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Protein

Ubiquitin/ISG15-conjugating enzyme E2 L6

Gene

Ube2l6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ISG15 transferase activity Source: MGI
  • ubiquitin binding Source: MGI
  • ubiquitin conjugating enzyme activity Source: GO_Central
  • ubiquitin-like protein transferase activity Source: MGI
  • ubiquitin protein ligase binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1169408 ISG15 antiviral mechanism
R-MMU-5656169 Termination of translesion DNA synthesis
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme L6
UbcM8
Ubiquitin carrier protein L6
Ubiquitin-protein ligase L6
Gene namesi
Name:Ube2l6
Synonyms:Ubce8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914500 Ube2l6

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000824791 – 153Ubiquitin/ISG15-conjugating enzyme E2 L6Add BLAST153

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9QZU9
PaxDbiQ9QZU9
PRIDEiQ9QZU9

PTM databases

iPTMnetiQ9QZU9
PhosphoSitePlusiQ9QZU9

Expressioni

Gene expression databases

BgeeiENSMUSG00000027078 Expressed in 98 organ(s), highest expression level in blood
CleanExiMM_UBE2L6
ExpressionAtlasiQ9QZU9 baseline and differential
GenevisibleiQ9QZU9 MM

Interactioni

Subunit structurei

Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099702

Structurei

3D structure databases

ProteinModelPortaliQ9QZU9
SMRiQ9QZU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0422 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455
HOVERGENiHBG063308
InParanoidiQ9QZU9
KOiK04553
OMAiSNENWKP
OrthoDBiEOG091G0QDO
TreeFamiTF313043

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QZU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMASKRVAKE LESLSKELPP YLRQLSSDDA NVLVWHMLLL PDQLPYGLKA
60 70 80 90 100
FQVRIDFPRE YPFKPPTLRF TTKIYHPNVR EDGLVCLPLI SNENWKPYTK
110 120 130 140 150
PYQVLEALNV LVSKPNLEEP VRLELADLLT QNPEMFRKKA EEFTLKFGVD

RPS
Length:153
Mass (Da):17,841
Last modified:May 26, 2009 - v3
Checksum:i71EEFF050CDE57F1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ATR9A2ATR9_MOUSE
Ubiquitin/ISG15-conjugating enzyme ...
Ube2l6
89Annotation score:

Sequence cautioni

The sequence AAD55978 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29D → Y in AAD55978 (Ref. 1) Curated1
Sequence conflicti63F → L in AAH08238 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159230 mRNA Translation: AAD55978.1 Different initiation.
AK010942 mRNA Translation: BAB27282.1
AK013452 mRNA Translation: BAB28861.1
AK152010 mRNA Translation: BAE30873.1
AK152113 mRNA Translation: BAE30957.1
AK168695 mRNA Translation: BAE40539.1
AK171629 mRNA Translation: BAE42574.1
CH466519 Genomic DNA Translation: EDL27303.1
BC008238 mRNA Translation: AAH08238.1
CCDSiCCDS16194.2
RefSeqiNP_064333.2, NM_019949.2
UniGeneiMm.38261

Genome annotation databases

EnsembliENSMUST00000102642; ENSMUSP00000099702; ENSMUSG00000027078
GeneIDi56791
KEGGimmu:56791
UCSCiuc012byn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159230 mRNA Translation: AAD55978.1 Different initiation.
AK010942 mRNA Translation: BAB27282.1
AK013452 mRNA Translation: BAB28861.1
AK152010 mRNA Translation: BAE30873.1
AK152113 mRNA Translation: BAE30957.1
AK168695 mRNA Translation: BAE40539.1
AK171629 mRNA Translation: BAE42574.1
CH466519 Genomic DNA Translation: EDL27303.1
BC008238 mRNA Translation: AAH08238.1
CCDSiCCDS16194.2
RefSeqiNP_064333.2, NM_019949.2
UniGeneiMm.38261

3D structure databases

ProteinModelPortaliQ9QZU9
SMRiQ9QZU9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099702

PTM databases

iPTMnetiQ9QZU9
PhosphoSitePlusiQ9QZU9

Proteomic databases

MaxQBiQ9QZU9
PaxDbiQ9QZU9
PRIDEiQ9QZU9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102642; ENSMUSP00000099702; ENSMUSG00000027078
GeneIDi56791
KEGGimmu:56791
UCSCiuc012byn.1 mouse

Organism-specific databases

CTDi9246
MGIiMGI:1914500 Ube2l6

Phylogenomic databases

eggNOGiKOG0422 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455
HOVERGENiHBG063308
InParanoidiQ9QZU9
KOiK04553
OMAiSNENWKP
OrthoDBiEOG091G0QDO
TreeFamiTF313043

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-1169408 ISG15 antiviral mechanism
R-MMU-5656169 Termination of translesion DNA synthesis
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiUbe2l6 mouse
PROiPR:Q9QZU9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027078 Expressed in 98 organ(s), highest expression level in blood
CleanExiMM_UBE2L6
ExpressionAtlasiQ9QZU9 baseline and differential
GenevisibleiQ9QZU9 MM

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUB2L6_MOUSE
AccessioniPrimary (citable) accession number: Q9QZU9
Secondary accession number(s): Q3U8R0, Q922F1, Q9CQN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 26, 2009
Last modified: November 7, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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