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UniProtKB - Q9QZQ0 (NPAS3_MOUSE)
Protein
Neuronal PAS domain-containing protein 3
Gene
Npas3
Organism
Mus musculus (Mouse)
Status
Functioni
May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness.
1 PublicationGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein heterodimerization activity Source: UniProtKB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- locomotory behavior Source: MGI
- maternal behavior Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- startle response Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Neuronal PAS domain-containing protein 3Short name: Neuronal PAS3 Alternative name(s): Basic-helix-loop-helix-PAS protein MOP6 Member of PAS protein 6 |
Gene namesi | Name:Npas3 Synonyms:Mop6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1351610, Npas3 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127409 | 1 – 925 | Neuronal PAS domain-containing protein 3Add BLAST | 925 |
Proteomic databases
MaxQBi | Q9QZQ0 |
PaxDbi | Q9QZQ0 |
PRIDEi | Q9QZQ0 |
ProteomicsDBi | 295509 |
PTM databases
iPTMneti | Q9QZQ0 |
PhosphoSitePlusi | Q9QZQ0 |
Expressioni
Tissue specificityi
Detected exclusively in adult brain in inhibitory interneurons.
Developmental stagei
Expression detected between 9.5 and 11.5 dpc in the developing neural tube. Was also expressed throughout the neuroepithelium of the developing central nervous system between 10. 5 and 12.5 dpc at 14.5 dpc, the expression became restricted to the neopallial layer of the cortex. At 12.5 dpc, expression was evident in nonneural tissues such as the developing dermis and mesenchyme surrounding the otic and nasal placodes. Expression was also detected in the developing cardiac valves, limb and developing kidney.
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
Interacts with ARNT; forms a heterodimer that binds core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:27782878).
1 PublicationGO - Molecular functioni
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000098975 |
Miscellaneous databases
RNActi | Q9QZQ0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 111 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 152 – 222 | PAS 1PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 324 – 394 | PAS 2PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 398 – 441 | PACAdd BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 60 – 71 | DNA-binding1 PublicationAdd BLAST | 12 | |
Regioni | 119 – 138 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 219 – 257 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 457 – 555 | DisorderedSequence analysisAdd BLAST | 99 | |
Regioni | 576 – 645 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 664 – 774 | DisorderedSequence analysisAdd BLAST | 111 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 229 – 257 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 461 – 511 | Basic and acidic residuesSequence analysisAdd BLAST | 51 | |
Compositional biasi | 525 – 548 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 576 – 598 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 601 – 617 | Basic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 664 – 699 | Polar residuesSequence analysisAdd BLAST | 36 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3558, Eukaryota |
InParanoidi | Q9QZQ0 |
PhylomeDBi | Q9QZQ0 |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3 |
Pfami | View protein in Pfam PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9QZQ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRAGAAANG TPQNVQGITS YQQRITAQHP LPNQSECRKI YRYDGIYCES
60 70 80 90 100
TYQNLQALRK EKSRDAARSR RGKENFEFYE LAKLLPLPAA ITSQLDKASI
110 120 130 140 150
IRLTISYLKM RDFANQGDPP WNLRMEGPPP NTSVKGAQRR RSPSALAIEV
160 170 180 190 200
FEAHLGSHIL QSLDGFVFAL NQEGKFLYIS ETVSIYLGLS QVELTGSSVF
210 220 230 240 250
DYVHPGDHVE MAEQLGMKLP PGRGLLSQGT TEDAASSASS SSQSETPEPV
260 270 280 290 300
ETTSPSLLTT DNTLERSFFI RMKSTLTKRG VHIKSSGYKV IHITGRLRLR
310 320 330 340 350
VPLSHGRTVP SQIMGLVVVA HALPPPTINE VRIDCHMFVT RVNMDLNIIY
360 370 380 390 400
CENRISDYMD LTPVDIVGKR CYHFIHAEDV EGIRHSHLDL LNKGQCVTKY
410 420 430 440 450
YRWMQKNGGY IWIQSSATIA INAKNANEKN IIWVNYLLSN PEYKDTPMDI
460 470 480 490 500
AQLPHLPEKA SESSETSDSE SDSKDTSGIT EDNENSKSDE KGNQSENSED
510 520 530 540 550
PEPDRKKSGS ACDNDMNCND DGHSSSNPDS RDSDDSFEHS DFEHPKAAED
560 570 580 590 600
GFGALGPMQI KVERYVESEA DLRLQPCESL TSDSAKDSDS ANEAGAQASS
610 620 630 640 650
KHQKRKRRRK RQKGGSASRR RLSSASSPGL DAGLVEPPRL LSSPHSASVL
660 670 680 690 700
KIKTEIAEPI NFDNESSIWN YPPNREISRN ESPYSMTKPP TSEHFPSPQG
710 720 730 740 750
QGGSIGGGGA LHVAIPDSVL TPPGADGTAG RKTQFSGTAP VPSDPLSPPL
760 770 780 790 800
SASPRDKHPG GGAGSGGGGP GASNSLLYTG DLEALQRLQA GNVVLPLVHR
810 820 830 840 850
VTGTLAATST AAQRVYTTGT IRYAPAEVTL AMQGNLLPNA HAVNFVDVNS
860 870 880 890 900
PGFGLDPKTP MEMLYHHVHR LNMSGPFGGA VSAASLTQMP GGNVFTTAEG
910 920
LFSTLPFPVY SNGIHAAQTL ERKED
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VQB2 | F8VQB2_MOUSE | Neuronal PAS domain-containing prot... | Npas3 | 925 | Annotation score: | ||
A0A1Y7VJG5 | A0A1Y7VJG5_MOUSE | Neuronal PAS domain-containing prot... | Npas3 | 923 | Annotation score: | ||
A0A1Y7VM06 | A0A1Y7VM06_MOUSE | Neuronal PAS domain-containing prot... | Npas3 | 907 | Annotation score: | ||
U5KBZ7 | U5KBZ7_MOUSE | Neuronal PAS domain protein 3 | Npas3 NPAS3 | 64 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 141 | R → L in AAG35181 (Ref. 2) Curated | 1 | |
Sequence conflicti | 156 | G → E in AAG35181 (Ref. 2) Curated | 1 | |
Sequence conflicti | 166 | F → L in AAG35181 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF173871 mRNA Translation: AAF14283.1 AF168769 mRNA Translation: AAG35181.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF173871 mRNA Translation: AAF14283.1 AF168769 mRNA Translation: AAG35181.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5SY7 | X-ray | 4.20 | B | 56-455 | [»] | |
AlphaFoldDBi | Q9QZQ0 | |||||
SMRi | Q9QZQ0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000098975 |
PTM databases
iPTMneti | Q9QZQ0 |
PhosphoSitePlusi | Q9QZQ0 |
Proteomic databases
MaxQBi | Q9QZQ0 |
PaxDbi | Q9QZQ0 |
PRIDEi | Q9QZQ0 |
ProteomicsDBi | 295509 |
Organism-specific databases
MGIi | MGI:1351610, Npas3 |
Phylogenomic databases
eggNOGi | KOG3558, Eukaryota |
InParanoidi | Q9QZQ0 |
PhylomeDBi | Q9QZQ0 |
Miscellaneous databases
ChiTaRSi | Npas3, mouse |
PROi | PR:Q9QZQ0 |
RNActi | Q9QZQ0, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3 |
Pfami | View protein in Pfam PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | NPAS3_MOUSE | |
Accessioni | Q9QZQ0Primary (citable) accession number: Q9QZQ0 Secondary accession number(s): Q9EQP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references