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Protein

F-box only protein 6

Gene

Fbxo6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans.By similarity2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • carbohydrate binding Source: MGI
  • ubiquitin-protein transferase activity Source: MGI

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair, Ubl conjugation pathway, Unfolded protein response

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 6
Alternative name(s):
F-box only protein 6b
F-box protein that recognizes sugar chains 2
F-box/G-domain protein 2
Gene namesi
Name:Fbxo6
Synonyms:Fbs2, Fbxo6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1354743 Fbxo6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198831 – 295F-box only protein 6Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249PhosphoserineBy similarity1
Modified residuei276PhosphoserineCombined sources1
Modified residuei280PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9QZN4
MaxQBiQ9QZN4
PaxDbiQ9QZN4
PeptideAtlasiQ9QZN4
PRIDEiQ9QZN4

PTM databases

iPTMnetiQ9QZN4
PhosphoSitePlusiQ9QZN4

Expressioni

Tissue specificityi

Present in liver and kidney (at protein level). Widely expressed.2 Publications

Developmental stagei

Weakly expressed in embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000055401 Expressed in 27 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_FBXO6
ExpressionAtlasiQ9QZN4 baseline and differential
GenevisibleiQ9QZN4 MM

Interactioni

Subunit structurei

Interacts with CHEK1 and CUL1 (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with VCP.By similarity2 Publications

Protein-protein interaction databases

BioGridi206095, 4 interactors
IntActiQ9QZN4, 2 interactors
MINTiQ9QZN4
STRINGi10090.ENSMUSP00000030858

Structurei

3D structure databases

ProteinModelPortaliQ9QZN4
SMRiQ9QZN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 48F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini69 – 250FBAPROSITE-ProRule annotationAdd BLAST182

Phylogenomic databases

eggNOGiENOG410IK6V Eukaryota
ENOG4111MF5 LUCA
GeneTreeiENSGT00390000003865
HOVERGENiHBG003593
InParanoidiQ9QZN4
KOiK10100
OrthoDBiEOG091G0G3L
PhylomeDBiQ9QZN4
TreeFamiTF320527

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039752 F-box_only
IPR008979 Galactose-bd-like_sf
PANTHERiPTHR12125 PTHR12125, 1 hit
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SM00256 FBOX, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9QZN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVHINELPEN ILLELFIHIP APQLLRNCRL VCRLWRDLID VVSLWKRKSL
60 70 80 90 100
REGFFTKDRC EPVEDWKVFY ILCSLQRNLL RNPCAEENLS SWRIDSNGGD
110 120 130 140 150
RWKVETLPGS CGTSFPDNKV KKYFVTSFEM CLKSQMVDLK AEGYCEELMD
160 170 180 190 200
TFRPDIVVKD WVAPRADCGC TYQLRVQLAS ADYIVLASFE PPPVTFQQWN
210 220 230 240 250
DAKWQEISHT FSDYPPGVRH ILFQHGGQDT QFWKGWYGPR VTNSSIIISH
260 270 280 290
RTAKNPPPAR TLPEETVVIG RRRRASDSNT HEGFFWQGLW QRLRR
Length:295
Mass (Da):34,493
Last modified:May 1, 2000 - v1
Checksum:iD515D3C25CC73B22
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A7H1A2A7H1_MOUSE
F-box only protein 6
Fbxo6
237Annotation score:
A2A7G9A2A7G9_MOUSE
F-box only protein 6
Fbxo6
228Annotation score:
Z4YN00Z4YN00_MOUSE
F-box only protein 6
Fbxo6
265Annotation score:
A2A7H3A2A7H3_MOUSE
F-box only protein 6
Fbxo6
64Annotation score:

Sequence cautioni

The sequence CAM14908 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAQ51914 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAQ52206 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77R → K in CAQ52204 (PubMed:19468303).Curated1
Sequence conflicti77R → K in CAQ52206 (PubMed:19468303).Curated1
Sequence conflicti77R → K in CAQ51912 (PubMed:19468303).Curated1
Sequence conflicti77R → K in CAQ51914 (PubMed:19468303).Curated1
Sequence conflicti77R → K in EDL14807 (Ref. 4) Curated1
Sequence conflicti77R → K in EDL14805 (Ref. 4) Curated1
Sequence conflicti77R → K in EDL14804 (Ref. 4) Curated1
Sequence conflicti252T → A in BAE29703 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176526 mRNA Translation: AAF09135.1
AK002840 mRNA Translation: BAB22397.1
AK150612 mRNA Translation: BAE29703.1
AK152888 mRNA Translation: BAE31571.1
AK165867 mRNA Translation: BAE38426.1
AK170743 mRNA Translation: BAE41996.1
AK171483 mRNA Translation: BAE42484.1
AL606929 Genomic DNA Translation: CAM14906.1
AL606929 Genomic DNA Translation: CAM14908.1 Sequence problems.
CU207376, CU207417 Genomic DNA Translation: CAQ51912.1
CU207376, CU207417 Genomic DNA Translation: CAQ51914.1 Sequence problems.
CU207417, CU207376 Genomic DNA Translation: CAQ52204.1
CU207417, CU207376 Genomic DNA Translation: CAQ52206.1 Sequence problems.
CH466594 Genomic DNA Translation: EDL14804.1
CH466594 Genomic DNA Translation: EDL14805.1
CH466594 Genomic DNA Translation: EDL14807.1
BC017512 mRNA Translation: AAH17512.1
CCDSiCCDS18933.1
RefSeqiNP_001157176.1, NM_001163704.1
NP_001157177.1, NM_001163705.1
NP_001157178.1, NM_001163706.1
NP_001157179.1, NM_001163707.1
NP_056612.1, NM_015797.4
UniGeneiMm.27445

Genome annotation databases

EnsembliENSMUST00000030858; ENSMUSP00000030858; ENSMUSG00000055401
ENSMUST00000056965; ENSMUSP00000062348; ENSMUSG00000055401
ENSMUST00000105706; ENSMUSP00000101331; ENSMUSG00000055401
ENSMUST00000168503; ENSMUSP00000130188; ENSMUSG00000055401
GeneIDi50762
KEGGimmu:50762
UCSCiuc008vud.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176526 mRNA Translation: AAF09135.1
AK002840 mRNA Translation: BAB22397.1
AK150612 mRNA Translation: BAE29703.1
AK152888 mRNA Translation: BAE31571.1
AK165867 mRNA Translation: BAE38426.1
AK170743 mRNA Translation: BAE41996.1
AK171483 mRNA Translation: BAE42484.1
AL606929 Genomic DNA Translation: CAM14906.1
AL606929 Genomic DNA Translation: CAM14908.1 Sequence problems.
CU207376, CU207417 Genomic DNA Translation: CAQ51912.1
CU207376, CU207417 Genomic DNA Translation: CAQ51914.1 Sequence problems.
CU207417, CU207376 Genomic DNA Translation: CAQ52204.1
CU207417, CU207376 Genomic DNA Translation: CAQ52206.1 Sequence problems.
CH466594 Genomic DNA Translation: EDL14804.1
CH466594 Genomic DNA Translation: EDL14805.1
CH466594 Genomic DNA Translation: EDL14807.1
BC017512 mRNA Translation: AAH17512.1
CCDSiCCDS18933.1
RefSeqiNP_001157176.1, NM_001163704.1
NP_001157177.1, NM_001163705.1
NP_001157178.1, NM_001163706.1
NP_001157179.1, NM_001163707.1
NP_056612.1, NM_015797.4
UniGeneiMm.27445

3D structure databases

ProteinModelPortaliQ9QZN4
SMRiQ9QZN4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206095, 4 interactors
IntActiQ9QZN4, 2 interactors
MINTiQ9QZN4
STRINGi10090.ENSMUSP00000030858

PTM databases

iPTMnetiQ9QZN4
PhosphoSitePlusiQ9QZN4

Proteomic databases

EPDiQ9QZN4
MaxQBiQ9QZN4
PaxDbiQ9QZN4
PeptideAtlasiQ9QZN4
PRIDEiQ9QZN4

Protocols and materials databases

DNASUi50762
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030858; ENSMUSP00000030858; ENSMUSG00000055401
ENSMUST00000056965; ENSMUSP00000062348; ENSMUSG00000055401
ENSMUST00000105706; ENSMUSP00000101331; ENSMUSG00000055401
ENSMUST00000168503; ENSMUSP00000130188; ENSMUSG00000055401
GeneIDi50762
KEGGimmu:50762
UCSCiuc008vud.2 mouse

Organism-specific databases

CTDi26270
MGIiMGI:1354743 Fbxo6

Phylogenomic databases

eggNOGiENOG410IK6V Eukaryota
ENOG4111MF5 LUCA
GeneTreeiENSGT00390000003865
HOVERGENiHBG003593
InParanoidiQ9QZN4
KOiK10100
OrthoDBiEOG091G0G3L
PhylomeDBiQ9QZN4
TreeFamiTF320527

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFbxo2 mouse
PROiPR:Q9QZN4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055401 Expressed in 27 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_FBXO6
ExpressionAtlasiQ9QZN4 baseline and differential
GenevisibleiQ9QZN4 MM

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039752 F-box_only
IPR008979 Galactose-bd-like_sf
PANTHERiPTHR12125 PTHR12125, 1 hit
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SM00256 FBOX, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX6_MOUSE
AccessioniPrimary (citable) accession number: Q9QZN4
Secondary accession number(s): A2A7H0
, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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