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Protein

Neuronal PAS domain-containing protein 3

Gene

Npas3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  • locomotory behavior Source: MGI
  • maternal behavior Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: GO_Central
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • startle response Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal PAS domain-containing protein 3
Short name:
Neuronal PAS3
Alternative name(s):
Basic-helix-loop-helix-PAS protein MOP6
Member of PAS protein 6
Gene namesi
Name:Npas3
Synonyms:Mop6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1351610 Npas3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274091 – 925Neuronal PAS domain-containing protein 3Add BLAST925

Proteomic databases

MaxQBiQ9QZQ0
PaxDbiQ9QZQ0
PRIDEiQ9QZQ0

PTM databases

iPTMnetiQ9QZQ0
PhosphoSitePlusiQ9QZQ0

Expressioni

Tissue specificityi

Detected exclusively in adult brain in inhibitory interneurons.

Developmental stagei

Expression detected between 9.5 and 11.5 dpc in the developing neural tube. Was also expressed throughout the neuroepithelium of the developing central nervous system between 10. 5 and 12.5 dpc at 14.5 dpc, the expression became restricted to the neopallial layer of the cortex. At 12.5 dpc, expression was evident in nonneural tissues such as the developing dermis and mesenchyme surrounding the otic and nasal placodes. Expression was also detected in the developing cardiac valves, limb and developing kidney.

Gene expression databases

CleanExiMM_NPAS3

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ARNT; forms a heterodimer that binds core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:27782878).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098975

Structurei

3D structure databases

ProteinModelPortaliQ9QZQ0
SMRiQ9QZQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 111bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini152 – 222PAS 1PROSITE-ProRule annotationAdd BLAST71
Domaini324 – 394PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini398 – 441PACAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 71DNA-binding1 PublicationAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi236 – 244Poly-Ser9
Compositional biasi706 – 709Poly-Gly4
Compositional biasi760 – 771Poly-GlyAdd BLAST12

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3558 Eukaryota
ENOG410YK57 LUCA
HOGENOMiHOG000113836
HOVERGENiHBG052656
InParanoidiQ9QZQ0
PhylomeDBiQ9QZQ0

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
PfamiView protein in Pfam
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9QZQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRAGAAANG TPQNVQGITS YQQRITAQHP LPNQSECRKI YRYDGIYCES
60 70 80 90 100
TYQNLQALRK EKSRDAARSR RGKENFEFYE LAKLLPLPAA ITSQLDKASI
110 120 130 140 150
IRLTISYLKM RDFANQGDPP WNLRMEGPPP NTSVKGAQRR RSPSALAIEV
160 170 180 190 200
FEAHLGSHIL QSLDGFVFAL NQEGKFLYIS ETVSIYLGLS QVELTGSSVF
210 220 230 240 250
DYVHPGDHVE MAEQLGMKLP PGRGLLSQGT TEDAASSASS SSQSETPEPV
260 270 280 290 300
ETTSPSLLTT DNTLERSFFI RMKSTLTKRG VHIKSSGYKV IHITGRLRLR
310 320 330 340 350
VPLSHGRTVP SQIMGLVVVA HALPPPTINE VRIDCHMFVT RVNMDLNIIY
360 370 380 390 400
CENRISDYMD LTPVDIVGKR CYHFIHAEDV EGIRHSHLDL LNKGQCVTKY
410 420 430 440 450
YRWMQKNGGY IWIQSSATIA INAKNANEKN IIWVNYLLSN PEYKDTPMDI
460 470 480 490 500
AQLPHLPEKA SESSETSDSE SDSKDTSGIT EDNENSKSDE KGNQSENSED
510 520 530 540 550
PEPDRKKSGS ACDNDMNCND DGHSSSNPDS RDSDDSFEHS DFEHPKAAED
560 570 580 590 600
GFGALGPMQI KVERYVESEA DLRLQPCESL TSDSAKDSDS ANEAGAQASS
610 620 630 640 650
KHQKRKRRRK RQKGGSASRR RLSSASSPGL DAGLVEPPRL LSSPHSASVL
660 670 680 690 700
KIKTEIAEPI NFDNESSIWN YPPNREISRN ESPYSMTKPP TSEHFPSPQG
710 720 730 740 750
QGGSIGGGGA LHVAIPDSVL TPPGADGTAG RKTQFSGTAP VPSDPLSPPL
760 770 780 790 800
SASPRDKHPG GGAGSGGGGP GASNSLLYTG DLEALQRLQA GNVVLPLVHR
810 820 830 840 850
VTGTLAATST AAQRVYTTGT IRYAPAEVTL AMQGNLLPNA HAVNFVDVNS
860 870 880 890 900
PGFGLDPKTP MEMLYHHVHR LNMSGPFGGA VSAASLTQMP GGNVFTTAEG
910 920
LFSTLPFPVY SNGIHAAQTL ERKED
Length:925
Mass (Da):100,458
Last modified:May 1, 2000 - v1
Checksum:iB6B07C9B6755B938
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VQB2F8VQB2_MOUSE
Neuronal PAS domain-containing prot...
Npas3
925Annotation score:
A0A1Y7VJG5A0A1Y7VJG5_MOUSE
Neuronal PAS domain-containing prot...
Npas3
894Annotation score:
A0A1Y7VM06A0A1Y7VM06_MOUSE
Neuronal PAS domain-containing prot...
Npas3
907Annotation score:
U5KBZ7U5KBZ7_MOUSE
Neuronal PAS domain protein 3
Npas3 NPAS3
64Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141R → L in AAG35181 (Ref. 2) Curated1
Sequence conflicti156G → E in AAG35181 (Ref. 2) Curated1
Sequence conflicti166F → L in AAG35181 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173871 mRNA Translation: AAF14283.1
AF168769 mRNA Translation: AAG35181.1
CCDSiCCDS25907.1
UniGeneiMm.247044
Mm.466545

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173871 mRNA Translation: AAF14283.1
AF168769 mRNA Translation: AAG35181.1
CCDSiCCDS25907.1
UniGeneiMm.247044
Mm.466545

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SY7X-ray4.20B56-455[»]
ProteinModelPortaliQ9QZQ0
SMRiQ9QZQ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098975

PTM databases

iPTMnetiQ9QZQ0
PhosphoSitePlusiQ9QZQ0

Proteomic databases

MaxQBiQ9QZQ0
PaxDbiQ9QZQ0
PRIDEiQ9QZQ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1351610 Npas3

Phylogenomic databases

eggNOGiKOG3558 Eukaryota
ENOG410YK57 LUCA
HOGENOMiHOG000113836
HOVERGENiHBG052656
InParanoidiQ9QZQ0
PhylomeDBiQ9QZQ0

Miscellaneous databases

ChiTaRSiNpas3 mouse
PROiPR:Q9QZQ0
SOURCEiSearch...

Gene expression databases

CleanExiMM_NPAS3

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
PfamiView protein in Pfam
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNPAS3_MOUSE
AccessioniPrimary (citable) accession number: Q9QZQ0
Secondary accession number(s): Q9EQP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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