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Protein

Interferon-activable protein 202

Gene

Ifi202

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and inhibits the activation of the AIM2 inflammasome, probably by sequestering cytoplasmic DNA and preventing its being bound by AIM2.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei84Mediates interaction with 53BP11
Sitei283Mediates interaction with 53BP11

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • double-stranded DNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processImmunity, Inflammatory response, Innate immunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon-activable protein 202
Short name:
Ifi-202
Alternative name(s):
Interferon-inducible protein p202
Lupus susceptibility protein p202
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ifi202
Synonyms:Ifi202a, Ifi202b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1347080 Ifi202a
MGI:1347083 Ifi202b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi48K → A: Strongly reduces affinity for DNA; when associated with A-53 and W-54. 1 Publication1
Mutagenesisi53K → A: Strongly reduces affinity for DNA; when associated with A-48 and W-54. 1 Publication1
Mutagenesisi54G → W: Strongly reduces affinity for DNA; when associated with A-48 and A-53. 1 Publication1
Mutagenesisi76K → A: Strongly reduces affinity for DNA; when associated with A-79 and A-236. 1 Publication1
Mutagenesisi79K → A: Strongly reduces affinity for DNA; when associated with A-76 and A-236. 1 Publication1
Mutagenesisi84H → F: Loss of interaction with 53BP1; when associated with F-283. 1 Publication1
Mutagenesisi166S → A: Strongly reduces affinity for DNA; when associated with. 1 Publication1
Mutagenesisi182 – 185NDKS → ADAA: Strongly reduces affinity for DNA. 1 Publication4
Mutagenesisi187T → A: Strongly reduces affinity for DNA; when associated with A-189 and A-198. 1 Publication1
Mutagenesisi189K → A: Strongly reduces affinity for DNA; when associated with A-187 and A-198. 1 Publication1
Mutagenesisi198K → A: Strongly reduces affinity for DNA; when associated with A-187 and A-189. 1 Publication1
Mutagenesisi222 – 224HLR → ALA: Strongly reduces affinity for DNA. 1 Publication3
Mutagenesisi226G → W: Strongly reduces affinity for DNA; when associated with A-166; A-227 and A-229. 1 Publication1
Mutagenesisi227N → A: Strongly reduces affinity for DNA; when associated with A-166; W-226 and A-229. 1 Publication1
Mutagenesisi229K → A: Strongly reduces affinity for DNA; when associated with A-166; W-226 and A-227. 1 Publication1
Mutagenesisi236N → A: Strongly reduces affinity for DNA; when associated with A-76 and A-79. 1 Publication1
Mutagenesisi283H → F: Loss of interaction with 53BP1; when associated with F-84. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001537191 – 445Interferon-activable protein 202Add BLAST445

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9R002

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R002

PRoteomics IDEntifications database

More...
PRIDEi
Q9R002

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9R002

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9R002

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By beta interferon. By IL6 in splenocytes (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026535 Expressed in 139 organ(s), highest expression level in cornea

CleanEx database of gene expression profiles

More...
CleanExi
MM_IFI202B

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9R002 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Also binds p53, the hypophosphorylated, growth-inhibitory form of the retinoblastoma protein and the p53-binding protein 1 (53BP1).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204945, 1 interactor

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9R002

Protein interaction database and analysis system

More...
IntActi
Q9R002, 4 interactors

Molecular INTeraction database

More...
MINTi
Q9R002

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000000266

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9R002

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9R002

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 243HIN-200 1PROSITE-ProRule annotationAdd BLAST198
Domaini244 – 441HIN-200 2PROSITE-ProRule annotationAdd BLAST198

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HIN-20 domains mediate dsDNA binding via electrostatic interactions.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HIN-200 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013296

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9R002

KEGG Orthology (KO)

More...
KOi
K12971

Identification of Orthologs from Complete Genome Data

More...
OMAi
FITISKY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02W0

TreeFam database of animal gene trees

More...
TreeFami
TF337385

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040205 HIN-200
IPR004021 HIN200/IF120x

The PANTHER Classification System

More...
PANTHERi
PTHR12200 PTHR12200, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02760 HIN, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50834 HIN_200, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9R002-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNRNLRSST NSEFSEGQHQ TPSSDSSGHG EDQPQASPGP NKKSHTPKKN
60 70 80 90 100
ISKGAVLHEK PMTVMVLTAT EPFNYKEGKE NMFHATVATE SQYYRVKVFN
110 120 130 140 150
MDLKEKFTEN KFITISKYFN SSGILEINET ATVSEAAPNQ IIEVPKNIIR
160 170 180 190 200
SAKETLKISK IKELDSGTLI YGVFAVEKKK VNDKSITFKI KDNEDNIKVV
210 220 230 240 250
WDKKQHNINY EKGDKLQLFS FHLRKGNGKP ILHSGNHSFI KGEKLLKESF
260 270 280 290 300
EGDGYHKGPK QVVALKATKL FTYDSIKSKK MFHATVATDT EFFRVMVFEE
310 320 330 340 350
NLEKKFIPGN TIALSDYFGM YGSLAIHEYS SVSEVKSQNK EDSSSSDERL
360 370 380 390 400
IEHLKICDLH LQTKERLVDG EFKVYRKSTG NNCICYGIWD DTGAMKVVVS
410 420 430 440
GQLTSVNCEI GNTIRLVCFE LTSNADEWFL RSTRYSYMEV IMPEK
Length:445
Mass (Da):50,466
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5EA0E93E143C58EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13 – 15EFS → DLA in AAF04260 (PubMed:10493828).Curated3
Sequence conflicti13 – 15EFS → DLA in AAH55888 (PubMed:15489334).Curated3
Sequence conflicti79K → N in ABB00055 (Ref. 3) Curated1
Sequence conflicti92Q → K in AAF04260 (PubMed:10493828).Curated1
Sequence conflicti92Q → K in AAH18233 (PubMed:15489334).Curated1
Sequence conflicti109E → G in ABB00055 (Ref. 3) Curated1
Sequence conflicti111K → Q in AAH18233 (PubMed:15489334).Curated1
Sequence conflicti127I → F in ABB00055 (Ref. 3) Curated1
Sequence conflicti141 – 142II → MF in AAA39312 (PubMed:2477366).Curated2
Sequence conflicti141 – 142II → MF in AAF04260 (PubMed:10493828).Curated2
Sequence conflicti141 – 142II → MF in ABB00055 (Ref. 3) Curated2
Sequence conflicti141 – 142II → MF in AAH18233 (PubMed:15489334).Curated2
Sequence conflicti141 – 142II → MF in AAH55888 (PubMed:15489334).Curated2
Sequence conflicti187T → I in ABB00055 (Ref. 3) Curated1
Sequence conflicti190I → V in ABB00055 (Ref. 3) Curated1
Sequence conflicti204K → E in AAA39312 (PubMed:2477366).Curated1
Sequence conflicti204K → E in AAF04260 (PubMed:10493828).Curated1
Sequence conflicti204K → E in ABB00055 (Ref. 3) Curated1
Sequence conflicti204K → E in AAH18233 (PubMed:15489334).Curated1
Sequence conflicti204K → E in AAH55888 (PubMed:15489334).Curated1
Sequence conflicti240I → V in AAF04260 (PubMed:10493828).Curated1
Sequence conflicti350L → P in AAA39312 (PubMed:2477366).Curated1
Sequence conflicti350L → P in AAF04260 (PubMed:10493828).Curated1
Sequence conflicti350L → P in ABB00055 (Ref. 3) Curated1
Sequence conflicti350L → P in AAH18233 (PubMed:15489334).Curated1
Sequence conflicti350L → P in AAH55888 (PubMed:15489334).Curated1
Sequence conflicti364K → E in AAA39312 (PubMed:2477366).Curated1
Sequence conflicti364K → E in AAF04260 (PubMed:10493828).Curated1
Sequence conflicti364K → E in ABB00055 (Ref. 3) Curated1
Sequence conflicti364K → E in AAH18233 (PubMed:15489334).Curated1
Sequence conflicti364K → E in AAH55888 (PubMed:15489334).Curated1
Sequence conflicti368V → F in AAA39312 (PubMed:2477366).Curated1
Sequence conflicti379T → S in AAA39312 (PubMed:2477366).Curated1
Sequence conflicti379T → S in AAF04260 (PubMed:10493828).Curated1
Sequence conflicti379T → S in ABB00055 (Ref. 3) Curated1
Sequence conflicti379T → S in AAH18233 (PubMed:15489334).Curated1
Sequence conflicti379T → S in AAH55888 (PubMed:15489334).Curated1
Sequence conflicti432S → A in AAA39312 (PubMed:2477366).Curated1
Sequence conflicti432S → A in AAF04260 (PubMed:10493828).Curated1
Sequence conflicti432S → A in ABB00055 (Ref. 3) Curated1
Sequence conflicti432S → A in AAH18233 (PubMed:15489334).Curated1
Sequence conflicti432S → A in AAH55888 (PubMed:15489334).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

NZB mice express 10 to 100 fold more Ifi202 in spleen than B6 or NZW mice. This could account for the high susceptibility of NZB mice to systemic lupus.

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M31418 mRNA Translation: AAA39312.1
AF140672 mRNA Translation: AAF04260.1
DQ222946 mRNA Translation: ABB00055.1
AC170584 Genomic DNA No translation available.
BC018233 mRNA Translation: AAH18233.1
BC055888 mRNA Translation: AAH55888.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35794.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A34457

NCBI Reference Sequences

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RefSeqi
NP_032353.2, NM_008327.2
NP_036070.2, NM_011940.2
XP_006536966.1, XM_006536903.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.218770

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000000266; ENSMUSP00000000266; ENSMUSG00000026535

Database of genes from NCBI RefSeq genomes

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GeneIDi
100044068
26388

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100044068
mmu:26388

UCSC genome browser

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UCSCi
uc007dsk.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31418 mRNA Translation: AAA39312.1
AF140672 mRNA Translation: AAF04260.1
DQ222946 mRNA Translation: ABB00055.1
AC170584 Genomic DNA No translation available.
BC018233 mRNA Translation: AAH18233.1
BC055888 mRNA Translation: AAH55888.1
CCDSiCCDS35794.1
PIRiA34457
RefSeqiNP_032353.2, NM_008327.2
NP_036070.2, NM_011940.2
XP_006536966.1, XM_006536903.2
UniGeneiMm.218770

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JBJX-ray2.69A/B46-242[»]
4JBKX-ray2.96A/B/C/D46-242[»]
4L5QX-ray2.23A46-243[»]
4L5RX-ray1.87C46-243[»]
4L5SX-ray2.94A/B46-243[»]
4L5TX-ray3.40A/B/C/D244-445[»]
4LNQX-ray2.00A/B53-245[»]
ProteinModelPortaliQ9R002
SMRiQ9R002
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204945, 1 interactor
ELMiQ9R002
IntActiQ9R002, 4 interactors
MINTiQ9R002
STRINGi10090.ENSMUSP00000000266

PTM databases

iPTMnetiQ9R002
PhosphoSitePlusiQ9R002

Proteomic databases

MaxQBiQ9R002
PaxDbiQ9R002
PRIDEiQ9R002

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000266; ENSMUSP00000000266; ENSMUSG00000026535
GeneIDi100044068
26388
KEGGimmu:100044068
mmu:26388
UCSCiuc007dsk.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26388
MGIiMGI:1347080 Ifi202a
MGI:1347083 Ifi202b

Phylogenomic databases

GeneTreeiENSGT00390000013296
InParanoidiQ9R002
KOiK12971
OMAiFITISKY
OrthoDBiEOG091G02W0
TreeFamiTF337385

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ifi202b mouse

Protein Ontology

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PROi
PR:Q9R002

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000026535 Expressed in 139 organ(s), highest expression level in cornea
CleanExiMM_IFI202B
GenevisibleiQ9R002 MM

Family and domain databases

InterProiView protein in InterPro
IPR040205 HIN-200
IPR004021 HIN200/IF120x
PANTHERiPTHR12200 PTHR12200, 2 hits
PfamiView protein in Pfam
PF02760 HIN, 2 hits
PROSITEiView protein in PROSITE
PS50834 HIN_200, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFI2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R002
Secondary accession number(s): E9QLD9
, P15091, Q38JF1, Q7TMN6, Q8VEL7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: December 5, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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