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Entry version 117 (18 Sep 2019)
Sequence version 1 (01 May 2000)
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Protein

Sodium/potassium/calcium exchanger 1

Gene

Slc24a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Calcium transport, Ion transport, Sensory transduction, Symport, Transport, Vision
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-425561 Sodium/Calcium exchangers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 1
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 1
Retinal rod Na-Ca+K exchanger
Solute carrier family 24 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc24a1
Synonyms:Nckx1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620080 Slc24a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 419ExtracellularSequence analysisAdd BLAST419
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Topological domaini441 – 464CytoplasmicSequence analysisAdd BLAST24
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 491ExtracellularSequence analysis6
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21
Topological domaini513 – 519CytoplasmicSequence analysis7
Transmembranei520 – 544HelicalSequence analysisAdd BLAST25
Topological domaini545 – 552ExtracellularSequence analysis8
Transmembranei553 – 569HelicalSequence analysisAdd BLAST17
Topological domaini570 – 989CytoplasmicSequence analysisAdd BLAST420
Transmembranei990 – 1010HelicalSequence analysisAdd BLAST21
Topological domaini1011 – 1017ExtracellularSequence analysis7
Transmembranei1018 – 1038HelicalSequence analysisAdd BLAST21
Topological domaini1039 – 1053CytoplasmicSequence analysisAdd BLAST15
Transmembranei1054 – 1074HelicalSequence analysisAdd BLAST21
Topological domaini1075 – 1092ExtracellularSequence analysisAdd BLAST18
Transmembranei1093 – 1113HelicalSequence analysisAdd BLAST21
Topological domaini1114 – 1121CytoplasmicSequence analysis8
Transmembranei1122 – 1142HelicalSequence analysisAdd BLAST21
Topological domaini1143 – 1150ExtracellularSequence analysis8
Transmembranei1151 – 1171HelicalSequence analysisAdd BLAST21
Topological domaini1172 – 1181CytoplasmicSequence analysis10

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002233041 – 1181Sodium/potassium/calcium exchanger 1Add BLAST1181
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – ?Not cleavedBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei625PhosphoserineSequence analysis1
Modified residuei690PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration and topology.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QZM6

PRoteomics IDEntifications database

More...
PRIDEi
Q9QZM6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the eye.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000051962

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QZM6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati461 – 501Alpha-1Add BLAST41
Repeati730 – 7411Add BLAST12
Repeati742 – 7542Add BLAST13
Repeati755 – 7663Add BLAST12
Repeati767 – 7784Add BLAST12
Repeati779 – 7915Add BLAST13
Repeati792 – 8046Add BLAST13
Repeati805 – 8177Add BLAST13
Repeati818 – 8308Add BLAST13
Repeati831 – 8439Add BLAST13
Repeati844 – 85610Add BLAST13
Repeati857 – 86911Add BLAST13
Repeati870 – 88112Add BLAST12
Repeati882 – 89313Add BLAST12
Repeati894 – 90514Add BLAST12
Repeati1061 – 1092Alpha-2Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni730 – 90514 X approximate tandem repeatsAdd BLAST176

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi952 – 974Poly-GluAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1307 Eukaryota
ENOG410Y9YY LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231933

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QZM6

KEGG Orthology (KO)

More...
KOi
K13749

Database of Orthologous Groups

More...
OrthoDBi
1168500at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9QZM6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004481 K/Na/Ca-exchanger
IPR004837 NaCa_Exmemb
IPR004817 SLC24A1

The PANTHER Classification System

More...
PANTHERi
PTHR10846 PTHR10846, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01699 Na_Ca_ex, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00927 2A1904, 1 hit
TIGR00367 TIGR00367, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QZM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKLIRMGTQ ERRLLRPKRL HWSRLLFFLG MLIIGSTYQH LRRPQNPPSM
60 70 80 90 100
WTKVSSQQPI KLAIRDLPND EITVTDKDPP EASSEVEGEM LAPQDTVIIG
110 120 130 140 150
EAAPSIAMED TPNPPITTKI TPTSLKNNYS PTTAGTRRQK ENIPPTPSRA
160 170 180 190 200
PSHFISTSGR QRVKSYTPKP RGGRKSSSPT HTREEGRMHT PSPAGAPRTI
210 220 230 240 250
SPTSTEKDSE TTATYRMLEP RSERTAGKTS LKRMVPNTRT FLTREVETDL
260 270 280 290 300
VTSPSLVGKN TLGSPRRGER NSSTTPLRAV LQPTPATSEE QVTASIRMGS
310 320 330 340 350
TPATTEGSTA AQRIGNPLSG TSTPAVRIAS VTDREKRPST AHGTLVTPQV
360 370 380 390 400
KAVLTTQVHR CVVVKPAPAV PMTPSPSMTA ILFPEAPTSG PSALPPGWPN
410 420 430 440 450
LHPKAEYPPD LFSVEDRRQG WVVLHIFGMT YVFVALAIVC DEYFVPALGV
460 470 480 490 500
ITDKLQISED VAGATFMAAG GSAPELFTSL IGVFISHSNV GIGTIVGSAV
510 520 530 540 550
FNILFVIGTC ALFSREILNL TWWPLFRDVS FYILDLSMLI VFFLDSLIAW
560 570 580 590 600
WESLLLLLAY ALYVFTMKWN KQIERWVKEQ LSRRPVAKVM ALGDLSKPSD
610 620 630 640 650
GAIEENEQQD NKKLKLPSVL TRGSSSASLH NSIIRSTIYH LMLHSLDPLG
660 670 680 690 700
EARPSKDKQE SLNQEARVLP QTKAESSSDE EEPAELPAVT VTPAPAPEDK
710 720 730 740 750
GDQEEDPGCQ EDVDEAEHRG DMTGEEGERE TEAEGKKDEE GETEAERKED
760 770 780 790 800
GQEEETETKG KEKQEGETES EGKDEQEGET EAEGKEADHE GETEAEGKEV
810 820 830 840 850
EHEGETEAEG TEDEQEGETE AEGKEVEQEG ETEAEGKEVE HEVETEAERK
860 870 880 890 900
ETNHEGETEA EGKEADHEGE TEAEGNVEHQ GETEAEGKVE HEGETEAGEK
910 920 930 940 950
DEHEGQSETQ ADDTEVKDGE GEAEANAEDQ CETAQGEKGA DGGGGSDGGD
960 970 980 990 1000
SEEEEDEEDE EEEEEEEEEE EEEESEEPLS LEWPESRQKQ AIYLFLLPIV
1010 1020 1030 1040 1050
FPLWLTIPDV RRQEARKFFV ITFLGSIIWI AMFSYLMVWW AHQVGETIGI
1060 1070 1080 1090 1100
SEEIMGLTIL AAGTSIPDLI TSVIVARKGL GDMAVSSSVG SNIFDITVGL
1110 1120 1130 1140 1150
PVPWLLFSLI NALQPIPVSS NGLFCAIVLL FLMLLFVIFS IASCKWRMNK
1160 1170 1180
ILGFTMFLLY FVFLVISVML EDRIISCPVS V
Length:1,181
Mass (Da):129,981
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB063C1C1193696AE
GO
Isoform 2 (identifier: Q9QZM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     598-710: Missing.

Show »
Length:1,068
Mass (Da):117,757
Checksum:i860796B1423E167B
GO
Isoform 3 (identifier: Q9QZM6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     616-710: Missing.

Show »
Length:1,086
Mass (Da):119,782
Checksum:i43790F23B8664175
GO
Isoform 4 (identifier: Q9QZM6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     652-679: Missing.

Show »
Length:1,153
Mass (Da):126,899
Checksum:i93DD50700AC53DCB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K8E1A0A0G2K8E1_RAT
Sodium/potassium/calcium exchanger ...
Slc24a1
1,074Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006161598 – 710Missing in isoform 2. CuratedAdd BLAST113
Alternative sequenceiVSP_006162616 – 710Missing in isoform 3. CuratedAdd BLAST95
Alternative sequenceiVSP_006163652 – 679Missing in isoform 4. CuratedAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF176688 mRNA Translation: AAD53121.1
U49235 mRNA Translation: AAB37753.1

NCBI Reference Sequences

More...
RefSeqi
NP_064475.1, NM_020090.1 [Q9QZM6-1]
XP_017451362.1, XM_017595873.1 [Q9QZM6-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56814

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:56814

UCSC genome browser

More...
UCSCi
RGD:620080 rat [Q9QZM6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176688 mRNA Translation: AAD53121.1
U49235 mRNA Translation: AAB37753.1
RefSeqiNP_064475.1, NM_020090.1 [Q9QZM6-1]
XP_017451362.1, XM_017595873.1 [Q9QZM6-1]

3D structure databases

SMRiQ9QZM6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051962

Proteomic databases

PaxDbiQ9QZM6
PRIDEiQ9QZM6

Genome annotation databases

GeneIDi56814
KEGGirno:56814
UCSCiRGD:620080 rat [Q9QZM6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9187
RGDi620080 Slc24a1

Phylogenomic databases

eggNOGiKOG1307 Eukaryota
ENOG410Y9YY LUCA
HOGENOMiHOG000231933
InParanoidiQ9QZM6
KOiK13749
OrthoDBi1168500at2759
PhylomeDBiQ9QZM6

Enzyme and pathway databases

ReactomeiR-RNO-425561 Sodium/Calcium exchangers

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9QZM6

Family and domain databases

InterProiView protein in InterPro
IPR004481 K/Na/Ca-exchanger
IPR004837 NaCa_Exmemb
IPR004817 SLC24A1
PANTHERiPTHR10846 PTHR10846, 2 hits
PfamiView protein in Pfam
PF01699 Na_Ca_ex, 2 hits
TIGRFAMsiTIGR00927 2A1904, 1 hit
TIGR00367 TIGR00367, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCKX1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QZM6
Secondary accession number(s): Q62932
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: May 1, 2000
Last modified: September 18, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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