPLPG ITVGDIGPKF GYEEMDNGYL KMDNYRIPRE
260 270 280 290 300
NMLMKYAQVK PDGTYVKPLS NKLTYGTMVF VRSFLVGSAA QSLSKACTIA
310 320 330 340 350
IRYSAVRRQS EIKRSEPEPQ ILDFQTQQYK LFPLLATAYA FHFLGRYIKE
360 370 380 390 400
TYMRINESIG QGDLSELPEL HALTAGLKAF TTWTANAGIE ECRMACGGHG
410 420 430 440 450
YSHSSGIPNI YVTFTPACTF EGENTVMMLQ TARFLMKIYD QVQSGKLVGG
460 470 480 490 500
MVSYLNDLPS QRIQPQQVAV WPTLVDINSL DSLTEAYKLR AARLVEIAAK
510 520 530 540 550
NLQAQVSHRK SKEVAWNLTS VDLVRASEAH CHYVTVKVFA DKLPKIQDRA
560 570 580 590 600
VQAVLRNLCL LYSLYGISQK GGDFLEGNII TGAQMSQVNS RILELLTVTR
610 620 630 640 650
PNAVALVDAF DFKDVTLGSV LGRYDGNVYE NLFEWAKKSP LNKTEVHESY
660
YKHLKPLQSK L
Length:661
Mass (Da):74,649
Last modified:July 27, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4140DB77A4CE7BE6
GO
Isoform 2 (identifier: Q9R0H0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-133: KLHMVNFVEP...MHPSQELQII → NSVHRGHPEP...FMPAWNLEIT

Show »
Length:661
Mass (Da):74,718
Checksum:i537E816BDE686154
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A848A2A848_MOUSE
Peroxisomal acyl-coenzyme A oxidase...
Acox1
625Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE41642 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22I → V in AAB62926 (PubMed:10672038).Curated1
Sequence conflicti263G → D in BAE41642 (PubMed:16141072).Curated1
Sequence conflicti516W → R in BAE41642 (PubMed:16141072).Curated1
Sequence conflicti523L → I in BAE41642 (PubMed:16141072).Curated1
Sequence conflicti648E → Q in AAB62926 (PubMed:10672038).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04247790 – 133KLHMV…ELQII → NSVHRGHPEPLDLHLGMFLP TLLHQATEEQQERFFMPAWN LEIT in isoform 2. 2 PublicationsAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF006688 mRNA Translation: AAB62926.1
AB034914 mRNA Translation: BAA86870.1
AK040566 mRNA Translation: BAC30628.1
AK170217 mRNA Translation: BAE41642.1 Different initiation.
AL607108 Genomic DNA No translation available.
AL669925 Genomic DNA No translation available.
CH466558 Genomic DNA Translation: EDL34562.1
CH466558 Genomic DNA Translation: EDL34563.1
BC056448 mRNA Translation: AAH56448.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25660.1 [Q9R0H0-2]
CCDS70354.1 [Q9R0H0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001258827.1, NM_001271898.1 [Q9R0H0-1]
NP_056544.2, NM_015729.3 [Q9R0H0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000066587; ENSMUSP00000063325; ENSMUSG00000020777 [Q9R0H0-2]
ENSMUST00000072948; ENSMUSP00000072717; ENSMUSG00000020777 [Q9R0H0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11430

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:11430

UCSC genome browser

More...
UCSCi
uc007mkj.2 mouse [Q9R0H0-1]
uc007mkl.2 mouse [Q9R0H0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006688 mRNA Translation: AAB62926.1
AB034914 mRNA Translation: BAA86870.1
AK040566 mRNA Translation: BAC30628.1
AK170217 mRNA Translation: BAE41642.1 Different initiation.
AL607108 Genomic DNA No translation available.
AL669925 Genomic DNA No translation available.
CH466558 Genomic DNA Translation: EDL34562.1
CH466558 Genomic DNA Translation: EDL34563.1
BC056448 mRNA Translation: AAH56448.1
CCDSiCCDS25660.1 [Q9R0H0-2]
CCDS70354.1 [Q9R0H0-1]
RefSeqiNP_001258827.1, NM_001271898.1 [Q9R0H0-1]
NP_056544.2, NM_015729.3 [Q9R0H0-2]

3D structure databases

SMRiQ9R0H0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi197926, 1 interactor
IntActiQ9R0H0, 4 interactors
MINTiQ9R0H0
STRINGi10090.ENSMUSP00000063325

PTM databases

iPTMnetiQ9R0H0
PhosphoSitePlusiQ9R0H0
SwissPalmiQ9R0H0

Proteomic databases

jPOSTiQ9R0H0
PaxDbiQ9R0H0
PeptideAtlasiQ9R0H0
PRIDEiQ9R0H0

Genome annotation databases

EnsembliENSMUST00000066587; ENSMUSP00000063325; ENSMUSG00000020777 [Q9R0H0-2]
ENSMUST00000072948; ENSMUSP00000072717; ENSMUSG00000020777 [Q9R0H0-1]
GeneIDi11430
KEGGimmu:11430
UCSCiuc007mkj.2 mouse [Q9R0H0-1]
uc007mkl.2 mouse [Q9R0H0-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51
MGIiMGI:1330812 Acox1

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00940000157287
HOGENOMiHOG000181256
InParanoidiQ9R0H0
KOiK00232
OMAiGRRFFTM
OrthoDBi416859at2759
TreeFamiTF300672

Enzyme and pathway databases

UniPathwayiUPA00661
ReactomeiR-MMU-390247 Beta-oxidation of very long chain fatty acids
R-MMU-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Acox1 mouse

Protein Ontology

More...
PROi
PR:Q9R0H0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020777 Expressed in 322 organ(s), highest expression level in liver
ExpressionAtlasiQ9R0H0 baseline and differential
GenevisibleiQ9R0H0 MM

Family and domain databases

CDDicd01150 AXO, 1 hit
Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACOX1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R0H0
Secondary accession number(s): A2A850
, O35616, Q3TDG0, Q8BYC3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 164 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again