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Protein

Serine incorporator 3

Gene

Serinc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm.By similarity

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-977347 Serine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 3
Alternative name(s):
Axotomy-induced glyco/Golgi protein 11 Publication
Short name:
AIGP-11 Publication
Axotomy-induced glycoprotein 11 Publication
Membrane protein TMS-1
Tumor differentially expressed protein 1
Gene namesi
Name:Serinc3
Synonyms:Aigp11 Publication, Diff33, Tde1, Tms1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1349457 Serinc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 96ExtracellularSequence analysisAdd BLAST96
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 132CytoplasmicSequence analysisAdd BLAST15
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 158ExtracellularSequence analysis5
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 206CytoplasmicSequence analysisAdd BLAST27
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 238ExtracellularSequence analysisAdd BLAST11
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 329CytoplasmicSequence analysisAdd BLAST70
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 405ExtracellularSequence analysisAdd BLAST55
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 445CytoplasmicSequence analysisAdd BLAST19
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467 – 472ExtracellularSequence analysis6

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189711 – 472Serine incorporator 3Add BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei371PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9QZI9
MaxQBiQ9QZI9
PaxDbiQ9QZI9
PRIDEiQ9QZI9

PTM databases

iPTMnetiQ9QZI9
PhosphoSitePlusiQ9QZI9
SwissPalmiQ9QZI9

Expressioni

Tissue specificityi

Highly expressed in the neuronal populations such as Purkinje cells in the cerebellum, brainstem and spinal motor neurons, locus coeruleus and raphe nuclei. Highly expressed also in thymus, kidney liver and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000017707 Expressed in 308 organ(s), highest expression level in lung
CleanExiMM_SERINC3
GenevisibleiQ9QZI9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017851

Structurei

3D structure databases

ProteinModelPortaliQ9QZI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00550000074522
HOGENOMiHOG000165463
HOVERGENiHBG025699
InParanoidiQ9QZI9
OMAiRMEEGNP
OrthoDBiEOG091G07WS
TreeFamiTF312881

Family and domain databases

InterProiView protein in InterPro
IPR029557 Serinc3
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF27 PTHR10383:SF27, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QZI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP ISKNSTVTRL IYAFILFLGT
60 70 80 90 100
IVSCIMMTEG IQTQLKKIPG FCEGGFQIKM VDTKAEKDCD VLVGFKAVYR
110 120 130 140 150
INFAVAIFFF AFFLLMLKVK TSKDPRAAVH NGFWFFKIAA IIGIMIGSFY
160 170 180 190 200
IPGGSFTEVW FVAGMLGASF FIIIQLVLLV DMAHSWNELW VNRMEEGNPR
210 220 230 240 250
LWYAALLSFT SLFYILSIVF AALLYVFYTK PDDCTENKVF ISLNLIFCVA
260 270 280 290 300
VSIVSILPKV QEHQPRSGLL QSSIITLYTL YLTWSAMTNE PERSCNPSLM
310 320 330 340 350
SIITHLTSPT VSPANSTTLA PAYAPPSQSG HFMNLDDIWG LIIFVFCLIY
360 370 380 390 400
SSFRTSSNSQ VNKLTLSGSD SVILGDTTNG ANDEEDGQPR RAVDNEKEGV
410 420 430 440 450
QYSYSFFHLM LCCASLYIMM TITSWYSPDA KFQKVSSKWL AVWFKMGSSW
460 470
LCLLLYLWTL VAPLVLTGRD FS
Length:472
Mass (Da):52,623
Last modified:October 31, 2003 - v2
Checksum:iF0EE1DA4BECE8CF0
GO

Sequence cautioni

The sequence AAA74236 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6G → A in AAD54420 (PubMed:10637174).Curated1
Sequence conflicti108F → I in BAC27253 (PubMed:16141072).Curated1
Sequence conflicti162V → F in AAH11295 (PubMed:15489334).Curated1
Sequence conflicti162V → F in AAH22901 (PubMed:15489334).Curated1
Sequence conflicti162V → F in AAH29026 (PubMed:15489334).Curated1
Sequence conflicti324A → R (PubMed:10637174).Curated1
Sequence conflicti324A → R (PubMed:7894057).Curated1
Sequence conflicti403S → N in AAH11295 (PubMed:15489334).Curated1
Sequence conflicti403S → N in AAH22901 (PubMed:15489334).Curated1
Sequence conflicti403S → N in AAH29026 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181684 mRNA Translation: AAD54420.1
AB029499 mRNA Translation: BAC44828.1
AB078029 Genomic DNA Translation: BAC05511.1
AK031101 mRNA Translation: BAC27253.1
AK150106 mRNA Translation: BAE29313.1
AK152720 mRNA Translation: BAE31443.1
AK155921 mRNA Translation: BAE33504.1
AK159347 mRNA Translation: BAE35009.1
AK159819 mRNA Translation: BAE35399.1
AK160005 mRNA Translation: BAE35553.1
AK160055 mRNA Translation: BAE35593.1
AK161981 mRNA Translation: BAE36664.1
AK164807 mRNA Translation: BAE37929.1
AK166924 mRNA Translation: BAE39119.1
AK170350 mRNA Translation: BAE41738.1
BC011295 mRNA Translation: AAH11295.1
BC022901 mRNA Translation: AAH22901.1
BC029026 mRNA Translation: AAH29026.1
L29441 mRNA Translation: AAA74236.1 Different initiation.
CCDSiCCDS17013.1
PIRiI53063
RefSeqiNP_036162.3, NM_012032.4
UniGeneiMm.218473
Mm.281691

Genome annotation databases

EnsembliENSMUST00000017851; ENSMUSP00000017851; ENSMUSG00000017707
GeneIDi26943
KEGGimmu:26943
UCSCiuc008ntg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181684 mRNA Translation: AAD54420.1
AB029499 mRNA Translation: BAC44828.1
AB078029 Genomic DNA Translation: BAC05511.1
AK031101 mRNA Translation: BAC27253.1
AK150106 mRNA Translation: BAE29313.1
AK152720 mRNA Translation: BAE31443.1
AK155921 mRNA Translation: BAE33504.1
AK159347 mRNA Translation: BAE35009.1
AK159819 mRNA Translation: BAE35399.1
AK160005 mRNA Translation: BAE35553.1
AK160055 mRNA Translation: BAE35593.1
AK161981 mRNA Translation: BAE36664.1
AK164807 mRNA Translation: BAE37929.1
AK166924 mRNA Translation: BAE39119.1
AK170350 mRNA Translation: BAE41738.1
BC011295 mRNA Translation: AAH11295.1
BC022901 mRNA Translation: AAH22901.1
BC029026 mRNA Translation: AAH29026.1
L29441 mRNA Translation: AAA74236.1 Different initiation.
CCDSiCCDS17013.1
PIRiI53063
RefSeqiNP_036162.3, NM_012032.4
UniGeneiMm.218473
Mm.281691

3D structure databases

ProteinModelPortaliQ9QZI9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017851

PTM databases

iPTMnetiQ9QZI9
PhosphoSitePlusiQ9QZI9
SwissPalmiQ9QZI9

Proteomic databases

EPDiQ9QZI9
MaxQBiQ9QZI9
PaxDbiQ9QZI9
PRIDEiQ9QZI9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017851; ENSMUSP00000017851; ENSMUSG00000017707
GeneIDi26943
KEGGimmu:26943
UCSCiuc008ntg.2 mouse

Organism-specific databases

CTDi10955
MGIiMGI:1349457 Serinc3

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00550000074522
HOGENOMiHOG000165463
HOVERGENiHBG025699
InParanoidiQ9QZI9
OMAiRMEEGNP
OrthoDBiEOG091G07WS
TreeFamiTF312881

Enzyme and pathway databases

ReactomeiR-MMU-977347 Serine biosynthesis

Miscellaneous databases

ChiTaRSiSerinc3 mouse
PROiPR:Q9QZI9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017707 Expressed in 308 organ(s), highest expression level in lung
CleanExiMM_SERINC3
GenevisibleiQ9QZI9 MM

Family and domain databases

InterProiView protein in InterPro
IPR029557 Serinc3
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF27 PTHR10383:SF27, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSERC3_MOUSE
AccessioniPrimary (citable) accession number: Q9QZI9
Secondary accession number(s): Q3U7C6
, Q62310, Q8BSP9, Q8CFD3, Q91VN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 31, 2003
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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