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UniProtKB - Q9QZZ4 (MYO15_MOUSE)

Entry version 174 (07 Oct 2020)
Sequence version 2 (04 Dec 2007)
Previous versions | rss
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Protein

Unconventional myosin-XV

Gene

Myo15a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles.By similarity2 Publications

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1299 – 1306ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
Biological processHearing
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-XV
Alternative name(s):
Unconventional myosin-15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo15a
Synonyms:Myo15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1261811, Myo15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Myo15a are the cause of shaker-2 (sh-2), a condition causing deafness, circling behavior, head tossing and hyperactivity. Auditory hair cells of affected animals have very short stereocilia and a long actin-containing protrusion at their basal end.

Keywords - Diseasei

Deafness, Disease mutation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234751 – 3511Unconventional myosin-XVAdd BLAST3511

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9QZZ4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9QZZ4

PRoteomics IDEntifications database

More...PRIDEi		Q9QZZ4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9QZZ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9QZZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the developing inner ear, expressed in cochlea and vestibular apparatus. Expression appears to be restricted to cochlear neurosensory cells and upper epithelial layer of macula saccula. Also expressed in macula utriculi and cristae ampullaris of the semicircular canals. In adult cochlear hair cells, highest expression in stereocilia and apical body.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000042678, Expressed in internal ear and 57 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9QZZ4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9QZZ4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips.

Interacts with FASLG (By similarity).

Interacts with EPS8.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		201662, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q9QZZ4, 3 interactors

Molecular INTeraction database

More...MINTi		Q9QZZ4

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000071777

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9QZZ4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9QZZ4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1206 – 1883Myosin motorPROSITE-ProRule annotationAdd BLAST678
Domaini1886 – 1908IQ 1PROSITE-ProRule annotationAdd BLAST23
Domaini1909 – 1938IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini2049 – 2195MyTH4 1PROSITE-ProRule annotationAdd BLAST147
Domaini2848 – 2934SH3PROSITE-ProRule annotationAdd BLAST87
Domaini3031 – 3185MyTH4 2PROSITE-ProRule annotationAdd BLAST155
Domaini3190 – 3511FERMPROSITE-ProRule annotationAdd BLAST322

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1776 – 1783Actin-bindingSequence analysis8
Regioni1872 – 2013Neck or regulatory domainAdd BLAST142
Regioni2014 – 3511TailAdd BLAST1498

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1307 – 1334Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4229, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155335

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9QZZ4

KEGG Orthology (KO)

More...KOi		K10361

Identification of Orthologs from Complete Genome Data

More...OMAi		SYPLAAC

Database of Orthologous Groups

More...OrthoDBi		14609at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9QZZ4

TreeFam database of animal gene trees

More...TreeFami		TF316834

Family and domain databases

Conserved Domains Database

More...CDDi		cd14473, FERM_B-lobe, 1 hit
cd13201, FERM_C_MyoXV, 1 hit
cd01387, MYSc_Myo15, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.530, 2 hits
2.30.29.30, 2 hits
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR035487, MYO15A
IPR001609, Myosin_head_motor_dom
IPR041795, MyoXV_FERM_C
IPR036057, MYSc_Myo15
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...PANTHERi		PTHR22692:SF21, PTHR22692:SF21, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00612, IQ, 2 hits
PF00063, Myosin_head, 1 hit
PF00784, MyTH4, 2 hits
PF07653, SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00015, IQ, 3 hits
SM00242, MYSc, 1 hit
SM00139, MyTH4, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47031, SSF47031, 1 hit
SSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50057, FERM_3, 1 hit
PS50096, IQ, 2 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51016, MYTH4, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QZZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADEEKKAKK GKKGKKAPEP EKPKRSLKGT SRLFMGFRDR TPKISKKGQF 
        60         70         80         90        100
RSASAFFWGL HTGPQKTKRK KKARTVLKST SKLMTQMRVG KKKRAMKGKK 
       110        120        130        140        150
PSFMVIRFPG RRGYGRLRPR AQSLSKASTA INWLTKKFLL KKAEESGSEQ 
       160        170        180        190        200
ATVDAWLQRS SSRVGSRKLP FPSGAEILRH GGRLRRFPRS HSIYSSGEPV 
       210        220        230        240        250
GFLPFEDEAP FRHAGSRKSL YGLEGFQDLG EYYDYHREGD DYYDQQSLYH 
       260        270        280        290        300
YEEQEPYLAE FGGYSPAWPP YDDYGYPPGD PYNYYHPDYY GDTLYPGYAY 
       310        320        330        340        350
GYGYGYDDFE PPYAPPSGYS SPYSYHDSFE SEAYPYSYYL DPYATHHMPY 
       360        370        380        390        400
PPYDFPYDTP YDIPYFDPYG VPYAEGVYGG GAEAIYPPGM PYVYPEEPAF 
       410        420        430        440        450
MYPWVPPPIM SPHNPYAHPM DDIAELEEPE ETGEERQSTS FRLPSAAFFE 
       460        470        480        490        500
QQGMDKPARS KLSLIRKFRL FPRPQVKLFG KEKLEVPLPP SLDIPLPLGD 
       510        520        530        540        550
AEGEEEEEEM PPVPTMPYTH PYWSFLTPRQ RNLQRALSAF GARQGLGFGP 
       560        570        580        590        600
EFGHPTPRPA TSLARFLKKT LSEKKPIPRL RGSQKARGGR PPVREAAYKR 
       610        620        630        640        650
FGYKLAGMDP DRPNTPIVLR RSQPQARNNN NSHGPPSPRP APRALTHWSA 
       660        670        680        690        700
LISPPMPAPS PSPASPLTPP FSPTFSRPPR LASPYGSLRQ HPPPWAAPAH 
       710        720        730        740        750
VPFPPQANWW GFAEPPGTSP EVAPDLLAFP VPRPSFRASR SRSRRAAYGF 
       760        770        780        790        800
PSPSLIGSRR RPHLPSPQPS LRSLPGQGYH SPLGPLSPQL SLRRGPFQPP 
       810        820        830        840        850
FPPPPRRPQS LREAFSLRRA SGRLGPPRSP VLGSPRPPSP PPLLKHGPRH 
       860        870        880        890        900
RSLNLPSRLP RTWRRLSEPP TRAVKPWVHR AYPPPPSAGP WGASTGALEQ 
       910        920        930        940        950
QENQREAEDS ETPWTVPPLA PSWDVDMPPT QRPPSPWPEG IGSLRGFSRP 
       960        970        980        990       1000
PPVPENPLLE HTSPSCEPQS EDRVSNLTGI FLGQHHDPGP GQLTKSADPS 
      1010       1020       1030       1040       1050
LEKPEEVVTL GDPQPPAEPE ALNPTPPNKN VVSERKVLRL SASYPLVTCK 
      1060       1070       1080       1090       1100
QARATWPQWH RWKTVSRTPA PLAPTRAPGP LLKAGEQPRA EPGRFAVVMP 
      1110       1120       1130       1140       1150
QVRGVSSFRP KGPAPVQPPE HPDQDPEQGP APQACSLRWP RLWPPTDAHC 
      1160       1170       1180       1190       1200
LWSRIRTYSS QSHLRGHGGD CHKSLWKKTR PQSWQNKMHS IRNLPSMRSR 
      1210       1220       1230       1240       1250
EQHREDGVED MTQLEDLQET TVLANLKTRF ERNLIYTYIG SILVSVNPYR 
      1260       1270       1280       1290       1300
MFAIYGPEQV QQYSGRALGE NPPHLFAIAN LAFAKMLDAK QNQCVIISGE 
      1310       1320       1330       1340       1350
SGSGKTEATK LILRCLAAMN QRRDVMQQIK ILEATPLLEA FGNAKTVRND 
      1360       1370       1380       1390       1400
NSSRFGKFVE IFLEGGVICG AITSQYLLEK SRIVFQAKNE RNYHIFYELL 
      1410       1420       1430       1440       1450
AGLPAQLRQA FSLQEAETYY YLNQGGNCEI AGKSDADDFR RLLAAMEVLG 
      1460       1470       1480       1490       1500
FTSEDQDSIF RILASILHLG NVYFEKHETD AQEVASVVSA REIQAVAELL 
      1510       1520       1530       1540       1550
QVSPEGLQKA ITFKVTETIR EKIFTPLTVE SAVDARDAIA KVLYALLFGW 
      1560       1570       1580       1590       1600
LITRVNALVS PKQDTLSIAI LDIYGFEDLS FNSFEQLCIN YANENLQYLF 
      1610       1620       1630       1640       1650
NKIVFQEEQE EYIREQMDWR EIAFADNQPC INLISLKPYG ILRILDDQCC 
      1660       1670       1680       1690       1700
FPQATDHTFL QKCHYHHGAN PLYSKPKMPL PEFTIKHYAG KVTYQVHKFL 
      1710       1720       1730       1740       1750
DKNHDQVRQD VLDLFVHSRT RVVAHLFSSH AAQTAPPRLG KSSSITRLYK 
      1760       1770       1780       1790       1800
AHTVAAKFQQ SLLDLVEKME RCNPLFVRCL KPNHKKEPGL FEPDVMMAQL 
      1810       1820       1830       1840       1850
RYSGVLETVR IRKEGFPVRL PFQVFIDRYR CLVALKLNVP ADGDMCVSLL 
      1860       1870       1880       1890       1900
SRLCTVTPDM YRVGISKLFL KEHLHQLLES MRERVQNRAA LTLQRYLRGF 
      1910       1920       1930       1940       1950
FIQRHFRSLR RKIILLQSRA RGFLARQRYQ QMRQSLLKFR SLVHTYVNRR 
      1960       1970       1980       1990       2000
RYLKLRAEQR RRAQEAWLRE QEELSKREVV PVRHLEVPAE VAGLLQAAAG 
      2010       2020       2030       2040       2050
LKLSSGPRVA VVRAPRLQAE PCVTLPLDIN NYPMAKFIRC HFKEPSFGML 
      2060       2070       2080       2090       2100
TVPLKMPLTR LPVEHHAEAI SVFKLILRFM GDPHLHGTQE MILGNYIVHQ 
      2110       2120       2130       2140       2150
GLVEPALRDE ILAQLANQVW RNPNAYNSKR GWLLLAACLS GFAPSPHLDK 
      2160       2170       2180       2190       2200
FLLKFVSDYG QNGFQAVCQH RLLQAMGSGA ARTFPPTQLE WTAIQEKASM 
      2210       2220       2230       2240       2250
ALDVSCFNGD QFSCPVHTWS TGEAVAGDIL KHRGLADGWR GWTVAMKNGV 
      2260       2270       2280       2290       2300
QWAELAGHDY VLDLVSDLEL LRDFPRQKSY FIVGAEGPLA GRGDTRGVFG 
      2310       2320       2330       2340       2350
NCWDSDEDTP TRPQPQDHVA KMPDLDGYCS HKEDGTNGET EAQRWTSNRQ 
      2360       2370       2380       2390       2400
AVDSIGESTV PPRELDGYLD SLFDPVLACG DADLEKPTAI AYRMKGGGQP 
      2410       2420       2430       2440       2450
GGGGGSTSED TSRRPPEPKL KPIPGLDAST LALQQAFIHR QAVLLAREMT 
      2460       2470       2480       2490       2500
LQALALQQQP LSATSRPQLP ERPLAPEARP KTVVGTGPPA KPVLVRPTPQ 
      2510       2520       2530       2540       2550
SWAPGSVAKA PKIPSKPVAV PILAQDWTAP ESISASPELV RYSTLNSEHF 
      2560       2570       2580       2590       2600
PQPTQQIRSI IKQYKQPPWA GHPEARRTDG GKVFRRPPDP HEEALMILKG 
      2610       2620       2630       2640       2650
QKTQLAVVPG TQVSREAVAM VKPVTSAPRP CMGPTPVQPS RSLEPPEDPV 
      2660       2670       2680       2690       2700
QTQLHRLVNP NFYGYQDIPW RIFLRKEVFY PKDNYSHPVQ LDLLFRQILH 
      2710       2720       2730       2740       2750
DTFSEACLRI SEDERLQMKA LFAQNQLDTQ RPLVTESVKR AAISMARDSW 
      2760       2770       2780       2790       2800
EIYFSRLFPA MGSVGTGVQI LAVSHTGIKL LQMVKGSKEA SRRLRVLCAY 
      2810       2820       2830       2840       2850
SFADILFVTM PSQNMLEFNL SNEKLILFSA RAQQVKTLVD TFILELKKDS 
      2860       2870       2880       2890       2900
DYVVAVRNFL SEDPELLSFH KGDIIHLQSL EPTRVGYSAG CVVRKKLVYL 
      2910       2920       2930       2940       2950
EELRRRGPDF GWRFGAVHGR VGRFPSELVQ PAAAPDFLQL PAEPGRGRAA 
      2960       2970       2980       2990       3000
AVAAAVASAA AAQEVGRRRE GPPVRARSAD SGEDSIALPP STMLEFAQKY 
      3010       3020       3030       3040       3050
FRDPRRRPRD GLKLKSKEDR ESKTLEDVLC FTKVPIQESL IELSDSNLNK 
      3060       3070       3080       3090       3100
MAVDMFVAVM RFMGDAPLKG QSELDVLCTL LKLCGDHEVM RDECYCQIVK 
      3110       3120       3130       3140       3150
QITDNSSPKQ DSCQRGWRLL YIMAAYYSCS EVFYPYLIRF LQHVSWTPGL 
      3160       3170       3180       3190       3200
PFQGIAKACE QNLQKTLRFG GRLEFPSNME LRAMLAGRSS KRQLFLLPGG 
      3210       3220       3230       3240       3250
LERHLKIKTC TVALDVIEGL CTEMALTRPE AFDEYVIFVV TNRGQHVCPL 
      3260       3270       3280       3290       3300
SCRAYILDVA SEMEQVDGGY TLWFRRVLWD QPLKFENELY VTMHYNQVLP 
      3310       3320       3330       3340       3350
DYLKGLFSSV PARQPTEQQL QQVSKLASLQ HRAKDHFYLP SVREVQEYIP 
      3360       3370       3380       3390       3400
AQLYHTTAGD TWLNLVSQHR QQTQALSPHQ ARAQFLGLLS AFPLFGSSFF 
      3410       3420       3430       3440       3450
FIQSCSNVLV PAPCILAVNH NGLNFLSTKT HELIVKIPLK EIQSTWTQQP 
      3460       3470       3480       3490       3500
TANSSYPYVE ISLGDVAAQR TMQLQLEQGL ELCRVVAVHV ESMLSAREER 
      3510 
LTLPPSEITL L
Length:3,511
Mass (Da):395,622
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB66F3E06F4B5983E
GO
Isoform 2 (identifier: Q9QZZ4-2) [UniParc]FASTAAdd to basket
Also known as: 1a

The sequence of this isoform differs from the canonical sequence as follows:
     1955-1972: Missing.

Show »
Length:3,493
Mass (Da):393,314
Checksum:i3079F6C54FBA524B
GO
Isoform 3 (identifier: Q9QZZ4-3) [UniParc]FASTAAdd to basket
Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-1187: Missing.
     1955-1972: Missing.

Show »
Length:2,306
Mass (Da):260,047
Checksum:iE0CE013113707EC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VXK7F6VXK7_MOUSE
Myosin XV
Myo15
1,784Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BEN6A0A571BEN6_MOUSE
Myosin XV
Myo15
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1141R → C in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti1141R → C in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti1330 – 1331Missing in AAC40124 (PubMed:9603735).Curated2
Sequence conflicti1579L → R in BAA36582 (PubMed:9703981).Curated1
Sequence conflicti2077L → M in AAC40124 (PubMed:9603735).Curated1
Sequence conflicti2139L → P in AAC40124 (PubMed:9603735).Curated1
Sequence conflicti2953A → V in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti2953A → V in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti2953A → V in AAP88403 (PubMed:14610277).Curated1
Sequence conflicti3195F → S in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti3195F → S in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti3195F → S in AAP88403 (PubMed:14610277).Curated1
Sequence conflicti3449Q → K in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti3449Q → K in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti3449Q → K in AAP88403 (PubMed:14610277).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti1779C → Y in sh-2. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0299441 – 1187Missing in isoform 3. 1 PublicationAdd BLAST1187
Alternative sequenceiVSP_0299451955 – 1972Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF144095 mRNA Translation: AAF05904.1
AY331132 mRNA Translation: AAP88402.1
AY331133 mRNA Translation: AAP88403.1
AL596090 Genomic DNA No translation available.
AL596386 Genomic DNA No translation available.
AF053130 mRNA Translation: AAC40124.1
AB014510 mRNA Translation: BAA36582.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS24792.1 [Q9QZZ4-1]
CCDS24793.1 [Q9QZZ4-3]
CCDS48811.1 [Q9QZZ4-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A59295
T42386

NCBI Reference Sequences

More...RefSeqi		NP_001096641.1, NM_001103171.1 [Q9QZZ4-2]
NP_034992.2, NM_010862.2 [Q9QZZ4-1]
NP_874357.2, NM_182698.2 [Q9QZZ4-3]
XP_017169821.1, XM_017314332.1
XP_017169822.1, XM_017314333.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000071880; ENSMUSP00000071777; ENSMUSG00000042678 [Q9QZZ4-1]
ENSMUST00000081823; ENSMUSP00000080507; ENSMUSG00000042678 [Q9QZZ4-3]
ENSMUST00000094135; ENSMUSP00000091686; ENSMUSG00000042678 [Q9QZZ4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		17910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:17910

UCSC genome browser

More...UCSCi		uc007jfz.1, mouse [Q9QZZ4-1]
uc007jga.1, mouse [Q9QZZ4-3]
uc007jgb.2, mouse [Q9QZZ4-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144095 mRNA Translation: AAF05904.1
AY331132 mRNA Translation: AAP88402.1
AY331133 mRNA Translation: AAP88403.1
AL596090 Genomic DNA No translation available.
AL596386 Genomic DNA No translation available.
AF053130 mRNA Translation: AAC40124.1
AB014510 mRNA Translation: BAA36582.1
CCDSiCCDS24792.1 [Q9QZZ4-1]
CCDS24793.1 [Q9QZZ4-3]
CCDS48811.1 [Q9QZZ4-2]
PIRiA59295
T42386
RefSeqiNP_001096641.1, NM_001103171.1 [Q9QZZ4-2]
NP_034992.2, NM_010862.2 [Q9QZZ4-1]
NP_874357.2, NM_182698.2 [Q9QZZ4-3]
XP_017169821.1, XM_017314332.1
XP_017169822.1, XM_017314333.1

3D structure databases

SMRiQ9QZZ4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201662, 4 interactors
IntActiQ9QZZ4, 3 interactors
MINTiQ9QZZ4
STRINGi10090.ENSMUSP00000071777

PTM databases

iPTMnetiQ9QZZ4
PhosphoSitePlusiQ9QZZ4

Proteomic databases

jPOSTiQ9QZZ4
PaxDbiQ9QZZ4
PRIDEiQ9QZZ4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		58384, 25 antibodies

Genome annotation databases

EnsembliENSMUST00000071880; ENSMUSP00000071777; ENSMUSG00000042678 [Q9QZZ4-1]
ENSMUST00000081823; ENSMUSP00000080507; ENSMUSG00000042678 [Q9QZZ4-3]
ENSMUST00000094135; ENSMUSP00000091686; ENSMUSG00000042678 [Q9QZZ4-2]
GeneIDi17910
KEGGimmu:17910
UCSCiuc007jfz.1, mouse [Q9QZZ4-1]
uc007jga.1, mouse [Q9QZZ4-3]
uc007jgb.2, mouse [Q9QZZ4-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		17910
MGIiMGI:1261811, Myo15

Phylogenomic databases

eggNOGiKOG4229, Eukaryota
GeneTreeiENSGT00940000155335
InParanoidiQ9QZZ4
KOiK10361
OMAiSYPLAAC
OrthoDBi14609at2759
PhylomeDBiQ9QZZ4
TreeFamiTF316834

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		17910, 4 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Myo15, mouse

Protein Ontology

More...PROi		PR:Q9QZZ4
RNActiQ9QZZ4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000042678, Expressed in internal ear and 57 other tissues
ExpressionAtlasiQ9QZZ4, baseline and differential
GenevisibleiQ9QZZ4, MM

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
cd13201, FERM_C_MyoXV, 1 hit
cd01387, MYSc_Myo15, 1 hit
Gene3Di1.25.40.530, 2 hits
2.30.29.30, 2 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR035487, MYO15A
IPR001609, Myosin_head_motor_dom
IPR041795, MyoXV_FERM_C
IPR036057, MYSc_Myo15
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR22692:SF21, PTHR22692:SF21, 1 hit
PfamiView protein in Pfam
PF00612, IQ, 2 hits
PF00063, Myosin_head, 1 hit
PF00784, MyTH4, 2 hits
PF07653, SH3_2, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00015, IQ, 3 hits
SM00242, MYSc, 1 hit
SM00139, MyTH4, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
SSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50057, FERM_3, 1 hit
PS50096, IQ, 2 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51016, MYTH4, 2 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO15_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QZZ4
Secondary accession number(s): A2A637
, A2A638, O70395, Q5SX93, Q7TMR5, Q7TMR6, Q9QWL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 4, 2007
Last modified: October 7, 2020
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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