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Protein

F-box/LRR-repeat protein 17

Gene

Fbxl17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 17
Alternative name(s):
F-box and leucine-rich repeat protein 17
F-box only protein 13
Gene namesi
Name:Fbxl17
Synonyms:Fbl17, Fbx13, Fbxo13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1354704 Fbxl17

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198661 – 701F-box/LRR-repeat protein 17Add BLAST701

Proteomic databases

PaxDbiQ9QZN1
PeptideAtlasiQ9QZN1
PRIDEiQ9QZN1

PTM databases

iPTMnetiQ9QZN1
PhosphoSitePlusiQ9QZN1

Expressioni

Gene expression databases

BgeeiENSMUSG00000023965 Expressed in 240 organ(s), highest expression level in cumulus cell
CleanExiMM_FBXL17
ExpressionAtlasiQ9QZN1 baseline and differential
GenevisibleiQ9QZN1 MM

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi206092, 1 interactor
STRINGi10090.ENSMUSP00000024761

Structurei

3D structure databases

ProteinModelPortaliQ9QZN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini318 – 365F-boxPROSITE-ProRule annotationAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 28Poly-Arg4
Compositional biasi84 – 89Poly-Pro6
Compositional biasi93 – 150Ala-richAdd BLAST58
Compositional biasi181 – 326Pro-richAdd BLAST146
Compositional biasi217 – 235Gly-richAdd BLAST19

Phylogenomic databases

eggNOGiKOG1947 Eukaryota
ENOG410XQ54 LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000169154
HOVERGENiHBG107935
InParanoidiQ9QZN1
KOiK10283
OMAiWSINDRC
OrthoDBiEOG091G0KDW
PhylomeDBiQ9QZN1
TreeFamiTF332421

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 11 hits
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QZN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGHLLSKEPR NRPSQKRPRC CSWCRRRRPL LRLPRRALAK ASPQPAAPRS
60 70 80 90 100
RDCFFRGPCM LCFIVHSPGA PASAGLEEEP PLSPPPPPPR DGAYAAVSSQ
110 120 130 140 150
HLARRYAALA AEDCAAAARR FLLSSAAAAA AAASSPASCC KELGLAAAAA
160 170 180 190 200
WEQQGRSLFL AGVGPVRFLG PLAAVQLFRA PPAPPPQAEP ATALEMVCKR
210 220 230 240 250
KGAGVPACTP CKQPRCGCGG CGGGGGGGGG PAGGGASPPR PPDAGCCQAP
260 270 280 290 300
EQPPPPLCPA PASPASECAP IVAAAGDTVR AGGTAPSSAQ QQPESGDADC
310 320 330 340 350
QEPPENPCDC HREPPPEIPD INQLPPSILL KIFSNLSLNE RCLSASLVCK
360 370 380 390 400
YWRDLCLDFQ FWKQLDLSSR QQVTDELLEK IASRSQNIIE INISDCRSLS
410 420 430 440 450
DSGVCVLAFK CPGLLRYTAY RCKQLSDTSI IAVASHCPLL QKVHVGNQDK
460 470 480 490 500
LTDEGLKQLG SRCRELKDIH FGQCYKISDE GMIVIAKSCL KLQRIYMQEN
510 520 530 540 550
KLVTDQSVKA FAEHCPELQY VGFMGCSVTS KGVIHLTKLR NLSSLDLRHI
560 570 580 590 600
TELDNETVME IVKRCKNLSS LNLCLNWIIN DRCVEVIAKE GQNLKELYLV
610 620 630 640 650
SCKITDYALI AIGRYSVTIE TVDVGWCKEI TDQGATLIAQ SSKSLRYLGL
660 670 680 690 700
MRCDKVNELT VEQLVQQYPH ITFSTVLQDC KRTLERAYQM GWTPNMSAAT

S
Length:701
Mass (Da):75,683
Last modified:May 5, 2009 - v3
Checksum:i314208800D0063CC
GO
Isoform 2 (identifier: Q9QZN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-474: Missing.
     475-502: YKISDEGMIVIAKSCLKLQRIYMQENKL → MDPFGFVLLDKEGMKYEKTQTKKPGKAK

Show »
Length:227
Mass (Da):25,656
Checksum:iF89A42FD2FDDB962
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9V9G3X9V9_MOUSE
F-box/LRR-repeat protein 17
Fbxl17 mCG_1995
220Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0094771 – 474Missing in isoform 2. 1 PublicationAdd BLAST474
Alternative sequenceiVSP_009478475 – 502YKISD…QENKL → MDPFGFVLLDKEGMKYEKTQ TKKPGKAK in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466537 Genomic DNA Translation: EDL38277.1
BC058120 mRNA Translation: AAH58120.1
BC138330 mRNA Translation: AAI38331.1
BC138331 mRNA Translation: AAI38332.1
AF176529 mRNA Translation: AAF09138.1
AK004419 mRNA Translation: BAC25082.1
CCDSiCCDS50162.1 [Q9QZN1-1]
RefSeqiNP_056609.1, NM_015794.1 [Q9QZN1-1]
UniGeneiMm.136366

Genome annotation databases

EnsembliENSMUST00000024761; ENSMUSP00000024761; ENSMUSG00000023965 [Q9QZN1-1]
GeneIDi50758
KEGGimmu:50758
UCSCiuc008dfj.2 mouse [Q9QZN1-2]
uc008dfl.2 mouse [Q9QZN1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466537 Genomic DNA Translation: EDL38277.1
BC058120 mRNA Translation: AAH58120.1
BC138330 mRNA Translation: AAI38331.1
BC138331 mRNA Translation: AAI38332.1
AF176529 mRNA Translation: AAF09138.1
AK004419 mRNA Translation: BAC25082.1
CCDSiCCDS50162.1 [Q9QZN1-1]
RefSeqiNP_056609.1, NM_015794.1 [Q9QZN1-1]
UniGeneiMm.136366

3D structure databases

ProteinModelPortaliQ9QZN1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206092, 1 interactor
STRINGi10090.ENSMUSP00000024761

PTM databases

iPTMnetiQ9QZN1
PhosphoSitePlusiQ9QZN1

Proteomic databases

PaxDbiQ9QZN1
PeptideAtlasiQ9QZN1
PRIDEiQ9QZN1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024761; ENSMUSP00000024761; ENSMUSG00000023965 [Q9QZN1-1]
GeneIDi50758
KEGGimmu:50758
UCSCiuc008dfj.2 mouse [Q9QZN1-2]
uc008dfl.2 mouse [Q9QZN1-1]

Organism-specific databases

CTDi64839
MGIiMGI:1354704 Fbxl17

Phylogenomic databases

eggNOGiKOG1947 Eukaryota
ENOG410XQ54 LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000169154
HOVERGENiHBG107935
InParanoidiQ9QZN1
KOiK10283
OMAiWSINDRC
OrthoDBiEOG091G0KDW
PhylomeDBiQ9QZN1
TreeFamiTF332421

Miscellaneous databases

ChiTaRSiFbxl17 mouse
PROiPR:Q9QZN1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023965 Expressed in 240 organ(s), highest expression level in cumulus cell
CleanExiMM_FBXL17
ExpressionAtlasiQ9QZN1 baseline and differential
GenevisibleiQ9QZN1 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 11 hits
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFXL17_MOUSE
AccessioniPrimary (citable) accession number: Q9QZN1
Secondary accession number(s): B2RRC1, Q8BTC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 5, 2009
Last modified: September 12, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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