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Protein

Cannabinoid receptor 2

Gene

Cnr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis (By similarity).By similarity

GO - Molecular functioni

  • cannabinoid receptor activity Source: RGD
  • G-protein coupled receptor activity Source: RGD

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: RGD
  • inflammatory response Source: UniProtKB-KW
  • negative regulation of action potential Source: RGD
  • negative regulation of inflammatory response Source: RGD
  • negative regulation of mast cell activation Source: RGD
  • negative regulation of nitric-oxide synthase activity Source: RGD
  • negative regulation of synaptic transmission, GABAergic Source: RGD
  • response to amphetamine Source: RGD
  • response to lipopolysaccharide Source: RGD
  • sensory perception of pain Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-RNO-373076 Class A/1 (Rhodopsin-like receptors)
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Cannabinoid receptor 2
Short name:
CB-2
Short name:
CB2
Short name:
rCB2
Gene namesi
Name:Cnr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi619713 Cnr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 59Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini60 – 71CytoplasmicSequence analysisAdd BLAST12
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 104ExtracellularSequence analysisAdd BLAST12
Transmembranei105 – 129Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 172Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini173 – 188ExtracellularSequence analysisAdd BLAST16
Transmembranei189 – 214Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini215 – 246CytoplasmicSequence analysisAdd BLAST32
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 279ExtracellularSequence analysisAdd BLAST12
Transmembranei280 – 301Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini302 – 360CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2470

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693251 – 360Cannabinoid receptor 2Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei335PhosphoserineBy similarity1
Modified residuei336PhosphoserineBy similarity1
Modified residuei338PhosphothreonineBy similarity1
Modified residuei352PhosphoserineBy similarity1

Post-translational modificationi

Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9QZN9

PTM databases

PhosphoSitePlusiQ9QZN9

Expressioni

Tissue specificityi

Expressed in spleen and brain by neurons and glial cells (at protein level). Expressed in lung, testis and thymus but not in heart, liver or kidney. Expressed in cerebellum, cortex and brainstem.4 Publications

Gene expression databases

BgeeiENSRNOG00000009260
ExpressionAtlasiQ9QZN9 baseline and differential
GenevisibleiQ9QZN9 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012342

Chemistry databases

BindingDBiQ9QZN9

Structurei

3D structure databases

ProteinModelPortaliQ9QZN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000049272
HOVERGENiHBG051045
InParanoidiQ9QZN9
KOiK04278
OMAiVNFHVFH
OrthoDBiEOG091G05O3
PhylomeDBiQ9QZN9
TreeFamiTF330052

Family and domain databases

CDDicd15341 7tmA_CB2, 1 hit
InterProiView protein in InterPro
IPR001551 Canbinoid_rcpt_2
IPR002230 Cnbnoid_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR22750:SF10 PTHR22750:SF10, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00523 CANABINOID2R
PR00362 CANNABINOIDR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QZN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGCRELELT NGSNGGLEFN PMKEYMILSD AQQIAVAVLC TLMGLLSALE
60 70 80 90 100
NVAVLYLILS SQRLRRKPSY LFIGSLAGAD FLASVIFACN FVIFHVFHGV
110 120 130 140 150
DSRNIFLLKI GSVTMTFTAS VGSLLLTAVD RYLCLCYPPT YKALVTRGRA
160 170 180 190 200
LVALGVMWVL SALISYLPLM GWTCCPSPCS ELFPLIPNDY LLGWLLFIAI
210 220 230 240 250
LFSGIIYTYG YVLWKAHQHV ASLAEHQDRQ VPGIARMRLD VRLAKTLGLV
260 270 280 290 300
MAVLLICWFP ALALMGHSLV TTLSDKVKEA FAFCSMLCLV NSMINPIIYA
310 320 330 340 350
LRSGEIRSAA QHCLTGWKKY LQGLGSEGKE EAPKSSVTET EAEVKTTTGP
360
GSRTPGCSNC
Note: No experimental confirmation available.
Length:360
Mass (Da):39,359
Last modified:February 10, 2009 - v3
Checksum:iE523C77055B24BE0
GO
Isoform 2 (identifier: Q9QZN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-360: VKTTTGPGSRTPGCSNC → TLVLKDKQEL...PNKAGQSTLL

Show »
Length:410
Mass (Da):45,163
Checksum:iAA1D8C55E78BF8B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti224A → T in AAG09710 (PubMed:12084572).Curated1
Sequence conflicti224A → T in AAG22010 (PubMed:12084572).Curated1
Sequence conflicti224A → T in AAG22011 (PubMed:12084572).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036231344 – 360VKTTT…GCSNC → TLVLKDKQELGGDCLLRTSS IHSPMLSLADSANRQDVRPH CPEELTWWCSVRRPISLPNK AGQSTLL in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176350 Genomic DNA Translation: AAF08535.1
AF218846 mRNA Translation: AAG09710.1
AF286721 Genomic DNA Translation: AAG22010.1
AF286722 Genomic DNA Translation: AAG22011.1
RefSeqiNP_001157614.1, NM_001164142.3 [Q9QZN9-1]
NP_001157615.1, NM_001164143.3 [Q9QZN9-1]
NP_065418.3, NM_020543.4 [Q9QZN9-2]
XP_017449092.1, XM_017593603.1 [Q9QZN9-2]
UniGeneiRn.48776

Genome annotation databases

EnsembliENSRNOT00000012342; ENSRNOP00000012342; ENSRNOG00000009260 [Q9QZN9-2]
ENSRNOT00000074998; ENSRNOP00000066697; ENSRNOG00000009260 [Q9QZN9-1]
GeneIDi57302
KEGGirno:57302
UCSCiRGD:619713 rat [Q9QZN9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCNR2_RAT
AccessioniPrimary (citable) accession number: Q9QZN9
Secondary accession number(s): Q9EP74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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