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Protein

Four and a half LIM domains protein 3

Gene

Fhl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

GO - Molecular functioni

  • actin binding Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 3
Short name:
FHL-3
Alternative name(s):
Skeletal muscle LIM-protein 2
Short name:
SLIM-2
Gene namesi
Name:Fhl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1341092 Fhl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000757412 – 289Four and a half LIM domains protein 3Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei157N6-acetyllysineCombined sources1
Modified residuei244N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9R059
MaxQBiQ9R059
PaxDbiQ9R059
PeptideAtlasiQ9R059
PRIDEiQ9R059

PTM databases

iPTMnetiQ9R059
PhosphoSitePlusiQ9R059

Expressioni

Tissue specificityi

In the adult, expressed at high levels in skeletal muscle and, to a lesser extent, in heart, lung, skin and kidney. During embryonic development, expressed ubiquitously at low levels.2 Publications

Gene expression databases

BgeeiENSMUSG00000032643 Expressed in 47 organ(s), highest expression level in zone of skin
CleanExiMM_FHL3
ExpressionAtlasiQ9R059 baseline and differential
GenevisibleiQ9R059 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Sox15P432677EBI-7332617,EBI-7332587

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199670, 1 interactor
IntActiQ9R059, 1 interactor
MINTiQ9R059
STRINGi10090.ENSMUSP00000040150

Structurei

3D structure databases

ProteinModelPortaliQ9R059
SMRiQ9R059
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 92LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini101 – 153LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53
Domaini162 – 212LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST51
Domaini221 – 275LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST55

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000231075
HOVERGENiHBG074526
InParanoidiQ9R059
OMAiYEDRHYH
OrthoDBiEOG091G07C5
PhylomeDBiQ9R059
TreeFamiTF314113

Family and domain databases

InterProiView protein in InterPro
IPR037987 FHL2/3/5
IPR001781 Znf_LIM
PANTHERiPTHR24205 PTHR24205, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9R059-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEAFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD
60 70 80 90 100
SRELFYEDRH FHEGCFRCCR CQRSLADEPF TCQDSELLCN ECYCTAFSSQ
110 120 130 140 150
CSACGETVMP GSRKLEYGGQ TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC
160 170 180 190 200
VPCYENKFAP RCARCSKTLT QGGVTYRDQP WHRECLVCTG CKTPLAGQQF
210 220 230 240 250
TSRDDDPYCV ACFGELFAPK CSSCKRPITG GSGGGEGAGL GGGKYVSFED
260 270 280
RHWHHSCFSC ARCSTSLVGQ GFVPDGDQVL CQGCSQAGP
Length:289
Mass (Da):31,795
Last modified:October 3, 2012 - v2
Checksum:i38168919F5303237
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJ68D6RJ68_MOUSE
Four and a half LIM domains protein...
Fhl3
120Annotation score:
F2Z455F2Z455_MOUSE
Four and a half LIM domains protein...
Fhl3
280Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77D → G in AAD32623 (PubMed:10049693).Curated1
Sequence conflicti91E → D in AAD32623 (PubMed:10049693).Curated1
Sequence conflicti95T → S in AAD32623 (PubMed:10049693).Curated1
Sequence conflicti137G → A in AAD53231 (PubMed:10906474).Curated1
Sequence conflicti157 – 159KFA → NLT in AAF73159 (Ref. 5) Curated3
Sequence conflicti192K → Q in AAD32623 (PubMed:10049693).Curated1
Sequence conflicti199Q → H in AAD53231 (PubMed:10906474).Curated1
Sequence conflicti205D → E in AAD32623 (PubMed:10049693).Curated1
Sequence conflicti225K → N in AAD53231 (PubMed:10906474).Curated1
Sequence conflicti229 – 238TGGSGGGEGA → V in AAD32623 (PubMed:10049693).Curated10
Sequence conflicti235G → A in AAD53231 (PubMed:10906474).Curated1
Sequence conflicti256S → N in AAD32623 (PubMed:10049693).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134772 mRNA Translation: AAD32623.1
AF114382 mRNA Translation: AAD53231.1
AL606907 Genomic DNA No translation available.
BC144903 mRNA Translation: AAI44904.1
BC145939 mRNA Translation: AAI45940.1
AF149826 mRNA Translation: AAF73159.1
CCDSiCCDS38874.1
RefSeqiNP_034343.2, NM_010213.3
XP_006502831.1, XM_006502768.3
UniGeneiMm.331856

Genome annotation databases

EnsembliENSMUST00000038684; ENSMUSP00000040150; ENSMUSG00000032643
GeneIDi14201
KEGGimmu:14201
UCSCiuc008uqv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134772 mRNA Translation: AAD32623.1
AF114382 mRNA Translation: AAD53231.1
AL606907 Genomic DNA No translation available.
BC144903 mRNA Translation: AAI44904.1
BC145939 mRNA Translation: AAI45940.1
AF149826 mRNA Translation: AAF73159.1
CCDSiCCDS38874.1
RefSeqiNP_034343.2, NM_010213.3
XP_006502831.1, XM_006502768.3
UniGeneiMm.331856

3D structure databases

ProteinModelPortaliQ9R059
SMRiQ9R059
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199670, 1 interactor
IntActiQ9R059, 1 interactor
MINTiQ9R059
STRINGi10090.ENSMUSP00000040150

PTM databases

iPTMnetiQ9R059
PhosphoSitePlusiQ9R059

Proteomic databases

EPDiQ9R059
MaxQBiQ9R059
PaxDbiQ9R059
PeptideAtlasiQ9R059
PRIDEiQ9R059

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038684; ENSMUSP00000040150; ENSMUSG00000032643
GeneIDi14201
KEGGimmu:14201
UCSCiuc008uqv.2 mouse

Organism-specific databases

CTDi2275
MGIiMGI:1341092 Fhl3

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000231075
HOVERGENiHBG074526
InParanoidiQ9R059
OMAiYEDRHYH
OrthoDBiEOG091G07C5
PhylomeDBiQ9R059
TreeFamiTF314113

Miscellaneous databases

PROiPR:Q9R059
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032643 Expressed in 47 organ(s), highest expression level in zone of skin
CleanExiMM_FHL3
ExpressionAtlasiQ9R059 baseline and differential
GenevisibleiQ9R059 MM

Family and domain databases

InterProiView protein in InterPro
IPR037987 FHL2/3/5
IPR001781 Znf_LIM
PANTHERiPTHR24205 PTHR24205, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFHL3_MOUSE
AccessioniPrimary (citable) accession number: Q9R059
Secondary accession number(s): A6H6N4, Q9JLP5, Q9WUH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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