Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 150 (13 Feb 2019)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Laminin subunit gamma-3

Gene

Lamc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3000157 Laminin interactions
R-MMU-8874081 MET activates PTK2 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit gamma-3
Alternative name(s):
Laminin-12 subunit gamma
Laminin-14 subunit gamma
Laminin-15 subunit gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lamc3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1344394 Lamc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001708029 – 1581Laminin subunit gamma-3Add BLAST1553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi280 ↔ 289PROSITE-ProRule annotation
Disulfide bondi282 ↔ 299PROSITE-ProRule annotation
Disulfide bondi301 ↔ 310PROSITE-ProRule annotation
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi313 ↔ 333PROSITE-ProRule annotation
Disulfide bondi336 ↔ 345PROSITE-ProRule annotation
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi338 ↔ 361PROSITE-ProRule annotation
Disulfide bondi364 ↔ 373PROSITE-ProRule annotation
Disulfide bondi376 ↔ 389PROSITE-ProRule annotation
Disulfide bondi392 ↔ 404PROSITE-ProRule annotation
Disulfide bondi394 ↔ 410PROSITE-ProRule annotation
Disulfide bondi412 ↔ 421PROSITE-ProRule annotation
Disulfide bondi424 ↔ 436PROSITE-ProRule annotation
Disulfide bondi439 ↔ 450PROSITE-ProRule annotation
Disulfide bondi441 ↔ 457PROSITE-ProRule annotation
Disulfide bondi459 ↔ 468PROSITE-ProRule annotation
Disulfide bondi471 ↔ 486PROSITE-ProRule annotation
Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi719 ↔ 727PROSITE-ProRule annotation
Disulfide bondi721 ↔ 734PROSITE-ProRule annotation
Disulfide bondi736 ↔ 745PROSITE-ProRule annotation
Disulfide bondi748 ↔ 764PROSITE-ProRule annotation
Disulfide bondi767 ↔ 775PROSITE-ProRule annotation
Disulfide bondi769 ↔ 786PROSITE-ProRule annotation
Disulfide bondi789 ↔ 798PROSITE-ProRule annotation
Disulfide bondi801 ↔ 819PROSITE-ProRule annotation
Disulfide bondi822 ↔ 836PROSITE-ProRule annotation
Disulfide bondi824 ↔ 843PROSITE-ProRule annotation
Disulfide bondi846 ↔ 855PROSITE-ProRule annotation
Glycosylationi849N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi858 ↔ 875PROSITE-ProRule annotation
Disulfide bondi878 ↔ 891PROSITE-ProRule annotation
Disulfide bondi880 ↔ 898PROSITE-ProRule annotation
Disulfide bondi900 ↔ 909PROSITE-ProRule annotation
Disulfide bondi912 ↔ 925PROSITE-ProRule annotation
Disulfide bondi928 ↔ 940PROSITE-ProRule annotation
Disulfide bondi930 ↔ 947PROSITE-ProRule annotation
Disulfide bondi949 ↔ 958PROSITE-ProRule annotation
Disulfide bondi961 ↔ 973PROSITE-ProRule annotation
Disulfide bondi976 ↔ 988PROSITE-ProRule annotation
Disulfide bondi978 ↔ 994PROSITE-ProRule annotation
Glycosylationi991N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi996 ↔ 1005PROSITE-ProRule annotation
Disulfide bondi1008 ↔ 1021PROSITE-ProRule annotation
Glycosylationi1162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1320N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1514N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9R0B6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R0B6

PRoteomics IDEntifications database

More...
PRIDEi
Q9R0B6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9R0B6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9R0B6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in capillaries and arterioles of kidney as well as in interstitial Leydig cells of testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026840 Expressed in 88 organ(s), highest expression level in meninx of hindbrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9R0B6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9R0B6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-3 is a subunit of laminin-12 (laminin-213), laminin-14 (laminin-423) and laminin-15 (laminin-523).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204801, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3018 Laminin-213 complex
CPX-3019 Laminin-423 complex
CPX-3021 Laminin-523 complex

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000028187

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9R0B6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9R0B6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 279Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini280 – 335Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini336 – 391Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini392 – 438Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST47
Domaini439 – 488Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST50
Domaini489 – 498Laminin EGF-like 5; first partPROSITE-ProRule annotation10
Domaini508 – 684Laminin IV type APROSITE-ProRule annotationAdd BLAST177
Domaini685 – 718Laminin EGF-like 5; second partPROSITE-ProRule annotationAdd BLAST34
Domaini719 – 766Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST48
Domaini767 – 821Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST55
Domaini822 – 877Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST56
Domaini878 – 927Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST50
Domaini928 – 975Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST48
Domaini976 – 1024Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1025 – 1581Domain II and IAdd BLAST557

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1029 – 1046Sequence analysisAdd BLAST18
Coiled coili1112 – 1153Sequence analysisAdd BLAST42
Coiled coili1208 – 1231Sequence analysisAdd BLAST24
Coiled coili1438 – 1468Sequence analysisAdd BLAST31
Coiled coili1510 – 1575Sequence analysisAdd BLAST66

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain IV is globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1836 Eukaryota
ENOG410XRDC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161559

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000019301

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG100808

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9R0B6

KEGG Orthology (KO)

More...
KOi
K06247

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCIQLAD

Database of Orthologous Groups

More...
OrthoDBi
156553at2759

TreeFam database of animal gene trees

More...
TreeFami
TF352481

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 11 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 6 hits
SM00180 EGF_Lam, 11 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 8 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 11 hits
PS50027 EGF_LAM_2, 10 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9R0B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSRVLSLL ATVASMALVI QETHFAAGAD MGSCYDGVGR AQRCLPEFEN
60 70 80 90 100
AAFGRRAEAS HTCGRPPEDF CPHVGAPGAG LQCQRCDDAD PGRRHDASYL
110 120 130 140 150
TDFHSPDDST WWQSPSMAFG VQYPTSVNLT LSLGKAYEIT YVRLKFHTSR
160 170 180 190 200
PESFAIYKRT YASGPWEPYQ YYSASCQKTY GRPEGHYLRP GEDERVAFCT
210 220 230 240 250
SEFSDISPLN GGNVAFSTLE GRPSAYNFEE SPVLQEWVTS TDILISLDRL
260 270 280 290 300
NTFGDDIFKD PRVLQSYYYA VSDFSVGGRC KCNGHASECE PNAAGQLACR
310 320 330 340 350
CQHNTTGVDC ERCLPFFQDR PWARGTAEDA NECLPCNCSG HSEECTFDRE
360 370 380 390 400
LYRSTGHGGH CQRCRDHTTG PHCERCEKNY YRWSPKTPCQ PCDCHPAGSL
410 420 430 440 450
SLQCDNSGVC PCKPTVTGWK CDRCLPGFHS LSEGGCRPCA CNVAGSLGTC
460 470 480 490 500
DPRSGNCPCK ENVEGSLCDR CRPGTFNLQP HNPVGCSSCF CYGHSKVCSP
510 520 530 540 550
AAGFQEHHIR SDFRHGAGGW QIRSMGVSKR PLQWSQSGLL LGLRGGEELS
560 570 580 590 600
APKKFLGDQR LSYGQPVILT LQVPPGGSPP PIQLRLEGAG LALSLRPSSL
610 620 630 640 650
PSPQDTRQPR RVQLQFLLQE TSEEAESPLP TFHFQRLLSN LTALSIWTSG
660 670 680 690 700
QGPGHSGQVL LCEVQLTSAW PQRELAPPAS WVETCLCPQG YTGQFCEFCA
710 720 730 740 750
LGYKREIPHG GPYANCIPCT CNQHGTCDPN TGICLCGHHT EGPSCERCMP
760 770 780 790 800
GFYGNAFSGR ADDCQPCPCP GQSACATIPE SGDVVCTHCP PGQRGRRCES
810 820 830 840 850
CEDGFFGDPL GLSGAPQPCR RCQCSGNVDL NAVGNCDPHS GHCLRCLYNT
860 870 880 890 900
TGAHCEHCRE GFYGSAVATR PVDKCAPCSC DLRGSVSEKT CNPVTGQCVC
910 920 930 940 950
LPYVSGRDCS RCSPGFYDLQ SGRGCQSCKC HPLGSLENKC HPKTGQCPCR
960 970 980 990 1000
PGVTGQACDR CQLGFFGFSI KGCRDCRCSP LGAASSQCHE NSTCVCRPGF
1010 1020 1030 1040 1050
VGYKCDRCQD NFFLADGDTG CQECPTCYAL VKEEAAKLKA RLMLMEGWLQ
1060 1070 1080 1090 1100
RSDCGSPWGP LDILQGEAPL GDVYQGHHLL QETRGTFLQQ MVGLEDSVKA
1110 1120 1130 1140 1150
TWEQLQVLRG HVHCAQAGAQ KTCIQLAELE ETLQSSEEEV LRAASALSFL
1160 1170 1180 1190 1200
ASLQKGSSTP TNWSHLASEA QILARSHRDT ATKIEATSER ALLASNASYE
1210 1220 1230 1240 1250
LLKLMEGRVA SEAQQELEDR YQEVQAAQTA LGIAVAEALP KAEKALATVK
1260 1270 1280 1290 1300
QVIGDAAPHL GLLVTPEAMN FQARGLSWKV KALEQKLEQK EPEVGQSVGA
1310 1320 1330 1340 1350
LQVEAGRALE KMEPFMQLRN KTTAAFTRAS SAVQAAKVTV IGAETLLADL
1360 1370 1380 1390 1400
EGMKLRSPLP KEQAALKKKA GSIRTRLLED TKRKTKQAER MLGNAASLSS
1410 1420 1430 1440 1450
STKKKSKEAE LMSKDNAKLS RALLREGKQG YRHASRLASQ TQATLRRASR
1460 1470 1480 1490 1500
LLLTSEAHKQ ELEEAKQVTS GLSTVERQIR ESRISLEKDT KVLSELLVKL
1510 1520 1530 1540 1550
GSLGVHQAPA QTLNETQRAL ESLRLQLDSH GALHHKLRQL EEESARQELQ
1560 1570 1580
IQSFEDDLAE IRADKHNLET ILSSLPENCA S
Length:1,581
Mass (Da):172,322
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6E83A8F9C678830
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ATM9A2ATM9_MOUSE
Laminin subunit gamma-3
Lamc3
1,537Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9L → F in AAD29851 (PubMed:10318827).Curated1
Sequence conflicti190P → T in AAD29851 (PubMed:10318827).Curated1
Sequence conflicti195R → K in AAD29851 (PubMed:10318827).Curated1
Sequence conflicti221G → S in AAD29851 (PubMed:10318827).Curated1
Sequence conflicti394C → R in AAD29851 (PubMed:10318827).Curated1
Sequence conflicti471C → Y in AAD29851 (PubMed:10318827).Curated1
Sequence conflicti1150L → LDEPQLFSLLLK in AAD29851 (PubMed:10318827).Curated1
Sequence conflicti1387Q → H in AAF08983 (Ref. 1) Curated1
Sequence conflicti1438 – 1439AS → TI in AAD29851 (PubMed:10318827).Curated2
Sequence conflicti1479I → V in AAF08983 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF083372 mRNA Translation: AAF08983.1
AL928893, BX511243 Genomic DNA Translation: CAM26043.1
BX511243, AL928893 Genomic DNA Translation: CAM26482.1
CH466542 Genomic DNA Translation: EDL08519.1
BC096366 mRNA Translation: AAH96366.1
AF079520 mRNA Translation: AAD29851.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15903.1

NCBI Reference Sequences

More...
RefSeqi
NP_035966.2, NM_011836.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.302362
Mm.69566

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000028187; ENSMUSP00000028187; ENSMUSG00000026840

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23928

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:23928

UCSC genome browser

More...
UCSCi
uc008jef.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083372 mRNA Translation: AAF08983.1
AL928893, BX511243 Genomic DNA Translation: CAM26043.1
BX511243, AL928893 Genomic DNA Translation: CAM26482.1
CH466542 Genomic DNA Translation: EDL08519.1
BC096366 mRNA Translation: AAH96366.1
AF079520 mRNA Translation: AAD29851.1
CCDSiCCDS15903.1
RefSeqiNP_035966.2, NM_011836.3
UniGeneiMm.302362
Mm.69566

3D structure databases

ProteinModelPortaliQ9R0B6
SMRiQ9R0B6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204801, 1 interactor
ComplexPortaliCPX-3018 Laminin-213 complex
CPX-3019 Laminin-423 complex
CPX-3021 Laminin-523 complex
STRINGi10090.ENSMUSP00000028187

PTM databases

iPTMnetiQ9R0B6
PhosphoSitePlusiQ9R0B6

Proteomic databases

MaxQBiQ9R0B6
PaxDbiQ9R0B6
PRIDEiQ9R0B6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028187; ENSMUSP00000028187; ENSMUSG00000026840
GeneIDi23928
KEGGimmu:23928
UCSCiuc008jef.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10319
MGIiMGI:1344394 Lamc3

Phylogenomic databases

eggNOGiKOG1836 Eukaryota
ENOG410XRDC LUCA
GeneTreeiENSGT00940000161559
HOGENOMiHOG000019301
HOVERGENiHBG100808
InParanoidiQ9R0B6
KOiK06247
OMAiTCIQLAD
OrthoDBi156553at2759
TreeFamiTF352481

Enzyme and pathway databases

ReactomeiR-MMU-3000157 Laminin interactions
R-MMU-8874081 MET activates PTK2 signaling

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9R0B6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026840 Expressed in 88 organ(s), highest expression level in meninx of hindbrain
ExpressionAtlasiQ9R0B6 baseline and differential
GenevisibleiQ9R0B6 MM

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 11 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00180 EGF_Lam, 11 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 8 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 11 hits
PS50027 EGF_LAM_2, 10 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMC3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R0B6
Secondary accession number(s): Q4VAI3, Q9WTW6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: July 27, 2011
Last modified: February 13, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again