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Protein

Motor neuron and pancreas homeobox protein 1

Gene

Mnx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative transcription factor involved in pancreas development and function.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi241 – 300HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Motor neuron and pancreas homeobox protein 1
Alternative name(s):
Homeobox protein HB9
Gene namesi
Name:Mnx1
Synonyms:Hlxb9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:109160 Mnx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489061 – 404Motor neuron and pancreas homeobox protein 1Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei80PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9QZW9
PaxDbiQ9QZW9
PRIDEiQ9QZW9

PTM databases

iPTMnetiQ9QZW9
PhosphoSitePlusiQ9QZW9

Expressioni

Gene expression databases

BgeeiENSMUSG00000001566 Expressed in 39 organ(s), highest expression level in thymus
CleanExiMM_MNX1
ExpressionAtlasiQ9QZW9 baseline and differential
GenevisibleiQ9QZW9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129503

Structurei

3D structure databases

ProteinModelPortaliQ9QZW9
SMRiQ9QZW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi40 – 50Poly-GlyAdd BLAST11
Compositional biasi99 – 105Poly-Gly7
Compositional biasi121 – 134Poly-AlaAdd BLAST14
Compositional biasi168 – 176Poly-Ala9
Compositional biasi315 – 324Poly-Gly10

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000234345
HOVERGENiHBG051910
InParanoidiQ9QZW9
OrthoDBiEOG091G0PFO

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QZW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG
60 70 80 90 100
TSSGASRSCS PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA
110 120 130 140 150
GGGGGAAGGP GTPHHHAHPG AAAAAAAAAA AAAAGGLALG LHPGGAQGGA
160 170 180 190 200
GLPAQAALYG HPVYSYSAAA AAAALAGQHP ALSYSYPQVQ GAHPAHPADP
210 220 230 240 250
IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK CRRPRTAFTS
260 270 280 290 300
QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK
310 320 330 340 350
KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD
360 370 380 390 400
LRDSDPDEDE DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ

PLPQ
Length:404
Mass (Da):41,331
Last modified:July 27, 2011 - v2
Checksum:i1D2B56CD645DB50A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2RSX2A2RSX2_MOUSE
Homeobox gene HB9
Mnx1 Hlxb9, mCG_7342
404Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232E → Q in AAD49613 (PubMed:10471502).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153046 mRNA Translation: AAD49613.1
AC164700 Genomic DNA No translation available.
CCDSiCCDS19150.1
UniGeneiMm.103760

Genome annotation databases

EnsembliENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153046 mRNA Translation: AAD49613.1
AC164700 Genomic DNA No translation available.
CCDSiCCDS19150.1
UniGeneiMm.103760

3D structure databases

ProteinModelPortaliQ9QZW9
SMRiQ9QZW9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129503

PTM databases

iPTMnetiQ9QZW9
PhosphoSitePlusiQ9QZW9

Proteomic databases

MaxQBiQ9QZW9
PaxDbiQ9QZW9
PRIDEiQ9QZW9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566

Organism-specific databases

MGIiMGI:109160 Mnx1

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000234345
HOVERGENiHBG051910
InParanoidiQ9QZW9
OrthoDBiEOG091G0PFO

Miscellaneous databases

PROiPR:Q9QZW9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001566 Expressed in 39 organ(s), highest expression level in thymus
CleanExiMM_MNX1
ExpressionAtlasiQ9QZW9 baseline and differential
GenevisibleiQ9QZW9 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMNX1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZW9
Secondary accession number(s): E9QPC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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