UniProtKB - Q9QZM8 (FBX17_MOUSE)
Protein
F-box only protein 17
Gene
Fbxo17
Organism
Mus musculus (Mouse)
Status
Functioni
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins (By similarity).By similarity
GO - Biological processi
- glycoprotein catabolic process Source: GO_Central
- protein ubiquitination Source: GOC
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
- ubiquitin-dependent ERAD pathway Source: GO_Central
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-8951664, Neddylation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: F-box only protein 17Alternative name(s): F-box only protein 26 |
Gene namesi | Name:Fbxo17 Synonyms:Fbx17, Fbxo26 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1354707, Fbxo17 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
- SCF ubiquitin ligase complex Source: UniProtKB
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119899 | 1 – 286 | F-box only protein 17Add BLAST | 286 |
Proteomic databases
PaxDbi | Q9QZM8 |
PRIDEi | Q9QZM8 |
ProteomicsDBi | 271880 [Q9QZM8-1] 271881 [Q9QZM8-2] |
Expressioni
Tissue specificityi
Expressed primarily in the brain.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000030598, Expressed in humerus cartilage element and 188 other tissues |
Genevisiblei | Q9QZM8, MM |
Interactioni
Subunit structurei
Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
Interacts with SKP1 and CUL1 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000032818 |
Miscellaneous databases
RNActi | Q9QZM8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 62 | F-boxPROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 107 – 283 | FBAPROSITE-ProRule annotationAdd BLAST | 177 |
Phylogenomic databases
eggNOGi | ENOG502RZA6, Eukaryota |
GeneTreei | ENSGT00940000162455 |
HOGENOMi | CLU_068548_0_0_1 |
InParanoidi | Q9QZM8 |
OMAi | QQFWAGH |
PhylomeDBi | Q9QZM8 |
TreeFami | TF320527 |
Family and domain databases
Gene3Di | 2.60.120.260, 1 hit |
InterProi | View protein in InterPro IPR007397, F-box-assoc_dom IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR039752, F-box_only IPR008979, Galactose-bd-like_sf |
PANTHERi | PTHR12125, PTHR12125, 1 hit |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit PF04300, FBA, 1 hit |
SMARTi | View protein in SMART SM01198, FBA, 1 hit SM00256, FBOX, 1 hit |
SUPFAMi | SSF49785, SSF49785, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS51114, FBA, 1 hit PS50181, FBOX, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9QZM8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGARPSRRQM TEARRLALTK LPPELLVQVL SHVPPRALVT RCRPVCRAWR
60 70 80 90 100
DLVDGPSIWL LQLARDRSAE GRALYALAQR CPADADADAD ADGNRHDEFP
110 120 130 140 150
FCALARFCLR APFGRNLIHN SCGEQGFRGW EVEHGGNGWA VEKNLTLVPG
160 170 180 190 200
APSQTCFVTS FEWCSKRQLV DLVKEGVWQE LLDSGQIEIC IADWWGAREN
210 220 230 240 250
CGCIYRLRVR LLDEYENEVV KFSASPNPVL QWTERSCRQV SHVFTNFGKG
260 270 280
IRYVSFEQYG RDTRSWVGHY GALVTHSSVR VRIRLS
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012981 | 240 – 242 | VSH → GLP in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_012982 | 243 – 286 | Missing in isoform 2. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF176532 mRNA Translation: AAF09141.1 BC026470 mRNA Translation: AAH26470.1 |
CCDSi | CCDS39863.2 [Q9QZM8-1] CCDS80688.1 [Q9QZM8-2] |
RefSeqi | NP_001297616.1, NM_001310687.1 [Q9QZM8-2] NP_056611.2, NM_015796.2 [Q9QZM8-1] |
Genome annotation databases
Ensembli | ENSMUST00000032818; ENSMUSP00000032818; ENSMUSG00000030598 [Q9QZM8-1] ENSMUST00000108278; ENSMUSP00000103913; ENSMUSG00000030598 [Q9QZM8-1] ENSMUST00000108279; ENSMUSP00000103914; ENSMUSG00000030598 [Q9QZM8-2] ENSMUST00000167118; ENSMUSP00000130422; ENSMUSG00000030598 [Q9QZM8-1] |
GeneIDi | 50760 |
KEGGi | mmu:50760 |
UCSCi | uc009fzl.2, mouse [Q9QZM8-2] uc009fzn.2, mouse [Q9QZM8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF176532 mRNA Translation: AAF09141.1 BC026470 mRNA Translation: AAH26470.1 |
CCDSi | CCDS39863.2 [Q9QZM8-1] CCDS80688.1 [Q9QZM8-2] |
RefSeqi | NP_001297616.1, NM_001310687.1 [Q9QZM8-2] NP_056611.2, NM_015796.2 [Q9QZM8-1] |
3D structure databases
SMRi | Q9QZM8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000032818 |
Proteomic databases
PaxDbi | Q9QZM8 |
PRIDEi | Q9QZM8 |
ProteomicsDBi | 271880 [Q9QZM8-1] 271881 [Q9QZM8-2] |
Protocols and materials databases
Antibodypediai | 68422, 52 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000032818; ENSMUSP00000032818; ENSMUSG00000030598 [Q9QZM8-1] ENSMUST00000108278; ENSMUSP00000103913; ENSMUSG00000030598 [Q9QZM8-1] ENSMUST00000108279; ENSMUSP00000103914; ENSMUSG00000030598 [Q9QZM8-2] ENSMUST00000167118; ENSMUSP00000130422; ENSMUSG00000030598 [Q9QZM8-1] |
GeneIDi | 50760 |
KEGGi | mmu:50760 |
UCSCi | uc009fzl.2, mouse [Q9QZM8-2] uc009fzn.2, mouse [Q9QZM8-1] |
Organism-specific databases
CTDi | 115290 |
MGIi | MGI:1354707, Fbxo17 |
Phylogenomic databases
eggNOGi | ENOG502RZA6, Eukaryota |
GeneTreei | ENSGT00940000162455 |
HOGENOMi | CLU_068548_0_0_1 |
InParanoidi | Q9QZM8 |
OMAi | QQFWAGH |
PhylomeDBi | Q9QZM8 |
TreeFami | TF320527 |
Enzyme and pathway databases
Reactomei | R-MMU-8951664, Neddylation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 50760, 4 hits in 53 CRISPR screens |
ChiTaRSi | Fbxo17, mouse |
PROi | PR:Q9QZM8 |
RNActi | Q9QZM8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030598, Expressed in humerus cartilage element and 188 other tissues |
Genevisiblei | Q9QZM8, MM |
Family and domain databases
Gene3Di | 2.60.120.260, 1 hit |
InterProi | View protein in InterPro IPR007397, F-box-assoc_dom IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR039752, F-box_only IPR008979, Galactose-bd-like_sf |
PANTHERi | PTHR12125, PTHR12125, 1 hit |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit PF04300, FBA, 1 hit |
SMARTi | View protein in SMART SM01198, FBA, 1 hit SM00256, FBOX, 1 hit |
SUPFAMi | SSF49785, SSF49785, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS51114, FBA, 1 hit PS50181, FBOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBX17_MOUSE | |
Accessioni | Q9QZM8Primary (citable) accession number: Q9QZM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2002 |
Last sequence update: | May 27, 2002 | |
Last modified: | April 7, 2021 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot