UniProtKB - Q9QZM5 (ABI1_RAT)
Abl interactor 1
Abi1
Functioni
GO - Molecular functioni
- protein tyrosine kinase activator activity Source: RGD
- SH3 domain binding Source: RGD
- transcription factor binding Source: RGD
GO - Biological processi
- actin polymerization or depolymerization Source: InterPro
- dendrite morphogenesis Source: RGD
- lamellipodium morphogenesis Source: RGD
- megakaryocyte development Source: RGD
- peptidyl-tyrosine phosphorylation Source: RGD
- postsynapse to nucleus signaling pathway Source: SynGO
- somitogenesis Source: RGD
Names & Taxonomyi
Protein namesi | Recommended name: Abl interactor 1Alternative name(s): Abelson interactor 1 Short name: Abi-1 Eps8 SH3 domain-binding protein Short name: Eps8-binding protein e3B1 |
Gene namesi | Name:Abi1Imported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621008, Abi1 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm By similarity
- lamellipodium 1 Publication
- filopodium 1 Publication
- growth cone 1 Publication
- postsynaptic density 2 Publications
Note: Localized to protruding lamellipodia and filopodia tips. May shuttle from the postsynaptic densities to the nucleus.2 Publications
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cell leading edge Source: RGD
- filopodium tip Source: RGD
- glutamatergic synapse Source: SynGO
- growth cone Source: UniProtKB-SubCell
- lamellipodium Source: RGD
- neuron projection Source: RGD
- postsynaptic density Source: UniProtKB-SubCell
- SCAR complex Source: RGD
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Nucleus, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 53 | Y → A: Not phosphorylated and perinuclear upon NMDA treatment. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000191789 | 2 – 476 | Abl interactor 1Add BLAST | 475 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 53 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 169 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 173 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 178 | PhosphoserineBy similarity | 1 | |
Modified residuei | 182 | PhosphoserineBy similarity | 1 | |
Modified residuei | 208 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 210 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 211 | PhosphoserineBy similarity | 1 | |
Modified residuei | 217 | PhosphoserineBy similarity | 1 | |
Modified residuei | 220 | PhosphoserineCombined sources | 1 | |
Modified residuei | 287 | PhosphoserineBy similarity | 1 | |
Modified residuei | 291 | PhosphoserineBy similarity | 1 | |
Modified residuei | 423 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 434 | PhosphoserineCombined sources | 1 | |
Modified residuei | 475 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q9QZM5 |
PaxDbi | Q9QZM5 |
PRIDEi | Q9QZM5 |
PTM databases
iPTMneti | Q9QZM5 |
PhosphoSitePlusi | Q9QZM5 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSRNOG00000031325, Expressed in Ammon's horn and 20 other tissues |
ExpressionAtlasi | Q9QZM5, baseline and differential |
Genevisiblei | Q9QZM5, RN |
Interactioni
Subunit structurei
Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, SOS1, SOS2, GRB2, SPTA1, NCKAP1/NAP1, the first SH3 domain of NCK1 and through its N-terminus with WASF1.
Part of a complex consisting of ABI1, STX1A and SNAP25.
Part of a complex consisting of ABI1, EPS8 and SOS1.
Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2.
Interacts (via SH3 domain) with SHANK2 and SHANK3, but not SHANK1; the interaction is direct.
Interacts with the heterodimer MYC:MAX; the interaction may enhance MYC:MAX transcriptional activity.
Interacts with FNBP1L (via the SH3 domain), WASF2, and CDC42, but only in the presence of FNBP1L (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsGO - Molecular functioni
- SH3 domain binding Source: RGD
- transcription factor binding Source: RGD
Protein-protein interaction databases
DIPi | DIP-36968N |
IntActi | Q9QZM5, 8 interactors |
MINTi | Q9QZM5 |
STRINGi | 10116.ENSRNOP00000054381 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 107 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 414 – 473 | SH3PROSITE-ProRule annotationAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 332 – 386 | Pro-richAdd BLAST | 55 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG2546, Eukaryota |
GeneTreei | ENSGT00940000154811 |
InParanoidi | Q9QZM5 |
PhylomeDBi | Q9QZM5 |
Family and domain databases
CDDi | cd11971, SH3_Abi1, 1 hit |
InterProi | View protein in InterPro IPR028457, ABI IPR028456, ABI1 IPR035725, Abi1_SH3 IPR012849, Abl-interactor_HHR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR000727, T_SNARE_dom |
PANTHERi | PTHR10460, PTHR10460, 2 hits PTHR10460:SF2, PTHR10460:SF2, 2 hits |
Pfami | View protein in Pfam PF07815, Abi_HHR, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS50192, T_SNARE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET
60 70 80 90 100
KAYTTQSLAS VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH
110 120 130 140 150
KEKVARREIG ILTTNKNTSR THKIIAPANM ERPVRYIRKP IDYTVLDDVG
160 170 180 190 200
HGVKHGNNQP ARTGTLSRTN PPTQKPPSPP VSGRGTLGRN TPYKTLEPVK
210 220 230 240 250
PPTVPNDYMT SPARLGSQHS PGRTASLNQR PRTHSGSSGG SGSRENSGSS
260 270 280 290 300
SIGIPIAVPT PSPPTAGPAA PGAAPGSQYG TMTRQISRHN STTSSTSSGG
310 320 330 340 350
YRRTPSVTAQ FSAQPHVNGG PLYSQNSISI APPPPPMPQL TPQIPLTGFV
360 370 380 390 400
ARVQENIADS PTPPPPPPPD DIPMFDDSPP PPPPPPVDYE DEEAAVVQYS
410 420 430 440 450
DPYADGDPAW APKNYIEKVV AIYDYTKDKD DELSFKEGAI IYVIKKNDDG
460 470
WFEGVCNRVT GLFPGNYVES IMHYTD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2VD09 | A2VD09_RAT | Abi1 protein | Abi1 | 481 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF176784 mRNA Translation: AAD55263.1 |
RefSeqi | XP_006254416.1, XM_006254354.3 |
Genome annotation databases
Ensembli | ENSRNOT00000091023; ENSRNOP00000071079; ENSRNOG00000031325 |
GeneIDi | 79249 |
UCSCi | RGD:621008, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF176784 mRNA Translation: AAD55263.1 |
RefSeqi | XP_006254416.1, XM_006254354.3 |
3D structure databases
SMRi | Q9QZM5 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-36968N |
IntActi | Q9QZM5, 8 interactors |
MINTi | Q9QZM5 |
STRINGi | 10116.ENSRNOP00000054381 |
PTM databases
iPTMneti | Q9QZM5 |
PhosphoSitePlusi | Q9QZM5 |
Proteomic databases
jPOSTi | Q9QZM5 |
PaxDbi | Q9QZM5 |
PRIDEi | Q9QZM5 |
Genome annotation databases
Ensembli | ENSRNOT00000091023; ENSRNOP00000071079; ENSRNOG00000031325 |
GeneIDi | 79249 |
UCSCi | RGD:621008, rat |
Organism-specific databases
CTDi | 10006 |
RGDi | 621008, Abi1 |
Phylogenomic databases
eggNOGi | KOG2546, Eukaryota |
GeneTreei | ENSGT00940000154811 |
InParanoidi | Q9QZM5 |
PhylomeDBi | Q9QZM5 |
Miscellaneous databases
PROi | PR:Q9QZM5 |
Gene expression databases
Bgeei | ENSRNOG00000031325, Expressed in Ammon's horn and 20 other tissues |
ExpressionAtlasi | Q9QZM5, baseline and differential |
Genevisiblei | Q9QZM5, RN |
Family and domain databases
CDDi | cd11971, SH3_Abi1, 1 hit |
InterProi | View protein in InterPro IPR028457, ABI IPR028456, ABI1 IPR035725, Abi1_SH3 IPR012849, Abl-interactor_HHR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR000727, T_SNARE_dom |
PANTHERi | PTHR10460, PTHR10460, 2 hits PTHR10460:SF2, PTHR10460:SF2, 2 hits |
Pfami | View protein in Pfam PF07815, Abi_HHR, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABI1_RAT | |
Accessioni | Q9QZM5Primary (citable) accession number: Q9QZM5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | October 7, 2020 | |
This is version 140 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families