Mnx1

Functionⁱ

Putative transcription factor involved in pancreas development and function.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	241 – 300	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

sequence-specific DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell morphogenesis involved in neuron differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 10482234
central nervous system neuron differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 10482234
diaphragm development
Source: MGI
Inferred from mutant phenotypeⁱ
- 10482234
dorsal/ventral neural tube patterning
Source: MGI
Inferred from direct assayⁱ
- 18590716
endocrine pancreas development
Source: MGI
Inferred from mutant phenotypeⁱ
- 10471501
motor neuron axon guidance
Source: MGI
Inferred from mutant phenotypeⁱ
- 10482234
nerve development
Source: MGI
Inferred from mutant phenotypeⁱ
- 11395002
neuron differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 11395002
neuron migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 10482234
neuron projection morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 10482234
pancreas development
Source: MGI
Inferred from mutant phenotypeⁱ
- 10471501
post-embryonic development
Source: MGI
Inferred from mutant phenotypeⁱ
- 10482234
regulation of transcription, DNA-templated Source: InterPro
respiratory system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 10482234
spinal cord motor neuron cell fate specification
Source: MGI
Inferred from mutant phenotypeⁱ
- 10482234

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Motor neuron and pancreas homeobox protein 1 Alternative name(s): Homeobox protein HB9
Gene namesⁱ	Name:Mnx1 Synonyms:Hlxb9
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:109160 Mnx1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048906	1 – 404	Motor neuron and pancreas homeobox protein 1Add BLAST		404

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	78	PhosphoserineBy similarity	1
Modified residueⁱ	80	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9QZW9
PaxDbⁱ	Q9QZW9
PRIDEⁱ	Q9QZW9

PTM databases

iPTMnetⁱ	Q9QZW9
PhosphoSitePlusⁱ	Q9QZW9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000001566 Expressed in 39 organ(s), highest expression level in thymus
CleanExⁱ	MM_MNX1
ExpressionAtlasⁱ	Q9QZW9 baseline and differential
Genevisibleⁱ	Q9QZW9 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000129503

STRINGⁱ

10090.ENSMUSP00000129503

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QZW9
SMRⁱ	Q9QZW9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	40 – 50	Poly-GlyAdd BLAST	11
Compositional biasⁱ	99 – 105	Poly-Gly	7
Compositional biasⁱ	121 – 134	Poly-AlaAdd BLAST	14
Compositional biasⁱ	168 – 176	Poly-Ala	9
Compositional biasⁱ	315 – 324	Poly-Gly	10

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144024
HOGENOMⁱ	HOG000234345
HOVERGENⁱ	HBG051910
InParanoidⁱ	Q9QZW9
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PFO

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9QZW9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG 
        60         70         80         90        100
TSSGASRSCS PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA 
       110        120        130        140        150
GGGGGAAGGP GTPHHHAHPG AAAAAAAAAA AAAAGGLALG LHPGGAQGGA 
       160        170        180        190        200
GLPAQAALYG HPVYSYSAAA AAAALAGQHP ALSYSYPQVQ GAHPAHPADP 
       210        220        230        240        250
IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK CRRPRTAFTS 
       260        270        280        290        300
QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK 
       310        320        330        340        350
KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD 
       360        370        380        390        400
LRDSDPDEDE DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ 

PLPQ

Length:404

Mass (Da):41,331

Last modified:July 27, 2011 - v2

Checksum:ⁱ1D2B56CD645DB50A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A2RSX2	A2RSX2_MOUSE		Homeobox gene HB9 Homeobox gene HB9 (Motor neuron and pancreas homeobox 1) (Motor neuron and pancreas homeobox protein 1)	Mnx1 Hlxb9, mCG_7342	404	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	232	E → Q in AAD49613 (PubMed:10471502).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF153046 mRNA Translation: AAD49613.1 AC164700 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19150.1
UniGeneⁱ	Mm.103760

Genome annotation databases

Ensemblⁱ	ENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566

Ensemblⁱ

ENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QZW9	Homeobox gene HB9		MOUSE		404	UniRef90_Q9QZW9
Uncharacterized protein		NEOLE		403
Motor neuron and pancreas homeobox 1		RAT		402
UPI00042AF834		PERMB		404
UPI000A309997		MUSPA		404
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9QZW9	Motor neuron and pancreas homeobox protein 1		HUMAN		401	UniRef50_P50219
Uncharacterized protein		PANPA		149
Motor neuron and pancreas homeobox 1		FELCA		408
motor neuron and pancreas homeobox protein 1		TURTR		405
LOW QUALITY PROTEIN: motor neuron and pancreas homeobox protein 1		Enhydra lutris kenyoni		404
+47

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF153046 mRNA Translation: AAD49613.1 AC164700 Genomic DNA No translation available.
CCDSⁱ	CCDS19150.1
UniGeneⁱ	Mm.103760

3D structure databases

ProteinModelPortalⁱ	Q9QZW9
SMRⁱ	Q9QZW9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000129503

STRINGⁱ

10090.ENSMUSP00000129503

PTM databases

iPTMnetⁱ	Q9QZW9
PhosphoSitePlusⁱ	Q9QZW9

Proteomic databases

MaxQBⁱ	Q9QZW9
PaxDbⁱ	Q9QZW9
PRIDEⁱ	Q9QZW9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566

Ensemblⁱ

ENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566

Organism-specific databases

MGIⁱ	MGI:109160 Mnx1

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
GeneTreeⁱ	ENSGT00910000144024
HOGENOMⁱ	HOG000234345
HOVERGENⁱ	HBG051910
InParanoidⁱ	Q9QZW9
OrthoDBⁱ	EOG091G0PFO

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9QZW9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000001566 Expressed in 39 organ(s), highest expression level in thymus
CleanExⁱ	MM_MNX1
ExpressionAtlasⁱ	Q9QZW9 baseline and differential
Genevisibleⁱ	Q9QZW9 MM

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MNX1_MOUSE
Accessionⁱ	Q9QZW9Primary (citable) accession number: Q9QZW9 Secondary accession number(s): E9QPC0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QZW9 (MNX1_MOUSE)

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Motor neuron and pancreas homeobox protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ