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Protein

Cathepsin J

Gene

Ctsj

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei138By similarity1
Active sitei276By similarity1
Active sitei300By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.B65 3474
ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1679131 Trafficking and processing of endosomal TLR
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-2132295 MHC class II antigen presentation
R-MMU-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Protein family/group databases

MEROPSiC01.038

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin J (EC:3.4.22.-)
Alternative name(s):
Cathepsin L-related protein
Cathepsin P
Catlrp-p
Gene namesi
Name:Ctsj
Synonyms:Ctsp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1349426 Ctsj

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002623018 – 113Activation peptideAdd BLAST96
ChainiPRO_0000026231114 – 334Cathepsin JAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi135 ↔ 178By similarity
Disulfide bondi169 ↔ 211By similarity
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi269 ↔ 322By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9R014
PeptideAtlasiQ9R014
PRIDEiQ9R014

Expressioni

Tissue specificityi

Expressed specifically in placenta.1 Publication

Gene expression databases

CleanExiMM_CTSJ
ExpressionAtlasiQ9R014 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071457

Structurei

3D structure databases

ProteinModelPortaliQ9R014
SMRiQ9R014
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140823
HOGENOMiHOG000230774
HOVERGENiHBG011513
InParanoidiQ9R014
KOiK09599
PhylomeDBiQ9R014
TreeFamiTF313739

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPTVLLLIL CFGVASGAQA HDPKLDAEWK DWKTKYAKSY SPKEEALRRA
60 70 80 90 100
VWEENMRMIK LHNKENSLGK NNFTMKMNKF GDQTSEEFRK SIDNIPIPAA
110 120 130 140 150
MTDPHAQNHV SIGLPDYKDW REEGYVTPVR NQGKCGSCWA FAAAGAIEGQ
160 170 180 190 200
MFWKTGNLTP LSVQNLLDCS KTVGNKGCQS GTAHQAFEYV LKNKGLEAEA
210 220 230 240 250
TYPYEGKDGP CRYRSENASA NITDYVNLPP NELYLWVAVA SIGPVSAAID
260 270 280 290 300
ASHDSFRFYN GGIYYEPNCS SYFVNHAVLV VGYGSEGDVK DGNNYWLIKN
310 320 330
SWGEEWGMNG YMQIAKDHNN HCGIASLASY PNIF
Length:334
Mass (Da):37,276
Last modified:December 20, 2005 - v2
Checksum:iA422B7679E76DD7C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti43Missing 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136272 mRNA Translation: AAF13142.1
AF158182 mRNA Translation: AAD41898.1
AY034579 Genomic DNA Translation: AAK58455.1
AK005526 mRNA Translation: BAB24099.1
AK131661 mRNA Translation: BAE20748.1
BC103769 mRNA Translation: AAI03770.1
RefSeqiNP_036137.1, NM_012007.1
XP_006517318.1, XM_006517255.1
UniGeneiMm.31948

Genome annotation databases

EnsembliENSMUST00000224224; ENSMUSP00000153389; ENSMUSG00000055298
GeneIDi26898
KEGGimmu:26898
UCSCiuc007qwa.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCATJ_MOUSE
AccessioniPrimary (citable) accession number: Q9R014
Secondary accession number(s): Q564D9, Q91XK6, Q9WV51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: December 20, 2005
Last modified: June 20, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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