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Entry version 174 (07 Oct 2020)
Sequence version 2 (04 Dec 2007)
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Protein

Unconventional myosin-XV

Gene

Myo15a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles.By similarity2 Publications

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1299 – 1306ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
Biological processHearing
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-XV
Alternative name(s):
Unconventional myosin-15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo15a
Synonyms:Myo15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1261811, Myo15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Myo15a are the cause of shaker-2 (sh-2), a condition causing deafness, circling behavior, head tossing and hyperactivity. Auditory hair cells of affected animals have very short stereocilia and a long actin-containing protrusion at their basal end.

Keywords - Diseasei

Deafness, Disease mutation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234751 – 3511Unconventional myosin-XVAdd BLAST3511

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9QZZ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QZZ4

PRoteomics IDEntifications database

More...
PRIDEi
Q9QZZ4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QZZ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QZZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the developing inner ear, expressed in cochlea and vestibular apparatus. Expression appears to be restricted to cochlear neurosensory cells and upper epithelial layer of macula saccula. Also expressed in macula utriculi and cristae ampullaris of the semicircular canals. In adult cochlear hair cells, highest expression in stereocilia and apical body.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042678, Expressed in internal ear and 57 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9QZZ4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9QZZ4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips.

Interacts with FASLG (By similarity).

Interacts with EPS8.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
201662, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9QZZ4, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9QZZ4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000071777

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9QZZ4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QZZ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1206 – 1883Myosin motorPROSITE-ProRule annotationAdd BLAST678
Domaini1886 – 1908IQ 1PROSITE-ProRule annotationAdd BLAST23
Domaini1909 – 1938IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini2049 – 2195MyTH4 1PROSITE-ProRule annotationAdd BLAST147
Domaini2848 – 2934SH3PROSITE-ProRule annotationAdd BLAST87
Domaini3031 – 3185MyTH4 2PROSITE-ProRule annotationAdd BLAST155
Domaini3190 – 3511FERMPROSITE-ProRule annotationAdd BLAST322

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1776 – 1783Actin-bindingSequence analysis8
Regioni1872 – 2013Neck or regulatory domainAdd BLAST142
Regioni2014 – 3511TailAdd BLAST1498

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1307 – 1334Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4229, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155335

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QZZ4

KEGG Orthology (KO)

More...
KOi
K10361

Identification of Orthologs from Complete Genome Data

More...
OMAi
SYPLAAC

Database of Orthologous Groups

More...
OrthoDBi
14609at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9QZZ4

TreeFam database of animal gene trees

More...
TreeFami
TF316834

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit
cd13201, FERM_C_MyoXV, 1 hit
cd01387, MYSc_Myo15, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.530, 2 hits
2.30.29.30, 2 hits
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR035487, MYO15A
IPR001609, Myosin_head_motor_dom
IPR041795, MyoXV_FERM_C
IPR036057, MYSc_Myo15
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR22692:SF21, PTHR22692:SF21, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00612, IQ, 2 hits
PF00063, Myosin_head, 1 hit
PF00784, MyTH4, 2 hits
PF07653, SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015, IQ, 3 hits
SM00242, MYSc, 1 hit
SM00139, MyTH4, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit
SSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057, FERM_3, 1 hit
PS50096, IQ, 2 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51016, MYTH4, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QZZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADEEKKAKK GKKGKKAPEP EKPKRSLKGT SRLFMGFRDR TPKISKKGQF
60 70 80 90 100
RSASAFFWGL HTGPQKTKRK KKARTVLKST SKLMTQMRVG KKKRAMKGKK
110 120 130 140 150
PSFMVIRFPG RRGYGRLRPR AQSLSKASTA INWLTKKFLL KKAEESGSEQ
160 170 180 190 200
ATVDAWLQRS SSRVGSRKLP FPSGAEILRH GGRLRRFPRS HSIYSSGEPV
210 220 230 240 250
GFLPFEDEAP FRHAGSRKSL YGLEGFQDLG EYYDYHREGD DYYDQQSLYH
260 270 280 290 300
YEEQEPYLAE FGGYSPAWPP YDDYGYPPGD PYNYYHPDYY GDTLYPGYAY
310 320 330 340 350
GYGYGYDDFE PPYAPPSGYS SPYSYHDSFE SEAYPYSYYL DPYATHHMPY
360 370 380 390 400
PPYDFPYDTP YDIPYFDPYG VPYAEGVYGG GAEAIYPPGM PYVYPEEPAF
410 420 430 440 450
MYPWVPPPIM SPHNPYAHPM DDIAELEEPE ETGEERQSTS FRLPSAAFFE
460 470 480 490 500
QQGMDKPARS KLSLIRKFRL FPRPQVKLFG KEKLEVPLPP SLDIPLPLGD
510 520 530 540 550
AEGEEEEEEM PPVPTMPYTH PYWSFLTPRQ RNLQRALSAF GARQGLGFGP
560 570 580 590 600
EFGHPTPRPA TSLARFLKKT LSEKKPIPRL RGSQKARGGR PPVREAAYKR
610 620 630 640 650
FGYKLAGMDP DRPNTPIVLR RSQPQARNNN NSHGPPSPRP APRALTHWSA
660 670 680 690 700
LISPPMPAPS PSPASPLTPP FSPTFSRPPR LASPYGSLRQ HPPPWAAPAH
710 720 730 740 750
VPFPPQANWW GFAEPPGTSP EVAPDLLAFP VPRPSFRASR SRSRRAAYGF
760 770 780 790 800
PSPSLIGSRR RPHLPSPQPS LRSLPGQGYH SPLGPLSPQL SLRRGPFQPP
810 820 830 840 850
FPPPPRRPQS LREAFSLRRA SGRLGPPRSP VLGSPRPPSP PPLLKHGPRH
860 870 880 890 900
RSLNLPSRLP RTWRRLSEPP TRAVKPWVHR AYPPPPSAGP WGASTGALEQ
910 920 930 940 950
QENQREAEDS ETPWTVPPLA PSWDVDMPPT QRPPSPWPEG IGSLRGFSRP
960 970 980 990 1000
PPVPENPLLE HTSPSCEPQS EDRVSNLTGI FLGQHHDPGP GQLTKSADPS
1010 1020 1030 1040 1050
LEKPEEVVTL GDPQPPAEPE ALNPTPPNKN VVSERKVLRL SASYPLVTCK
1060 1070 1080 1090 1100
QARATWPQWH RWKTVSRTPA PLAPTRAPGP LLKAGEQPRA EPGRFAVVMP
1110 1120 1130 1140 1150
QVRGVSSFRP KGPAPVQPPE HPDQDPEQGP APQACSLRWP RLWPPTDAHC
1160 1170 1180 1190 1200
LWSRIRTYSS QSHLRGHGGD CHKSLWKKTR PQSWQNKMHS IRNLPSMRSR
1210 1220 1230 1240 1250
EQHREDGVED MTQLEDLQET TVLANLKTRF ERNLIYTYIG SILVSVNPYR
1260 1270 1280 1290 1300
MFAIYGPEQV QQYSGRALGE NPPHLFAIAN LAFAKMLDAK QNQCVIISGE
1310 1320 1330 1340 1350
SGSGKTEATK LILRCLAAMN QRRDVMQQIK ILEATPLLEA FGNAKTVRND
1360 1370 1380 1390 1400
NSSRFGKFVE IFLEGGVICG AITSQYLLEK SRIVFQAKNE RNYHIFYELL
1410 1420 1430 1440 1450
AGLPAQLRQA FSLQEAETYY YLNQGGNCEI AGKSDADDFR RLLAAMEVLG
1460 1470 1480 1490 1500
FTSEDQDSIF RILASILHLG NVYFEKHETD AQEVASVVSA REIQAVAELL
1510 1520 1530 1540 1550
QVSPEGLQKA ITFKVTETIR EKIFTPLTVE SAVDARDAIA KVLYALLFGW
1560 1570 1580 1590 1600
LITRVNALVS PKQDTLSIAI LDIYGFEDLS FNSFEQLCIN YANENLQYLF
1610 1620 1630 1640 1650
NKIVFQEEQE EYIREQMDWR EIAFADNQPC INLISLKPYG ILRILDDQCC
1660 1670 1680 1690 1700
FPQATDHTFL QKCHYHHGAN PLYSKPKMPL PEFTIKHYAG KVTYQVHKFL
1710 1720 1730 1740 1750
DKNHDQVRQD VLDLFVHSRT RVVAHLFSSH AAQTAPPRLG KSSSITRLYK
1760 1770 1780 1790 1800
AHTVAAKFQQ SLLDLVEKME RCNPLFVRCL KPNHKKEPGL FEPDVMMAQL
1810 1820 1830 1840 1850
RYSGVLETVR IRKEGFPVRL PFQVFIDRYR CLVALKLNVP ADGDMCVSLL
1860 1870 1880 1890 1900
SRLCTVTPDM YRVGISKLFL KEHLHQLLES MRERVQNRAA LTLQRYLRGF
1910 1920 1930 1940 1950
FIQRHFRSLR RKIILLQSRA RGFLARQRYQ QMRQSLLKFR SLVHTYVNRR
1960 1970 1980 1990 2000
RYLKLRAEQR RRAQEAWLRE QEELSKREVV PVRHLEVPAE VAGLLQAAAG
2010 2020 2030 2040 2050
LKLSSGPRVA VVRAPRLQAE PCVTLPLDIN NYPMAKFIRC HFKEPSFGML
2060 2070 2080 2090 2100
TVPLKMPLTR LPVEHHAEAI SVFKLILRFM GDPHLHGTQE MILGNYIVHQ
2110 2120 2130 2140 2150
GLVEPALRDE ILAQLANQVW RNPNAYNSKR GWLLLAACLS GFAPSPHLDK
2160 2170 2180 2190 2200
FLLKFVSDYG QNGFQAVCQH RLLQAMGSGA ARTFPPTQLE WTAIQEKASM
2210 2220 2230 2240 2250
ALDVSCFNGD QFSCPVHTWS TGEAVAGDIL KHRGLADGWR GWTVAMKNGV
2260 2270 2280 2290 2300
QWAELAGHDY VLDLVSDLEL LRDFPRQKSY FIVGAEGPLA GRGDTRGVFG
2310 2320 2330 2340 2350
NCWDSDEDTP TRPQPQDHVA KMPDLDGYCS HKEDGTNGET EAQRWTSNRQ
2360 2370 2380 2390 2400
AVDSIGESTV PPRELDGYLD SLFDPVLACG DADLEKPTAI AYRMKGGGQP
2410 2420 2430 2440 2450
GGGGGSTSED TSRRPPEPKL KPIPGLDAST LALQQAFIHR QAVLLAREMT
2460 2470 2480 2490 2500
LQALALQQQP LSATSRPQLP ERPLAPEARP KTVVGTGPPA KPVLVRPTPQ
2510 2520 2530 2540 2550
SWAPGSVAKA PKIPSKPVAV PILAQDWTAP ESISASPELV RYSTLNSEHF
2560 2570 2580 2590 2600
PQPTQQIRSI IKQYKQPPWA GHPEARRTDG GKVFRRPPDP HEEALMILKG
2610 2620 2630 2640 2650
QKTQLAVVPG TQVSREAVAM VKPVTSAPRP CMGPTPVQPS RSLEPPEDPV
2660 2670 2680 2690 2700
QTQLHRLVNP NFYGYQDIPW RIFLRKEVFY PKDNYSHPVQ LDLLFRQILH
2710 2720 2730 2740 2750
DTFSEACLRI SEDERLQMKA LFAQNQLDTQ RPLVTESVKR AAISMARDSW
2760 2770 2780 2790 2800
EIYFSRLFPA MGSVGTGVQI LAVSHTGIKL LQMVKGSKEA SRRLRVLCAY
2810 2820 2830 2840 2850
SFADILFVTM PSQNMLEFNL SNEKLILFSA RAQQVKTLVD TFILELKKDS
2860 2870 2880 2890 2900
DYVVAVRNFL SEDPELLSFH KGDIIHLQSL EPTRVGYSAG CVVRKKLVYL
2910 2920 2930 2940 2950
EELRRRGPDF GWRFGAVHGR VGRFPSELVQ PAAAPDFLQL PAEPGRGRAA
2960 2970 2980 2990 3000
AVAAAVASAA AAQEVGRRRE GPPVRARSAD SGEDSIALPP STMLEFAQKY
3010 3020 3030 3040 3050
FRDPRRRPRD GLKLKSKEDR ESKTLEDVLC FTKVPIQESL IELSDSNLNK
3060 3070 3080 3090 3100
MAVDMFVAVM RFMGDAPLKG QSELDVLCTL LKLCGDHEVM RDECYCQIVK
3110 3120 3130 3140 3150
QITDNSSPKQ DSCQRGWRLL YIMAAYYSCS EVFYPYLIRF LQHVSWTPGL
3160 3170 3180 3190 3200
PFQGIAKACE QNLQKTLRFG GRLEFPSNME LRAMLAGRSS KRQLFLLPGG
3210 3220 3230 3240 3250
LERHLKIKTC TVALDVIEGL CTEMALTRPE AFDEYVIFVV TNRGQHVCPL
3260 3270 3280 3290 3300
SCRAYILDVA SEMEQVDGGY TLWFRRVLWD QPLKFENELY VTMHYNQVLP
3310 3320 3330 3340 3350
DYLKGLFSSV PARQPTEQQL QQVSKLASLQ HRAKDHFYLP SVREVQEYIP
3360 3370 3380 3390 3400
AQLYHTTAGD TWLNLVSQHR QQTQALSPHQ ARAQFLGLLS AFPLFGSSFF
3410 3420 3430 3440 3450
FIQSCSNVLV PAPCILAVNH NGLNFLSTKT HELIVKIPLK EIQSTWTQQP
3460 3470 3480 3490 3500
TANSSYPYVE ISLGDVAAQR TMQLQLEQGL ELCRVVAVHV ESMLSAREER
3510
LTLPPSEITL L
Length:3,511
Mass (Da):395,622
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB66F3E06F4B5983E
GO
Isoform 2 (identifier: Q9QZZ4-2) [UniParc]FASTAAdd to basket
Also known as: 1a

The sequence of this isoform differs from the canonical sequence as follows:
     1955-1972: Missing.

Show »
Length:3,493
Mass (Da):393,314
Checksum:i3079F6C54FBA524B
GO
Isoform 3 (identifier: Q9QZZ4-3) [UniParc]FASTAAdd to basket
Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-1187: Missing.
     1955-1972: Missing.

Show »
Length:2,306
Mass (Da):260,047
Checksum:iE0CE013113707EC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VXK7F6VXK7_MOUSE
Myosin XV
Myo15
1,784Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BEN6A0A571BEN6_MOUSE
Myosin XV
Myo15
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1141R → C in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti1141R → C in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti1330 – 1331Missing in AAC40124 (PubMed:9603735).Curated2
Sequence conflicti1579L → R in BAA36582 (PubMed:9703981).Curated1
Sequence conflicti2077L → M in AAC40124 (PubMed:9603735).Curated1
Sequence conflicti2139L → P in AAC40124 (PubMed:9603735).Curated1
Sequence conflicti2953A → V in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti2953A → V in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti2953A → V in AAP88403 (PubMed:14610277).Curated1
Sequence conflicti3195F → S in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti3195F → S in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti3195F → S in AAP88403 (PubMed:14610277).Curated1
Sequence conflicti3449Q → K in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti3449Q → K in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti3449Q → K in AAP88403 (PubMed:14610277).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti1779C → Y in sh-2. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0299441 – 1187Missing in isoform 3. 1 PublicationAdd BLAST1187
Alternative sequenceiVSP_0299451955 – 1972Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF144095 mRNA Translation: AAF05904.1
AY331132 mRNA Translation: AAP88402.1
AY331133 mRNA Translation: AAP88403.1
AL596090 Genomic DNA No translation available.
AL596386 Genomic DNA No translation available.
AF053130 mRNA Translation: AAC40124.1
AB014510 mRNA Translation: BAA36582.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24792.1 [Q9QZZ4-1]
CCDS24793.1 [Q9QZZ4-3]
CCDS48811.1 [Q9QZZ4-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A59295
T42386

NCBI Reference Sequences

More...
RefSeqi
NP_001096641.1, NM_001103171.1 [Q9QZZ4-2]
NP_034992.2, NM_010862.2 [Q9QZZ4-1]
NP_874357.2, NM_182698.2 [Q9QZZ4-3]
XP_017169821.1, XM_017314332.1
XP_017169822.1, XM_017314333.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000071880; ENSMUSP00000071777; ENSMUSG00000042678 [Q9QZZ4-1]
ENSMUST00000081823; ENSMUSP00000080507; ENSMUSG00000042678 [Q9QZZ4-3]
ENSMUST00000094135; ENSMUSP00000091686; ENSMUSG00000042678 [Q9QZZ4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17910

UCSC genome browser

More...
UCSCi
uc007jfz.1, mouse [Q9QZZ4-1]
uc007jga.1, mouse [Q9QZZ4-3]
uc007jgb.2, mouse [Q9QZZ4-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144095 mRNA Translation: AAF05904.1
AY331132 mRNA Translation: AAP88402.1
AY331133 mRNA Translation: AAP88403.1
AL596090 Genomic DNA No translation available.
AL596386 Genomic DNA No translation available.
AF053130 mRNA Translation: AAC40124.1
AB014510 mRNA Translation: BAA36582.1
CCDSiCCDS24792.1 [Q9QZZ4-1]
CCDS24793.1 [Q9QZZ4-3]
CCDS48811.1 [Q9QZZ4-2]
PIRiA59295
T42386
RefSeqiNP_001096641.1, NM_001103171.1 [Q9QZZ4-2]
NP_034992.2, NM_010862.2 [Q9QZZ4-1]
NP_874357.2, NM_182698.2 [Q9QZZ4-3]
XP_017169821.1, XM_017314332.1
XP_017169822.1, XM_017314333.1

3D structure databases

SMRiQ9QZZ4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201662, 4 interactors
IntActiQ9QZZ4, 3 interactors
MINTiQ9QZZ4
STRINGi10090.ENSMUSP00000071777

PTM databases

iPTMnetiQ9QZZ4
PhosphoSitePlusiQ9QZZ4

Proteomic databases

jPOSTiQ9QZZ4
PaxDbiQ9QZZ4
PRIDEiQ9QZZ4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
58384, 25 antibodies

Genome annotation databases

EnsembliENSMUST00000071880; ENSMUSP00000071777; ENSMUSG00000042678 [Q9QZZ4-1]
ENSMUST00000081823; ENSMUSP00000080507; ENSMUSG00000042678 [Q9QZZ4-3]
ENSMUST00000094135; ENSMUSP00000091686; ENSMUSG00000042678 [Q9QZZ4-2]
GeneIDi17910
KEGGimmu:17910
UCSCiuc007jfz.1, mouse [Q9QZZ4-1]
uc007jga.1, mouse [Q9QZZ4-3]
uc007jgb.2, mouse [Q9QZZ4-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
17910
MGIiMGI:1261811, Myo15

Phylogenomic databases

eggNOGiKOG4229, Eukaryota
GeneTreeiENSGT00940000155335
InParanoidiQ9QZZ4
KOiK10361
OMAiSYPLAAC
OrthoDBi14609at2759
PhylomeDBiQ9QZZ4
TreeFamiTF316834

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
17910, 4 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Myo15, mouse

Protein Ontology

More...
PROi
PR:Q9QZZ4
RNActiQ9QZZ4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042678, Expressed in internal ear and 57 other tissues
ExpressionAtlasiQ9QZZ4, baseline and differential
GenevisibleiQ9QZZ4, MM

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
cd13201, FERM_C_MyoXV, 1 hit
cd01387, MYSc_Myo15, 1 hit
Gene3Di1.25.40.530, 2 hits
2.30.29.30, 2 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR035487, MYO15A
IPR001609, Myosin_head_motor_dom
IPR041795, MyoXV_FERM_C
IPR036057, MYSc_Myo15
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR22692:SF21, PTHR22692:SF21, 1 hit
PfamiView protein in Pfam
PF00612, IQ, 2 hits
PF00063, Myosin_head, 1 hit
PF00784, MyTH4, 2 hits
PF07653, SH3_2, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00015, IQ, 3 hits
SM00242, MYSc, 1 hit
SM00139, MyTH4, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
SSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50057, FERM_3, 1 hit
PS50096, IQ, 2 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51016, MYTH4, 2 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO15_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QZZ4
Secondary accession number(s): A2A637
, A2A638, O70395, Q5SX93, Q7TMR5, Q7TMR6, Q9QWL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 4, 2007
Last modified: October 7, 2020
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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