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Protein

Transducin beta-like protein 2

Gene

Tbl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transducin beta-like protein 2
Gene namesi
Name:Tbl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1351652 Tbl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512711 – 442Transducin beta-like protein 2Add BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki164Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei428PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9R099
MaxQBiQ9R099
PaxDbiQ9R099
PRIDEiQ9R099

PTM databases

iPTMnetiQ9R099
PhosphoSitePlusiQ9R099
SwissPalmiQ9R099

Expressioni

Gene expression databases

BgeeiENSMUSG00000005374 Expressed in 258 organ(s), highest expression level in heart
CleanExiMM_TBL2
ExpressionAtlasiQ9R099 baseline and differential
GenevisibleiQ9R099 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205175, 2 interactors
IntActiQ9R099, 3 interactors
MINTiQ9R099
STRINGi10090.ENSMUSP00000115011

Structurei

3D structure databases

ProteinModelPortaliQ9R099
SMRiQ9R099
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati84 – 123WD 1Add BLAST40
Repeati130 – 170WD 2Add BLAST41
Repeati182 – 222WD 3Add BLAST41
Repeati224 – 263WD 4Add BLAST40
Repeati273 – 312WD 5Add BLAST40
Repeati323 – 362WD 6Add BLAST40
Repeati366 – 404WD 7Add BLAST39

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2096 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00390000013836
HOGENOMiHOG000007065
HOVERGENiHBG009735
InParanoidiQ9R099
OMAiTMPCRLA
OrthoDBiEOG091G063D
PhylomeDBiQ9R099
TreeFamiTF315054

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9R099-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELPQMPELM GLSLLVGLLA LVATAAVARG WLRAEEKPSQ PVCQKENEPK
60 70 80 90 100
KSGSKKQKQN QRVRKEKPQQ HSFTHPLLAA ALKSHSGNIS CMDFSSNGKY
110 120 130 140 150
LATCADDRTV RIWSTKDFLQ REHRSMRANV ELDHATLVRF SPDCRAFIVW
160 170 180 190 200
LANGDTLRVF KMTKREDGGF TFTATPEDFP KKHKAPIINI GIADTGKFIM
210 220 230 240 250
TASSDTTVLI WNLKGQVLST INTNQMNNSH AVISPCSRFV GSCGFTPDVK
260 270 280 290 300
VWEVCFGKKG EFQEVLRAFE LKGHSASVHS FAFSNDSRRM ASVSKDGTWK
310 320 330 340 350
LWDTDVEYKK QQDPYLLRTG RFEEASTMPC RLALSPDTHV LALATGTNIH
360 370 380 390 400
LFNTRRGEKE EYFECVHGEC IADLTFDITG RFLASCGDRA VRLFHNTPGH
410 420 430 440
RAVVEEMQSL LKRASSESTR QRLQQQLTQA QEALKSLGAL KK
Length:442
Mass (Da):49,584
Last modified:July 27, 2011 - v2
Checksum:i483685E07C66BA40
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WI46F8WI46_MOUSE
Transducin beta-like protein 2
Tbl2
153Annotation score:
D3YZH8D3YZH8_MOUSE
Transducin beta-like protein 2
Tbl2
190Annotation score:
D6RI48D6RI48_MOUSE
Transducin beta-like protein 2
Tbl2
66Annotation score:
A0A0J9YUN1A0A0J9YUN1_MOUSE
Transducin beta-like protein 2
Tbl2
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156T → S in AAF06825 (PubMed:10575226).Curated1
Sequence conflicti357G → A in AAF06825 (PubMed:10575226).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097523 mRNA Translation: AAF06825.1
AK132366 mRNA Translation: BAE21128.1
AK165686 mRNA Translation: BAE38338.1
BC039273 mRNA Translation: AAH39273.1
BC048185 mRNA Translation: AAH48185.1
CCDSiCCDS19735.1
RefSeqiNP_038791.2, NM_013763.2
UniGeneiMm.36746
Mm.441276

Genome annotation databases

EnsembliENSMUST00000153183; ENSMUSP00000115011; ENSMUSG00000005374
GeneIDi27368
KEGGimmu:27368
UCSCiuc008zxu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097523 mRNA Translation: AAF06825.1
AK132366 mRNA Translation: BAE21128.1
AK165686 mRNA Translation: BAE38338.1
BC039273 mRNA Translation: AAH39273.1
BC048185 mRNA Translation: AAH48185.1
CCDSiCCDS19735.1
RefSeqiNP_038791.2, NM_013763.2
UniGeneiMm.36746
Mm.441276

3D structure databases

ProteinModelPortaliQ9R099
SMRiQ9R099
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205175, 2 interactors
IntActiQ9R099, 3 interactors
MINTiQ9R099
STRINGi10090.ENSMUSP00000115011

PTM databases

iPTMnetiQ9R099
PhosphoSitePlusiQ9R099
SwissPalmiQ9R099

Proteomic databases

EPDiQ9R099
MaxQBiQ9R099
PaxDbiQ9R099
PRIDEiQ9R099

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000153183; ENSMUSP00000115011; ENSMUSG00000005374
GeneIDi27368
KEGGimmu:27368
UCSCiuc008zxu.1 mouse

Organism-specific databases

CTDi26608
MGIiMGI:1351652 Tbl2

Phylogenomic databases

eggNOGiKOG2096 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00390000013836
HOGENOMiHOG000007065
HOVERGENiHBG009735
InParanoidiQ9R099
OMAiTMPCRLA
OrthoDBiEOG091G063D
PhylomeDBiQ9R099
TreeFamiTF315054

Miscellaneous databases

ChiTaRSiTbl2 mouse
PROiPR:Q9R099
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005374 Expressed in 258 organ(s), highest expression level in heart
CleanExiMM_TBL2
ExpressionAtlasiQ9R099 baseline and differential
GenevisibleiQ9R099 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBL2_MOUSE
AccessioniPrimary (citable) accession number: Q9R099
Secondary accession number(s): Q8CFY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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