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Protein

Deoxyribonuclease-2-alpha

Gene

Dnase2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells (By similarity).By similarity

Miscellaneous

Not required for the generation of the characteristic DNA fragmentation observed in apoptotic cells, but for the degradation of DNA from dying cells.By similarity

Catalytic activityi

Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei298By similarity1

GO - Molecular functioni

  • deoxyribonuclease II activity Source: GO_Central
  • endodeoxyribonuclease activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Endonuclease, Hydrolase, Nuclease
Biological processApoptosis

Enzyme and pathway databases

BRENDAi3.1.22.1 5301
ReactomeiR-RNO-432720 Lysosome Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribonuclease-2-alpha (EC:3.1.22.1)
Alternative name(s):
Acid DNase
Deoxyribonuclease II alpha
Short name:
DNase II alpha
Lysosomal DNase II
Gene namesi
Name:Dnase2
Synonyms:Dnase2a, Dnl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621457 Dnase2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000729420 – 350Deoxyribonuclease-2-alphaAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 162Sequence analysis
Glycosylationi89N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi215N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi269N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi270 ↔ 350Sequence analysis
Glycosylationi293N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi311 ↔ 330Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QZK8
PRIDEiQ9QZK8

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSRNOG00000023830 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiQ9QZK8 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014887

Structurei

3D structure databases

SMRiQ9QZK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNase II family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3825 Eukaryota
ENOG4111G8U LUCA
GeneTreeiENSGT00390000002634
HOGENOMiHOG000261682
HOVERGENiHBG051387
InParanoidiQ9QZK8
KOiK01158
OMAiLQVQFWQ
OrthoDBiEOG091G08N7
PhylomeDBiQ9QZK8
TreeFamiTF314536

Family and domain databases

InterProiView protein in InterPro
IPR004947 DNase_II
PANTHERiPTHR10858 PTHR10858, 1 hit
PfamiView protein in Pfam
PF03265 DNase_II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPSSLLLA ALLWVPAEAL SCYGDSGRPV DWFVVYKLPA NSGSGDKPWK
60 70 80 90 100
GLMYKYMDQN SEGWQDGVGH IDSKDGAVGL TLQPLYQKNS SQLAFLLYND
110 120 130 140 150
QPPKSSSAQD SSSRGHTKGV LLLDQEGGFW LVHSVPRFPS PASSGAYSWP
160 170 180 190 200
PNARTYGQTL LCVSLPFSQF PGIGKQLTYT YPLVYDHKLE GIFAQKLPDL
210 220 230 240 250
EEVTKGHHVL REPWNSSVIL TSRAGTTFQS FAKFGKFGDD LYSGWLAAAL
260 270 280 290 300
GTNLQVQFWP NSPGILPSNC SGTHKILDVT ETGFPGPSGP TFNATEDHSK
310 320 330 340 350
WCVAPEGPWV CVGDMNRNKR ETHRGGGTLC TQVPALWKAF RSLVKACKPC
Length:350
Mass (Da):38,175
Last modified:May 1, 2000 - v1
Checksum:i6483AF5AC13C5111
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178975 mRNA Translation: AAF13597.1
BC091124 mRNA Translation: AAH91124.1
RefSeqiNP_612548.1, NM_138539.2
UniGeneiRn.9509

Genome annotation databases

EnsembliENSRNOT00000014887; ENSRNOP00000014887; ENSRNOG00000023830
GeneIDi171575
KEGGirno:171575

Similar proteinsi

Entry informationi

Entry nameiDNS2A_RAT
AccessioniPrimary (citable) accession number: Q9QZK8
Secondary accession number(s): Q5BKC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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