UniProtKB - Q9QZZ4 (MYO15_MOUSE)
Protein
Unconventional myosin-XV
Gene
Myo15a
Organism
Mus musculus (Mouse)
Status
Functioni
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles.By similarity2 Publications
Caution
Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1299 – 1306 | ATPSequence analysis | 8 |
GO - Molecular functioni
- actin-dependent ATPase activity Source: GO_Central
- actin filament binding Source: GO_Central
- ATP binding Source: UniProtKB-KW
- microfilament motor activity Source: GO_Central
GO - Biological processi
- actin filament organization Source: GO_Central
- inner ear morphogenesis Source: MGI
- locomotory behavior Source: MGI
- sensory perception of sound Source: MGI
- vesicle transport along actin filament Source: GO_Central
Keywordsi
Molecular function | Actin-binding, Motor protein, Myosin |
Biological process | Hearing |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Unconventional myosin-XVAlternative name(s): Unconventional myosin-15 |
Gene namesi | Name:Myo15a Synonyms:Myo15 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1261811, Myo15 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- stereocilium 1 Publication
Note: Localizes to stereocilium tips in cochlear and vestibular hair cells.
Cytoskeleton
- actin cytoskeleton Source: GO_Central
- myosin complex Source: UniProtKB-KW
Other locations
- actin-based cell projection Source: GO_Central
- cytoplasm Source: GO_Central
- stereocilium Source: MGI
- stereocilium bundle Source: MGI
- vesicle Source: GO_Central
Keywords - Cellular componenti
Cell projection, Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Defects in Myo15a are the cause of shaker-2 (sh-2), a condition causing deafness, circling behavior, head tossing and hyperactivity. Auditory hair cells of affected animals have very short stereocilia and a long actin-containing protrusion at their basal end.
Keywords - Diseasei
Deafness, Disease mutationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123475 | 1 – 3511 | Unconventional myosin-XVAdd BLAST | 3511 |
Proteomic databases
jPOSTi | Q9QZZ4 |
PaxDbi | Q9QZZ4 |
PRIDEi | Q9QZZ4 |
PTM databases
iPTMneti | Q9QZZ4 |
PhosphoSitePlusi | Q9QZZ4 |
Expressioni
Tissue specificityi
In the developing inner ear, expressed in cochlea and vestibular apparatus. Expression appears to be restricted to cochlear neurosensory cells and upper epithelial layer of macula saccula. Also expressed in macula utriculi and cristae ampullaris of the semicircular canals. In adult cochlear hair cells, highest expression in stereocilia and apical body.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000042678, Expressed in internal ear and 57 other tissues |
ExpressionAtlasi | Q9QZZ4, baseline and differential |
Genevisiblei | Q9QZZ4, MM |
Interactioni
Subunit structurei
Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips.
Interacts with FASLG (By similarity).
Interacts with EPS8.
By similarity2 PublicationsBinary interactionsi
Q9QZZ4
With | #Exp. | IntAct |
---|---|---|
Whrn [Q80VW5] | 5 | EBI-4281382,EBI-7417603 |
GO - Molecular functioni
- actin filament binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 201662, 4 interactors |
IntActi | Q9QZZ4, 3 interactors |
MINTi | Q9QZZ4 |
STRINGi | 10090.ENSMUSP00000071777 |
Miscellaneous databases
RNActi | Q9QZZ4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1206 – 1883 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 678 | |
Domaini | 1886 – 1908 | IQ 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Domaini | 1909 – 1938 | IQ 2PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 2049 – 2195 | MyTH4 1PROSITE-ProRule annotationAdd BLAST | 147 | |
Domaini | 2848 – 2934 | SH3PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 3031 – 3185 | MyTH4 2PROSITE-ProRule annotationAdd BLAST | 155 | |
Domaini | 3190 – 3511 | FERMPROSITE-ProRule annotationAdd BLAST | 322 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1776 – 1783 | Actin-bindingSequence analysis | 8 | |
Regioni | 1872 – 2013 | Neck or regulatory domainAdd BLAST | 142 | |
Regioni | 2014 – 3511 | TailAdd BLAST | 1498 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1307 – 1334 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG4229, Eukaryota |
GeneTreei | ENSGT00940000155335 |
InParanoidi | Q9QZZ4 |
OMAi | SYPLAAC |
OrthoDBi | 14609at2759 |
PhylomeDBi | Q9QZZ4 |
TreeFami | TF316834 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13201, FERM_C_MyoXV, 1 hit cd01387, MYSc_Myo15, 1 hit |
Gene3Di | 1.25.40.530, 2 hits 2.30.29.30, 2 hits 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR035487, MYO15A IPR001609, Myosin_head_motor_dom IPR041795, MyoXV_FERM_C IPR036057, MYSc_Myo15 IPR000857, MyTH4_dom IPR038185, MyTH4_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR22692:SF21, PTHR22692:SF21, 1 hit |
Pfami | View protein in Pfam PF00612, IQ, 2 hits PF00063, Myosin_head, 1 hit PF00784, MyTH4, 2 hits PF07653, SH3_2, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 3 hits SM00242, MYSc, 1 hit SM00139, MyTH4, 2 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF50044, SSF50044, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS50096, IQ, 2 hits PS51456, MYOSIN_MOTOR, 1 hit PS51016, MYTH4, 2 hits PS50002, SH3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9QZZ4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADEEKKAKK GKKGKKAPEP EKPKRSLKGT SRLFMGFRDR TPKISKKGQF
60 70 80 90 100
RSASAFFWGL HTGPQKTKRK KKARTVLKST SKLMTQMRVG KKKRAMKGKK
110 120 130 140 150
PSFMVIRFPG RRGYGRLRPR AQSLSKASTA INWLTKKFLL KKAEESGSEQ
160 170 180 190 200
ATVDAWLQRS SSRVGSRKLP FPSGAEILRH GGRLRRFPRS HSIYSSGEPV
210 220 230 240 250
GFLPFEDEAP FRHAGSRKSL YGLEGFQDLG EYYDYHREGD DYYDQQSLYH
260 270 280 290 300
YEEQEPYLAE FGGYSPAWPP YDDYGYPPGD PYNYYHPDYY GDTLYPGYAY
310 320 330 340 350
GYGYGYDDFE PPYAPPSGYS SPYSYHDSFE SEAYPYSYYL DPYATHHMPY
360 370 380 390 400
PPYDFPYDTP YDIPYFDPYG VPYAEGVYGG GAEAIYPPGM PYVYPEEPAF
410 420 430 440 450
MYPWVPPPIM SPHNPYAHPM DDIAELEEPE ETGEERQSTS FRLPSAAFFE
460 470 480 490 500
QQGMDKPARS KLSLIRKFRL FPRPQVKLFG KEKLEVPLPP SLDIPLPLGD
510 520 530 540 550
AEGEEEEEEM PPVPTMPYTH PYWSFLTPRQ RNLQRALSAF GARQGLGFGP
560 570 580 590 600
EFGHPTPRPA TSLARFLKKT LSEKKPIPRL RGSQKARGGR PPVREAAYKR
610 620 630 640 650
FGYKLAGMDP DRPNTPIVLR RSQPQARNNN NSHGPPSPRP APRALTHWSA
660 670 680 690 700
LISPPMPAPS PSPASPLTPP FSPTFSRPPR LASPYGSLRQ HPPPWAAPAH
710 720 730 740 750
VPFPPQANWW GFAEPPGTSP EVAPDLLAFP VPRPSFRASR SRSRRAAYGF
760 770 780 790 800
PSPSLIGSRR RPHLPSPQPS LRSLPGQGYH SPLGPLSPQL SLRRGPFQPP
810 820 830 840 850
FPPPPRRPQS LREAFSLRRA SGRLGPPRSP VLGSPRPPSP PPLLKHGPRH
860 870 880 890 900
RSLNLPSRLP RTWRRLSEPP TRAVKPWVHR AYPPPPSAGP WGASTGALEQ
910 920 930 940 950
QENQREAEDS ETPWTVPPLA PSWDVDMPPT QRPPSPWPEG IGSLRGFSRP
960 970 980 990 1000
PPVPENPLLE HTSPSCEPQS EDRVSNLTGI FLGQHHDPGP GQLTKSADPS
1010 1020 1030 1040 1050
LEKPEEVVTL GDPQPPAEPE ALNPTPPNKN VVSERKVLRL SASYPLVTCK
1060 1070 1080 1090 1100
QARATWPQWH RWKTVSRTPA PLAPTRAPGP LLKAGEQPRA EPGRFAVVMP
1110 1120 1130 1140 1150
QVRGVSSFRP KGPAPVQPPE HPDQDPEQGP APQACSLRWP RLWPPTDAHC
1160 1170 1180 1190 1200
LWSRIRTYSS QSHLRGHGGD CHKSLWKKTR PQSWQNKMHS IRNLPSMRSR
1210 1220 1230 1240 1250
EQHREDGVED MTQLEDLQET TVLANLKTRF ERNLIYTYIG SILVSVNPYR
1260 1270 1280 1290 1300
MFAIYGPEQV QQYSGRALGE NPPHLFAIAN LAFAKMLDAK QNQCVIISGE
1310 1320 1330 1340 1350
SGSGKTEATK LILRCLAAMN QRRDVMQQIK ILEATPLLEA FGNAKTVRND
1360 1370 1380 1390 1400
NSSRFGKFVE IFLEGGVICG AITSQYLLEK SRIVFQAKNE RNYHIFYELL
1410 1420 1430 1440 1450
AGLPAQLRQA FSLQEAETYY YLNQGGNCEI AGKSDADDFR RLLAAMEVLG
1460 1470 1480 1490 1500
FTSEDQDSIF RILASILHLG NVYFEKHETD AQEVASVVSA REIQAVAELL
1510 1520 1530 1540 1550
QVSPEGLQKA ITFKVTETIR EKIFTPLTVE SAVDARDAIA KVLYALLFGW
1560 1570 1580 1590 1600
LITRVNALVS PKQDTLSIAI LDIYGFEDLS FNSFEQLCIN YANENLQYLF
1610 1620 1630 1640 1650
NKIVFQEEQE EYIREQMDWR EIAFADNQPC INLISLKPYG ILRILDDQCC
1660 1670 1680 1690 1700
FPQATDHTFL QKCHYHHGAN PLYSKPKMPL PEFTIKHYAG KVTYQVHKFL
1710 1720 1730 1740 1750
DKNHDQVRQD VLDLFVHSRT RVVAHLFSSH AAQTAPPRLG KSSSITRLYK
1760 1770 1780 1790 1800
AHTVAAKFQQ SLLDLVEKME RCNPLFVRCL KPNHKKEPGL FEPDVMMAQL
1810 1820 1830 1840 1850
RYSGVLETVR IRKEGFPVRL PFQVFIDRYR CLVALKLNVP ADGDMCVSLL
1860 1870 1880 1890 1900
SRLCTVTPDM YRVGISKLFL KEHLHQLLES MRERVQNRAA LTLQRYLRGF
1910 1920 1930 1940 1950
FIQRHFRSLR RKIILLQSRA RGFLARQRYQ QMRQSLLKFR SLVHTYVNRR
1960 1970 1980 1990 2000
RYLKLRAEQR RRAQEAWLRE QEELSKREVV PVRHLEVPAE VAGLLQAAAG
2010 2020 2030 2040 2050
LKLSSGPRVA VVRAPRLQAE PCVTLPLDIN NYPMAKFIRC HFKEPSFGML
2060 2070 2080 2090 2100
TVPLKMPLTR LPVEHHAEAI SVFKLILRFM GDPHLHGTQE MILGNYIVHQ
2110 2120 2130 2140 2150
GLVEPALRDE ILAQLANQVW RNPNAYNSKR GWLLLAACLS GFAPSPHLDK
2160 2170 2180 2190 2200
FLLKFVSDYG QNGFQAVCQH RLLQAMGSGA ARTFPPTQLE WTAIQEKASM
2210 2220 2230 2240 2250
ALDVSCFNGD QFSCPVHTWS TGEAVAGDIL KHRGLADGWR GWTVAMKNGV
2260 2270 2280 2290 2300
QWAELAGHDY VLDLVSDLEL LRDFPRQKSY FIVGAEGPLA GRGDTRGVFG
2310 2320 2330 2340 2350
NCWDSDEDTP TRPQPQDHVA KMPDLDGYCS HKEDGTNGET EAQRWTSNRQ
2360 2370 2380 2390 2400
AVDSIGESTV PPRELDGYLD SLFDPVLACG DADLEKPTAI AYRMKGGGQP
2410 2420 2430 2440 2450
GGGGGSTSED TSRRPPEPKL KPIPGLDAST LALQQAFIHR QAVLLAREMT
2460 2470 2480 2490 2500
LQALALQQQP LSATSRPQLP ERPLAPEARP KTVVGTGPPA KPVLVRPTPQ
2510 2520 2530 2540 2550
SWAPGSVAKA PKIPSKPVAV PILAQDWTAP ESISASPELV RYSTLNSEHF
2560 2570 2580 2590 2600
PQPTQQIRSI IKQYKQPPWA GHPEARRTDG GKVFRRPPDP HEEALMILKG
2610 2620 2630 2640 2650
QKTQLAVVPG TQVSREAVAM VKPVTSAPRP CMGPTPVQPS RSLEPPEDPV
2660 2670 2680 2690 2700
QTQLHRLVNP NFYGYQDIPW RIFLRKEVFY PKDNYSHPVQ LDLLFRQILH
2710 2720 2730 2740 2750
DTFSEACLRI SEDERLQMKA LFAQNQLDTQ RPLVTESVKR AAISMARDSW
2760 2770 2780 2790 2800
EIYFSRLFPA MGSVGTGVQI LAVSHTGIKL LQMVKGSKEA SRRLRVLCAY
2810 2820 2830 2840 2850
SFADILFVTM PSQNMLEFNL SNEKLILFSA RAQQVKTLVD TFILELKKDS
2860 2870 2880 2890 2900
DYVVAVRNFL SEDPELLSFH KGDIIHLQSL EPTRVGYSAG CVVRKKLVYL
2910 2920 2930 2940 2950
EELRRRGPDF GWRFGAVHGR VGRFPSELVQ PAAAPDFLQL PAEPGRGRAA
2960 2970 2980 2990 3000
AVAAAVASAA AAQEVGRRRE GPPVRARSAD SGEDSIALPP STMLEFAQKY
3010 3020 3030 3040 3050
FRDPRRRPRD GLKLKSKEDR ESKTLEDVLC FTKVPIQESL IELSDSNLNK
3060 3070 3080 3090 3100
MAVDMFVAVM RFMGDAPLKG QSELDVLCTL LKLCGDHEVM RDECYCQIVK
3110 3120 3130 3140 3150
QITDNSSPKQ DSCQRGWRLL YIMAAYYSCS EVFYPYLIRF LQHVSWTPGL
3160 3170 3180 3190 3200
PFQGIAKACE QNLQKTLRFG GRLEFPSNME LRAMLAGRSS KRQLFLLPGG
3210 3220 3230 3240 3250
LERHLKIKTC TVALDVIEGL CTEMALTRPE AFDEYVIFVV TNRGQHVCPL
3260 3270 3280 3290 3300
SCRAYILDVA SEMEQVDGGY TLWFRRVLWD QPLKFENELY VTMHYNQVLP
3310 3320 3330 3340 3350
DYLKGLFSSV PARQPTEQQL QQVSKLASLQ HRAKDHFYLP SVREVQEYIP
3360 3370 3380 3390 3400
AQLYHTTAGD TWLNLVSQHR QQTQALSPHQ ARAQFLGLLS AFPLFGSSFF
3410 3420 3430 3440 3450
FIQSCSNVLV PAPCILAVNH NGLNFLSTKT HELIVKIPLK EIQSTWTQQP
3460 3470 3480 3490 3500
TANSSYPYVE ISLGDVAAQR TMQLQLEQGL ELCRVVAVHV ESMLSAREER
3510
LTLPPSEITL L
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6VXK7 | F6VXK7_MOUSE | Myosin XV | Myo15 | 1,784 | Annotation score: | ||
A0A571BEN6 | A0A571BEN6_MOUSE | Myosin XV | Myo15 | 77 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1141 | R → C in AAF05904 (PubMed:10552926).Curated | 1 | |
Sequence conflicti | 1141 | R → C in AAP88402 (PubMed:14610277).Curated | 1 | |
Sequence conflicti | 1330 – 1331 | Missing in AAC40124 (PubMed:9603735).Curated | 2 | |
Sequence conflicti | 1579 | L → R in BAA36582 (PubMed:9703981).Curated | 1 | |
Sequence conflicti | 2077 | L → M in AAC40124 (PubMed:9603735).Curated | 1 | |
Sequence conflicti | 2139 | L → P in AAC40124 (PubMed:9603735).Curated | 1 | |
Sequence conflicti | 2953 | A → V in AAF05904 (PubMed:10552926).Curated | 1 | |
Sequence conflicti | 2953 | A → V in AAP88402 (PubMed:14610277).Curated | 1 | |
Sequence conflicti | 2953 | A → V in AAP88403 (PubMed:14610277).Curated | 1 | |
Sequence conflicti | 3195 | F → S in AAF05904 (PubMed:10552926).Curated | 1 | |
Sequence conflicti | 3195 | F → S in AAP88402 (PubMed:14610277).Curated | 1 | |
Sequence conflicti | 3195 | F → S in AAP88403 (PubMed:14610277).Curated | 1 | |
Sequence conflicti | 3449 | Q → K in AAF05904 (PubMed:10552926).Curated | 1 | |
Sequence conflicti | 3449 | Q → K in AAP88402 (PubMed:14610277).Curated | 1 | |
Sequence conflicti | 3449 | Q → K in AAP88403 (PubMed:14610277).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 1779 | C → Y in sh-2. 2 Publications | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029944 | 1 – 1187 | Missing in isoform 3. 1 PublicationAdd BLAST | 1187 | |
Alternative sequenceiVSP_029945 | 1955 – 1972 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF144095 mRNA Translation: AAF05904.1 AY331132 mRNA Translation: AAP88402.1 AY331133 mRNA Translation: AAP88403.1 AL596090 Genomic DNA No translation available. AL596386 Genomic DNA No translation available. AF053130 mRNA Translation: AAC40124.1 AB014510 mRNA Translation: BAA36582.1 |
CCDSi | CCDS24792.1 [Q9QZZ4-1] CCDS24793.1 [Q9QZZ4-3] CCDS48811.1 [Q9QZZ4-2] |
PIRi | A59295 T42386 |
RefSeqi | NP_001096641.1, NM_001103171.1 [Q9QZZ4-2] NP_034992.2, NM_010862.2 [Q9QZZ4-1] NP_874357.2, NM_182698.2 [Q9QZZ4-3] XP_017169821.1, XM_017314332.1 XP_017169822.1, XM_017314333.1 |
Genome annotation databases
Ensembli | ENSMUST00000071880; ENSMUSP00000071777; ENSMUSG00000042678 [Q9QZZ4-1] ENSMUST00000081823; ENSMUSP00000080507; ENSMUSG00000042678 [Q9QZZ4-3] ENSMUST00000094135; ENSMUSP00000091686; ENSMUSG00000042678 [Q9QZZ4-2] |
GeneIDi | 17910 |
KEGGi | mmu:17910 |
UCSCi | uc007jfz.1, mouse [Q9QZZ4-1] uc007jga.1, mouse [Q9QZZ4-3] uc007jgb.2, mouse [Q9QZZ4-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF144095 mRNA Translation: AAF05904.1 AY331132 mRNA Translation: AAP88402.1 AY331133 mRNA Translation: AAP88403.1 AL596090 Genomic DNA No translation available. AL596386 Genomic DNA No translation available. AF053130 mRNA Translation: AAC40124.1 AB014510 mRNA Translation: BAA36582.1 |
CCDSi | CCDS24792.1 [Q9QZZ4-1] CCDS24793.1 [Q9QZZ4-3] CCDS48811.1 [Q9QZZ4-2] |
PIRi | A59295 T42386 |
RefSeqi | NP_001096641.1, NM_001103171.1 [Q9QZZ4-2] NP_034992.2, NM_010862.2 [Q9QZZ4-1] NP_874357.2, NM_182698.2 [Q9QZZ4-3] XP_017169821.1, XM_017314332.1 XP_017169822.1, XM_017314333.1 |
3D structure databases
SMRi | Q9QZZ4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201662, 4 interactors |
IntActi | Q9QZZ4, 3 interactors |
MINTi | Q9QZZ4 |
STRINGi | 10090.ENSMUSP00000071777 |
PTM databases
iPTMneti | Q9QZZ4 |
PhosphoSitePlusi | Q9QZZ4 |
Proteomic databases
jPOSTi | Q9QZZ4 |
PaxDbi | Q9QZZ4 |
PRIDEi | Q9QZZ4 |
Protocols and materials databases
Antibodypediai | 58384, 25 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000071880; ENSMUSP00000071777; ENSMUSG00000042678 [Q9QZZ4-1] ENSMUST00000081823; ENSMUSP00000080507; ENSMUSG00000042678 [Q9QZZ4-3] ENSMUST00000094135; ENSMUSP00000091686; ENSMUSG00000042678 [Q9QZZ4-2] |
GeneIDi | 17910 |
KEGGi | mmu:17910 |
UCSCi | uc007jfz.1, mouse [Q9QZZ4-1] uc007jga.1, mouse [Q9QZZ4-3] uc007jgb.2, mouse [Q9QZZ4-2] |
Organism-specific databases
CTDi | 17910 |
MGIi | MGI:1261811, Myo15 |
Phylogenomic databases
eggNOGi | KOG4229, Eukaryota |
GeneTreei | ENSGT00940000155335 |
InParanoidi | Q9QZZ4 |
OMAi | SYPLAAC |
OrthoDBi | 14609at2759 |
PhylomeDBi | Q9QZZ4 |
TreeFami | TF316834 |
Miscellaneous databases
BioGRID-ORCSi | 17910, 4 hits in 17 CRISPR screens |
ChiTaRSi | Myo15, mouse |
PROi | PR:Q9QZZ4 |
RNActi | Q9QZZ4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042678, Expressed in internal ear and 57 other tissues |
ExpressionAtlasi | Q9QZZ4, baseline and differential |
Genevisiblei | Q9QZZ4, MM |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13201, FERM_C_MyoXV, 1 hit cd01387, MYSc_Myo15, 1 hit |
Gene3Di | 1.25.40.530, 2 hits 2.30.29.30, 2 hits 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR035487, MYO15A IPR001609, Myosin_head_motor_dom IPR041795, MyoXV_FERM_C IPR036057, MYSc_Myo15 IPR000857, MyTH4_dom IPR038185, MyTH4_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR22692:SF21, PTHR22692:SF21, 1 hit |
Pfami | View protein in Pfam PF00612, IQ, 2 hits PF00063, Myosin_head, 1 hit PF00784, MyTH4, 2 hits PF07653, SH3_2, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 3 hits SM00242, MYSc, 1 hit SM00139, MyTH4, 2 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF50044, SSF50044, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS50096, IQ, 2 hits PS51456, MYOSIN_MOTOR, 1 hit PS51016, MYTH4, 2 hits PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYO15_MOUSE | |
Accessioni | Q9QZZ4Primary (citable) accession number: Q9QZZ4 Secondary accession number(s): A2A637 Q9QWL6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | December 4, 2007 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families