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Protein

Serine racemase

Gene

Srr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.5 Publications

Catalytic activityi

L-serine = D-serine.4 Publications
D-serine = pyruvate + NH3.1 Publication
L-serine = pyruvate + NH3.3 Publications

Cofactori

pyridoxal 5'-phosphate2 Publications

Activity regulationi

Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51ATPCurated1
Active sitei56Proton acceptorBy similarity1
Active sitei84Proton acceptorBy similarity1
Binding sitei121ATPBy similarity1
Binding sitei135SubstrateBy similarity1
Metal bindingi210MagnesiumBy similarity1
Metal bindingi214Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi216MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Isomerase, Lyase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.3.1.17 3474
5.1.1.18 3474
ReactomeiR-MMU-977347 Serine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine racemase1 Publication (EC:5.1.1.184 Publications)
Alternative name(s):
D-serine ammonia-lyase
D-serine dehydratase (EC:4.3.1.181 Publication)
L-serine ammonia-lyase
L-serine dehydratase (EC:4.3.1.173 Publications)
Gene namesi
Name:Srr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1351636 Srr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi51K → A: Impairs ATP-binding inducing a 80% decrease in enzyme activity. 1
Mutagenesisi113C → S: Abolishes S-nitrosylation. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL1075306

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001856511 – 339Serine racemaseAdd BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei71PhosphothreonineCombined sources1
Modified residuei113S-nitrosocysteine1 Publication1

Post-translational modificationi

S-nitrosylated, leading to decrease the enzyme activity.1 Publication

Keywords - PTMi

Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbiQ9QZX7
PeptideAtlasiQ9QZX7
PRIDEiQ9QZX7

PTM databases

iPTMnetiQ9QZX7
PhosphoSitePlusiQ9QZX7

Expressioni

Tissue specificityi

Detected in brain (at protein level). Brain.

Gene expression databases

BgeeiENSMUSG00000001323 Expressed in 268 organ(s), highest expression level in liver
CleanExiMM_SRR
ExpressionAtlasiQ9QZX7 baseline and differential
GenevisibleiQ9QZX7 MM

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205172, 4 interactors
IntActiQ9QZX7, 2 interactors
MINTiQ9QZX7
STRINGi10090.ENSMUSP00000067552

Chemistry databases

BindingDBiQ9QZX7

Structurei

3D structure databases

ProteinModelPortaliQ9QZX7
SMRiQ9QZX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni238 – 239Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1250 Eukaryota
COG1171 LUCA
GeneTreeiENSGT00550000075026
HOVERGENiHBG023167
InParanoidiQ9QZX7
KOiK12235
OMAiLIHPFDH
OrthoDBiEOG091G0FSJ
PhylomeDBiQ9QZX7
TreeFamiTF313346

Family and domain databases

InterProiView protein in InterPro
IPR001926 PLP-dep
IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
PROSITEiView protein in PROSITE
PS00165 DEHYDRATASE_SER_THR, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QZX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCAQYCISFA DVEKAHINIQ DSIHLTPVLT SSILNQIAGR NLFFKCELFQ
60 70 80 90 100
KTGSFKIRGA LNAIRGLIPD TPEEKPKAVV THSSGNHGQA LTYAAKLEGI
110 120 130 140 150
PAYIVVPQTA PNCKKLAIQA YGASIVYCDP SDESREKVTQ RIMQETEGIL
160 170 180 190 200
VHPNQEPAVI AGQGTIALEV LNQVPLVDAL VVPVGGGGMV AGIAITIKAL
210 220 230 240 250
KPSVKVYAAE PSNADDCYQS KLKGELTPNL HPPETIADGV KSSIGLNTWP
260 270 280 290 300
IIRDLVDDVF TVTEDEIKYA TQLVWGRMKL LIEPTAGVAL AAVLSQHFQT
310 320 330
VSPEVKNVCI VLSGGNVDLT SLNWVGQAER PAPYQTVSV
Length:339
Mass (Da):36,359
Last modified:May 1, 2000 - v1
Checksum:iB9AE9A9336358728
GO
Isoform 2 (identifier: Q9QZX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-198: Missing.

Show »
Length:314
Mass (Da):34,030
Checksum:i0BB6492649FF8491
GO
Isoform 3 (identifier: Q9QZX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-339: Missing.

Note: No experimental confirmation available.
Show »
Length:182
Mass (Da):19,694
Checksum:i23075946C01AF288
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8Y5D6A8Y5D6_MOUSE
Serine racemase
Srr
113Annotation score:
Z4YMF3Z4YMF3_MOUSE
Serine racemase
Srr
166Annotation score:

Sequence cautioni

The sequence CAI24255 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111P → T in BAC25712 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025013174 – 198Missing in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_025014183 – 339Missing in isoform 3. CuratedAdd BLAST157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148321 mRNA Translation: AAF08701.1
AK031687 mRNA Translation: BAC27514.1
AK028034 mRNA Translation: BAC25712.1
AK043738 mRNA Translation: BAC31637.1
AK157122 mRNA Translation: BAE33968.1
AK170096 mRNA Translation: BAE41561.1
AL604066 Genomic DNA Translation: CAI24252.1
AL604066 Genomic DNA Translation: CAI24253.1
AL604066 Genomic DNA Translation: CAI24254.1
AL604066 Genomic DNA Translation: CAI24255.1 Sequence problems.
BC011164 mRNA Translation: AAH11164.1
AB232340 mRNA Translation: BAE19920.1
AB232341 mRNA Translation: BAE19921.1
AB232342 mRNA Translation: BAE19922.1
AB232343 mRNA Translation: BAE19923.1
AB235396 mRNA Translation: BAE44529.1
CCDSiCCDS25038.1 [Q9QZX7-1]
RefSeqiNP_001156783.1, NM_001163311.1 [Q9QZX7-1]
NP_038789.1, NM_013761.4 [Q9QZX7-1]
XP_006533520.1, XM_006533457.3 [Q9QZX7-1]
XP_017170058.1, XM_017314569.1 [Q9QZX7-1]
XP_017170059.1, XM_017314570.1 [Q9QZX7-1]
XP_017170060.1, XM_017314571.1 [Q9QZX7-1]
UniGeneiMm.131443
Mm.220843
Mm.412219

Genome annotation databases

EnsembliENSMUST00000065211; ENSMUSP00000067552; ENSMUSG00000001323 [Q9QZX7-1]
ENSMUST00000108447; ENSMUSP00000104086; ENSMUSG00000001323 [Q9QZX7-2]
ENSMUST00000108448; ENSMUSP00000104087; ENSMUSG00000001323 [Q9QZX7-1]
ENSMUST00000121738; ENSMUSP00000113372; ENSMUSG00000001323 [Q9QZX7-1]
ENSMUST00000128556; ENSMUSP00000120012; ENSMUSG00000001323 [Q9QZX7-3]
GeneIDi27364
KEGGimmu:27364
UCSCiuc007kcr.2 mouse [Q9QZX7-1]
uc011xzd.1 mouse [Q9QZX7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148321 mRNA Translation: AAF08701.1
AK031687 mRNA Translation: BAC27514.1
AK028034 mRNA Translation: BAC25712.1
AK043738 mRNA Translation: BAC31637.1
AK157122 mRNA Translation: BAE33968.1
AK170096 mRNA Translation: BAE41561.1
AL604066 Genomic DNA Translation: CAI24252.1
AL604066 Genomic DNA Translation: CAI24253.1
AL604066 Genomic DNA Translation: CAI24254.1
AL604066 Genomic DNA Translation: CAI24255.1 Sequence problems.
BC011164 mRNA Translation: AAH11164.1
AB232340 mRNA Translation: BAE19920.1
AB232341 mRNA Translation: BAE19921.1
AB232342 mRNA Translation: BAE19922.1
AB232343 mRNA Translation: BAE19923.1
AB235396 mRNA Translation: BAE44529.1
CCDSiCCDS25038.1 [Q9QZX7-1]
RefSeqiNP_001156783.1, NM_001163311.1 [Q9QZX7-1]
NP_038789.1, NM_013761.4 [Q9QZX7-1]
XP_006533520.1, XM_006533457.3 [Q9QZX7-1]
XP_017170058.1, XM_017314569.1 [Q9QZX7-1]
XP_017170059.1, XM_017314570.1 [Q9QZX7-1]
XP_017170060.1, XM_017314571.1 [Q9QZX7-1]
UniGeneiMm.131443
Mm.220843
Mm.412219

3D structure databases

ProteinModelPortaliQ9QZX7
SMRiQ9QZX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205172, 4 interactors
IntActiQ9QZX7, 2 interactors
MINTiQ9QZX7
STRINGi10090.ENSMUSP00000067552

Chemistry databases

BindingDBiQ9QZX7
ChEMBLiCHEMBL1075306

PTM databases

iPTMnetiQ9QZX7
PhosphoSitePlusiQ9QZX7

Proteomic databases

PaxDbiQ9QZX7
PeptideAtlasiQ9QZX7
PRIDEiQ9QZX7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065211; ENSMUSP00000067552; ENSMUSG00000001323 [Q9QZX7-1]
ENSMUST00000108447; ENSMUSP00000104086; ENSMUSG00000001323 [Q9QZX7-2]
ENSMUST00000108448; ENSMUSP00000104087; ENSMUSG00000001323 [Q9QZX7-1]
ENSMUST00000121738; ENSMUSP00000113372; ENSMUSG00000001323 [Q9QZX7-1]
ENSMUST00000128556; ENSMUSP00000120012; ENSMUSG00000001323 [Q9QZX7-3]
GeneIDi27364
KEGGimmu:27364
UCSCiuc007kcr.2 mouse [Q9QZX7-1]
uc011xzd.1 mouse [Q9QZX7-2]

Organism-specific databases

CTDi63826
MGIiMGI:1351636 Srr

Phylogenomic databases

eggNOGiKOG1250 Eukaryota
COG1171 LUCA
GeneTreeiENSGT00550000075026
HOVERGENiHBG023167
InParanoidiQ9QZX7
KOiK12235
OMAiLIHPFDH
OrthoDBiEOG091G0FSJ
PhylomeDBiQ9QZX7
TreeFamiTF313346

Enzyme and pathway databases

BRENDAi4.3.1.17 3474
5.1.1.18 3474
ReactomeiR-MMU-977347 Serine biosynthesis

Miscellaneous databases

PROiPR:Q9QZX7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001323 Expressed in 268 organ(s), highest expression level in liver
CleanExiMM_SRR
ExpressionAtlasiQ9QZX7 baseline and differential
GenevisibleiQ9QZX7 MM

Family and domain databases

InterProiView protein in InterPro
IPR001926 PLP-dep
IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
PROSITEiView protein in PROSITE
PS00165 DEHYDRATASE_SER_THR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRR_MOUSE
AccessioniPrimary (citable) accession number: Q9QZX7
Secondary accession number(s): Q401M7
, Q5SWE4, Q5SWE5, Q5SWE7, Q8BT19, Q8CD11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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