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Protein

Zinc finger protein 346

Gene

Znf346

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (By similarity) (PubMed:10488071). May bind to specific miRNA hairpins (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75Zinc 1By similarity1
Metal bindingi78Zinc 1By similarity1
Metal bindingi91Zinc 1; via tele nitrogenBy similarity1
Metal bindingi97Zinc 1; via pros nitrogenBy similarity1
Metal bindingi136Zinc 2By similarity1
Metal bindingi139Zinc 2By similarity1
Metal bindingi152Zinc 2; via tele nitrogenBy similarity1
Metal bindingi158Zinc 2; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 104Matrin-type 1Add BLAST35
Zinc fingeri131 – 165Matrin-type 2Add BLAST35
Zinc fingeri182 – 216Matrin-type 3Add BLAST35
Zinc fingeri236 – 270Matrin-type 4Add BLAST35

GO - Molecular functioni

  • double-stranded RNA binding Source: MGI
  • enzyme binding Source: MGI
  • miRNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • positive regulation of apoptotic process Source: MGI

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 346
Alternative name(s):
Just another zinc finger protein
Gene namesi
Name:Znf346
Synonyms:Jaz, Zfp346
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1349417 Zfp346

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi91H → A: No loss of dsRNA binding capacity. Binding capacity was reduced 40-60%; when associated with A-203. Binding capacity was reduced to 5-10%; when associated with A-152 and A-203. Loss of binding capacity; when associated with A-152; A-203 and A-257. 1 Publication1
Mutagenesisi152H → A: No loss of dsRNA binding capacity. Loss of 40-60% dsRNA binding; when associated with A-203. Binding capacity was reduced to 5-10%; when associated with A-91 and A-203. Loss of binding capacity; when associated with A-91; A-203 and A-257. 1 Publication1
Mutagenesisi203H → A: No loss of dsRNA binding capacity. Binding capacity was reduced 40-60%; when associated with A-91. Binding capacity was reduced to 5-10%; when associated with A-91 and A-152. Loss of binding capacity; when associated with A-91; A-152 and A-257. 1 Publication1
Mutagenesisi257H → A: No loss of dsRNA binding capacity. Loss of 5-10 % dsRNA binding capacity; when associated with A-152 and A-203. Loss of binding capacity; when associated with A-91; A-152 and A-203. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001918101 – 294Zinc finger protein 346Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9R0B7
MaxQBiQ9R0B7
PaxDbiQ9R0B7
PRIDEiQ9R0B7

PTM databases

iPTMnetiQ9R0B7
PhosphoSitePlusiQ9R0B7

Expressioni

Tissue specificityi

Expressed in all tissues tested, including heart, brain, spleen, lung, liver, muscle, kidney and testis. Exogenous expression induced apoptosis.1 Publication

Gene expression databases

BgeeiENSMUSG00000021481 Expressed in 267 organ(s), highest expression level in thymus
CleanExiMM_ZFP346
ExpressionAtlasiQ9R0B7 baseline and differential
GenevisibleiQ9R0B7 MM

Interactioni

Subunit structurei

Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205063, 1 interactor
STRINGi10090.ENSMUSP00000021937

Structurei

3D structure databases

ProteinModelPortaliQ9R0B7
SMRiQ9R0B7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 104Matrin-type 1Add BLAST35
Zinc fingeri131 – 165Matrin-type 2Add BLAST35
Zinc fingeri182 – 216Matrin-type 3Add BLAST35
Zinc fingeri236 – 270Matrin-type 4Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ4K Eukaryota
ENOG4111JFP LUCA
GeneTreeiENSGT00510000046606
HOGENOMiHOG000008682
HOVERGENiHBG061007
InParanoidiQ9R0B7
PhylomeDBiQ9R0B7
TreeFamiTF350019

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SM00451 ZnF_U1, 4 hits
SUPFAMiSSF57667 SSF57667, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9R0B7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MECPAPDATD AADPGEAGPY KGSEEPEGRE PDGVRFDRER ARRLWEAVSG
60 70 80 90 100
AQPAGREEVE HMIQKNQCLF TSTQCKVCCA MLISESQKLA HYQSKKHANK
110 120 130 140 150
VKRYLAIHGM ETIKGDVKRL DSDQKSSRSK DKNHCCPICN MTFSSPAVAQ
160 170 180 190 200
SHYLGKTHAK SLKLKQQSTK GAALQQNREM LDPDKFCSLC HSTFNDPAMA
210 220 230 240 250
QQHYMGKRHR KQETKLKLMA HYGRLADPAV SDLPAGKGYP CKTCKIVLNS
260 270 280 290
IEQYQAHVSG FKHKNQSPKT LVTLGSQTPV QTQPTPKDSS TVQD
Length:294
Mass (Da):32,698
Last modified:May 1, 2000 - v1
Checksum:i6BD916262EDBA71E
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q7N8E9Q7N8_MOUSE
Zinc finger protein 346
Zfp346
309Annotation score:
E9PYN2E9PYN2_MOUSE
Zinc finger protein 346
Zfp346
262Annotation score:
F7CTY2F7CTY2_MOUSE
Zinc finger protein 346
Zfp346
238Annotation score:
E0CY94E0CY94_MOUSE
Zinc finger protein 346
Zfp346
151Annotation score:
E0CYN4E0CYN4_MOUSE
Zinc finger protein 346
Zfp346 mCG_3202
135Annotation score:
E0CZ32E0CZ32_MOUSE
Zinc finger protein 346
Zfp346 mCG_3202
132Annotation score:
E0CYH6E0CYH6_MOUSE
Zinc finger protein 346
Zfp346
101Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083339 mRNA Translation: AAD52017.1
BC055075 mRNA Translation: AAH55075.1
CCDSiCCDS26539.1
RefSeqiNP_036147.1, NM_012017.2
UniGeneiMm.22795

Genome annotation databases

EnsembliENSMUST00000021937; ENSMUSP00000021937; ENSMUSG00000021481
GeneIDi26919
KEGGimmu:26919
UCSCiuc007qpy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083339 mRNA Translation: AAD52017.1
BC055075 mRNA Translation: AAH55075.1
CCDSiCCDS26539.1
RefSeqiNP_036147.1, NM_012017.2
UniGeneiMm.22795

3D structure databases

ProteinModelPortaliQ9R0B7
SMRiQ9R0B7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205063, 1 interactor
STRINGi10090.ENSMUSP00000021937

PTM databases

iPTMnetiQ9R0B7
PhosphoSitePlusiQ9R0B7

Proteomic databases

EPDiQ9R0B7
MaxQBiQ9R0B7
PaxDbiQ9R0B7
PRIDEiQ9R0B7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021937; ENSMUSP00000021937; ENSMUSG00000021481
GeneIDi26919
KEGGimmu:26919
UCSCiuc007qpy.1 mouse

Organism-specific databases

CTDi26919
MGIiMGI:1349417 Zfp346

Phylogenomic databases

eggNOGiENOG410IQ4K Eukaryota
ENOG4111JFP LUCA
GeneTreeiENSGT00510000046606
HOGENOMiHOG000008682
HOVERGENiHBG061007
InParanoidiQ9R0B7
PhylomeDBiQ9R0B7
TreeFamiTF350019

Miscellaneous databases

ChiTaRSiZfp346 mouse
PROiPR:Q9R0B7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021481 Expressed in 267 organ(s), highest expression level in thymus
CleanExiMM_ZFP346
ExpressionAtlasiQ9R0B7 baseline and differential
GenevisibleiQ9R0B7 MM

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SM00451 ZnF_U1, 4 hits
SUPFAMiSSF57667 SSF57667, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN346_MOUSE
AccessioniPrimary (citable) accession number: Q9R0B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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