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Protein

Tumor necrosis factor receptor superfamily member 10B

Gene

Tnfrsf10b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-3371378 Regulation by c-FLIP
R-MMU-5213460 RIPK1-mediated regulated necrosis
R-MMU-5218900 CASP8 activity is inhibited
R-MMU-69416 Dimerization of procaspase-8
R-MMU-75158 TRAIL signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 10B
Alternative name(s):
Death receptor 5
MK
CD_antigen: CD262
Gene namesi
Name:Tnfrsf10b
Synonyms:Dr5, Killer
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1341090 Tnfrsf10b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini53 – 180ExtracellularSequence analysisAdd BLAST128
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 381CytoplasmicSequence analysisAdd BLAST180

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 52Sequence analysisAdd BLAST52
ChainiPRO_000003458153 – 381Tumor necrosis factor receptor superfamily member 10BAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi74 ↔ 85PROSITE-ProRule annotationBy similarity
Disulfide bondi88 ↔ 105PROSITE-ProRule annotationBy similarity
Disulfide bondi108 ↔ 121PROSITE-ProRule annotationBy similarity
Disulfide bondi111 ↔ 129PROSITE-ProRule annotationBy similarity
Disulfide bondi131 ↔ 145PROSITE-ProRule annotationBy similarity
Disulfide bondi148 ↔ 161PROSITE-ProRule annotationBy similarity
Disulfide bondi151 ↔ 169PROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9QZM4
MaxQBiQ9QZM4
PaxDbiQ9QZM4
PeptideAtlasiQ9QZM4
PRIDEiQ9QZM4

PTM databases

iPTMnetiQ9QZM4
PhosphoSitePlusiQ9QZM4

Expressioni

Tissue specificityi

Highly expressed in heart, lung and kidney.

Inductioni

TNFRSF10B is regulated by the tumor suppressor p53.

Gene expression databases

BgeeiENSMUSG00000022074 Expressed in 53 organ(s), highest expression level in fibroblast
GenevisibleiQ9QZM4 MM

Interactioni

Subunit structurei

Monomer. Can interact with TRADD and RIPK1. Three TNFRSF10B molecules interact with the TNFSF10 homotrimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QZM4, 1 interactor
STRINGi10090.ENSMUSP00000022663

Structurei

3D structure databases

ProteinModelPortaliQ9QZM4
SMRiQ9QZM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 86TNFR-Cys 1Add BLAST61
Repeati87 – 129TNFR-Cys 2Add BLAST43
Repeati130 – 169TNFR-Cys 3Add BLAST40
Domaini273 – 356DeathPROSITE-ProRule annotationAdd BLAST84

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZX0 Eukaryota
ENOG4111ZZM LUCA
GeneTreeiENSGT00730000110985
HOGENOMiHOG000142423
HOVERGENiHBG061626
InParanoidiQ9QZM4
KOiK04722
OMAiCTPWSDL
OrthoDBiEOG091G0MOV
TreeFamiTF333916

Family and domain databases

CDDicd08315 Death_TRAILR_DR4_DR5, 1 hit
cd10580 TNFRSF10, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020465 TNFR_10
IPR034024 TNFRSF10_N
IPR034029 TNFRSF10A/B_death
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PIRSFiPIRSF037867 CD261_antigen, 1 hit
PRINTSiPR01956 TNFACTORR10
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 2 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPPGPSTPT ASAAARADHY TPGLRPLPKR RLLYSFALLL AVLQAVFVPV
60 70 80 90 100
TANPAHNRPA GLQRPEESPS RGPCLAGQYL SEGNCKPCRE GIDYTSHSNH
110 120 130 140 150
SLDSCILCTV CKEDKVVETR CNITTNTVCR CKPGTFEDKD SPEICQSCSN
160 170 180 190 200
CTDGEEELTS CTPRENRKCV SKTAWASWHK LGLWIGLLVP VVLLIGALLV
210 220 230 240 250
WKTGAWRQWL LCIKRGCERD PESANSVHSS LLDRQTSSTT NDSNHNTEPG
260 270 280 290 300
KTQKTGKKLL VPVNGNDSAD DLKFIFEYCS DIVPFDSWNR LMRQLGLTDN
310 320 330 340 350
QIQMVKAETL VTREALYQML LKWRHQTGRS ASINHLLDAL EAVEERDAME
360 370 380
KIEDYAVKSG RFTYQNAAAQ PETGPGGSQC V
Length:381
Mass (Da):42,165
Last modified:July 27, 2011 - v3
Checksum:i222531758F4ADE0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42V → M in BAA96462 (Ref. 2) Curated1
Sequence conflicti42V → M in BAA96463 (Ref. 2) Curated1
Sequence conflicti97H → R in BAA96463 (Ref. 2) Curated1
Sequence conflicti128V → E in BAA96463 (Ref. 2) Curated1
Sequence conflicti180K → N in BAA96463 (Ref. 2) Curated1
Sequence conflicti187L → AT in BAA96463 (Ref. 2) Curated1
Sequence conflicti215R → RAYP in BAA96463 (Ref. 2) Curated1
Sequence conflicti229S → L in BAA96462 (Ref. 2) Curated1
Sequence conflicti229S → L in BAA96463 (Ref. 2) Curated1
Sequence conflicti306K → R in BAA96463 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176833 mRNA Translation: AAD52656.1
AB031081 mRNA Translation: BAA96462.1
AB031082 Genomic DNA Translation: BAA96463.1
AK050753 mRNA Translation: BAC34404.1
AK080069 mRNA Translation: BAC37821.1
AK154993 mRNA Translation: BAE32980.1
BC065141 mRNA Translation: AAH65141.1
CCDSiCCDS27243.1
RefSeqiNP_064671.2, NM_020275.4
UniGeneiMm.193430

Genome annotation databases

EnsembliENSMUST00000022663; ENSMUSP00000022663; ENSMUSG00000022074
GeneIDi21933
KEGGimmu:21933
UCSCiuc007umu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176833 mRNA Translation: AAD52656.1
AB031081 mRNA Translation: BAA96462.1
AB031082 Genomic DNA Translation: BAA96463.1
AK050753 mRNA Translation: BAC34404.1
AK080069 mRNA Translation: BAC37821.1
AK154993 mRNA Translation: BAE32980.1
BC065141 mRNA Translation: AAH65141.1
CCDSiCCDS27243.1
RefSeqiNP_064671.2, NM_020275.4
UniGeneiMm.193430

3D structure databases

ProteinModelPortaliQ9QZM4
SMRiQ9QZM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QZM4, 1 interactor
STRINGi10090.ENSMUSP00000022663

PTM databases

iPTMnetiQ9QZM4
PhosphoSitePlusiQ9QZM4

Proteomic databases

EPDiQ9QZM4
MaxQBiQ9QZM4
PaxDbiQ9QZM4
PeptideAtlasiQ9QZM4
PRIDEiQ9QZM4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022663; ENSMUSP00000022663; ENSMUSG00000022074
GeneIDi21933
KEGGimmu:21933
UCSCiuc007umu.2 mouse

Organism-specific databases

CTDi8795
MGIiMGI:1341090 Tnfrsf10b

Phylogenomic databases

eggNOGiENOG410IZX0 Eukaryota
ENOG4111ZZM LUCA
GeneTreeiENSGT00730000110985
HOGENOMiHOG000142423
HOVERGENiHBG061626
InParanoidiQ9QZM4
KOiK04722
OMAiCTPWSDL
OrthoDBiEOG091G0MOV
TreeFamiTF333916

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-3371378 Regulation by c-FLIP
R-MMU-5213460 RIPK1-mediated regulated necrosis
R-MMU-5218900 CASP8 activity is inhibited
R-MMU-69416 Dimerization of procaspase-8
R-MMU-75158 TRAIL signaling

Miscellaneous databases

PROiPR:Q9QZM4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022074 Expressed in 53 organ(s), highest expression level in fibroblast
GenevisibleiQ9QZM4 MM

Family and domain databases

CDDicd08315 Death_TRAILR_DR4_DR5, 1 hit
cd10580 TNFRSF10, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020465 TNFR_10
IPR034024 TNFRSF10_N
IPR034029 TNFRSF10A/B_death
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PIRSFiPIRSF037867 CD261_antigen, 1 hit
PRINTSiPR01956 TNFACTORR10
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 2 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTR10B_MOUSE
AccessioniPrimary (citable) accession number: Q9QZM4
Secondary accession number(s): Q6GSD9, Q9JJL5, Q9JJL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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