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Protein

Cardiotrophin-like cytokine factor 1

Gene

Clcf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiotrophin-like cytokine factor 1
Alternative name(s):
B-cell-stimulating factor 3
Short name:
BSF-3
Novel neurotrophin-1
Short name:
NNT-1
Gene namesi
Name:Clcf1
Synonyms:Bsf3, Nnt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1930088 Clcf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176788

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001561728 – 225Cardiotrophin-like cytokine factor 1Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QZM3
PRIDEiQ9QZM3

PTM databases

PhosphoSitePlusiQ9QZM3

Expressioni

Gene expression databases

BgeeiENSMUSG00000040663 Expressed in 184 organ(s), highest expression level in lymph node
CleanExiMM_CLCF1
ExpressionAtlasiQ9QZM3 baseline and differential
GenevisibleiQ9QZM3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QZM3, 1 interactor
STRINGi10090.ENSMUSP00000045562

Structurei

3D structure databases

ProteinModelPortaliQ9QZM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVWG Eukaryota
ENOG4111HCM LUCA
GeneTreeiENSGT00510000048856
HOGENOMiHOG000111785
HOVERGENiHBG050737
InParanoidiQ9QZM3
KOiK05421
OMAiTSLLHFC
OrthoDBiEOG091G0LAL
PhylomeDBiQ9QZM3
TreeFamiTF333266

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR010681 PRF/CT
PANTHERiPTHR21353 PTHR21353, 1 hit
PfamiView protein in Pfam
PF06875 PRF, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QZM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLRAGDSWG MLACLCTVLW HLPAVPALNR TGDPGPGPSI QKTYDLTRYL
60 70 80 90 100
EHQLRSLAGT YLNYLGPPFN EPDFNPPRLG AETLPRATVN LEVWRSLNDR
110 120 130 140 150
LRLTQNYEAY SHLLCYLRGL NRQAATAELR RSLAHFCTSL QGLLGSIAGV
160 170 180 190 200
MATLGYPLPQ PLPGTEPAWA PGPAHSDFLQ KMDDFWLLKE LQTWLWRSAK
210 220
DFNRLKKKMQ PPAASVTLHL EAHGF
Length:225
Mass (Da):25,261
Last modified:May 1, 2000 - v1
Checksum:i68B1FEAAB7F1A950
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIL9D6RIL9_MOUSE
Cardiotrophin-like cytokine factor ...
Clcf1
44Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176913 mRNA Translation: AAF00993.1
BC104258 mRNA Translation: AAI04259.1
BC104259 mRNA Translation: AAI04260.1
CH466612 Genomic DNA Translation: EDL33037.1
CCDSiCCDS29423.1
RefSeqiNP_001296967.1, NM_001310038.2
NP_001296968.1, NM_001310039.1
NP_064336.1, NM_019952.5
UniGeneiMm.347919

Genome annotation databases

EnsembliENSMUST00000046506; ENSMUSP00000045562; ENSMUSG00000040663
ENSMUST00000180925; ENSMUSP00000138037; ENSMUSG00000097629
GeneIDi56708
KEGGimmu:56708
UCSCiuc008fzj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176913 mRNA Translation: AAF00993.1
BC104258 mRNA Translation: AAI04259.1
BC104259 mRNA Translation: AAI04260.1
CH466612 Genomic DNA Translation: EDL33037.1
CCDSiCCDS29423.1
RefSeqiNP_001296967.1, NM_001310038.2
NP_001296968.1, NM_001310039.1
NP_064336.1, NM_019952.5
UniGeneiMm.347919

3D structure databases

ProteinModelPortaliQ9QZM3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QZM3, 1 interactor
STRINGi10090.ENSMUSP00000045562

Chemistry databases

ChEMBLiCHEMBL2176788

PTM databases

PhosphoSitePlusiQ9QZM3

Proteomic databases

PaxDbiQ9QZM3
PRIDEiQ9QZM3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046506; ENSMUSP00000045562; ENSMUSG00000040663
ENSMUST00000180925; ENSMUSP00000138037; ENSMUSG00000097629
GeneIDi56708
KEGGimmu:56708
UCSCiuc008fzj.1 mouse

Organism-specific databases

CTDi23529
MGIiMGI:1930088 Clcf1

Phylogenomic databases

eggNOGiENOG410IVWG Eukaryota
ENOG4111HCM LUCA
GeneTreeiENSGT00510000048856
HOGENOMiHOG000111785
HOVERGENiHBG050737
InParanoidiQ9QZM3
KOiK05421
OMAiTSLLHFC
OrthoDBiEOG091G0LAL
PhylomeDBiQ9QZM3
TreeFamiTF333266

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions

Miscellaneous databases

PROiPR:Q9QZM3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040663 Expressed in 184 organ(s), highest expression level in lymph node
CleanExiMM_CLCF1
ExpressionAtlasiQ9QZM3 baseline and differential
GenevisibleiQ9QZM3 MM

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR010681 PRF/CT
PANTHERiPTHR21353 PTHR21353, 1 hit
PfamiView protein in Pfam
PF06875 PRF, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLCF1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZM3
Secondary accession number(s): Q3SXK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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