UniProtKB - Q9QZW9 (MNX1_MOUSE)
Protein
Motor neuron and pancreas homeobox protein 1
Gene
Mnx1
Organism
Mus musculus (Mouse)
Status
Functioni
Putative transcription factor involved in pancreas development and function.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 241 – 300 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell morphogenesis involved in neuron differentiation Source: MGI
- central nervous system development Source: GO_Central
- central nervous system neuron differentiation Source: MGI
- diaphragm development Source: MGI
- dorsal/ventral neural tube patterning Source: MGI
- endocrine pancreas development Source: MGI
- motor neuron axon guidance Source: MGI
- nerve development Source: MGI
- neuron differentiation Source: MGI
- neuron migration Source: MGI
- neuron projection morphogenesis Source: MGI
- pancreas development Source: MGI
- post-embryonic development Source: MGI
- respiratory system development Source: MGI
- spinal cord motor neuron cell fate specification Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Motor neuron and pancreas homeobox protein 1Alternative name(s): Homeobox protein HB9 |
Gene namesi | Name:Mnx1 Synonyms:Hlxb9 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109160, Mnx1 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Cytosol
- cytosol Source: MGI
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048906 | 1 – 404 | Motor neuron and pancreas homeobox protein 1Add BLAST | 404 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 78 | PhosphoserineBy similarity | 1 | |
Modified residuei | 80 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | Q9QZW9 |
PaxDbi | Q9QZW9 |
PRIDEi | Q9QZW9 |
PTM databases
iPTMneti | Q9QZW9 |
PhosphoSitePlusi | Q9QZW9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000001566, Expressed in thymus and 49 other tissues |
Genevisiblei | Q9QZW9, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000129503 |
Miscellaneous databases
RNActi | Q9QZW9, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 40 – 50 | Poly-GlyAdd BLAST | 11 | |
Compositional biasi | 99 – 105 | Poly-Gly | 7 | |
Compositional biasi | 121 – 134 | Poly-AlaAdd BLAST | 14 | |
Compositional biasi | 168 – 176 | Poly-Ala | 9 | |
Compositional biasi | 315 – 324 | Poly-Gly | 10 |
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000160059 |
InParanoidi | Q9QZW9 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR042768, MNX1/Ceh-12 |
PANTHERi | PTHR24335, PTHR24335, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9QZW9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG
60 70 80 90 100
TSSGASRSCS PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA
110 120 130 140 150
GGGGGAAGGP GTPHHHAHPG AAAAAAAAAA AAAAGGLALG LHPGGAQGGA
160 170 180 190 200
GLPAQAALYG HPVYSYSAAA AAAALAGQHP ALSYSYPQVQ GAHPAHPADP
210 220 230 240 250
IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK CRRPRTAFTS
260 270 280 290 300
QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK
310 320 330 340 350
KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD
360 370 380 390 400
LRDSDPDEDE DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ
PLPQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2RSX2 | A2RSX2_MOUSE | Motor neuron and pancreas homeobox ... | Mnx1 | 404 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 232 | E → Q in AAD49613 (PubMed:10471502).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF153046 mRNA Translation: AAD49613.1 AC164700 Genomic DNA No translation available. |
CCDSi | CCDS19150.1 |
Genome annotation databases
Ensembli | ENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF153046 mRNA Translation: AAD49613.1 AC164700 Genomic DNA No translation available. |
CCDSi | CCDS19150.1 |
3D structure databases
SMRi | Q9QZW9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000129503 |
PTM databases
iPTMneti | Q9QZW9 |
PhosphoSitePlusi | Q9QZW9 |
Proteomic databases
MaxQBi | Q9QZW9 |
PaxDbi | Q9QZW9 |
PRIDEi | Q9QZW9 |
Protocols and materials databases
Antibodypediai | 33173, 196 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566 |
Organism-specific databases
MGIi | MGI:109160, Mnx1 |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000160059 |
InParanoidi | Q9QZW9 |
Miscellaneous databases
PROi | PR:Q9QZW9 |
RNActi | Q9QZW9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001566, Expressed in thymus and 49 other tissues |
Genevisiblei | Q9QZW9, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR042768, MNX1/Ceh-12 |
PANTHERi | PTHR24335, PTHR24335, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MNX1_MOUSE | |
Accessioni | Q9QZW9Primary (citable) accession number: Q9QZW9 Secondary accession number(s): E9QPC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2004 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot