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UniProtKB - Q9QZK2 (BCAR3_MOUSE)

Entry version 139 (10 Feb 2021)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Breast cancer anti-estrogen resistance protein 3 homolog

Gene

Bcar3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:12517963). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:10896938). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (PubMed:25499443). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (PubMed:25499443). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (PubMed:19365570). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (PubMed:22801373). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (PubMed:22801373). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (PubMed:10896938). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity).By similarity5 Publications

Caution

The guanine nucleotide exchange factor (GEF) activity is controversial. One study showed GEF activity towards RALA, RAP1A and RRAS (PubMed:10896938). However, in another study, a construct containing only the Ras-GEF domain lacks GEF activity towards RAP1 (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Breast cancer anti-estrogen resistance protein 3 homolog
Alternative name(s):
p130Cas-binding protein AND-34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Bcar3
Synonyms:And34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1352501, Bcar3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout mice are generally normal and viable (PubMed:19365570). Retinal white circular lesions in anterior chamber derived from the lens cortex (PubMed:19365570). Retinal lens is partially opaque and irregular in structure, with rupture leading to cortical lens fragments floating in the aqueous humor (PubMed:19365570). Abnormally deep anterior chamber with anterior synechiae, ectropion uveae, mild to moderate retinal ganglion loss, and a small pigmented pre-retinal membrane overlying the optic nerve (PubMed:19365570). Reduced phosphorylation of AKT1 and BCAR1 in lens epithelial cells (PubMed:19365570). Retinal lens abnormalities develop progressively postnatally; at postnatal day 3 (P3) there is anterior lens vacuolization and liquefaction of lens cortical fibers (PubMed:19365570). At P24 there is evidence of extensive lens cortex vacuolation and early lens extrusion, progressing to extrusion of lens cortical material at P33 (PubMed:19365570).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002302862 – 820Breast cancer anti-estrogen resistance protein 3 homologAdd BLAST819

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei176PhosphoserineBy similarity1
Modified residuei284PhosphoserineBy similarity1
Modified residuei329N6-methyllysineBy similarity1
Modified residuei353PhosphoserineBy similarity1
Modified residuei358PhosphoserineBy similarity1
Modified residuei370PhosphoserineCombined sources1
Modified residuei437Omega-N-methylarginineBy similarity1
Modified residuei466PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9QZK2

PeptideAtlas

More...PeptideAtlasi		Q9QZK2

PRoteomics IDEntifications database

More...PRIDEi		Q9QZK2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9QZK2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9QZK2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in the lung and brain, with lower expression in splenic lymphocytes and liver (at protein level) (PubMed:19365570). Expressed in splenic lymphocytes (at protein level) (PubMed:19365570). Expressed in the lymph node cortical region, periphery of the splenic white pulp and in alveolar lung fibroblasts (PubMed:19365570). Expressed in epithelial cells in the lens equatorial region and early stage nucleated cortical lens fiber cells (PubMed:19365570). Expressed in the thymus (PubMed:10438950). Expressed in B-cells (PubMed:12517963).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by IL1A and LTA, in thymus cortical reticular cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000028121, Expressed in primary oocyte and 282 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9QZK2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on integrin mediated-tyrosine phosphorylation of PTPRA (PubMed:22801373). Within the complex, interacts (via SH2 domain) with PTPRA (when phosphorylated on 'Tyr-825') (PubMed:22801373).

Interacts (via Ras-GEF domain) with BCAR1 (PubMed:10438950, PubMed:10896938, PubMed:12517963).

Interacts with (via Ras-GEF domain) NEDD9 (PubMed:12517963).

Interacts with PTK2B/FAK1 (PubMed:10896938).

Interacts with PTPN1.

Interacts (via SH2 domain) with EGFR (when tyrosine-phosphorylated) (By similarity).

By similarity4 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		205895, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000029766

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9QZK2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9QZK2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini148 – 247SH2PROSITE-ProRule annotationAdd BLAST100
Domaini543 – 813Ras-GEFPROSITE-ProRule annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni739 – 743Mediates the interaction with BCAR1/p130CASBy similarity5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH2 domain mediates interaction with tyrosine-phosphorylated proteins (PubMed:10896938, PubMed:22801373). However, not involved in the binding to phosphorylated BCAR1 (PubMed:10896938). Required for cell cycle progression in response to INS/insulin (By similarity). Required for regulation of EGF-induced DNA synthesis (By similarity).By similarity2 Publications
The Ras-GEF domain appears to adopt a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is probably required for interaction with BCAR1.1 Publication

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPX3, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015281_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9QZK2

Identification of Orthologs from Complete Genome Data

More...OMAi		CSAFHAF

Database of Orthologous Groups

More...OrthoDBi		138275at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9QZK2

TreeFam database of animal gene trees

More...TreeFami		TF323756

Family and domain databases

Conserved Domains Database

More...CDDi		cd10337, SH2_BCAR3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.840.10, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028849, BCAR3
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR044102, SH2_SHEP1/BCAR3/NSP1

The PANTHER Classification System

More...PANTHERi		PTHR14247:SF10, PTHR14247:SF10, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00617, RasGEF, 1 hit
PF00017, SH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00147, RasGEF, 1 hit
SM00252, SH2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48366, SSF48366, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50009, RASGEF_CAT, 1 hit
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QZK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGKFASLP RNMPVNHQFP LASSMDLLSS KSPLAERRTD AYQDVSIHGT 
        60         70         80         90        100
LPRKKKGPPS IRSCDNAGHS KSPRQSSPLT QDIIQENPLQ DRKGENFIFR 
       110        120        130        140        150
DPYLLDPTLE YVKFSKERHI MDRTPERLKK ELEEELLLSS EDLRSHAWYH 
       160        170        180        190        200
GRIPRQVSEN LVQRDGDFLV RDSLSSPGNF VLTCQWKNLA QHFKINRTVL 
       210        220        230        240        250
RLSEAYSRVQ YQFEMESFDS IPGLVRCYVG NRRPISQQSG AIIFQPINRT 
       260        270        280        290        300
VPLWCLEERY GTSPGRGREG SLAEGRPDVV KRLSLTTGSS IQAREHSLPR 
       310        320        330        340        350
GNLLRNKEKS GSQPACLDHV QDRKALTLKA HQSESHLPIG CKLPPQSPSM 
       360        370        380        390        400
DTSPCPSSPV FRTGSEPTLS PALVRRFSSD ARTGEALRGS DSQLCPKPPP 
       410        420        430        440        450
KPCKVPFLKT PPSPSPWLTS EANYCELNPA FAVGCDRGAK LPMQAHDSHE 
       460        470        480        490        500
MLLTAKQNGP SGPRNSGINY MILDGDDQAR HWDPLAVQTD EGQEDKTKFV 
       510        520        530        540        550
PPLMETVSSF RPNDFESKLL PPENKPLETA MLKHAKELFT NHDARVIAQH 
       560        570        580        590        600
MLSVDCKVAR ILEVSEDRKR SMGVSSGLEL ITLPHGRQLR LDIIERHNTM 
       610        620        630        640        650
AIGIAVDILG CTGTLENRAG TLNKIIQVAV ELKDAMGDLY AFSAIMKALE 
       660        670        680        690        700
MPQITRLEKT WTALRHHYTQ TAILYEKQLK PFSKILHEGR ESTYVPASNV 
       710        720        730        740        750
SVPLLMPLVT LMERQAVTFE GTDMWENNDE SCEILLNHLA TARFMAEASE 
       760        770        780        790        800
SYRMNAERIL ADFQPDEEMT EILRTEFQMR LLWGSKGAEV NQNERYDKFN 
       810        820
QILTALSRKL EPPSGKQAEL
Length:820
Mass (Da):92,263
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69DDACECDE869F01
GO
Isoform 2 (identifier: Q9QZK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Show »
Length:700
Mass (Da):78,735
Checksum:i569413486AA3F464
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGV2A0A0G2JGV2_MOUSE
Breast cancer anti-estrogen resista...
Bcar3
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFC0A0A0G2JFC0_MOUSE
Breast cancer anti-estrogen resista...
Bcar3
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDE7A0A0G2JDE7_MOUSE
Breast cancer anti-estrogen resista...
Bcar3
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDR4A0A0G2JDR4_MOUSE
Breast cancer anti-estrogen resista...
Bcar3
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36E → G in BAE25587 (PubMed:16141072).Curated1
Sequence conflicti525K → E in BAE25587 (PubMed:16141072).Curated1
Sequence conflicti795R → G in BAE38160 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0178151 – 120Missing in isoform 2. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF179566 mRNA Translation: AAD53182.1
AK143894 mRNA Translation: BAE25587.1
AK165396 mRNA Translation: BAE38160.1
BC023930 mRNA Translation: AAH23930.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS17810.1 [Q9QZK2-1]

NCBI Reference Sequences

More...RefSeqi		NP_038895.1, NM_013867.2 [Q9QZK2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000029766; ENSMUSP00000029766; ENSMUSG00000028121 [Q9QZK2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		29815

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:29815

UCSC genome browser

More...UCSCi		uc008req.2, mouse [Q9QZK2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179566 mRNA Translation: AAD53182.1
AK143894 mRNA Translation: BAE25587.1
AK165396 mRNA Translation: BAE38160.1
BC023930 mRNA Translation: AAH23930.1
CCDSiCCDS17810.1 [Q9QZK2-1]
RefSeqiNP_038895.1, NM_013867.2 [Q9QZK2-1]

3D structure databases

SMRiQ9QZK2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi205895, 1 interactor
STRINGi10090.ENSMUSP00000029766

PTM databases

iPTMnetiQ9QZK2
PhosphoSitePlusiQ9QZK2

Proteomic databases

PaxDbiQ9QZK2
PeptideAtlasiQ9QZK2
PRIDEiQ9QZK2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2973, 153 antibodies

Genome annotation databases

EnsembliENSMUST00000029766; ENSMUSP00000029766; ENSMUSG00000028121 [Q9QZK2-1]
GeneIDi29815
KEGGimmu:29815
UCSCiuc008req.2, mouse [Q9QZK2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8412
MGIiMGI:1352501, Bcar3

Phylogenomic databases

eggNOGiENOG502QPX3, Eukaryota
GeneTreeiENSGT00940000154130
HOGENOMiCLU_015281_0_0_1
InParanoidiQ9QZK2
OMAiCSAFHAF
OrthoDBi138275at2759
PhylomeDBiQ9QZK2
TreeFamiTF323756

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		29815, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Bcar3, mouse

Protein Ontology

More...PROi		PR:Q9QZK2
RNActiQ9QZK2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000028121, Expressed in primary oocyte and 282 other tissues
GenevisibleiQ9QZK2, MM

Family and domain databases

CDDicd10337, SH2_BCAR3, 1 hit
Gene3Di1.10.840.10, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR028849, BCAR3
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR044102, SH2_SHEP1/BCAR3/NSP1
PANTHERiPTHR14247:SF10, PTHR14247:SF10, 1 hit
PfamiView protein in Pfam
PF00617, RasGEF, 1 hit
PF00017, SH2, 1 hit
SMARTiView protein in SMART
SM00147, RasGEF, 1 hit
SM00252, SH2, 1 hit
SUPFAMiSSF48366, SSF48366, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50009, RASGEF_CAT, 1 hit
PS50001, SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCAR3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QZK2
Secondary accession number(s): Q3TNC9, Q3UP10
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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