UniProtKB - Q9QZZ6 (DERM_MOUSE)
Protein
Dermatopontin
Gene
Dpt
Organism
Mus musculus (Mouse)
Status
Functioni
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity (By similarity). Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.By similarity2 Publications
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- collagen fibril organization Source: MGI
- negative regulation of cell population proliferation Source: MGI
Keywordsi
Biological process | Cell adhesion |
Names & Taxonomyi
Protein namesi | Recommended name: DermatopontinAlternative name(s): Early quiescence protein 1 Short name: EQ-1 Tyrosine-rich acidic matrix protein Short name: TRAMP |
Gene namesi | Name:Dpt |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1928392 Dpt |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular space Source: BHF-UCL
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Disruption phenotypei
Mice have reduced skin elasticity, a decrease in skin-thickness, and lower collagen content in the skin.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | By similarityAdd BLAST | 18 | |
ChainiPRO_0000007369 | 19 – 201 | DermatopontinAdd BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | Pyrrolidone carboxylic acidBy similarity | 1 | |
Modified residuei | 23 | SulfotyrosineSequence analysis | 1 | |
Disulfide bondi | 50 ↔ 77 | By similarity | ||
Disulfide bondi | 90 ↔ 132 | Or C-90 with C-133By similarity | ||
Disulfide bondi | 106 ↔ 133 | Or C-106 with C-132By similarity | ||
Disulfide bondi | 139 ↔ 196 | By similarity | ||
Disulfide bondi | 143 ↔ 189 | Sequence analysis | ||
Modified residuei | 162 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 164 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 167 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 194 | SulfotyrosineSequence analysis | 1 |
Post-translational modificationi
Sulfated on tyrosine residue(s).By similarity
Keywords - PTMi
Disulfide bond, Pyrrolidone carboxylic acid, SulfationProteomic databases
MaxQBi | Q9QZZ6 |
PaxDbi | Q9QZZ6 |
PRIDEi | Q9QZZ6 |
PTM databases
PhosphoSitePlusi | Q9QZZ6 |
Expressioni
Inductioni
Induced by cell quiescence.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000026574 Expressed in 184 organ(s), highest expression level in semi-lunar valve |
Genevisiblei | Q9QZZ6 MM |
Interactioni
Subunit structurei
Interacts with TGFB1, DCN and collagen.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000027861 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 26 – 79 | 1-1Add BLAST | 54 | |
Repeati | 70 – 75 | 2-1 | 6 | |
Repeati | 80 – 135 | 1-2Add BLAST | 56 | |
Repeati | 125 – 130 | 2-2 | 6 | |
Repeati | 181 – 186 | 2-3 | 6 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 19 – 186 | 2 X 53-55 AA tandem repeatsAdd BLAST | 168 | |
Regioni | 70 – 186 | 3 X 6 AA tandem repeats of D-R-[EQ]-W-[NQK]-[FY]Add BLAST | 117 |
Sequence similaritiesi
Belongs to the dermatopontin family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG410IGCN Eukaryota ENOG4111HSK LUCA |
GeneTreei | ENSGT00390000010760 |
HOGENOMi | HOG000013186 |
InParanoidi | Q9QZZ6 |
OMAi | NRAGTEW |
OrthoDBi | 1271391at2759 |
PhylomeDBi | Q9QZZ6 |
TreeFami | TF328602 |
Family and domain databases
InterProi | View protein in InterPro IPR026645 Dermatopontin_fam |
PANTHERi | PTHR15040 PTHR15040, 1 hit |
Pfami | View protein in Pfam PF14704 DERM, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9QZZ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLTLLWVLL PLVTTAWGQY GGYGYPYQQY QDYGDDGWVN LNRQGFSYQC
60 70 80 90 100
PHGQVVVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM
110 120 130 140 150
EWYQKCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWMTTEYP
160 170 180 190 200
SHYGEDMDMI SYDYDFYMRG ATTTFSAVER DRQWKFIMCR MTDYDCEFEN
V
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 64 | S → T in BAB31905 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF143374 mRNA Translation: AAD54221.1 AK019890 mRNA Translation: BAB31905.1 BC046420 mRNA Translation: AAH46420.1 |
CCDSi | CCDS15437.1 |
RefSeqi | NP_062733.1, NM_019759.2 |
Genome annotation databases
Ensembli | ENSMUST00000027861; ENSMUSP00000027861; ENSMUSG00000026574 |
GeneIDi | 56429 |
KEGGi | mmu:56429 |
UCSCi | uc007diq.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF143374 mRNA Translation: AAD54221.1 AK019890 mRNA Translation: BAB31905.1 BC046420 mRNA Translation: AAH46420.1 |
CCDSi | CCDS15437.1 |
RefSeqi | NP_062733.1, NM_019759.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000027861 |
PTM databases
PhosphoSitePlusi | Q9QZZ6 |
Proteomic databases
MaxQBi | Q9QZZ6 |
PaxDbi | Q9QZZ6 |
PRIDEi | Q9QZZ6 |
Genome annotation databases
Ensembli | ENSMUST00000027861; ENSMUSP00000027861; ENSMUSG00000026574 |
GeneIDi | 56429 |
KEGGi | mmu:56429 |
UCSCi | uc007diq.1 mouse |
Organism-specific databases
CTDi | 1805 |
MGIi | MGI:1928392 Dpt |
Phylogenomic databases
eggNOGi | ENOG410IGCN Eukaryota ENOG4111HSK LUCA |
GeneTreei | ENSGT00390000010760 |
HOGENOMi | HOG000013186 |
InParanoidi | Q9QZZ6 |
OMAi | NRAGTEW |
OrthoDBi | 1271391at2759 |
PhylomeDBi | Q9QZZ6 |
TreeFami | TF328602 |
Miscellaneous databases
ChiTaRSi | Dpt mouse |
PROi | PR:Q9QZZ6 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026574 Expressed in 184 organ(s), highest expression level in semi-lunar valve |
Genevisiblei | Q9QZZ6 MM |
Family and domain databases
InterProi | View protein in InterPro IPR026645 Dermatopontin_fam |
PANTHERi | PTHR15040 PTHR15040, 1 hit |
Pfami | View protein in Pfam PF14704 DERM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DERM_MOUSE | |
Accessioni | Q9QZZ6Primary (citable) accession number: Q9QZZ6 Secondary accession number(s): Q9D2B6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | October 16, 2019 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot