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Protein

NTF2-related export protein 1

Gene

Nxt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (By similarity).By similarity

GO - Molecular functioni

  • protein transporter activity Source: GO_Central
  • Ran GTPase binding Source: MGI

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript

Names & Taxonomyi

Protein namesi
Recommended name:
NTF2-related export protein 1
Gene namesi
Name:Nxt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1929619 Nxt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001947942 – 140NTF2-related export protein 1Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QZV9
MaxQBiQ9QZV9
PaxDbiQ9QZV9
PeptideAtlasiQ9QZV9
PRIDEiQ9QZV9

PTM databases

PhosphoSitePlusiQ9QZV9

Expressioni

Gene expression databases

BgeeiENSMUSG00000036992 Expressed in 286 organ(s), highest expression level in testis
CleanExiMM_NXT1
GenevisibleiQ9QZV9 MM

Interactioni

Subunit structurei

Heterodimer with NXF1. Forms a complex with RANGAP1, RANBP2/NUP358 and NXF1. Interacts (via NTF2 domain) with NXF1. Stabilizes the NTF2 domain of NXF1 by heterodimerization. The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export. Preferentially binds Ran-GTP. Associates with NXF2, NXF3 and NXF5. Does not bind nucleoporins (NPC) directly, its association to NPC is mediated by NXF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208013, 5 interactors
IntActiQ9QZV9, 1 interactor
STRINGi10090.ENSMUSP00000038329

Structurei

3D structure databases

ProteinModelPortaliQ9QZV9
SMRiQ9QZV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 135NTF2PROSITE-ProRule annotationAdd BLAST120

Phylogenomic databases

eggNOGiKOG4353 Eukaryota
ENOG4111TWR LUCA
GeneTreeiENSGT00510000046494
HOGENOMiHOG000231890
HOVERGENiHBG018207
InParanoidiQ9QZV9
KOiK14285
OMAiYYSTMDK
OrthoDBiEOG091G0SMX
PhylomeDBiQ9QZV9
TreeFamiTF318944

Family and domain databases

CDDicd00780 NTF2, 1 hit
InterProiView protein in InterPro
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
PROSITEiView protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVDFKTYV DQACRAAEEF VNVYYTTMDK RRRLLSRLYM GTATLVWNGN
60 70 80 90 100
AVSGQESLSE FFEMLPSSEF QISVVDCQPV HDDATPSQTT VLVVICGTVK
110 120 130 140
FEGNKQRDFN QNFILTAQAS PSNTVWKIAS DCFRFQDWAS
Length:140
Mass (Da):15,847
Last modified:March 1, 2001 - v2
Checksum:i358EAFDC19FE4594
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100K → N in BAB22670 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156958 mRNA Translation: AAD54943.2
AK003254 mRNA Translation: BAB22670.1
AK168314 mRNA Translation: BAE40254.1
BC023672 mRNA Translation: AAH23672.1
CCDSiCCDS16840.1
RefSeqiNP_001103629.1, NM_001110159.1
NP_062735.4, NM_019761.6
UniGeneiMm.34663

Genome annotation databases

EnsembliENSMUST00000047177; ENSMUSP00000038329; ENSMUSG00000036992
ENSMUST00000109961; ENSMUSP00000105587; ENSMUSG00000036992
GeneIDi56488
KEGGimmu:56488
UCSCiuc008mtf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156958 mRNA Translation: AAD54943.2
AK003254 mRNA Translation: BAB22670.1
AK168314 mRNA Translation: BAE40254.1
BC023672 mRNA Translation: AAH23672.1
CCDSiCCDS16840.1
RefSeqiNP_001103629.1, NM_001110159.1
NP_062735.4, NM_019761.6
UniGeneiMm.34663

3D structure databases

ProteinModelPortaliQ9QZV9
SMRiQ9QZV9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208013, 5 interactors
IntActiQ9QZV9, 1 interactor
STRINGi10090.ENSMUSP00000038329

PTM databases

PhosphoSitePlusiQ9QZV9

Proteomic databases

EPDiQ9QZV9
MaxQBiQ9QZV9
PaxDbiQ9QZV9
PeptideAtlasiQ9QZV9
PRIDEiQ9QZV9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047177; ENSMUSP00000038329; ENSMUSG00000036992
ENSMUST00000109961; ENSMUSP00000105587; ENSMUSG00000036992
GeneIDi56488
KEGGimmu:56488
UCSCiuc008mtf.2 mouse

Organism-specific databases

CTDi29107
MGIiMGI:1929619 Nxt1

Phylogenomic databases

eggNOGiKOG4353 Eukaryota
ENOG4111TWR LUCA
GeneTreeiENSGT00510000046494
HOGENOMiHOG000231890
HOVERGENiHBG018207
InParanoidiQ9QZV9
KOiK14285
OMAiYYSTMDK
OrthoDBiEOG091G0SMX
PhylomeDBiQ9QZV9
TreeFamiTF318944

Enzyme and pathway databases

ReactomeiR-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript

Miscellaneous databases

PROiPR:Q9QZV9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036992 Expressed in 286 organ(s), highest expression level in testis
CleanExiMM_NXT1
GenevisibleiQ9QZV9 MM

Family and domain databases

CDDicd00780 NTF2, 1 hit
InterProiView protein in InterPro
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
PROSITEiView protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNXT1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZV9
Secondary accession number(s): Q3THE3, Q9D1P7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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