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Protein

DNA polymerase subunit gamma-2, mitochondrial

Gene

Polg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-directed DNA polymerase activity Source: MGI
  • identical protein binding Source: IntAct

GO - Biological processi

  • DNA repair Source: MGI
  • DNA replication Source: MGI
  • in utero embryonic development Source: MGI
  • mitochondrial DNA metabolic process Source: MGI
  • mitochondrial DNA replication Source: GO_Central
  • mitochondrion morphogenesis Source: MGI
  • respiratory electron transport chain Source: MGI

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase subunit gamma-2, mitochondrial (EC:2.7.7.7)
Alternative name(s):
DNA polymerase gamma accessory 55 kDa subunit
Short name:
p55
Mitochondrial DNA polymerase accessory subunit
MtPolB
PolG-beta
Gene namesi
Name:Polg2
Synonyms:Mtpolb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1354947 Polg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000007315? – 459DNA polymerase subunit gamma-2, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiQ9QZM2
PaxDbiQ9QZM2
PRIDEiQ9QZM2

PTM databases

iPTMnetiQ9QZM2
PhosphoSitePlusiQ9QZM2

Expressioni

Gene expression databases

BgeeiENSMUSG00000020718 Expressed in 242 organ(s), highest expression level in retina
ExpressionAtlasiQ9QZM2 baseline and differential
GenevisibleiQ9QZM2 MM

Interactioni

Subunit structurei

Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-853043,EBI-853043

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-2094 DNA polymerase gamma complex
IntActiQ9QZM2, 1 interactor
MINTiQ9QZM2
STRINGi10090.ENSMUSP00000021060

Structurei

Secondary structure

1459
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9QZM2
SMRiQ9QZM2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QZM2

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2298 Eukaryota
COG0423 LUCA
GeneTreeiENSGT00390000000244
HOGENOMiHOG000049133
HOVERGENiHBG051401
InParanoidiQ9QZM2
KOiK02333
OMAiNFPWGKE
OrthoDBiEOG091G0B28
TreeFamiTF103005

Family and domain databases

CDDicd00774 GlyRS-like_core, 1 hit
Gene3Di3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR027031 Gly-tRNA_synthase/POLG2
IPR033731 GlyRS-like_core
IPR027030 POLG2
PANTHERiPTHR10745 PTHR10745, 1 hit
PTHR10745:SF8 PTHR10745:SF8, 1 hit
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9QZM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRCGGGARAC RRACRCWLSG YAGPADGTQQ PDAPEHAVAR EALVDLCRRR
60 70 80 90 100
HFFSGTPQQL STAALLSGCH ARFGPLGVEL RKNLASQWWS SMVVFREQVF
110 120 130 140 150
AVDSLHQEPG SSQPRDSAFR LVSPESIREI LQDREPSKEQ LVAFLENLLK
160 170 180 190 200
TSGKLRATLL HGALEHYVNC LDLVNRKLPF GLAQIGVCFH PVSNSNQTPS
210 220 230 240 250
SVTRVGEKTE ASLVWFTPTR TSSQWLDFWL RHRLLWWRKF AMSPSNFSSA
260 270 280 290 300
DCQDELGRKG SKLYYSFPWG KEPIETLWNL GDQELLHTYP GNVSTIQGRD
310 320 330 340 350
GRKNVVPCVL SVSGDVDLGT LAYLYDSFQL AENSFARKKS LQRKVLKLHP
360 370 380 390 400
CLAPIKVALD VGKGPTVELR QVCQGLLNEL LENGISVWPG YSETVHSSLE
410 420 430 440 450
QLHSKYDEMS VLFSVLVTET TLENGLIQLR SRDTTMKEMM HISKLRDFLV

KYLASASNV
Length:459
Mass (Da):51,467
Last modified:July 27, 2011 - v2
Checksum:i052C790C2AF9A249
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REU1D6REU1_MOUSE
DNA polymerase subunit gamma-2, mit...
Polg2
170Annotation score:
F2Z482F2Z482_MOUSE
DNA polymerase subunit gamma-2, mit...
Polg2
162Annotation score:
D6RFU3D6RFU3_MOUSE
DNA polymerase subunit gamma-2, mit...
Polg2
126Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53F → L in AAD56641 (PubMed:10666468).Curated1
Sequence conflicti226L → S in AAB62894 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177202 mRNA Translation: AAD56641.1
AL603664 Genomic DNA No translation available.
AF006072 mRNA Translation: AAB62894.1
CCDSiCCDS25561.1
RefSeqiNP_056625.2, NM_015810.2
UniGeneiMm.859

Genome annotation databases

EnsembliENSMUST00000021060; ENSMUSP00000021060; ENSMUSG00000020718
GeneIDi50776
KEGGimmu:50776
UCSCiuc007lzm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177202 mRNA Translation: AAD56641.1
AL603664 Genomic DNA No translation available.
AF006072 mRNA Translation: AAB62894.1
CCDSiCCDS25561.1
RefSeqiNP_056625.2, NM_015810.2
UniGeneiMm.859

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G5HX-ray1.95A/B/C/D17-459[»]
1G5IX-ray2.30A/B/C/D17-459[»]
ProteinModelPortaliQ9QZM2
SMRiQ9QZM2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2094 DNA polymerase gamma complex
IntActiQ9QZM2, 1 interactor
MINTiQ9QZM2
STRINGi10090.ENSMUSP00000021060

PTM databases

iPTMnetiQ9QZM2
PhosphoSitePlusiQ9QZM2

Proteomic databases

MaxQBiQ9QZM2
PaxDbiQ9QZM2
PRIDEiQ9QZM2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021060; ENSMUSP00000021060; ENSMUSG00000020718
GeneIDi50776
KEGGimmu:50776
UCSCiuc007lzm.2 mouse

Organism-specific databases

CTDi11232
MGIiMGI:1354947 Polg2

Phylogenomic databases

eggNOGiKOG2298 Eukaryota
COG0423 LUCA
GeneTreeiENSGT00390000000244
HOGENOMiHOG000049133
HOVERGENiHBG051401
InParanoidiQ9QZM2
KOiK02333
OMAiNFPWGKE
OrthoDBiEOG091G0B28
TreeFamiTF103005

Miscellaneous databases

ChiTaRSiPolg2 mouse
EvolutionaryTraceiQ9QZM2
PROiPR:Q9QZM2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020718 Expressed in 242 organ(s), highest expression level in retina
ExpressionAtlasiQ9QZM2 baseline and differential
GenevisibleiQ9QZM2 MM

Family and domain databases

CDDicd00774 GlyRS-like_core, 1 hit
Gene3Di3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR027031 Gly-tRNA_synthase/POLG2
IPR033731 GlyRS-like_core
IPR027030 POLG2
PANTHERiPTHR10745 PTHR10745, 1 hit
PTHR10745:SF8 PTHR10745:SF8, 1 hit
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPOG2_MOUSE
AccessioniPrimary (citable) accession number: Q9QZM2
Secondary accession number(s): B1ARB5, O35614
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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