Motor neuron and pancreas homeobox protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
• sequence-specific double-stranded DNA binding Source: MGI

GO - Biological processⁱ

• cell morphogenesis involved in neuron differentiation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity."
    Arber S., Han B., Mendelsohn M., Smith M., Jessell T.M., Sockanathan S.
    Neuron 23:659-674(1999) [PubMed] [Europe PMC] [Abstract]
• central nervous system development Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• central nervous system neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity."
    Arber S., Han B., Mendelsohn M., Smith M., Jessell T.M., Sockanathan S.
    Neuron 23:659-674(1999) [PubMed] [Europe PMC] [Abstract]
• diaphragm development Source: MGIInferred from mutant phenotypeⁱ
  • "Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity."
    Arber S., Han B., Mendelsohn M., Smith M., Jessell T.M., Sockanathan S.
    Neuron 23:659-674(1999) [PubMed] [Europe PMC] [Abstract]
• dorsal/ventral neural tube patterning Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism."
    Cho A., Ko H.W., Eggenschwiler J.T.
    Dev Biol 321:27-39(2008) [PubMed] [Europe PMC] [Abstract]
• endocrine pancreas development Source: MGIInferred from mutant phenotypeⁱ
  • "Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9."
    Li H., Arber S., Jessell T.M., Edlund H.
    Nat Genet 23:67-70(1999) [PubMed] [Europe PMC] [Abstract]
• motor neuron axon guidance Source: MGIInferred from mutant phenotypeⁱ
  • "Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity."
    Arber S., Han B., Mendelsohn M., Smith M., Jessell T.M., Sockanathan S.
    Neuron 23:659-674(1999) [PubMed] [Europe PMC] [Abstract]
• nerve development Source: MGIInferred from mutant phenotypeⁱ
  • "Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation."
    Yang X., Arber S., William C., Li L., Tanabe Y., Jessell T.M., Birchmeier C., Burden S.J.
    Neuron 30:399-410(2001) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation."
    Yang X., Arber S., William C., Li L., Tanabe Y., Jessell T.M., Birchmeier C., Burden S.J.
    Neuron 30:399-410(2001) [PubMed] [Europe PMC] [Abstract]
• neuron migration Source: MGIInferred from mutant phenotypeⁱ
  • "Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity."
    Arber S., Han B., Mendelsohn M., Smith M., Jessell T.M., Sockanathan S.
    Neuron 23:659-674(1999) [PubMed] [Europe PMC] [Abstract]
• neuron projection morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity."
    Arber S., Han B., Mendelsohn M., Smith M., Jessell T.M., Sockanathan S.
    Neuron 23:659-674(1999) [PubMed] [Europe PMC] [Abstract]
• pancreas development Source: MGIInferred from mutant phenotypeⁱ
  • "Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9."
    Li H., Arber S., Jessell T.M., Edlund H.
    Nat Genet 23:67-70(1999) [PubMed] [Europe PMC] [Abstract]
• post-embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity."
    Arber S., Han B., Mendelsohn M., Smith M., Jessell T.M., Sockanathan S.
    Neuron 23:659-674(1999) [PubMed] [Europe PMC] [Abstract]
• respiratory system development Source: MGIInferred from mutant phenotypeⁱ
  • "Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity."
    Arber S., Han B., Mendelsohn M., Smith M., Jessell T.M., Sockanathan S.
    Neuron 23:659-674(1999) [PubMed] [Europe PMC] [Abstract]
• spinal cord motor neuron cell fate specification Source: MGIInferred from mutant phenotypeⁱ
  • "Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity."
    Arber S., Han B., Mendelsohn M., Smith M., Jessell T.M., Sockanathan S.
    Neuron 23:659-674(1999) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG 
        60         70         80         90        100
TSSGASRSCS PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA 
       110        120        130        140        150
GGGGGAAGGP GTPHHHAHPG AAAAAAAAAA AAAAGGLALG LHPGGAQGGA 
       160        170        180        190        200
GLPAQAALYG HPVYSYSAAA AAAALAGQHP ALSYSYPQVQ GAHPAHPADP 
       210        220        230        240        250
IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK CRRPRTAFTS 
       260        270        280        290        300
QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK 
       310        320        330        340        350
KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD 
       360        370        380        390        400
LRDSDPDEDE DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ 

PLPQ                                                   

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot