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Entry version 154 (02 Jun 2021)
Sequence version 3 (25 Apr 2018)
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Protein

Baculoviral IAP repeat-containing protein 1e

Gene

Naip5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria such as Legionella or Salmonella (PubMed:12526741, PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158).

Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158).

The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158).

May contribute to prevent motor-neuron apoptosis induced by a variety of signals (By similarity).

By similarity5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi315ZincPROSITE-ProRule annotation1
Metal bindingi318ZincPROSITE-ProRule annotation1
Metal bindingi335ZincPROSITE-ProRule annotation1
Metal bindingi342ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi473 – 478ATPCombined sources1 Publication6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Immunity, Inflammatory response, Innate immunity
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I32.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 1e
Alternative name(s):
Neuronal apoptosis inhibitory protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Naip52 Publications
Synonyms:Birc1e, Naip-rs3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1298220, Naip5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1 – 40Missing : Abolishes production of IL1B in response to bacterial flagellin. 1 PublicationAdd BLAST40
Mutagenesisi11R → I: Strongly reduces production of IL1B in response to bacterial flagellin; then associated with F-15. 1 Publication1
Mutagenesisi15I → F: Strongly reduces production of IL1B in response to bacterial flagellin; then associated with I-11. 1 Publication1
Mutagenesisi106 – 108GNS → STR: Strongly reduces production of IL1B in response to bacterial flagellin. 1 Publication3
Mutagenesisi626 – 627II → AA: Strongly reduced interaction with flagellin. 1 Publication2
Mutagenesisi837 – 838QT → AA: Mildly reduced interaction with flagellin. 1 Publication2
Mutagenesisi839 – 840FL → AA: Mildly reduced interaction with flagellin. 1 Publication2
Mutagenesisi840L → R: Strongly reduces production of IL1B in response to bacterial flagellin. 1 Publication1
Mutagenesisi841 – 842WF → AA: Mildly reduced interaction with flagellin. 1 Publication2
Mutagenesisi843 – 844QF → AA: Strongly reduced interaction with flagellin. 1 Publication2
Mutagenesisi844F → C: Strongly reduces production of IL1B in response to bacterial flagellin. 1 Publication1
Mutagenesisi847G → E: Strongly reduces production of IL1B in response to bacterial flagellin. 1 Publication1
Mutagenesisi847G → K: Nearly abolishes interaction with flagellin. 1 Publication1
Mutagenesisi848 – 849LW → AA: Strongly reduced interaction with flagellin. 1 Publication2
Mutagenesisi857S → Y: No effect on production of IL1B in response to bacterial flagellin. 1 Publication1
Mutagenesisi974 – 975YE → AA: Strongly reduced interaction with flagellin. 1 Publication2
Mutagenesisi1329 – 1330CR → AA: Reduced interaction with flagellin. 1 Publication2
Mutagenesisi1390 – 1403Missing : Abolishes production of IL1B in response to bacterial flagellin. 1 PublicationAdd BLAST14

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001223441 – 1403Baculoviral IAP repeat-containing protein 1eAdd BLAST1403

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9R016

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R016

PRoteomics IDEntifications database

More...
PRIDEi
Q9R016

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
273675
344822

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9R016

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9R016

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in macrophages (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000071203, Expressed in intestine and 116 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NLRC4 inflammasome, at least composed of NLRC4, caspase-1 (CASP1) and some NAIP protein. Flagellin binding by NAIP5 triggers assembly of the inflammasome, a huge complex that contains a single NAIP5 chain and multiple copies of NLRC4 (PubMed:29182158).

4 Publications

(Microbial infection) Interacts with S.typhimurium (Salmonella) flagellin.

3 Publications

(Microbial infection) Interacts with L.pneumophila flagellin.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-59148N

Protein interaction database and analysis system

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IntActi
Q9R016, 8 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000058611

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9R016, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9R016

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati60 – 127BIR 1Add BLAST68
Repeati159 – 227BIR 2Add BLAST69
Repeati278 – 345BIR 3Add BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini464 – 759NACHTPROSITE-ProRule annotationAdd BLAST296

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1101, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163369

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_005648_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9R016

Identification of Orthologs from Complete Genome Data

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OMAi
ESTRESH

Database of Orthologous Groups

More...
OrthoDBi
268914at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9R016

TreeFam database of animal gene trees

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TreeFami
TF105356

Family and domain databases

Conserved Domains Database

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CDDi
cd00022, BIR, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001370, BIR_rpt
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR028789, Naip
IPR040535, NLRC4_HD
IPR041075, NOD2_WH
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR46914, PTHR46914, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00653, BIR, 3 hits
PF05729, NACHT, 1 hit
PF17889, NLRC4_HD, 1 hit
PF17779, NOD2_WH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00238, BIR, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01282, BIR_REPEAT_1, 2 hits
PS50143, BIR_REPEAT_2, 3 hits
PS50837, NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9R016-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEHGESSED RISEIDYEFL PELSALLGVD AFQVAKSQEE EEHKERMKMK
60 70 80 90 100
KGFNSQMRSE AKRLKTFETY DTFRSWTPQE MAAAGFYHTG VRLGVQCFCC
110 120 130 140 150
SLILFGNSLR KLPIERHKKL RPECEFLQGK DVGNIGKYDI RVKRPEKMLR
160 170 180 190 200
GGKARYHEEE ARLESFEDWP FYAHGTSPRV LSAAGFVFTG KRDTVQCFSC
210 220 230 240 250
GGSLGNWEEG DDPWKEHAKW FPKCEFLQSK KSSEEIAQYI QSYEGFVHVT
260 270 280 290 300
GEHFVKSWVR RELPMVSAYC NDSVFANEEL RMDMFKDWPQ ESPVGVEALV
310 320 330 340 350
RAGFFYTGKK DIVRCFSCGG CLEKWAEGDD PMEDHIKFFP ECVFLQTLKS
360 370 380 390 400
SAEVIPTLQS QYALPEATET TRESNHGDAA AVHSTVVDLG RSEAQWFQEA
410 420 430 440 450
RSLSEQLRDN YTKATFRHMN LPEVCSSLGT DHLLSCDVSI ISKHISQPVQ
460 470 480 490 500
EALTIPEVFS NLNSVMCVEG ETGSGKTTFL KRIAFLWASG CCPLLYRFQL
510 520 530 540 550
VFYLSLSSIT PDQGLANIIC AQLLGAGGCI SEVCLSSSIQ QLQHQVLFLL
560 570 580 590 600
DDYSGLASLP QALHTLITKN YLSRTCLLIA VHTNRVRDIR LYLGTSLEIQ
610 620 630 640 650
EFPFYNTVSV LRKFFSHDII CVEKLIIYFI DNKDLQGVYK TPLFVAAVCT
660 670 680 690 700
DWIQNASAQD KFQDVTLFQS YMQYLSLKYK ATAEPLQATV SSCGQLALTG
710 720 730 740 750
LFSSCFEFNS DDLAEAGVDE DEKLTTLLMS KFTAQRLRPV YRFLGPLFQE
760 770 780 790 800
FLAAVRLTEL LSSDRQEDQD LGLYYLRQID SPLKAINSFN IFLYYVSSHS
810 820 830 840 850
SSKAAPTVVS HLLQLVDEKE SLENMSENED YMKLHPQTFL WFQFVRGLWL
860 870 880 890 900
VSPESSSSFV SEHLLRLALI FAYESNTVAE CSPFILQFLR GKTLALRVLN
910 920 930 940 950
LQYFRDHPES LLLLRSLKVS INGNKMSSYV DYSFKTYFEN LQPPAIDEEY
960 970 980 990 1000
TSAFEHISEW RRNFAQDEEI IKNYENIRPR ALPDISEGYW KLSPKPCKIP
1010 1020 1030 1040 1050
KLEVQVNNTD AADQALLQVL MEVFSASQSI EFRLFNSSGF LESICPALEL
1060 1070 1080 1090 1100
SKASVTKCSM SRLELSRAEQ ELLLTLPALQ SLEVSETNQL PEQLFHNLHK
1110 1120 1130 1140 1150
FLGLKELCVR LDGKPNVLSV LPREFPNLLH MEKLSIQTST ESDLSKLVKF
1160 1170 1180 1190 1200
IQNFPNLHVF HLKCDFLSNC ESLMAVLASC KKLREIEFSG RCFEAMTFVN
1210 1220 1230 1240 1250
ILPNFVSLKI LNLKDQQFPD KETSEKFAQA LGSLRNLEEL LVPTGDGIHQ
1260 1270 1280 1290 1300
VAKLIVRQCL QLPCLRVLTF HDILDDDSVI EIARAATSGG FQKLENLDIS
1310 1320 1330 1340 1350
MNHKITEEGY RNFFQALDNL PNLQELNICR NIPGRIQVQA TTVKALGQCV
1360 1370 1380 1390 1400
SRLPSLIRLH MLSWLLDEED MKVINDVKER HPQSKRLIIF WKLIVPFSPV

ILE
Length:1,403
Mass (Da):159,839
Last modified:April 25, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04C04877908103EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92R → K in AAD56760 (PubMed:10486205).1
Sequence conflicti92R → K in AAC52974 (PubMed:8975718).1
Sequence conflicti144R → S in AAD56760 (PubMed:10486205).1
Sequence conflicti144R → S in AAC52974 (PubMed:8975718).1
Sequence conflicti242S → G in AAD56760 (PubMed:10486205).Curated1
Sequence conflicti472T → A in AAD56760 (PubMed:10486205).Curated1
Sequence conflicti516A → D in AAD56760 (PubMed:10486205).Curated1
Sequence conflicti521A → T in AAD56760 (PubMed:10486205).Curated1
Sequence conflicti533V → A in AAD56760 (PubMed:10486205).Curated1
Sequence conflicti538S → I in AAD56760 (PubMed:10486205).Curated1
Sequence conflicti1092E → D in AAD56760 (PubMed:10486205).Curated1
Sequence conflicti1116N → D in AAD56764 (PubMed:10501978).1
Sequence conflicti1116N → D in AAD56760 (PubMed:10486205).1
Sequence conflicti1123R → G in AAD56764 (PubMed:10501978).1
Sequence conflicti1123R → G in AAD56760 (PubMed:10486205).1
Sequence conflicti1129L → H in AAD56764 (PubMed:10501978).1
Sequence conflicti1137Q → R in AAD56764 (PubMed:10501978).1
Sequence conflicti1242V → I in AAD56760 (PubMed:10486205).Curated1
Sequence conflicti1276D → N in AAD56760 (PubMed:10486205).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Part of the Lgn1 locus that determines susceptibility to the intracellular pathogen L.pneumophila. Susceptibility differs between inbred mouse strains. Strain C57BL/6J is not permissive, i.e. L.pneumophila cannot multiply in C57BL/6J macrophages, contrary to the situation in mouse strain A/J. Strain FVB/NJ macrophages display intermediate permissiveness for intracellular proliferation of L.pneumophila.1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF135492 mRNA Translation: AAD56764.1
AF131205 Genomic DNA Translation: AAD56760.1
AY146999 mRNA Translation: AAN60211.1
CT009518 Genomic DNA No translation available.
CT030167 Genomic DNA No translation available.
BC070433 mRNA Translation: AAH70433.1
U66326 Genomic DNA Translation: AAC52974.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS26727.1

NCBI Reference Sequences

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RefSeqi
NP_035000.2, NM_010870.2
XP_011242930.1, XM_011244628.1
XP_017170904.1, XM_017315415.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000049789; ENSMUSP00000058611; ENSMUSG00000071203

Database of genes from NCBI RefSeq genomes

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GeneIDi
17951

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17951

UCSC genome browser

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UCSCi
uc007rql.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135492 mRNA Translation: AAD56764.1
AF131205 Genomic DNA Translation: AAD56760.1
AY146999 mRNA Translation: AAN60211.1
CT009518 Genomic DNA No translation available.
CT030167 Genomic DNA No translation available.
BC070433 mRNA Translation: AAH70433.1
U66326 Genomic DNA Translation: AAC52974.1
CCDSiCCDS26727.1
RefSeqiNP_035000.2, NM_010870.2
XP_011242930.1, XM_011244628.1
XP_017170904.1, XM_017315415.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YUDelectron microscopy4.28A1-1403[»]
6B5Belectron microscopy5.20A1-1403[»]
SMRiQ9R016
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-59148N
IntActiQ9R016, 8 interactors
STRINGi10090.ENSMUSP00000058611

Protein family/group databases

MEROPSiI32.001

PTM databases

iPTMnetiQ9R016
PhosphoSitePlusiQ9R016

Proteomic databases

MaxQBiQ9R016
PaxDbiQ9R016
PRIDEiQ9R016
ProteomicsDBi273675
344822

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
17951

Genome annotation databases

EnsembliENSMUST00000049789; ENSMUSP00000058611; ENSMUSG00000071203
GeneIDi17951
KEGGimmu:17951
UCSCiuc007rql.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
17951
MGIiMGI:1298220, Naip5

Phylogenomic databases

eggNOGiKOG1101, Eukaryota
GeneTreeiENSGT00940000163369
HOGENOMiCLU_005648_0_0_1
InParanoidiQ9R016
OMAiESTRESH
OrthoDBi268914at2759
PhylomeDBiQ9R016
TreeFamiTF105356

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
17951, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Naip5, mouse

Protein Ontology

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PROi
PR:Q9R016
RNActiQ9R016, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000071203, Expressed in intestine and 116 other tissues

Family and domain databases

CDDicd00022, BIR, 3 hits
Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001370, BIR_rpt
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR028789, Naip
IPR040535, NLRC4_HD
IPR041075, NOD2_WH
IPR027417, P-loop_NTPase
PANTHERiPTHR46914, PTHR46914, 1 hit
PfamiView protein in Pfam
PF00653, BIR, 3 hits
PF05729, NACHT, 1 hit
PF17889, NLRC4_HD, 1 hit
PF17779, NOD2_WH, 1 hit
SMARTiView protein in SMART
SM00238, BIR, 3 hits
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS01282, BIR_REPEAT_1, 2 hits
PS50143, BIR_REPEAT_2, 3 hits
PS50837, NACHT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIR1E_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R016
Secondary accession number(s): O09121
, O09122, P81703, Q8CGT2, Q9R029
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: April 25, 2018
Last modified: June 2, 2021
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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