H2afy

Functionⁱ

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (By similarity). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (By similarity) (PubMed:16107708).By similarity1 Publication

Isoform 1: Binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation (By similarity). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728).By similarity1 Publication

Isoform 2: Represses SOD3 gene expression.1 Publication

GO - Molecular functionⁱ

chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 12082075
chromatin DNA binding Source: MGI
DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
double-stranded methylated DNA binding Source: MGI
enzyme binding Source: MGI
nucleosomal DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18936163
promoter-specific chromatin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18936163
protein heterodimerization activity Source: InterPro
protein kinase binding Source: MGI
protein serine/threonine kinase inhibitor activity Source: MGI
rDNA binding Source: MGI
RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
transcription regulatory region DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
dosage compensation
Source: MGI
Inferred from sequence orthologyⁱ
- 15053874
establishment of protein localization to chromatin Source: MGI
negative regulation of cell cycle G2/M phase transition Source: MGI
negative regulation of gene expression, epigenetic Source: MGI
negative regulation of histone H3-K27 methylation Source: MGI
negative regulation of histone H3-K4 methylation Source: MGI
negative regulation of histone phosphorylation Source: MGI
negative regulation of protein localization to chromosome, telomeric region Source: MGI
negative regulation of protein serine/threonine kinase activity Source: MGI
negative regulation of response to oxidative stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23022728
negative regulation of transcription by RNA polymerase II Source: MGI
negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24071584
nucleosome assembly Source: InterPro
positive regulation of gene expression, epigenetic Source: MGI
positive regulation of keratinocyte differentiation Source: MGI
positive regulation of maintenance of mitotic sister chromatid cohesion Source: MGI
positive regulation of response to oxidative stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23022728
regulation of gene expression, epigenetic Source: MGI
regulation of lipid metabolic process
Source: MGI
Inferred from direct assayⁱ
- 25526730
regulation of response to oxidative stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23022728

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, DNA-binding

Molecular function

Chromatin regulator, DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Core histone macro-H2A.1 Short name: Histone macroH2A1 Short name: mH2A1 Alternative name(s): H2A.y H2A/y
Gene namesⁱ	Name:H2afy
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:1349392 H2afy

Keywords - Cellular componentⁱ

Chromosome, Nucleosome core, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000227904	1 – 372	Core histone macro-H2A.1Add BLAST		372

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	18	N6-methyllysineBy similarity	1
Modified residueⁱ	116	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	116	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linkⁱ	117	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	123	N6,N6-dimethyllysine; alternateBy similarity	1
Modified residueⁱ	123	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	123	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	129	PhosphothreonineCombined sources	1
Cross-linkⁱ	167	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	170	PhosphoserineCombined sources	1
Modified residueⁱ	173	PhosphoserineCombined sources	1
Modified residueⁱ	178	PhosphothreonineCombined sources	1
Cross-linkⁱ	189	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	323	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationⁱ

Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9QZQ8
PaxDbⁱ	Q9QZQ8
PeptideAtlas More...PeptideAtlasⁱ	Q9QZQ8
PRIDEⁱ	Q9QZQ8

PTM databases

iPTMnetⁱ	Q9QZQ8
PhosphoSitePlusⁱ	Q9QZQ8
SwissPalmⁱ	Q9QZQ8

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with high levels in testis. Present in liver, kidney and adrenal gland (at protein level). In the liver, present in hepatocytes and at a lesser extent in cells of the bile ducts. In the kidney, expressed in proximal and distal convoluted tubules and in straight proximal tubules. In the adrenal gland, present in inner cells of the cortex and medulla.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000015937 Expressed in 326 organ(s), highest expression level in cochlea
CleanExⁱ	MM_H2AFY
Genevisibleⁱ	Q9QZQ8 MM

Interactionⁱ

Subunit structureⁱ

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with SPOP. Part of a complex consisting of H2AFY, CUL3 and SPOP. Interacts with HDAC1 and HDAC2 (By similarity).By similarity

GO - Molecular functionⁱ

enzyme binding Source: MGI
protein heterodimerization activity Source: InterPro
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	205061, 4 interactors
IntActⁱ	Q9QZQ8, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q9QZQ8
STRINGⁱ	10090.ENSMUSP00000016081

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QZQ8
SMRⁱ	Q9QZQ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 117	Histone H2AAdd BLAST		116
Domainⁱ	184 – 370	MacroPROSITE-ProRule annotationAdd BLAST		187

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	116 – 161	Lys-richAdd BLAST		46

Phylogenomic databases

eggNOGⁱ	ENOG410IV3A Eukaryota KOG1756 Eukaryota KOG2633 Eukaryota COG2110 LUCA COG5262 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143981
HOGENOMⁱ	HOG000234653
HOVERGENⁱ	HBG009342
InParanoidⁱ	Q9QZQ8
KEGG Orthology (KO) More...KOⁱ	K11251
OMAⁱ	HSEVSNL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XGD
PhylomeDBⁱ	Q9QZQ8
TreeFamⁱ	TF332276

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00074 H2A, 1 hit cd02904 Macro_H2A_like, 1 hit
Gene3Dⁱ	1.10.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR021171 Core_histone_macro-H2A IPR009072 Histone-fold IPR002119 Histone_H2A IPR007125 Histone_H2A/H2B/H3 IPR032454 Histone_H2A_C IPR002589 Macro_dom IPR035796 Macro_H2A
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00125 Histone, 1 hit PF16211 Histone_H2A_C, 1 hit PF01661 Macro, 1 hit
PIRSFⁱ	PIRSF037942 Core_histone_macro-H2A, 1 hit
PRINTSⁱ	PR00620 HISTONEH2A
SMARTⁱ	View protein in SMART SM00506 A1pp, 1 hit SM00414 H2A, 1 hit
SUPFAMⁱ	SSF47113 SSF47113, 1 hit
PROSITEⁱ	View protein in PROSITE PS51154 MACRO, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 2 (identifier: Q9QZQ8-1) [UniParc]FASTA Add to basket

Also known as: mH2A1.21 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSRGGKKKS TKTSRSAKAG VIFPVGRMLR YIKKGHPKYR IGVGAPVYMA 
        60         70         80         90        100
AVLEYLTAEI LELAGNAARD NKKGRVTPRH ILLAVANDEE LNQLLKGVTI 
       110        120        130        140        150
ASGGVLPNIH PELLAKKRGS KGKLEAIITP PPAKKAKSPS QKKPVAKKTG 
       160        170        180        190        200
GKKGARKSKK KQGEVSKAAS ADSTTEGTPT DGFTVLSTKS LFLGQKLNLI 
       210        220        230        240        250
HSEISNLAGF EVEAIINPTN ADIDLKDDLG NTLEKKGGKE FVEAVLELRK 
       260        270        280        290        300
KNGPLEVAGA AISAGHGLPA KFVIHCNSPV WGADKCEELL EKTVKNCLAL 
       310        320        330        340        350
ADDRKLKSIA FPSIGSGRNG FPKQTAAQLI LKAISSYFVS TMSSSIKTVY 
       360        370 
FMLFDSESIG IYVQEMAKLD AN

Note: Major form. The preferential expression of isoform 2 over that of isoform 1 requires the presence of DDX5/DDX17.1 Publication

Length:372

Mass (Da):39,735

Last modified:January 23, 2007 - v3

Checksum:ⁱ076CF76A34FACAA0

GO

Isoform 1 (identifier: Q9QZQ8-2) [UniParc]FASTA Add to basket

Also known as: mH2A1.11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
198-217: NLIHSEISNLAGFEVEAIIN → QVVQADIASIDSDAVVH
221-229: ADIDLKDDL → TDFYTGGEV

« Hide

        10         20         30         40         50
MSSRGGKKKS TKTSRSAKAG VIFPVGRMLR YIKKGHPKYR IGVGAPVYMA 
        60         70         80         90        100
AVLEYLTAEI LELAGNAARD NKKGRVTPRH ILLAVANDEE LNQLLKGVTI 
       110        120        130        140        150
ASGGVLPNIH PELLAKKRGS KGKLEAIITP PPAKKAKSPS QKKPVAKKTG 
       160        170        180        190        200
GKKGARKSKK KQGEVSKAAS ADSTTEGTPT DGFTVLSTKS LFLGQKLQVV 
       210        220        230        240        250
QADIASIDSD AVVHPTNTDF YTGGEVGNTL EKKGGKEFVE AVLELRKKNG 
       260        270        280        290        300
PLEVAGAAIS AGHGLPAKFV IHCNSPVWGA DKCEELLEKT VKNCLALADD 
       310        320        330        340        350
RKLKSIAFPS IGSGRNGFPK QTAAQLILKA ISSYFVSTMS SSIKTVYFML 
       360 
FDSESIGIYV QEMAKLDAN

Note: Preferentially expressed over isoform 2 in the absence of DDX5/DDX17.1 Publication

Show »

Length:369

Mass (Da):39,290

Checksum:ⁱ33F123DE5C9C46EC

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_017596	198 – 217	NLIHS…EAIIN → QVVQADIASIDSDAVVH in isoform 1. 2 PublicationsAdd BLAST		20
Alternative sequenceⁱVSP_017597	221 – 229	ADIDLKDDL → TDFYTGGEV in isoform 1. 2 Publications		9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF171080 mRNA Translation: AAD53745.1 AF171081 mRNA Translation: AAD53746.1 AB071988 mRNA Translation: BAB68541.1 BC006955 mRNA Translation: AAH06955.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS26557.1 [Q9QZQ8-1] CCDS49278.1 [Q9QZQ8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001152985.1, NM_001159513.1 NP_001152986.1, NM_001159514.1 [Q9QZQ8-2] NP_001152987.1, NM_001159515.1 NP_036145.1, NM_012015.2 [Q9QZQ8-1]
UniGeneⁱ	Mm.283802 Mm.478369

Genome annotation databases

Ensemblⁱ	ENSMUST00000016081; ENSMUSP00000016081; ENSMUSG00000015937 [Q9QZQ8-1] ENSMUST00000045788; ENSMUSP00000038221; ENSMUSG00000015937 [Q9QZQ8-2]
GeneIDⁱ	26914
KEGGⁱ	mmu:26914
UCSC genome browser More...UCSCⁱ	uc007qsf.2 mouse [Q9QZQ8-1] uc007qsg.2 mouse [Q9QZQ8-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QZQ8	Uncharacterized protein (Fragment)		MOUSE		40	UniRef100_Q9QZQ8

Protein	Similar proteins		Species	Score	Length	Source
Q9QZQ8	Core histone macro-H2A.1	)	HUMAN		372	UniRef90_O75367
Core histone macro-H2A.1		CHICK		372
Core histone macro-H2A.1	)	RAT		371
Core histone macro-H2A		MACMU		372
Core histone macro-H2A		PANTR		372
+432
Q9QZQ8-2	Uncharacterized protein (Fragment)		MICSU		406	UniRef90_Q9QZQ8-2
Core histone macro-H2A		XENTR		369
Core histone macro-H2A		XENLA		369
Core histone macro-H2A		LEPOC		369
Core histone macro-H2A		MESAU		369
+23

Protein	Similar proteins		Species	Score	Length	Source
Q9QZQ8	Core histone macro-H2A.1	)	HUMAN		372	UniRef50_O75367
Core histone macro-H2A.1		CHICK		372
Core histone macro-H2A.1	)	RAT		371
Core histone macro-H2A		MACMU		372
Core histone macro-H2A		PANTR		372
+510
Q9QZQ8-2	Uncharacterized protein (Fragment)		MICSU		406	UniRef50_Q9QZQ8-2
Core histone macro-H2A		XENLA		369
Core histone macro-H2A		LEPOC		369
Core histone macro-H2A		XENTR		369
Core histone macro-H2A		MESAU		369
+64

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF171080 mRNA Translation: AAD53745.1 AF171081 mRNA Translation: AAD53746.1 AB071988 mRNA Translation: BAB68541.1 BC006955 mRNA Translation: AAH06955.1
CCDSⁱ	CCDS26557.1 [Q9QZQ8-1] CCDS49278.1 [Q9QZQ8-2]
RefSeqⁱ	NP_001152985.1, NM_001159513.1 NP_001152986.1, NM_001159514.1 [Q9QZQ8-2] NP_001152987.1, NM_001159515.1 NP_036145.1, NM_012015.2 [Q9QZQ8-1]
UniGeneⁱ	Mm.283802 Mm.478369

3D structure databases

ProteinModelPortalⁱ	Q9QZQ8
SMRⁱ	Q9QZQ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	205061, 4 interactors
IntActⁱ	Q9QZQ8, 6 interactors
MINTⁱ	Q9QZQ8
STRINGⁱ	10090.ENSMUSP00000016081

PTM databases

iPTMnetⁱ	Q9QZQ8
PhosphoSitePlusⁱ	Q9QZQ8
SwissPalmⁱ	Q9QZQ8

Proteomic databases

EPDⁱ	Q9QZQ8
PaxDbⁱ	Q9QZQ8
PeptideAtlasⁱ	Q9QZQ8
PRIDEⁱ	Q9QZQ8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000016081; ENSMUSP00000016081; ENSMUSG00000015937 [Q9QZQ8-1] ENSMUST00000045788; ENSMUSP00000038221; ENSMUSG00000015937 [Q9QZQ8-2]
GeneIDⁱ	26914
KEGGⁱ	mmu:26914
UCSCⁱ	uc007qsf.2 mouse [Q9QZQ8-1] uc007qsg.2 mouse [Q9QZQ8-2]

Organism-specific databases

CTDⁱ	9555
MGIⁱ	MGI:1349392 H2afy

Phylogenomic databases

eggNOGⁱ	ENOG410IV3A Eukaryota KOG1756 Eukaryota KOG2633 Eukaryota COG2110 LUCA COG5262 LUCA
GeneTreeⁱ	ENSGT00910000143981
HOGENOMⁱ	HOG000234653
HOVERGENⁱ	HBG009342
InParanoidⁱ	Q9QZQ8
KOⁱ	K11251
OMAⁱ	HSEVSNL
OrthoDBⁱ	EOG091G0XGD
PhylomeDBⁱ	Q9QZQ8
TreeFamⁱ	TF332276

Miscellaneous databases

ChiTaRSⁱ	H2afy mouse
Protein Ontology More...PROⁱ	PR:Q9QZQ8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000015937 Expressed in 326 organ(s), highest expression level in cochlea
CleanExⁱ	MM_H2AFY
Genevisibleⁱ	Q9QZQ8 MM

Family and domain databases

CDDⁱ	cd00074 H2A, 1 hit cd02904 Macro_H2A_like, 1 hit
Gene3Dⁱ	1.10.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR021171 Core_histone_macro-H2A IPR009072 Histone-fold IPR002119 Histone_H2A IPR007125 Histone_H2A/H2B/H3 IPR032454 Histone_H2A_C IPR002589 Macro_dom IPR035796 Macro_H2A
Pfamⁱ	View protein in Pfam PF00125 Histone, 1 hit PF16211 Histone_H2A_C, 1 hit PF01661 Macro, 1 hit
PIRSFⁱ	PIRSF037942 Core_histone_macro-H2A, 1 hit
PRINTSⁱ	PR00620 HISTONEH2A
SMARTⁱ	View protein in SMART SM00506 A1pp, 1 hit SM00414 H2A, 1 hit
SUPFAMⁱ	SSF47113 SSF47113, 1 hit
PROSITEⁱ	View protein in PROSITE PS51154 MACRO, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H2AY_MOUSE
Accessionⁱ	Q9QZQ8Primary (citable) accession number: Q9QZQ8 Secondary accession number(s): Q91VZ2, Q9QZQ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QZQ8 (H2AY_MOUSE)

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Core histone macro-H2A.1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ