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UniProtKB - Q9QZZ4 (MYO15_MOUSE)

Protein

Unconventional myosin-XV

Gene

Myo15a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles.By similarity2 Publications

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1299 – 1306ATPSequence analysis8

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • inner ear morphogenesis Source: MGI
  • locomotory behavior Source: MGI
  • sensory perception of sound Source: MGI
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
Biological processHearing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XV
Alternative name(s):
Unconventional myosin-15
Gene namesi
Name:Myo15a
Synonyms:Myo15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1261811 Myo15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Defects in Myo15a are the cause of shaker-2 (sh-2), a condition causing deafness, circling behavior, head tossing and hyperactivity. Auditory hair cells of affected animals have very short stereocilia and a long actin-containing protrusion at their basal end.

Keywords - Diseasei

Deafness, Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234751 – 3511Unconventional myosin-XVAdd BLAST3511

Proteomic databases

PaxDbiQ9QZZ4
PRIDEiQ9QZZ4

PTM databases

iPTMnetiQ9QZZ4
PhosphoSitePlusiQ9QZZ4

Expressioni

Tissue specificityi

In the developing inner ear, expressed in cochlea and vestibular apparatus. Expression appears to be restricted to cochlear neurosensory cells and upper epithelial layer of macula saccula. Also expressed in macula utriculi and cristae ampullaris of the semicircular canals. In adult cochlear hair cells, highest expression in stereocilia and apical body.1 Publication

Gene expression databases

BgeeiENSMUSG00000042678 Expressed in 34 organ(s), highest expression level in internal ear
CleanExiMM_MYO15
ExpressionAtlasiQ9QZZ4 baseline and differential
GenevisibleiQ9QZZ4 MM

Interactioni

Subunit structurei

Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips. Interacts with FASLG (By similarity). Interacts with EPS8.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
WhrnQ80VW55EBI-4281382,EBI-7417603

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi201662, 2 interactors
IntActiQ9QZZ4, 3 interactors
MINTiQ9QZZ4
STRINGi10090.ENSMUSP00000071777

Structurei

3D structure databases

ProteinModelPortaliQ9QZZ4
SMRiQ9QZZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1206 – 1883Myosin motorPROSITE-ProRule annotationAdd BLAST678
Domaini1886 – 1908IQ 1PROSITE-ProRule annotationAdd BLAST23
Domaini1909 – 1938IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini2049 – 2195MyTH4 1PROSITE-ProRule annotationAdd BLAST147
Domaini2848 – 2934SH3PROSITE-ProRule annotationAdd BLAST87
Domaini3031 – 3185MyTH4 2PROSITE-ProRule annotationAdd BLAST155
Domaini3190 – 3511FERMPROSITE-ProRule annotationAdd BLAST322

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1776 – 1783Actin-bindingSequence analysis8
Regioni1872 – 2013Neck or regulatory domainAdd BLAST142
Regioni2014 – 3511TailAdd BLAST1498

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1307 – 1334Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOVERGENiHBG052554
InParanoidiQ9QZZ4
KOiK10361
OMAiQAMGRAQ
OrthoDBiEOG091G006G
PhylomeDBiQ9QZZ4
TreeFamiTF316834

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd01387 MYSc_Myo15, 1 hit
Gene3Di1.25.40.530, 2 hits
2.30.29.30, 2 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR035487 MYO15A
IPR001609 Myosin_head_motor_dom
IPR036057 MYSc_Myo15
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR13140:SF379 PTHR13140:SF379, 1 hit
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QZZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADEEKKAKK GKKGKKAPEP EKPKRSLKGT SRLFMGFRDR TPKISKKGQF 
        60         70         80         90        100
RSASAFFWGL HTGPQKTKRK KKARTVLKST SKLMTQMRVG KKKRAMKGKK 
       110        120        130        140        150
PSFMVIRFPG RRGYGRLRPR AQSLSKASTA INWLTKKFLL KKAEESGSEQ 
       160        170        180        190        200
ATVDAWLQRS SSRVGSRKLP FPSGAEILRH GGRLRRFPRS HSIYSSGEPV 
       210        220        230        240        250
GFLPFEDEAP FRHAGSRKSL YGLEGFQDLG EYYDYHREGD DYYDQQSLYH 
       260        270        280        290        300
YEEQEPYLAE FGGYSPAWPP YDDYGYPPGD PYNYYHPDYY GDTLYPGYAY 
       310        320        330        340        350
GYGYGYDDFE PPYAPPSGYS SPYSYHDSFE SEAYPYSYYL DPYATHHMPY 
       360        370        380        390        400
PPYDFPYDTP YDIPYFDPYG VPYAEGVYGG GAEAIYPPGM PYVYPEEPAF 
       410        420        430        440        450
MYPWVPPPIM SPHNPYAHPM DDIAELEEPE ETGEERQSTS FRLPSAAFFE 
       460        470        480        490        500
QQGMDKPARS KLSLIRKFRL FPRPQVKLFG KEKLEVPLPP SLDIPLPLGD 
       510        520        530        540        550
AEGEEEEEEM PPVPTMPYTH PYWSFLTPRQ RNLQRALSAF GARQGLGFGP 
       560        570        580        590        600
EFGHPTPRPA TSLARFLKKT LSEKKPIPRL RGSQKARGGR PPVREAAYKR 
       610        620        630        640        650
FGYKLAGMDP DRPNTPIVLR RSQPQARNNN NSHGPPSPRP APRALTHWSA 
       660        670        680        690        700
LISPPMPAPS PSPASPLTPP FSPTFSRPPR LASPYGSLRQ HPPPWAAPAH 
       710        720        730        740        750
VPFPPQANWW GFAEPPGTSP EVAPDLLAFP VPRPSFRASR SRSRRAAYGF 
       760        770        780        790        800
PSPSLIGSRR RPHLPSPQPS LRSLPGQGYH SPLGPLSPQL SLRRGPFQPP 
       810        820        830        840        850
FPPPPRRPQS LREAFSLRRA SGRLGPPRSP VLGSPRPPSP PPLLKHGPRH 
       860        870        880        890        900
RSLNLPSRLP RTWRRLSEPP TRAVKPWVHR AYPPPPSAGP WGASTGALEQ 
       910        920        930        940        950
QENQREAEDS ETPWTVPPLA PSWDVDMPPT QRPPSPWPEG IGSLRGFSRP 
       960        970        980        990       1000
PPVPENPLLE HTSPSCEPQS EDRVSNLTGI FLGQHHDPGP GQLTKSADPS 
      1010       1020       1030       1040       1050
LEKPEEVVTL GDPQPPAEPE ALNPTPPNKN VVSERKVLRL SASYPLVTCK 
      1060       1070       1080       1090       1100
QARATWPQWH RWKTVSRTPA PLAPTRAPGP LLKAGEQPRA EPGRFAVVMP 
      1110       1120       1130       1140       1150
QVRGVSSFRP KGPAPVQPPE HPDQDPEQGP APQACSLRWP RLWPPTDAHC 
      1160       1170       1180       1190       1200
LWSRIRTYSS QSHLRGHGGD CHKSLWKKTR PQSWQNKMHS IRNLPSMRSR 
      1210       1220       1230       1240       1250
EQHREDGVED MTQLEDLQET TVLANLKTRF ERNLIYTYIG SILVSVNPYR 
      1260       1270       1280       1290       1300
MFAIYGPEQV QQYSGRALGE NPPHLFAIAN LAFAKMLDAK QNQCVIISGE 
      1310       1320       1330       1340       1350
SGSGKTEATK LILRCLAAMN QRRDVMQQIK ILEATPLLEA FGNAKTVRND 
      1360       1370       1380       1390       1400
NSSRFGKFVE IFLEGGVICG AITSQYLLEK SRIVFQAKNE RNYHIFYELL 
      1410       1420       1430       1440       1450
AGLPAQLRQA FSLQEAETYY YLNQGGNCEI AGKSDADDFR RLLAAMEVLG 
      1460       1470       1480       1490       1500
FTSEDQDSIF RILASILHLG NVYFEKHETD AQEVASVVSA REIQAVAELL 
      1510       1520       1530       1540       1550
QVSPEGLQKA ITFKVTETIR EKIFTPLTVE SAVDARDAIA KVLYALLFGW 
      1560       1570       1580       1590       1600
LITRVNALVS PKQDTLSIAI LDIYGFEDLS FNSFEQLCIN YANENLQYLF 
      1610       1620       1630       1640       1650
NKIVFQEEQE EYIREQMDWR EIAFADNQPC INLISLKPYG ILRILDDQCC 
      1660       1670       1680       1690       1700
FPQATDHTFL QKCHYHHGAN PLYSKPKMPL PEFTIKHYAG KVTYQVHKFL 
      1710       1720       1730       1740       1750
DKNHDQVRQD VLDLFVHSRT RVVAHLFSSH AAQTAPPRLG KSSSITRLYK 
      1760       1770       1780       1790       1800
AHTVAAKFQQ SLLDLVEKME RCNPLFVRCL KPNHKKEPGL FEPDVMMAQL 
      1810       1820       1830       1840       1850
RYSGVLETVR IRKEGFPVRL PFQVFIDRYR CLVALKLNVP ADGDMCVSLL 
      1860       1870       1880       1890       1900
SRLCTVTPDM YRVGISKLFL KEHLHQLLES MRERVQNRAA LTLQRYLRGF 
      1910       1920       1930       1940       1950
FIQRHFRSLR RKIILLQSRA RGFLARQRYQ QMRQSLLKFR SLVHTYVNRR 
      1960       1970       1980       1990       2000
RYLKLRAEQR RRAQEAWLRE QEELSKREVV PVRHLEVPAE VAGLLQAAAG 
      2010       2020       2030       2040       2050
LKLSSGPRVA VVRAPRLQAE PCVTLPLDIN NYPMAKFIRC HFKEPSFGML 
      2060       2070       2080       2090       2100
TVPLKMPLTR LPVEHHAEAI SVFKLILRFM GDPHLHGTQE MILGNYIVHQ 
      2110       2120       2130       2140       2150
GLVEPALRDE ILAQLANQVW RNPNAYNSKR GWLLLAACLS GFAPSPHLDK 
      2160       2170       2180       2190       2200
FLLKFVSDYG QNGFQAVCQH RLLQAMGSGA ARTFPPTQLE WTAIQEKASM 
      2210       2220       2230       2240       2250
ALDVSCFNGD QFSCPVHTWS TGEAVAGDIL KHRGLADGWR GWTVAMKNGV 
      2260       2270       2280       2290       2300
QWAELAGHDY VLDLVSDLEL LRDFPRQKSY FIVGAEGPLA GRGDTRGVFG 
      2310       2320       2330       2340       2350
NCWDSDEDTP TRPQPQDHVA KMPDLDGYCS HKEDGTNGET EAQRWTSNRQ 
      2360       2370       2380       2390       2400
AVDSIGESTV PPRELDGYLD SLFDPVLACG DADLEKPTAI AYRMKGGGQP 
      2410       2420       2430       2440       2450
GGGGGSTSED TSRRPPEPKL KPIPGLDAST LALQQAFIHR QAVLLAREMT 
      2460       2470       2480       2490       2500
LQALALQQQP LSATSRPQLP ERPLAPEARP KTVVGTGPPA KPVLVRPTPQ 
      2510       2520       2530       2540       2550
SWAPGSVAKA PKIPSKPVAV PILAQDWTAP ESISASPELV RYSTLNSEHF 
      2560       2570       2580       2590       2600
PQPTQQIRSI IKQYKQPPWA GHPEARRTDG GKVFRRPPDP HEEALMILKG 
      2610       2620       2630       2640       2650
QKTQLAVVPG TQVSREAVAM VKPVTSAPRP CMGPTPVQPS RSLEPPEDPV 
      2660       2670       2680       2690       2700
QTQLHRLVNP NFYGYQDIPW RIFLRKEVFY PKDNYSHPVQ LDLLFRQILH 
      2710       2720       2730       2740       2750
DTFSEACLRI SEDERLQMKA LFAQNQLDTQ RPLVTESVKR AAISMARDSW 
      2760       2770       2780       2790       2800
EIYFSRLFPA MGSVGTGVQI LAVSHTGIKL LQMVKGSKEA SRRLRVLCAY 
      2810       2820       2830       2840       2850
SFADILFVTM PSQNMLEFNL SNEKLILFSA RAQQVKTLVD TFILELKKDS 
      2860       2870       2880       2890       2900
DYVVAVRNFL SEDPELLSFH KGDIIHLQSL EPTRVGYSAG CVVRKKLVYL 
      2910       2920       2930       2940       2950
EELRRRGPDF GWRFGAVHGR VGRFPSELVQ PAAAPDFLQL PAEPGRGRAA 
      2960       2970       2980       2990       3000
AVAAAVASAA AAQEVGRRRE GPPVRARSAD SGEDSIALPP STMLEFAQKY 
      3010       3020       3030       3040       3050
FRDPRRRPRD GLKLKSKEDR ESKTLEDVLC FTKVPIQESL IELSDSNLNK 
      3060       3070       3080       3090       3100
MAVDMFVAVM RFMGDAPLKG QSELDVLCTL LKLCGDHEVM RDECYCQIVK 
      3110       3120       3130       3140       3150
QITDNSSPKQ DSCQRGWRLL YIMAAYYSCS EVFYPYLIRF LQHVSWTPGL 
      3160       3170       3180       3190       3200
PFQGIAKACE QNLQKTLRFG GRLEFPSNME LRAMLAGRSS KRQLFLLPGG 
      3210       3220       3230       3240       3250
LERHLKIKTC TVALDVIEGL CTEMALTRPE AFDEYVIFVV TNRGQHVCPL 
      3260       3270       3280       3290       3300
SCRAYILDVA SEMEQVDGGY TLWFRRVLWD QPLKFENELY VTMHYNQVLP 
      3310       3320       3330       3340       3350
DYLKGLFSSV PARQPTEQQL QQVSKLASLQ HRAKDHFYLP SVREVQEYIP 
      3360       3370       3380       3390       3400
AQLYHTTAGD TWLNLVSQHR QQTQALSPHQ ARAQFLGLLS AFPLFGSSFF 
      3410       3420       3430       3440       3450
FIQSCSNVLV PAPCILAVNH NGLNFLSTKT HELIVKIPLK EIQSTWTQQP 
      3460       3470       3480       3490       3500
TANSSYPYVE ISLGDVAAQR TMQLQLEQGL ELCRVVAVHV ESMLSAREER 
      3510 
LTLPPSEITL L
Length:3,511
Mass (Da):395,622
Last modified:December 4, 2007 - v2
Checksum:iB66F3E06F4B5983E
GO
Isoform 2 (identifier: Q9QZZ4-2) [UniParc]FASTAAdd to basket
Also known as: 1a

The sequence of this isoform differs from the canonical sequence as follows:
     1955-1972: Missing.

Show »
Length:3,493
Mass (Da):393,314
Checksum:i3079F6C54FBA524B
GO
Isoform 3 (identifier: Q9QZZ4-3) [UniParc]FASTAAdd to basket
Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-1187: Missing.
     1955-1972: Missing.

Show »
Length:2,306
Mass (Da):260,047
Checksum:iE0CE013113707EC8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VXK7F6VXK7_MOUSE
Myosin XV
Myo15
1,784Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1141R → C in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti1141R → C in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti1330 – 1331Missing in AAC40124 (PubMed:9603735).Curated2
Sequence conflicti1579L → R in BAA36582 (PubMed:9703981).Curated1
Sequence conflicti2077L → M in AAC40124 (PubMed:9603735).Curated1
Sequence conflicti2139L → P in AAC40124 (PubMed:9603735).Curated1
Sequence conflicti2953A → V in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti2953A → V in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti2953A → V in AAP88403 (PubMed:14610277).Curated1
Sequence conflicti3195F → S in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti3195F → S in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti3195F → S in AAP88403 (PubMed:14610277).Curated1
Sequence conflicti3449Q → K in AAF05904 (PubMed:10552926).Curated1
Sequence conflicti3449Q → K in AAP88402 (PubMed:14610277).Curated1
Sequence conflicti3449Q → K in AAP88403 (PubMed:14610277).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1779C → Y in sh-2. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0299441 – 1187Missing in isoform 3. 1 PublicationAdd BLAST1187
Alternative sequenceiVSP_0299451955 – 1972Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144095 mRNA Translation: AAF05904.1
AY331132 mRNA Translation: AAP88402.1
AY331133 mRNA Translation: AAP88403.1
AL596090, AL596386 Genomic DNA Translation: CAI24082.2
AL596090, AL596386 Genomic DNA Translation: CAM14761.1
AL596090, AL596386 Genomic DNA Translation: CAM14762.1
AL596386, AL596090 Genomic DNA Translation: CAI35347.1
AL596386, AL596090 Genomic DNA Translation: CAM21169.1
AL596386, AL596090 Genomic DNA Translation: CAM21170.1
AF053130 mRNA Translation: AAC40124.1
AB014510 mRNA Translation: BAA36582.1
CCDSiCCDS24792.1 [Q9QZZ4-1]
CCDS24793.1 [Q9QZZ4-3]
CCDS48811.1 [Q9QZZ4-2]
PIRiA59295
T42386
RefSeqiNP_001096641.1, NM_001103171.1 [Q9QZZ4-2]
NP_034992.2, NM_010862.2 [Q9QZZ4-1]
NP_874357.2, NM_182698.2 [Q9QZZ4-3]
XP_017169821.1, XM_017314332.1 [Q9QZZ4-1]
XP_017169822.1, XM_017314333.1 [Q9QZZ4-2]
UniGeneiMm.89960

Genome annotation databases

EnsembliENSMUST00000071880; ENSMUSP00000071777; ENSMUSG00000042678 [Q9QZZ4-1]
ENSMUST00000081823; ENSMUSP00000080507; ENSMUSG00000042678 [Q9QZZ4-3]
ENSMUST00000094135; ENSMUSP00000091686; ENSMUSG00000042678 [Q9QZZ4-2]
GeneIDi17910
KEGGimmu:17910
UCSCiuc007jfz.1 mouse [Q9QZZ4-1]
uc007jga.1 mouse [Q9QZZ4-3]
uc007jgb.2 mouse [Q9QZZ4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144095 mRNA Translation: AAF05904.1
AY331132 mRNA Translation: AAP88402.1
AY331133 mRNA Translation: AAP88403.1
AL596090, AL596386 Genomic DNA Translation: CAI24082.2
AL596090, AL596386 Genomic DNA Translation: CAM14761.1
AL596090, AL596386 Genomic DNA Translation: CAM14762.1
AL596386, AL596090 Genomic DNA Translation: CAI35347.1
AL596386, AL596090 Genomic DNA Translation: CAM21169.1
AL596386, AL596090 Genomic DNA Translation: CAM21170.1
AF053130 mRNA Translation: AAC40124.1
AB014510 mRNA Translation: BAA36582.1
CCDSiCCDS24792.1 [Q9QZZ4-1]
CCDS24793.1 [Q9QZZ4-3]
CCDS48811.1 [Q9QZZ4-2]
PIRiA59295
T42386
RefSeqiNP_001096641.1, NM_001103171.1 [Q9QZZ4-2]
NP_034992.2, NM_010862.2 [Q9QZZ4-1]
NP_874357.2, NM_182698.2 [Q9QZZ4-3]
XP_017169821.1, XM_017314332.1 [Q9QZZ4-1]
XP_017169822.1, XM_017314333.1 [Q9QZZ4-2]
UniGeneiMm.89960

3D structure databases

ProteinModelPortaliQ9QZZ4
SMRiQ9QZZ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201662, 2 interactors
IntActiQ9QZZ4, 3 interactors
MINTiQ9QZZ4
STRINGi10090.ENSMUSP00000071777

PTM databases

iPTMnetiQ9QZZ4
PhosphoSitePlusiQ9QZZ4

Proteomic databases

PaxDbiQ9QZZ4
PRIDEiQ9QZZ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071880; ENSMUSP00000071777; ENSMUSG00000042678 [Q9QZZ4-1]
ENSMUST00000081823; ENSMUSP00000080507; ENSMUSG00000042678 [Q9QZZ4-3]
ENSMUST00000094135; ENSMUSP00000091686; ENSMUSG00000042678 [Q9QZZ4-2]
GeneIDi17910
KEGGimmu:17910
UCSCiuc007jfz.1 mouse [Q9QZZ4-1]
uc007jga.1 mouse [Q9QZZ4-3]
uc007jgb.2 mouse [Q9QZZ4-2]

Organism-specific databases

CTDi17910
MGIiMGI:1261811 Myo15

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOVERGENiHBG052554
InParanoidiQ9QZZ4
KOiK10361
OMAiQAMGRAQ
OrthoDBiEOG091G006G
PhylomeDBiQ9QZZ4
TreeFamiTF316834

Miscellaneous databases

PROiPR:Q9QZZ4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042678 Expressed in 34 organ(s), highest expression level in internal ear
CleanExiMM_MYO15
ExpressionAtlasiQ9QZZ4 baseline and differential
GenevisibleiQ9QZZ4 MM

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd01387 MYSc_Myo15, 1 hit
Gene3Di1.25.40.530, 2 hits
2.30.29.30, 2 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR035487 MYO15A
IPR001609 Myosin_head_motor_dom
IPR036057 MYSc_Myo15
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR13140:SF379 PTHR13140:SF379, 1 hit
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYO15_MOUSE
AccessioniPrimary (citable) accession number: Q9QZZ4
Secondary accession number(s): A2A637
, A2A638, O70395, Q5SX93, Q7TMR5, Q7TMR6, Q9QWL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 4, 2007
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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